| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 27,525,640 | 27,525,640 | 0 | 0.74 | 0.86 | +0.12 | hold |
| BAILLIE GIFFORD & CO | 12,894,703 | 12,236,465 | -658,238 | 0.03 | 0.03 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 10,624,185 | 10,624,185 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Capital World Investors | 0 | 7,933,613 | +7,933,613 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 9,079,539 | 7,350,000 | -1,729,539 | 5.99 | 6.03 | +0.05 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 4,590,103 | 4,500,000 | -90,103 | 0.00 | 0.00 | +0.00 | sell |
| ORBIMED ADVISORS LLC | 4,180,768 | 4,180,768 | 0 | 0.20 | 0.25 | +0.06 | hold |
| ArrowMark Colorado Holdings LLC | 4,105,095 | 4,105,095 | 0 | 0.14 | 0.16 | +0.03 | hold |
| BlackRock, Inc. | 3,988,692 | 4,096,643 | +107,951 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 2,533,635 | 3,257,311 | +723,676 | 0.01 | 0.02 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 2,177,600 | 2,608,400 | +430,800 | 0.01 | 0.02 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,300,000 | 2,582,816 | +282,816 | 0.43 | 0.50 | +0.07 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 2,946,703 | 2,486,893 | -459,810 | 0.01 | 0.01 | -0.00 | sell |
| UBS Group AG | 0 | 1,975,348 | +1,975,348 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 753,887 | 1,482,715 | +728,828 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 922,214 | 1,284,533 | +362,319 | 0.00 | 0.00 | +0.00 | buy |
| Novo Holdings A/S | 1,126,915 | 1,126,915 | 0 | 0.15 | 0.20 | +0.05 | hold |
| Opaleye Management Inc. | 800,000 | 965,000 | +165,000 | 0.35 | 0.49 | +0.15 | buy |
| MORGAN STANLEY | 589,653 | 937,385 | +347,732 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 1,096,575 | 928,594 | -167,981 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 2,282,696 | 916,237 | -1,366,459 | 0.01 | 0.01 | -0.01 | sell |
| CITADEL ADVISORS LLC | 1,499,640 | 597,251 | -902,389 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 241,866 | 589,213 | +347,347 | 0.05 | 0.13 | +0.08 | buy |
| Intellectus Partners, LLC | 545,533 | 547,533 | +2,000 | 0.36 | 0.36 | -0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 234,064 | 417,396 | +183,332 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 407,384 | 406,991 | -393 | 0.00 | 0.00 | +0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 340,267 | 340,267 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 323,229 | 324,802 | +1,573 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 58,237 | 305,579 | +247,342 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 205,707 | 299,813 | +94,106 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 281,795 | +281,795 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 355,747 | 281,033 | -74,714 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 129,904 | 250,226 | +120,322 | 0.00 | 0.00 | +0.00 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 195,500 | 236,900 | +41,400 | 0.11 | 0.14 | +0.02 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 13,371 | 178,839 | +165,468 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 117,158 | 168,682 | +51,524 | 0.17 | 0.21 | +0.03 | buy |
| OSAIC HOLDINGS, INC. | 104,254 | 132,014 | +27,760 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 105,952 | 128,407 | +22,455 | 0.00 | 0.00 | +0.00 | buy |
| TrueMark Investments, LLC | 134,414 | 124,089 | -10,325 | 0.11 | 0.12 | +0.00 | sell |
| Polar Asset Management Partners Inc. | 117,830 | 117,830 | 0 | 0.01 | 0.01 | -0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 117,126 | 116,887 | -239 | 0.00 | 0.00 | +0.00 | sell |
| ArchPoint Investors | 115,055 | 115,055 | 0 | 0.10 | 0.11 | +0.01 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 113,653 | 113,773 | +120 | 0.00 | 0.00 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 232,424 | 104,594 | -127,830 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 0 | 103,610 | +103,610 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 0 | 91,754 | +91,754 | 0.00 | 0.02 | +0.02 | buy |
| Moloney Securities Asset Management, LLC | 0 | 90,400 | +90,400 | 0.00 | 0.04 | +0.04 | buy |
| GROUP ONE TRADING LLC | 74,984 | 89,204 | +14,220 | 0.01 | 0.01 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 87,000 | 87,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Brevan Howard Capital Management LP | 12,886 | 83,519 | +70,633 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 39,447 | 81,621 | +42,174 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 65,097 | 74,901 | +9,804 | 0.00 | 0.00 | +0.00 | buy |
| SALEM INVESTMENT COUNSELORS INC | 191,150 | 73,650 | -117,500 | 0.01 | 0.01 | -0.01 | sell |
| STIFEL FINANCIAL CORP | 74,814 | 71,514 | -3,300 | 0.00 | 0.00 | +0.00 | sell |
| Creative Planning | 35,799 | 71,426 | +35,627 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 10,486 | 71,086 | +60,600 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 64,304 | 64,304 | 0 | 0.01 | 0.02 | +0.00 | hold |
| Centiva Capital, LP | 0 | 62,899 | +62,899 | 0.00 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 56,674 | 62,629 | +5,955 | 0.02 | 0.02 | +0.00 | buy |
| Erste Asset Management GmbH | 62,000 | 62,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Resolute Advisors LLC | 61,576 | 61,576 | 0 | 0.03 | 0.04 | +0.00 | hold |
| Squarepoint Ops LLC | 13,318 | 57,685 | +44,367 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 35,659 | 57,466 | +21,807 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 29,838 | 54,709 | +24,871 | 0.01 | 0.01 | +0.01 | buy |
| Cerity Partners LLC | 53,057 | 53,057 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BANK OF MONTREAL /CAN/ | 58,013 | 51,447 | -6,566 | 0.00 | 0.00 | +0.00 | sell |
| STANSBERRY ASSET MANAGEMENT, LLC | 83,937 | 40,474 | -43,463 | 0.03 | 0.02 | -0.01 | sell |
| SIGNATURE ESTATE & INVESTMENT ADVISORS LLC | 39,668 | 39,668 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 22,293 | 38,351 | +16,058 | 0.00 | 0.00 | +0.00 | buy |
| Green Alpha Advisors, LLC | 48,515 | 37,835 | -10,680 | 0.10 | 0.09 | -0.01 | sell |
| Quadrature Capital Ltd | 59,617 | 36,456 | -23,161 | 0.00 | 0.00 | -0.00 | sell |
| BRANDYWINE MANAGERS, LLC | 28,488 | 28,488 | 0 | 0.08 | 0.09 | +0.01 | hold |
| EVERGREEN CAPITAL MANAGEMENT LLC | 11,902 | 28,289 | +16,387 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 27,678 | 24,099 | -3,579 | 0.03 | 0.03 | -0.00 | sell |
| FIL Ltd | 123,879 | 24,061 | -99,818 | 0.00 | 0.00 | -0.00 | sell |
| JGP Global Gestao de Recursos Ltda. | 22,598 | 22,598 | 0 | 0.12 | 0.15 | +0.04 | hold |
| Vanguard Personalized Indexing Management, LLC | 14,951 | 22,377 | +7,426 | 0.00 | 0.00 | +0.00 | buy |
| Clarkston Capital Partners, LLC | 22,000 | 22,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 0 | 21,664 | +21,664 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 21,497 | 21,499 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Pathstone Holdings, LLC | 31,503 | 21,363 | -10,140 | 0.00 | 0.00 | -0.00 | sell |
| RPO LLC | 0 | 20,937 | +20,937 | 0.00 | 0.08 | +0.08 | buy |
| Ballentine Partners, LLC | 20,732 | 19,942 | -790 | 0.00 | 0.00 | +0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 23,209 | 18,428 | -4,781 | 0.00 | 0.00 | -0.00 | sell |
| Diametric Capital, LP | 0 | 18,104 | +18,104 | 0.00 | 0.04 | +0.04 | buy |
| Lantern Wealth Advisors, LLC | 23,300 | 18,000 | -5,300 | 0.04 | 0.03 | -0.01 | sell |
| CIBC WORLD MARKET INC. | 17,665 | 16,865 | -800 | 0.00 | 0.00 | +0.00 | sell |
| Farther Finance Advisors, LLC | 16,499 | 15,893 | -606 | 0.00 | 0.00 | +0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 15,703 | +15,703 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 11,750 | 15,400 | +3,650 | 0.00 | 0.00 | +0.00 | buy |
| SCOTIA CAPITAL INC. | 15,124 | 15,124 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Walleye Capital LLC | 256,881 | 15,000 | -241,881 | 0.01 | 0.00 | -0.01 | sell |
| ADAR1 Capital Management, LLC | 114,981 | 14,981 | -100,000 | 0.05 | 0.01 | -0.04 | sell |
| Mariner, LLC | 0 | 14,540 | +14,540 | 0.00 | 0.00 | +0.00 | buy |
| PFG Investments, LLC | 14,000 | 14,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ProShare Advisors LLC | 17,412 | 13,990 | -3,422 | 0.00 | 0.00 | -0.00 | sell |
| Cetera Investment Advisers | 13,877 | 13,806 | -71 | 0.00 | 0.00 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 13,521 | +13,521 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 5,234 | 12,616 | +7,382 | 0.00 | 0.00 | +0.00 | buy |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 11,000 | 12,600 | +1,600 | 0.00 | 0.00 | +0.00 | buy |