| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 20,763,323 | 22,909,753 | +2,146,430 | 0.55 | 1.49 | +0.94 | buy |
| FIL Ltd | 0 | 1,875,872 | +1,875,872 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 259,296 | 601,241 | +341,945 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 702,900 | 993,300 | +290,400 | 0.01 | 0.01 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 3,146,833 | 3,412,005 | +265,172 | 0.02 | 0.02 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 146,190 | 350,670 | +204,480 | 0.06 | 0.17 | +0.11 | buy |
| TORONTO DOMINION BANK | 175 | 140,000 | +139,825 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 133,654 | +133,654 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 112,092 | 243,440 | +131,348 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 20,986 | 120,657 | +99,671 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 240,225 | 335,992 | +95,767 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 30,100 | 102,870 | +72,770 | 0.01 | 0.02 | +0.02 | buy |
| HSBC HOLDINGS PLC | 33,798 | 90,324 | +56,526 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 56,477 | +56,477 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 4,009 | 56,860 | +52,851 | 0.00 | 0.01 | +0.01 | buy |
| STIFEL FINANCIAL CORP | 64,623 | 110,145 | +45,522 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 416,178 | 460,900 | +44,722 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 39,472 | +39,472 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 210,076 | 247,378 | +37,302 | 0.12 | 0.16 | +0.03 | buy |
| MQS Management LLC | 0 | 35,223 | +35,223 | 0.00 | 0.11 | +0.11 | buy |
| HRT FINANCIAL LP | 62,201 | 90,562 | +28,361 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,423 | 33,566 | +26,143 | 0.01 | 0.04 | +0.03 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 92,971 | 111,188 | +18,217 | 0.00 | 0.00 | +0.00 | buy |
| JGP Global Gestao de Recursos Ltda. | 0 | 17,417 | +17,417 | 0.00 | 0.06 | +0.06 | buy |
| GTS SECURITIES LLC | 16,143 | 31,748 | +15,605 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 14,853 | +14,853 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 14,259 | +14,259 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 13,720 | +13,720 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 0 | 13,112 | +13,112 | 0.00 | 0.00 | +0.00 | buy |
| Intellectus Partners, LLC | 876,633 | 887,283 | +10,650 | 1.28 | 1.46 | +0.19 | buy |
| Farther Finance Advisors, LLC | 0 | 10,012 | +10,012 | 0.00 | 0.00 | +0.00 | buy |
| B. Riley Wealth Advisors, Inc. | 10,500 | 19,500 | +9,000 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 2,608 | 10,596 | +7,988 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 83,867 | 91,367 | +7,500 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 34,043 | 40,971 | +6,928 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 40,000 | 45,400 | +5,400 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 89,375 | 94,567 | +5,192 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 34,214 | 38,855 | +4,641 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 4,262 | 8,104 | +3,842 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 13,385 | 16,894 | +3,509 | 0.04 | 0.06 | +0.02 | buy |
| Pacifica Partners Inc. | 2,635 | 4,820 | +2,185 | 0.01 | 0.01 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 6,000 | 8,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 538 | 2,468 | +1,930 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 6,085 | 7,685 | +1,600 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 11,800 | 13,164 | +1,364 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 882 | 2,003 | +1,121 | 0.00 | 0.00 | +0.00 | buy |
| NBC SECURITIES, INC. | 6,720 | 7,720 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 255,298 | 256,144 | +846 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 2,234 | 2,955 | +721 | 0.00 | 0.00 | +0.00 | buy |
| C M BIDWELL & ASSOCIATES LTD | 394 | 758 | +364 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 51,760 | 52,007 | +247 | 0.00 | 0.00 | +0.00 | buy |
| CVA Family Office, LLC | 0 | 230 | +230 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Trading LLC | 538 | 748 | +210 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 150 | +150 | 0.00 | 0.00 | +0.00 | buy |
| Financial Synergies Wealth Advisors, Inc. | 0 | 89 | +89 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 4,180,768 | 4,180,768 | 0 | 0.41 | 0.48 | +0.07 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 86,624 | 86,624 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 10,624,185 | 10,624,185 | 0 | 0.05 | 0.06 | +0.01 | hold |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 250,248 | 250,248 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BRANDYWINE MANAGERS, LLC | 56,976 | 56,976 | 0 | 0.44 | 0.36 | -0.09 | hold |
| COOKSON PEIRCE & CO INC | 20,000 | 20,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Polar Asset Management Partners Inc. | 117,830 | 117,830 | 0 | 0.01 | 0.02 | +0.01 | hold |
| NORGES BANK | 922,214 | 922,214 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Novo Holdings A/S | 1,126,915 | 1,126,915 | 0 | 0.38 | 0.40 | +0.01 | hold |
| MACQUARIE GROUP LTD | 119,399 | 119,399 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 87,000 | 87,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sumitomo Mitsui Trust Group, Inc. | 62,759 | 62,759 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 1,151 | 1,151 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ArchPoint Investors | 115,055 | 115,055 | 0 | 0.20 | 0.27 | +0.07 | hold |
| ArrowMark Colorado Holdings LLC | 4,105,095 | 4,105,095 | 0 | 0.23 | 0.26 | +0.03 | hold |
| Casdin Capital, LLC | 2,360,129 | 2,360,129 | 0 | 1.21 | 1.33 | +0.12 | hold |
| Duquesne Family Office LLC | 659,750 | 659,750 | 0 | 0.11 | 0.12 | +0.01 | hold |
| Cerity Partners LLC | 20,557 | 20,557 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NewEdge Advisors, LLC | 300 | 300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MISSION WEALTH MANAGEMENT, LP | 10,651 | 10,651 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 2,300 | 2,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Global Retirement Partners, LLC | 416 | 416 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Nan Fung Group Holdings Ltd | 12,521 | 12,521 | 0 | 0.05 | 0.04 | -0.00 | hold |
| Belmont Capital, LLC | 510,000 | 510,000 | 0 | 1.27 | 1.24 | -0.02 | hold |
| Resolute Advisors LLC | 57,526 | 57,526 | 0 | 0.04 | 0.04 | +0.00 | hold |
| Founders Fund VII Management, LLC | 3,773,530 | 3,773,530 | 0 | 89.37 | 89.83 | +0.45 | hold |
| Founders Fund Growth Management, LLC | 407,017 | 407,017 | 0 | 5.10 | 2.81 | -2.29 | hold |
| Eagle Bay Advisors LLC | 710 | 710 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Beaird Harris Wealth Management, LLC | 600 | 600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Erste Asset Management GmbH | 62,000 | 62,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| SEARLE & CO. | 13,900 | 13,900 | 0 | 0.02 | 0.02 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| CGC Financial Services, LLC | 40 | 0 | -40 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 670 | 610 | -60 | 0.00 | 0.00 | +0.00 | sell |
| Coppell Advisory Solutions LLC | 252 | 0 | -252 | 0.01 | 0.00 | -0.01 | sell |
| Allworth Financial LP | 335 | 0 | -335 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 18,916 | 18,540 | -376 | 0.00 | 0.00 | +0.00 | sell |
| GUGGENHEIM CAPITAL LLC | 12,195 | 11,738 | -457 | 0.00 | 0.00 | +0.00 | sell |
| Integrity Financial Corp /WA | 13,050 | 12,050 | -1,000 | 0.05 | 0.05 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 8,471 | 6,285 | -2,186 | 0.00 | 0.00 | -0.00 | sell |
| Cambridge Investment Research Advisors, Inc. | 34,335 | 31,626 | -2,709 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 293,570 | 289,886 | -3,684 | 0.00 | 0.00 | +0.00 | sell |
| Stratos Wealth Advisors, LLC | 48,500 | 43,500 | -5,000 | 0.01 | 0.01 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 176,534 | 171,516 | -5,018 | 0.00 | 0.00 | +0.00 | sell |