| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 3,136,680 | 5,536,876 | +2,400,196 | 1.73 | 2.76 | +1.02 | buy |
| JANUS HENDERSON GROUP PLC | 3,813,433 | 2,197,860 | +1,615,573 | 0.08 | 0.04 | 0.00 | sell |
| Frazier Life Sciences Management, L.P. | 350,000 | 1,308,138 | +958,138 | 0.58 | 1.83 | +1.25 | buy |
| Allianz Asset Management GmbH | 1,884,411 | 932,000 | +952,411 | 0.10 | 0.04 | -0.06 | sell |
| Clearbridge Investments, LLC | 3,279,567 | 4,011,956 | +732,389 | 0.10 | 0.11 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 1,009,020 | 387,362 | +621,658 | 0.16 | 0.05 | -0.11 | sell |
| STEMPOINT CAPITAL LP | 26,421 | 250,438 | +224,017 | 0.30 | 2.82 | +2.51 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 262,500 | 87,500 | +175,000 | 0.01 | 0.00 | 0.00 | sell |
| XY Capital Ltd | 305,397 | 362,627 | +57,230 | 7.27 | 8.74 | +1.47 | buy |
| C WorldWide Group Holding A/S | 460,000 | 510,000 | +50,000 | 0.21 | 0.24 | +0.04 | buy |
| Penserra Capital Management LLC | 67,159 | 20,978 | +46,181 | 0.04 | 0.01 | -0.03 | sell |
| Capital World Investors | 6,008,419 | 6,036,185 | +27,766 | 0.04 | 0.03 | -0.00 | buy |
| ALPS ADVISORS INC | 76,298 | 60,798 | +15,500 | 0.02 | 0.01 | 0.00 | sell |
| Orion Porfolio Solutions, LLC | 36,259 | 48,433 | +12,174 | 0.01 | 0.02 | 0.00 | buy |
| BAROMETER CAPITAL MANAGEMENT INC. | 17,300 | 23,600 | +6,300 | 0.23 | 0.23 | -0.00 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 16,689 | 21,974 | +5,285 | 0.01 | 0.01 | 0.00 | buy |
| Marks Group Wealth Management, Inc | 10,331 | 14,253 | +3,922 | 0.04 | 0.05 | +0.01 | buy |
| DCF Advisers, LLC | 90,000 | 91,000 | +1,000 | 1.75 | 1.53 | -0.22 | buy |
| Retirement Wealth Solutions LLC | 53 | 69 | +16 | 0.00 | 0.00 | +0.00 | buy |
| Legacy Wealth Asset Management, LLC | 22,285 | 21,968 | -317 | 0.22 | 0.20 | -0.03 | sell |
| China Universal Asset Management Co., Ltd. | 12,544 | 11,627 | -917 | 0.04 | 0.04 | -0.00 | sell |
| Candriam S.C.A. | 240,941 | 238,897 | -2,044 | 0.05 | 0.05 | -0.01 | sell |
| WealthPlan Investment Management, LLC | 39,393 | 36,761 | -2,632 | 0.14 | 0.09 | -0.05 | sell |
| Virtus Investment Advisers, LLC | 13,435 | 10,328 | -3,107 | 0.13 | 0.12 | -0.01 | sell |
| NEOS Investment Management LLC | 64,262 | 58,835 | -5,427 | 0.04 | 0.03 | -0.02 | sell |
| TEMA ETFS LLC | 64,262 | 58,835 | -5,427 | 0.69 | 0.55 | -0.15 | sell |
| SECTORAL ASSET MANAGEMENT INC | 29,920 | 15,840 | -14,080 | 0.84 | 0.37 | -0.48 | sell |
| LMR Partners LLP | 62,479 | 44,070 | -18,409 | 0.05 | 0.02 | -0.02 | sell |
| Hennion & Walsh Asset Management, Inc. | 187,747 | 168,090 | -19,657 | 0.30 | 0.24 | -0.06 | sell |
| Rock Springs Capital Management LP | 904,592 | 871,392 | -33,200 | 1.87 | 1.90 | +0.03 | sell |
| MPM BioImpact LLC | 833,659 | 745,060 | -88,599 | 5.18 | 4.51 | -0.67 | sell |
| ADAR1 Capital Management, LLC | 940,858 | 850,437 | -90,421 | 6.54 | 4.83 | -1.71 | sell |
| JENNISON ASSOCIATES LLC | 712,300 | 592,332 | -119,968 | 0.02 | 0.01 | -0.01 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 294,947 | 134,895 | -160,052 | 12.71 | 5.88 | -6.84 | sell |
| Alberta Investment Management Corp | 196,262 | 22,000 | -174,262 | 0.05 | 0.01 | -0.04 | sell |
| BAMCO INC /NY/ | 1,829,494 | 1,587,814 | -241,680 | 0.19 | 0.15 | -0.04 | sell |