| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 6,959,032 | 6,574,032 | -385,000 | 1.23 | 1.23 | +0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 5,707,262 | +5,707,262 | 0.00 | 1.14 | +1.14 | buy |
| Frazier Life Sciences Management, L.P. | 1,902,320 | 1,902,320 | 0 | 0.90 | 0.92 | +0.02 | hold |
| CITADEL ADVISORS LLC | 1,687,846 | 1,688,632 | +786 | 0.02 | 0.02 | +0.00 | buy |
| BAMCO INC /NY/ | 1,418,005 | 1,658,318 | +240,313 | 0.07 | 0.09 | +0.03 | buy |
| ADAR1 Capital Management, LLC | 1,246,520 | 1,425,367 | +178,847 | 1.64 | 1.61 | -0.03 | buy |
| FMR LLC | 1,440,406 | 1,262,391 | -178,015 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 635,213 | 865,146 | +229,933 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 811,546 | 814,707 | +3,161 | 0.73 | 0.90 | +0.17 | buy |
| C WorldWide Group Holding A/S | 510,000 | 510,000 | 0 | 0.16 | 0.21 | +0.05 | hold |
| UBS Group AG | 1,782,252 | 504,191 | -1,278,061 | 0.01 | 0.00 | -0.00 | sell |
| B Group, Inc. | 400,000 | 450,646 | +50,646 | 5.23 | 6.28 | +1.06 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 299,844 | 393,167 | +93,323 | 0.00 | 0.01 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 269,975 | 346,466 | +76,491 | 0.38 | 0.72 | +0.34 | buy |
| TWO SIGMA INVESTMENTS, LP | 29,523 | 309,723 | +280,200 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 602,954 | 291,639 | -311,315 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 196,853 | 275,818 | +78,965 | 1.86 | 3.71 | +1.85 | buy |
| JANE STREET GROUP, LLC | 382,062 | 267,926 | -114,136 | 0.01 | 0.01 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 181,133 | 243,557 | +62,424 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 237,739 | +237,739 | 0.00 | 0.01 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 204,982 | 214,323 | +9,341 | 0.12 | 0.14 | +0.01 | buy |
| Tidal Investments LLC | 0 | 183,691 | +183,691 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 173,946 | 174,234 | +288 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 132,189 | 132,189 | 0 | 0.43 | 0.52 | +0.09 | hold |
| STATE STREET CORP | 136,428 | 118,813 | -17,615 | 0.00 | 0.00 | -0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 65,814 | 116,560 | +50,746 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 149,434 | 110,587 | -38,847 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 373,399 | 94,678 | -278,721 | 0.04 | 0.01 | -0.03 | sell |
| MORGAN STANLEY | 289,705 | 94,397 | -195,308 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 92,107 | 90,848 | -1,259 | 0.01 | 0.01 | -0.00 | sell |
| Legal & General Group Plc | 387,800 | 70,014 | -317,786 | 0.00 | 0.00 | -0.00 | sell |
| BAROMETER CAPITAL MANAGEMENT INC. | 0 | 66,500 | +66,500 | 0.00 | 0.43 | +0.43 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 56,895 | 65,248 | +8,353 | 0.00 | 0.00 | +0.00 | buy |
| DCF Advisers, LLC | 97,500 | 63,500 | -34,000 | 0.57 | 0.45 | -0.12 | sell |
| D. E. Shaw & Co., Inc. | 238,609 | 63,243 | -175,366 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 38,457 | 47,511 | +9,054 | 0.18 | 0.25 | +0.06 | buy |
| XTX Topco Ltd | 0 | 47,072 | +47,072 | 0.00 | 0.02 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 86,640 | 37,440 | -49,200 | 0.00 | 0.00 | -0.00 | sell |
| WealthPlan Investment Management, LLC | 36,761 | 36,761 | 0 | 0.04 | 0.04 | -0.00 | hold |
| Point72 Asset Management, L.P. | 0 | 35,120 | +35,120 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 90,000 | 30,000 | -60,000 | 0.01 | 0.00 | -0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 46,935 | 29,835 | -17,100 | 0.00 | 0.00 | -0.00 | sell |
| Headlands Technologies LLC | 15,846 | 28,109 | +12,263 | 0.02 | 0.06 | +0.04 | buy |
| Invesco Ltd. | 30,594 | 26,558 | -4,036 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 96,442 | 25,709 | -70,733 | 0.00 | 0.00 | -0.00 | sell |
| Legacy Wealth Asset Management, LLC | 15,903 | 24,925 | +9,022 | 0.07 | 0.11 | +0.05 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 151,318 | 24,781 | -126,537 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 23,879 | 23,879 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Squarepoint Ops LLC | 0 | 19,463 | +19,463 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 15,100 | 15,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bridgefront Capital, LLC | 0 | 14,529 | +14,529 | 0.00 | 0.07 | +0.07 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 14,300 | +14,300 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 22,099 | 13,900 | -8,199 | 0.00 | 0.00 | -0.00 | sell |
| Persistent Asset Partners Ltd | 12,339 | 12,339 | 0 | 0.10 | 0.09 | -0.01 | hold |
| AXQ CAPITAL, LP | 0 | 10,694 | +10,694 | 0.00 | 0.03 | +0.03 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 10,544 | +10,544 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 10,019 | +10,019 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 19,032 | 7,718 | -11,314 | 0.01 | 0.00 | -0.01 | sell |
| JPMORGAN CHASE & CO | 293,703 | 6,781 | -286,922 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 6,380 | 6,085 | -295 | 0.01 | 0.01 | +0.00 | sell |
| SG Americas Securities, LLC | 10,396 | 5,799 | -4,597 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 103,118 | 5,459 | -97,659 | 0.01 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 93,140 | 5,422 | -87,718 | 0.00 | 0.00 | -0.00 | sell |
| Daiwa Securities Group Inc. | 150 | 5,400 | +5,250 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1 | 3,531 | +3,530 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 173 | 1,735 | +1,562 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 17,771 | 1,023 | -16,748 | 0.00 | 0.00 | -0.00 | sell |
| FIFTH THIRD BANCORP | 0 | 1,004 | +1,004 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 5,151 | 959 | -4,192 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 1,329 | 957 | -372 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 768 | 873 | +105 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 884 | 753 | -131 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 157 | 628 | +471 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 979 | 289 | -690 | 0.00 | 0.00 | -0.00 | sell |
| Quent Capital, LLC | 230 | 230 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ASSETMARK, INC | 233 | 208 | -25 | 0.00 | 0.00 | -0.00 | sell |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 202 | 202 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EverSource Wealth Advisors, LLC | 203 | 184 | -19 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 159 | 147 | -12 | 0.00 | 0.00 | +0.00 | sell |
| Smartleaf Asset Management LLC | 331 | 132 | -199 | 0.00 | 0.00 | -0.00 | sell |
| AMERIFLEX GROUP, INC. | 62 | 62 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BESSEMER GROUP INC | 145 | 54 | -91 | 0.00 | 0.00 | -0.00 | sell |
| Advisory Services Network, LLC | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 1 | 44 | +43 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 40 | 40 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IFP Advisors, Inc | 94 | 33 | -61 | 0.00 | 0.00 | -0.00 | sell |
| Parallel Advisors, LLC | 0 | 27 | +27 | 0.00 | 0.00 | +0.00 | buy |
| Bell Investment Advisors, Inc | 16 | 26 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 325 | 21 | -304 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 9 | 9 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 281 | 5 | -276 | 0.00 | 0.00 | -0.00 | sell |
| Blue Trust, Inc. | 5 | 5 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ROYAL BANK OF CANADA | 14,757 | 0 | -14,757 | 0.00 | 0.00 | -0.00 | sell |
| MAI Capital Management | 19 | 0 | -19 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 101,782 | 0 | -101,782 | 0.00 | 0.00 | -0.00 | sell |
| OPPENHEIMER ASSET MANAGEMENT INC. | 10,608 | 0 | -10,608 | 0.00 | 0.00 | -0.00 | sell |
| PRIVATE TRUST CO NA | 206 | 0 | -206 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 231,802 | 0 | -231,802 | 0.00 | 0.00 | -0.00 | sell |
| North Star Investment Management Corp. | 27 | 0 | -27 | 0.00 | 0.00 | -0.00 | sell |
| Clearbridge Investments, LLC | 1,808,035 | 0 | -1,808,035 | 0.03 | 0.00 | -0.03 | sell |