| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 0 | 380,303 | +380,303 | 0.00 | 0.50 | +0.50 | buy |
| Polar Capital Holdings Plc | 75,000 | 250,000 | +175,000 | 0.02 | 0.03 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 494,905 | 582,449 | +87,544 | 0.16 | 0.10 | -0.06 | buy |
| Aberdeen Group plc | 0 | 84,428 | +84,428 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 0 | 47,086 | +47,086 | 0.00 | 0.23 | +0.23 | buy |
| Point72 Asset Management, L.P. | 493,997 | 520,890 | +26,893 | 0.05 | 0.03 | -0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 95,808 | 108,869 | +13,061 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 57,978 | 68,715 | +10,737 | 0.45 | 0.23 | -0.22 | buy |
| XTX Topco Ltd | 0 | 10,600 | +10,600 | 0.00 | 0.01 | +0.01 | buy |
| RAYMOND JAMES FINANCIAL INC | 10,347 | 18,222 | +7,875 | 0.00 | 0.00 | -0.00 | buy |
| AlphaQuest LLC | 2,189 | 9,196 | +7,007 | 0.01 | 0.02 | +0.01 | buy |
| BLAIR WILLIAM & CO/IL | 12,895 | 16,230 | +3,335 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 137,087 | 140,221 | +3,134 | 0.00 | 0.00 | -0.00 | buy |
| Quarry LP | 0 | 2,011 | +2,011 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 641,739 | 643,269 | +1,530 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 14,788 | 16,113 | +1,325 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 73,039 | 74,211 | +1,172 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 17,498 | 18,288 | +790 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 8 | 593 | +585 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 278 | 764 | +486 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 3,392 | 3,793 | +401 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 26 | 331 | +305 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 2,854 | 3,069 | +215 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 3,502 | 3,658 | +156 | 0.00 | 0.00 | -0.00 | buy |
| Steward Partners Investment Advisory, LLC | 550 | 650 | +100 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 64 | +64 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS | 0 | 59 | +59 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| DUNCKER STREETT & CO INC | 437 | 437 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MAI Capital Management | 5 | 5 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ORBIMED ADVISORS LLC | 32,400 | 32,400 | 0 | 0.03 | 0.01 | -0.01 | hold |
| Ameritas Investment Partners, Inc. | 598 | 598 | 0 | 0.00 | 0.00 | -0.00 | hold |
| North Star Investment Management Corp. | 1,800 | 1,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEA Management Company, LLC | 1,090,793 | 1,090,793 | 0 | 2.34 | 1.46 | -0.88 | hold |
| MetLife Investment Management, LLC | 3,639 | 3,639 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rock Springs Capital Management LP | 35,719 | 35,719 | 0 | 0.05 | 0.04 | -0.02 | hold |
| 72 Investment Holdings, LLC | 276,831 | 276,831 | 0 | 21.46 | 13.54 | -7.92 | hold |
| SBI Securities Co., Ltd. | 7 | 7 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Deep Track Capital, LP | 874,614 | 874,614 | 0 | 1.25 | 0.49 | -0.76 | hold |
| Spire Wealth Management | 39 | 39 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Qiming U.S. Ventures Management, LLC | 368,085 | 368,085 | 0 | 27.40 | 27.74 | +0.34 | hold |
| Atlas Venture Life Science Advisors, LLC | 1,137,149 | 1,137,149 | 0 | 5.28 | 3.79 | -1.49 | hold |
| Siren, L.L.C. | 418,833 | 418,833 | 0 | 0.70 | 0.41 | -0.29 | hold |
| Police & Firemen's Retirement System of New Jersey | 1,226 | 1,226 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,000 | 3,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 211 | 211 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allworth Financial LP | 3 | 0 | -3 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 3,033 | 3,019 | -14 | 0.00 | 0.00 | -0.00 | sell |
| Avior Wealth Management, LLC | 20 | 0 | -20 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 41 | 0 | -41 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 41 | 0 | -41 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 91,757 | 91,704 | -53 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 146 | 82 | -64 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 87 | 0 | -87 | 0.00 | 0.00 | -0.00 | sell |
| MEEDER ASSET MANAGEMENT INC | 357 | 0 | -357 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 5,298 | 4,831 | -467 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 4,110 | 3,616 | -494 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 9,602 | 9,069 | -533 | 0.00 | 0.00 | -0.00 | sell |
| KLP KAPITALFORVALTNING AS | 1,400 | 0 | -1,400 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 7,720 | 6,097 | -1,623 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 124,079 | 122,438 | -1,641 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 60,547 | 58,211 | -2,336 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 23,301 | 20,944 | -2,357 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 10,384 | 7,241 | -3,143 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 4,325 | 566 | -3,759 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,850 | 442 | -4,408 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 5,539 | 0 | -5,539 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 5,703 | 0 | -5,703 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 5,710 | 0 | -5,710 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 5,778 | 0 | -5,778 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 6,988 | 373 | -6,615 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 7,604 | 0 | -7,604 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 389,490 | 381,799 | -7,691 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 41,228 | 30,955 | -10,273 | 0.01 | 0.01 | -0.01 | sell |
| Ally Bridge Group (NY) LLC | 70,678 | 59,723 | -10,955 | 2.31 | 0.94 | -1.37 | sell |
| BlackRock, Inc. | 452,449 | 441,430 | -11,019 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 14,553 | 0 | -14,553 | 0.00 | 0.00 | -0.00 | sell |
| Tri Locum Partners LP | 144,216 | 128,381 | -15,835 | 1.14 | 1.15 | +0.01 | sell |
| MARSHALL WACE, LLP | 18,461 | 0 | -18,461 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 705,794 | 680,517 | -25,277 | 0.01 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 102,094 | 50,094 | -52,000 | 0.03 | 0.01 | -0.02 | sell |
| Verition Fund Management LLC | 62,094 | 0 | -62,094 | 0.01 | 0.00 | -0.01 | sell |
| Schonfeld Strategic Advisors LLC | 113,065 | 30,475 | -82,590 | 0.03 | 0.00 | -0.02 | sell |
| CITADEL ADVISORS LLC | 369,733 | 253,250 | -116,483 | 0.01 | 0.00 | -0.01 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 117,556 | 0 | -117,556 | 0.08 | 0.00 | -0.08 | sell |