| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Atlas Venture Life Science Advisors, LLC | 1,137,149 | 1,137,149 | 0 | 7.24 | 1.05 | -6.18 | hold |
| NEA Management Company, LLC | 1,090,793 | 1,090,793 | 0 | 2.87 | 0.45 | -2.42 | hold |
| Lynx1 Capital Management LP | 0 | 677,915 | +677,915 | 0.00 | 1.10 | +1.10 | buy |
| Nantahala Capital Management, LLC | 0 | 600,000 | +600,000 | 0.00 | 0.29 | +0.29 | buy |
| VANGUARD GROUP INC | 395,659 | 489,639 | +93,980 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 446,698 | 457,399 | +10,701 | 0.00 | 0.00 | -0.00 | buy |
| TCG Crossover Management, LLC | 416,301 | 416,301 | 0 | 0.98 | 0.11 | -0.87 | hold |
| Siren, L.L.C. | 418,833 | 347,718 | -71,115 | 0.78 | 0.08 | -0.70 | sell |
| JANE STREET GROUP, LLC | 0 | 288,457 | +288,457 | 0.00 | 0.00 | +0.00 | buy |
| 72 Investment Holdings, LLC | 276,831 | 276,831 | 0 | 19.51 | 4.38 | -15.13 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 196,827 | +196,827 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 162,932 | 162,760 | -172 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 260,333 | 161,092 | -99,241 | 0.01 | 0.00 | -0.01 | sell |
| STATE STREET CORP | 124,569 | 146,221 | +21,652 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 64,455 | 78,984 | +14,529 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 40,400 | 74,900 | +34,500 | 0.00 | 0.00 | -0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 58,911 | 65,548 | +6,637 | 0.15 | 0.03 | -0.12 | buy |
| F/m Investments LLC | 55,245 | 65,548 | +10,303 | 0.10 | 0.02 | -0.08 | buy |
| CITADEL ADVISORS LLC | 153,928 | 58,329 | -95,599 | 0.01 | 0.00 | -0.01 | sell |
| XTX Topco Ltd | 43,538 | 57,067 | +13,529 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 57,273 | 55,640 | -1,633 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 15,681 | 51,950 | +36,269 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 0 | 40,766 | +40,766 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 48,407 | 40,647 | -7,760 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 563,681 | 37,857 | -525,824 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 33,790 | +33,790 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 28,247 | +28,247 | 0.00 | 0.01 | +0.01 | buy |
| Quantinno Capital Management LP | 6,143 | 27,597 | +21,454 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 7,108 | 27,065 | +19,957 | 0.01 | 0.00 | -0.00 | buy |
| Quadrature Capital Ltd | 0 | 27,064 | +27,064 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 26,885 | +26,885 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 148,971 | 23,031 | -125,940 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 0 | 19,772 | +19,772 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 19,313 | 18,855 | -458 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 23,101 | 16,329 | -6,772 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 3,731 | 12,758 | +9,027 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 11,409 | 11,237 | -172 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 8,757 | 10,590 | +1,833 | 0.00 | 0.00 | -0.00 | buy |
| Jain Global LLC | 0 | 10,574 | +10,574 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 0 | 10,439 | +10,439 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 9,343 | 10,250 | +907 | 0.00 | 0.00 | -0.00 | buy |
| AlphaQuest LLC | 2,468 | 7,703 | +5,235 | 0.01 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 4,000 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 3,138 | 3,146 | +8 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,000 | 3,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 815 | 1,930 | +1,115 | 0.00 | 0.00 | -0.00 | buy |
| North Star Investment Management Corp. | 1,800 | 1,800 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 1,750 | 1,500 | -250 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 1,314 | 1,487 | +173 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,038 | 1,391 | +353 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 2,286 | 1,373 | -913 | 0.00 | 0.00 | -0.00 | sell |
| TD Waterhouse Canada Inc. | 0 | 800 | +800 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 337 | 607 | +270 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 598 | 598 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 526 | 526 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 458 | 458 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DUNCKER STREETT & CO INC | 437 | 437 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 416 | 408 | -8 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 0 | 302 | +302 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 211 | 208 | -3 | 0.00 | 0.00 | -0.00 | sell |
| Optiver Holding B.V. | 116 | 116 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 110 | +110 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 89 | 102 | +13 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 91 | +91 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 40 | 40 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Global Retirement Partners, LLC | 0 | 35 | +35 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 5 | 5 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 2 | 2 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allworth Financial LP | 92 | 1 | -91 | 0.00 | 0.00 | -0.00 | sell |
| Sunbelt Securities, Inc. | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROYAL BANK OF CANADA | 5,992 | 0 | -5,992 | 0.00 | 0.00 | -0.00 | sell |
| EMERALD ADVISERS, LLC | 16,469 | 0 | -16,469 | 0.03 | 0.00 | -0.03 | sell |
| ORBIMED ADVISORS LLC | 32,400 | 0 | -32,400 | 0.04 | 0.00 | -0.04 | sell |
| ALLIANCEBERNSTEIN L.P. | 7,700 | 0 | -7,700 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 60,804 | 0 | -60,804 | 0.72 | 0.00 | -0.72 | sell |
| MetLife Investment Management, LLC | 3,945 | 0 | -3,945 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 2,693 | 0 | -2,693 | 0.00 | 0.00 | -0.00 | sell |
| Cormorant Asset Management, LP | 465,000 | 0 | -465,000 | 1.54 | 0.00 | -1.54 | sell |
| Arax Advisory Partners | 3,610 | 0 | -3,610 | 0.00 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 35,719 | 0 | -35,719 | 0.10 | 0.00 | -0.10 | sell |
| Point72 Asset Management, L.P. | 531,969 | 0 | -531,969 | 0.06 | 0.00 | -0.06 | sell |
| UBS Group AG | 53,103 | 0 | -53,103 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 38,260 | 0 | -38,260 | 0.02 | 0.00 | -0.02 | sell |
| Wealthspire Advisors, LLC | 65 | 0 | -65 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 90,186 | 0 | -90,186 | 0.03 | 0.00 | -0.03 | sell |
| Eversept Partners, LP | 20,856 | 0 | -20,856 | 0.08 | 0.00 | -0.08 | sell |
| EverSource Wealth Advisors, LLC | 89 | 0 | -89 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 57,983 | 0 | -57,983 | 0.00 | 0.00 | -0.00 | sell |
| Versant Capital Management, Inc | 271 | 0 | -271 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 50,094 | 0 | -50,094 | 0.01 | 0.00 | -0.01 | sell |
| Tri Locum Partners LP | 337,764 | 0 | -337,764 | 3.72 | 0.00 | -3.72 | sell |
| Polar Capital Holdings Plc | 264,694 | 0 | -264,694 | 0.06 | 0.00 | -0.06 | sell |
| Blue Owl Capital Holdings LP | 105,000 | 0 | -105,000 | 1.56 | 0.00 | -1.56 | sell |
| Nuveen, LLC | 9,264 | 0 | -9,264 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 40,235 | 0 | -40,235 | 0.19 | 0.00 | -0.19 | sell |
| JPMORGAN CHASE & CO | 199,249 | 0 | -199,249 | 0.00 | 0.00 | -0.00 | sell |
| Quarry LP | 4,375 | 0 | -4,375 | 0.05 | 0.00 | -0.05 | sell |
| True Wealth Design, LLC | 19 | 0 | -19 | 0.00 | 0.00 | -0.00 | sell |