| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 6,567,892 | 3,813,433 | +2,754,459 | 0.09 | 0.08 | 0.00 | sell |
| Clearbridge Investments, LLC | 1,862,842 | 3,279,567 | +1,416,725 | 0.04 | 0.10 | +0.06 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,762,954 | 2,884,810 | +1,121,856 | 0.03 | 0.06 | 0.00 | buy |
| RTW INVESTMENTS, LP | 2,509,119 | 3,136,680 | +627,561 | 0.99 | 1.73 | +0.74 | buy |
| Allianz Asset Management GmbH | 1,505,866 | 1,884,411 | +378,545 | 0.06 | 0.10 | +0.04 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 841,735 | 1,009,020 | +167,285 | 0.10 | 0.16 | +0.06 | buy |
| LMR Partners LLP | 19,840 | 62,479 | +42,639 | 0.01 | 0.05 | +0.04 | buy |
| MPM BioImpact LLC | 800,000 | 833,659 | +33,659 | 2.97 | 5.18 | +2.20 | buy |
| DCF Advisers, LLC | 64,750 | 90,000 | +25,250 | 0.86 | 1.75 | +0.89 | buy |
| Nan Fung Group Holdings Ltd | 235,000 | 253,675 | +18,675 | 5.26 | 7.48 | +2.21 | buy |
| Bellevue Group AG | 13,000 | 20,000 | +7,000 | 0.01 | 0.02 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 183,317 | 187,747 | +4,430 | 0.22 | 0.30 | +0.08 | buy |
| China Universal Asset Management Co., Ltd. | 11,061 | 12,544 | +1,483 | 0.03 | 0.04 | +0.02 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,095 | 1,336 | +241 | 0.00 | 0.00 | +0.00 | buy |
| Retirement Wealth Solutions LLC | 38 | 53 | +15 | 0.00 | 0.00 | +0.00 | buy |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | 20,000 | 15,000 | -5,000 | 0.12 | 0.12 | +0.00 | sell |
| ALPS ADVISORS INC | 88,395 | 76,298 | -12,097 | 0.01 | 0.02 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 309,128 | 295,728 | -13,400 | 0.01 | 0.01 | +0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 44,800 | 29,920 | -14,880 | 0.78 | 0.84 | +0.06 | sell |
| BAROMETER CAPITAL MANAGEMENT INC. | 39,100 | 17,300 | -21,800 | 0.37 | 0.23 | -0.13 | sell |
| Alberta Investment Management Corp | 232,293 | 196,262 | -36,031 | 0.04 | 0.05 | +0.01 | sell |
| C WorldWide Group Holding A/S | 500,000 | 460,000 | -40,000 | 0.16 | 0.21 | +0.05 | sell |
| Privium Fund Management B.V. | 185,062 | 132,189 | -52,873 | 1.10 | 1.25 | +0.15 | sell |
| BAMCO INC /NY/ | 1,909,088 | 1,829,494 | -79,594 | 0.13 | 0.19 | +0.06 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,354,025 | 2,268,216 | -85,809 | 0.01 | 0.01 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 1,045,837 | 940,858 | -104,979 | 5.65 | 6.54 | +0.90 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 403,630 | 294,947 | -108,683 | 9.28 | 12.71 | +3.43 | sell |
| Candriam S.C.A. | 375,479 | 240,941 | -134,538 | 0.06 | 0.05 | -0.00 | sell |
| Rock Springs Capital Management LP | 1,305,337 | 904,592 | -400,745 | 1.30 | 1.87 | +0.57 | sell |
| Capital World Investors | 6,433,424 | 6,008,419 | -425,005 | 0.03 | 0.04 | +0.01 | sell |
| Woodline Partners LP | 1,759,797 | 1,201,016 | -558,781 | 0.31 | 0.28 | -0.03 | sell |