| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ALLIANCEBERNSTEIN L.P. | 0 | 705,794 | +705,794 | 0.00 | 0.01 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 154,495 | 494,905 | +340,410 | 0.04 | 0.16 | +0.11 | buy |
| Woodline Partners LP | 0 | 102,094 | +102,094 | 0.00 | 0.03 | +0.03 | buy |
| FRANKLIN RESOURCES INC | 0 | 91,757 | +91,757 | 0.00 | 0.00 | +0.00 | buy |
| Tri Locum Partners LP | 64,014 | 144,216 | +80,202 | 0.51 | 1.14 | +0.62 | buy |
| Polar Capital Holdings Plc | 0 | 75,000 | +75,000 | 0.00 | 0.02 | +0.02 | buy |
| Ally Bridge Group (NY) LLC | 0 | 70,678 | +70,678 | 0.00 | 2.31 | +2.31 | buy |
| UBS Group AG | 9,730 | 73,039 | +63,309 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 579,563 | 641,739 | +62,176 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 444,850 | 493,997 | +49,147 | 0.05 | 0.05 | -0.00 | buy |
| Walleye Capital LLC | 0 | 41,228 | +41,228 | 0.00 | 0.01 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 0 | 32,400 | +32,400 | 0.00 | 0.03 | +0.03 | buy |
| Deep Track Capital, LP | 850,000 | 874,614 | +24,614 | 0.91 | 1.25 | +0.34 | buy |
| MILLENNIUM MANAGEMENT LLC | 72,261 | 95,808 | +23,547 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 18,461 | +18,461 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 12,814 | 23,301 | +10,487 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 10,384 | +10,384 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 49,451 | 57,978 | +8,527 | 0.28 | 0.45 | +0.18 | buy |
| ROYAL BANK OF CANADA | 0 | 7,720 | +7,720 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 7,604 | +7,604 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 5,778 | +5,778 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 5,710 | +5,710 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 5,539 | +5,539 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 118,765 | 124,079 | +5,314 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 442 | 4,850 | +4,408 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 566 | 4,325 | +3,759 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 57,830 | 60,547 | +2,717 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 449,950 | 452,449 | +2,499 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4,909 | 6,988 | +2,079 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 13,052 | 14,553 | +1,501 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 3,175 | 4,110 | +935 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 4,432 | 5,298 | +866 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 2,561 | 3,392 | +831 | 0.00 | 0.00 | +0.00 | buy |
| North Star Investment Management Corp. | 1,000 | 1,800 | +800 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 12,200 | 12,895 | +695 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 8,911 | 9,602 | +691 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 550 | +550 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 14,353 | 14,788 | +435 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 1,777 | 2,189 | +412 | 0.01 | 0.01 | +0.01 | buy |
| MEEDER ASSET MANAGEMENT INC | 0 | 357 | +357 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 3,350 | 3,502 | +152 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 16 | 146 | +130 | 0.00 | 0.00 | +0.00 | buy |
| Spire Wealth Management | 0 | 39 | +39 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 4 | 8 | +4 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 22 | 26 | +4 | 0.00 | 0.00 | -0.00 | buy |
| Allworth Financial LP | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 85 | 87 | +2 | 0.00 | 0.00 | +0.00 | buy |
| DUNCKER STREETT & CO INC | 437 | 437 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 598 | 598 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIGNATUREFD, LLC | 41 | 41 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEA Management Company, LLC | 1,090,793 | 1,090,793 | 0 | 1.99 | 2.34 | +0.36 | hold |
| MetLife Investment Management, LLC | 3,639 | 3,639 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rock Springs Capital Management LP | 35,719 | 35,719 | 0 | 0.04 | 0.05 | +0.01 | hold |
| Avior Wealth Management, LLC | 20 | 20 | 0 | 0.00 | 0.00 | +0.00 | hold |
| 72 Investment Holdings, LLC | 276,831 | 276,831 | 0 | 19.89 | 21.46 | +1.57 | hold |
| Qiming U.S. Ventures Management, LLC | 368,085 | 368,085 | 0 | 23.95 | 27.40 | +3.45 | hold |
| Atlas Venture Life Science Advisors, LLC | 1,137,149 | 1,137,149 | 0 | 3.52 | 5.28 | +1.76 | hold |
| Siren, L.L.C. | 418,833 | 418,833 | 0 | 0.70 | 0.70 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,000 | 3,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 211 | 211 | 0 | 0.00 | 0.00 | +0.00 | hold |
| City State Bank | 20 | 0 | -20 | 0.00 | 0.00 | -0.00 | sell |
| TD Waterhouse Canada Inc. | 29 | 0 | -29 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 17,567 | 17,498 | -69 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 434 | 278 | -156 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 3,261 | 3,033 | -228 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 137,497 | 137,087 | -410 | 0.00 | 0.00 | +0.00 | sell |
| Quarry LP | 600 | 0 | -600 | 0.01 | 0.00 | -0.01 | sell |
| HRT FINANCIAL LP | 6,642 | 5,703 | -939 | 0.00 | 0.00 | +0.00 | sell |
| Jaffetilchin Investment Partners, LLC | 945 | 0 | -945 | 0.00 | 0.00 | -0.00 | sell |
| BROWN BROTHERS HARRIMAN & CO | 2,854 | 0 | -2,854 | 0.00 | 0.00 | -0.00 | sell |
| Vestcor Inc | 3,000 | 0 | -3,000 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 12,391 | 2,854 | -9,537 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 142,645 | 113,065 | -29,580 | 0.04 | 0.03 | -0.01 | sell |
| Hudson Bay Capital Management LP | 30,000 | 0 | -30,000 | 0.01 | 0.00 | -0.01 | sell |
| Verition Fund Management LLC | 93,289 | 62,094 | -31,195 | 0.02 | 0.01 | -0.01 | sell |
| ExodusPoint Capital Management, LP | 41,257 | 0 | -41,257 | 0.01 | 0.00 | -0.01 | sell |
| VANGUARD GROUP INC | 436,861 | 389,490 | -47,371 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 529,173 | 369,733 | -159,440 | 0.02 | 0.01 | -0.01 | sell |
| Cormorant Asset Management, LP | 265,826 | 0 | -265,826 | 0.47 | 0.00 | -0.47 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 391,166 | 117,556 | -273,610 | 0.23 | 0.08 | -0.14 | sell |