| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 0 | 770,645 | +770,645 | 0.00 | 0.78 | +0.78 | buy |
| VANGUARD GROUP INC | 266,667 | 468,303 | +201,636 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 265,826 | 456,085 | +190,259 | 0.07 | 0.05 | -0.02 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 116,858 | +116,858 | 0.00 | 0.04 | +0.04 | buy |
| STATE STREET CORP | 18,100 | 99,888 | +81,788 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 58,241 | 139,658 | +81,417 | 0.00 | 0.00 | -0.00 | buy |
| Tri Locum Partners LP | 0 | 71,428 | +71,428 | 0.00 | 0.61 | +0.61 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 40,303 | +40,303 | 0.00 | 0.01 | +0.01 | buy |
| Rock Springs Capital Management LP | 0 | 35,719 | +35,719 | 0.00 | 0.04 | +0.04 | buy |
| HRT FINANCIAL LP | 0 | 32,524 | +32,524 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 0 | 29,534 | +29,534 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 60,894 | 84,201 | +23,307 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 0 | 19,148 | +19,148 | 0.00 | 0.00 | +0.00 | buy |
| NEA Management Company, LLC | 1,072,936 | 1,090,793 | +17,857 | 5.99 | 2.78 | -3.21 | buy |
| Atlas Venture Life Science Advisors, LLC | 1,119,292 | 1,137,149 | +17,857 | 9.30 | 4.06 | -5.24 | buy |
| ExodusPoint Capital Management, LP | 40,902 | 55,928 | +15,026 | 0.05 | 0.02 | -0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 3,147 | 17,567 | +14,420 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 8,227 | +8,227 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 7,210 | +7,210 | 0.00 | 0.05 | +0.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 6,355 | +6,355 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 10,293 | 15,282 | +4,989 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 0 | 4,413 | +4,413 | 0.00 | 0.00 | +0.00 | buy |
| Lynx1 Capital Management LP | 0 | 3,800 | +3,800 | 0.00 | 0.05 | +0.05 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 3,000 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 2,493 | +2,493 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 1,589 | +1,589 | 0.00 | 0.00 | +0.00 | buy |
| North Star Investment Management Corp. | 1,000 | 2,000 | +1,000 | 0.01 | 0.00 | -0.00 | buy |
| BROWN BROTHERS HARRIMAN & CO | 0 | 813 | +813 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 653 | +653 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 598 | +598 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 566 | +566 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 442 | +442 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 439 | +439 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 400 | 632 | +232 | 0.01 | 0.01 | -0.01 | buy |
| AMALGAMATED BANK | 0 | 211 | +211 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 73 | +73 | 0.00 | 0.00 | +0.00 | buy |
| DUNCKER STREETT & CO INC | 437 | 437 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Avior Wealth Management, LLC | 20 | 20 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 72 Investment Holdings, LLC | 276,831 | 276,831 | 0 | 37.14 | 23.57 | -13.58 | hold |
| Qiming U.S. Ventures Management, LLC | 368,085 | 368,085 | 0 | 36.93 | 23.69 | -13.24 | hold |
| City State Bank | 20 | 20 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD Waterhouse Canada Inc. | 29 | 29 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Kelly Financial Services LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 6 | 0 | -6 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 529,180 | 529,173 | -7 | 0.04 | 0.02 | -0.03 | sell |
| Tower Research Capital LLC (TRC) | 50 | 0 | -50 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 389 | 0 | -389 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 3,602 | 0 | -3,602 | 0.03 | 0.00 | -0.03 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 3,773 | 0 | -3,773 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 13,407 | 9,103 | -4,304 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 5,027 | 0 | -5,027 | 0.00 | 0.00 | -0.00 | sell |
| Artal Group S.A. | 419,226 | 413,072 | -6,154 | 0.97 | 0.36 | -0.61 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 537,490 | 529,155 | -8,335 | 0.76 | 0.31 | -0.45 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 9,893 | 0 | -9,893 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 11,276 | 0 | -11,276 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 13,163 | 0 | -13,163 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 23,211 | 5,750 | -17,461 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 140,091 | 122,384 | -17,707 | 0.12 | 0.03 | -0.09 | sell |
| CITIGROUP INC | 19,289 | 1,358 | -17,931 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 25,814 | 0 | -25,814 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 45,171 | 8,991 | -36,180 | 0.00 | 0.00 | -0.00 | sell |
| Monashee Investment Management LLC | 55,364 | 0 | -55,364 | 0.59 | 0.00 | -0.59 | sell |
| Invesco Ltd. | 72,419 | 0 | -72,419 | 0.00 | 0.00 | -0.00 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 73,821 | 0 | -73,821 | 0.28 | 0.00 | -0.28 | sell |
| FMR LLC | 727,205 | 639,125 | -88,080 | 0.00 | 0.00 | -0.00 | sell |
| Cormorant Asset Management, LP | 529,170 | 265,826 | -263,344 | 2.10 | 0.52 | -1.57 | sell |