| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 6,378,128 | 6,197,423 | -180,705 | 0.01 | 0.01 | -0.00 | sell |
| Capital World Investors | 6,008,419 | 6,036,185 | +27,766 | 0.04 | 0.03 | -0.00 | buy |
| RTW INVESTMENTS, LP | 3,136,680 | 5,536,876 | +2,400,196 | 1.73 | 2.76 | +1.02 | buy |
| Clearbridge Investments, LLC | 3,279,567 | 4,011,956 | +732,389 | 0.10 | 0.11 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 3,813,433 | 2,197,860 | -1,615,573 | 0.08 | 0.04 | -0.04 | sell |
| BAMCO INC /NY/ | 1,829,494 | 1,587,814 | -241,680 | 0.19 | 0.15 | -0.04 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 3,647,225 | 1,376,963 | -2,270,262 | 0.03 | 0.01 | -0.02 | sell |
| Frazier Life Sciences Management, L.P. | 350,000 | 1,308,138 | +958,138 | 0.58 | 1.83 | +1.25 | buy |
| Woodline Partners LP | 1,201,016 | 1,201,016 | 0 | 0.28 | 0.22 | -0.06 | hold |
| Allianz Asset Management GmbH | 1,884,411 | 932,000 | -952,411 | 0.10 | 0.04 | -0.06 | sell |
| Rock Springs Capital Management LP | 904,592 | 871,392 | -33,200 | 1.87 | 1.90 | +0.03 | sell |
| ADAR1 Capital Management, LLC | 940,858 | 850,437 | -90,421 | 6.54 | 4.83 | -1.71 | sell |
| MPM BioImpact LLC | 833,659 | 745,060 | -88,599 | 5.18 | 4.51 | -0.67 | sell |
| JENNISON ASSOCIATES LLC | 712,300 | 592,332 | -119,968 | 0.02 | 0.01 | -0.01 | sell |
| C WorldWide Group Holding A/S | 460,000 | 510,000 | +50,000 | 0.21 | 0.24 | +0.04 | buy |
| BlackRock, Inc. | 515,241 | 455,287 | -59,954 | 0.00 | 0.00 | -0.00 | sell |
| B Group, Inc. | 400,000 | 400,000 | 0 | 12.56 | 12.08 | -0.48 | hold |
| Connor, Clark & Lunn Investment Management Ltd. | 1,009,020 | 387,362 | -621,658 | 0.16 | 0.05 | -0.11 | sell |
| CITADEL ADVISORS LLC | 382,469 | 366,213 | -16,256 | 0.01 | 0.01 | -0.00 | sell |
| XY Capital Ltd | 305,397 | 362,627 | +57,230 | 7.27 | 8.74 | +1.47 | buy |
| MORGAN STANLEY | 2,634,559 | 289,101 | -2,345,458 | 0.01 | 0.00 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 307,955 | 279,661 | -28,294 | 0.01 | 0.01 | -0.00 | sell |
| NAN FUNG TRINITY (HK) Ltd | 0 | 269,975 | +269,975 | 0.00 | 1.13 | +1.13 | buy |
| Point72 Asset Management, L.P. | 88,170 | 252,400 | +164,230 | 0.01 | 0.02 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 26,421 | 250,438 | +224,017 | 0.30 | 2.82 | +2.51 | buy |
| UBS Group AG | 393,117 | 241,650 | -151,467 | 0.00 | 0.00 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 178,714 | 239,247 | +60,533 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 240,941 | 238,897 | -2,044 | 0.05 | 0.05 | -0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 84,500 | 232,900 | +148,400 | 0.00 | 0.01 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 0 | 231,000 | +231,000 | 0.00 | 0.20 | +0.20 | buy |
| RAYMOND JAMES FINANCIAL INC | 125,967 | 189,913 | +63,946 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 138,830 | 174,480 | +35,650 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 187,747 | 168,090 | -19,657 | 0.30 | 0.24 | -0.06 | sell |
| HSBC HOLDINGS PLC | 25,000 | 158,254 | +133,254 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,268,216 | 153,037 | -2,115,179 | 0.01 | 0.00 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 232,503 | 149,744 | -82,759 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 162,698 | 146,017 | -16,681 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 73,591 | 144,322 | +70,731 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 137,649 | 138,724 | +1,075 | 0.00 | 0.00 | -0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 294,947 | 134,895 | -160,052 | 12.71 | 5.88 | -6.84 | sell |
| Privium Fund Management B.V. | 132,189 | 132,189 | 0 | 1.25 | 1.00 | -0.24 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 2,884,810 | 104,513 | -2,780,297 | 0.06 | 0.00 | -0.06 | sell |
| Tower Research Capital LLC (TRC) | 24,863 | 104,466 | +79,603 | 0.03 | 0.10 | +0.07 | buy |
| Qube Research & Technologies Ltd | 0 | 97,273 | +97,273 | 0.00 | 0.00 | +0.00 | buy |
| DCF Advisers, LLC | 90,000 | 91,000 | +1,000 | 1.75 | 1.53 | -0.22 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 262,500 | 87,500 | -175,000 | 0.01 | 0.00 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 166,063 | 85,247 | -80,816 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 838 | 84,026 | +83,188 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 82,370 | 81,836 | -534 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 2,132,201 | 77,857 | -2,054,344 | 0.00 | 0.01 | +0.01 | sell |
| Cubist Systematic Strategies, LLC | 93,645 | 74,193 | -19,452 | 0.04 | 0.03 | -0.02 | sell |
| Jump Financial, LLC | 0 | 66,003 | +66,003 | 0.00 | 0.03 | +0.03 | buy |
| AXA S.A. | 65,814 | 65,814 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ALPS ADVISORS INC | 76,298 | 60,798 | -15,500 | 0.02 | 0.01 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 38,200 | 60,100 | +21,900 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 64,262 | 58,835 | -5,427 | 0.04 | 0.03 | -0.02 | sell |
| TEMA ETFS LLC | 64,262 | 58,835 | -5,427 | 0.69 | 0.55 | -0.15 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 58,492 | 56,522 | -1,970 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 56,473 | +56,473 | 0.00 | 0.01 | +0.01 | buy |
| KEYSTONE INVESTORS PTE LTD | 0 | 55,210 | +55,210 | 0.00 | 0.40 | +0.40 | buy |
| Orion Porfolio Solutions, LLC | 36,259 | 48,433 | +12,174 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 54,544 | 47,599 | -6,945 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 62,479 | 44,070 | -18,409 | 0.05 | 0.02 | -0.02 | sell |
| MML INVESTORS SERVICES, LLC | 27,807 | 43,679 | +15,872 | 0.00 | 0.00 | +0.00 | buy |
| WealthPlan Investment Management, LLC | 39,393 | 36,761 | -2,632 | 0.14 | 0.09 | -0.05 | sell |
| DekaBank Deutsche Girozentrale | 36,648 | 36,648 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LPL Financial LLC | 24,309 | 31,864 | +7,555 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 296,278 | 30,771 | -265,507 | 0.03 | 0.00 | -0.02 | sell |
| BANK OF MONTREAL /CAN/ | 22,991 | 29,782 | +6,791 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 27,545 | +27,545 | 0.00 | 0.07 | +0.07 | buy |
| MARSHALL WACE, LLP | 27,931 | 24,456 | -3,475 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 18,365 | 24,438 | +6,073 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 295,728 | 24,128 | -271,600 | 0.01 | 0.00 | -0.01 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 514 | 24,046 | +23,532 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 22,098 | 23,820 | +1,722 | 0.00 | 0.00 | -0.00 | buy |
| BAROMETER CAPITAL MANAGEMENT INC. | 17,300 | 23,600 | +6,300 | 0.23 | 0.23 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 91,504 | 22,699 | -68,805 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 37,693 | 22,166 | -15,527 | 0.00 | 0.00 | -0.00 | sell |
| Alberta Investment Management Corp | 196,262 | 22,000 | -174,262 | 0.05 | 0.01 | -0.04 | sell |
| OPPENHEIMER ASSET MANAGEMENT INC. | 16,689 | 21,974 | +5,285 | 0.01 | 0.01 | +0.00 | buy |
| Legacy Wealth Asset Management, LLC | 22,285 | 21,968 | -317 | 0.22 | 0.20 | -0.03 | sell |
| M&T BANK CORP | 22,130 | 21,825 | -305 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 0 | 21,705 | +21,705 | 0.00 | 0.00 | +0.00 | buy |
| Penserra Capital Management LLC | 67,159 | 20,978 | -46,181 | 0.04 | 0.01 | -0.03 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 401,082 | 20,364 | -380,718 | 0.01 | 0.00 | -0.01 | sell |
| ROYAL BANK OF CANADA | 13,771 | 18,707 | +4,936 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 29,920 | 15,840 | -14,080 | 0.84 | 0.37 | -0.48 | sell |
| DIMENSIONAL FUND ADVISORS LP | 15,572 | 15,572 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Erste Asset Management GmbH | 15,100 | 15,100 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Cerity Partners LLC | 11,617 | 14,268 | +2,651 | 0.00 | 0.00 | +0.00 | buy |
| Marks Group Wealth Management, Inc | 10,331 | 14,253 | +3,922 | 0.04 | 0.05 | +0.01 | buy |
| Walleye Capital LLC | 22,276 | 13,949 | -8,327 | 0.01 | 0.00 | -0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 0 | 11,785 | +11,785 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 12,544 | 11,627 | -917 | 0.04 | 0.04 | -0.00 | sell |
| NJ State Employees Deferred Compensation Plan | 11,300 | 11,300 | 0 | 0.05 | 0.05 | -0.01 | hold |
| STIFEL FINANCIAL CORP | 8,138 | 11,248 | +3,110 | 0.00 | 0.00 | +0.00 | buy |
| TRUIST FINANCIAL CORP | 6,607 | 10,389 | +3,782 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 13,435 | 10,328 | -3,107 | 0.13 | 0.12 | -0.01 | sell |
| JPMORGAN CHASE & CO | 45,455 | 9,791 | -35,664 | 0.00 | 0.00 | -0.00 | sell |
| Kingsview Wealth Management, LLC | 9,323 | 9,038 | -285 | 0.01 | 0.01 | -0.00 | sell |