| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Verition Fund Management LLC | 58,086 | 140,091 | +82,005 | 0.03 | 0.12 | +0.09 | buy |
| Invesco Ltd. | 0 | 72,419 | +72,419 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 60,894 | +60,894 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 45,171 | +45,171 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 5,610 | 40,902 | +35,292 | 0.00 | 0.05 | +0.04 | buy |
| Qube Research & Technologies Ltd | 1,005 | 23,211 | +22,206 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 7,365 | 25,814 | +18,449 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 13,407 | +13,407 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 13,163 | +13,163 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 5,600 | 18,100 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 11,276 | +11,276 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 5,027 | +5,027 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 3,773 | +3,773 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 3,602 | +3,602 | 0.00 | 0.03 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 3,147 | +3,147 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 17,007 | 19,289 | +2,282 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 57,374 | 58,241 | +867 | 0.00 | 0.00 | +0.00 | buy |
| Artal Group S.A. | 418,605 | 419,226 | +621 | 0.68 | 0.97 | +0.29 | buy |
| Quarry LP | 0 | 400 | +400 | 0.00 | 0.01 | +0.01 | buy |
| MACQUARIE GROUP LTD | 0 | 389 | +389 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 529,173 | 529,180 | +7 | 0.02 | 0.04 | +0.02 | buy |
| DUNCKER STREETT & CO INC | 437 | 437 | 0 | 0.00 | 0.01 | +0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 9,893 | 9,893 | 0 | 0.00 | 0.00 | +0.00 | hold |
| North Star Investment Management Corp. | 1,000 | 1,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| NEA Management Company, LLC | 1,072,936 | 1,072,936 | 0 | 2.74 | 5.99 | +3.25 | hold |
| CWM, LLC | 6 | 6 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 73,821 | 73,821 | 0 | 0.16 | 0.28 | +0.12 | hold |
| Cormorant Asset Management, LP | 529,170 | 529,170 | 0 | 1.21 | 2.10 | +0.88 | hold |
| Point72 Asset Management, L.P. | 265,826 | 265,826 | 0 | 0.04 | 0.07 | +0.03 | hold |
| 72 Investment Holdings, LLC | 276,831 | 276,831 | 0 | 58.92 | 37.14 | -21.78 | hold |
| Qiming U.S. Ventures Management, LLC | 368,085 | 368,085 | 0 | 16.15 | 36.93 | +20.78 | hold |
| City State Bank | 20 | 20 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Atlas Venture Life Science Advisors, LLC | 1,119,292 | 1,119,292 | 0 | 6.39 | 9.30 | +2.91 | hold |
| TD Waterhouse Canada Inc. | 29 | 29 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Kelly Financial Services LLC | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FMR LLC | 727,205 | 727,205 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 4 | 0 | -4 | 0.00 | 0.00 | -0.00 | sell |
| Orion Capital Management LLC | 20 | 0 | -20 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 10,510 | 10,293 | -217 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,962 | 50 | -3,912 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 270,974 | 266,667 | -4,307 | 0.00 | 0.00 | +0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 546,325 | 537,490 | -8,835 | 0.43 | 0.76 | +0.33 | sell |
| Monashee Investment Management LLC | 90,805 | 55,364 | -35,441 | 0.77 | 0.59 | -0.18 | sell |