| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Atlas Venture Life Science Advisors, LLC | 0 | 1,119,292 | +1,119,292 | 0.00 | 6.39 | +6.39 | buy |
| NEA Management Company, LLC | 0 | 1,072,936 | +1,072,936 | 0.00 | 2.74 | +2.74 | buy |
| FMR LLC | 0 | 727,205 | +727,205 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 546,325 | +546,325 | 0.00 | 0.43 | +0.43 | buy |
| CITADEL ADVISORS LLC | 0 | 529,173 | +529,173 | 0.00 | 0.02 | +0.02 | buy |
| Cormorant Asset Management, LP | 0 | 529,170 | +529,170 | 0.00 | 1.21 | +1.21 | buy |
| Artal Group S.A. | 0 | 418,605 | +418,605 | 0.00 | 0.68 | +0.68 | buy |
| Qiming U.S. Ventures Management, LLC | 0 | 368,085 | +368,085 | 0.00 | 16.15 | +16.15 | buy |
| 72 Investment Holdings, LLC | 0 | 276,831 | +276,831 | 0.00 | 58.92 | +58.92 | buy |
| VANGUARD GROUP INC | 0 | 270,974 | +270,974 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 265,826 | +265,826 | 0.00 | 0.04 | +0.04 | buy |
| Monashee Investment Management LLC | 0 | 90,805 | +90,805 | 0.00 | 0.77 | +0.77 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 73,821 | +73,821 | 0.00 | 0.16 | +0.16 | buy |
| Verition Fund Management LLC | 0 | 58,086 | +58,086 | 0.00 | 0.03 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 57,374 | +57,374 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 17,007 | +17,007 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 10,510 | +10,510 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 9,893 | +9,893 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 7,365 | +7,365 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 5,610 | +5,610 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 5,600 | +5,600 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 3,962 | +3,962 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 1,005 | +1,005 | 0.00 | 0.00 | +0.00 | buy |
| North Star Investment Management Corp. | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| DUNCKER STREETT & CO INC | 0 | 437 | +437 | 0.00 | 0.00 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 0 | 29 | +29 | 0.00 | 0.00 | +0.00 | buy |
| Orion Capital Management LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| City State Bank | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 6 | +6 | 0.00 | 0.00 | 0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| Kelly Financial Services LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |