| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Woodline Partners LP | 223,032 | 801,394 | +578,362 | 0.07 | 0.23 | +0.15 | buy |
| JANUS HENDERSON GROUP PLC | 3,686,754 | 4,243,226 | +556,472 | 0.06 | 0.07 | 0.00 | buy |
| Paradigm Biocapital Advisors LP | 865,297 | 1,142,383 | +277,086 | 1.94 | 1.89 | -0.05 | buy |
| TD ASSET MANAGEMENT INC | 101,085 | 216,970 | +115,885 | 0.00 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,625,115 | 2,716,594 | +91,479 | 0.01 | 0.01 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 57,198 | 144,838 | +87,640 | 0.02 | 0.05 | 0.00 | buy |
| BAMCO INC /NY/ | 1,512,061 | 1,579,349 | +67,288 | 0.12 | 0.11 | -0.00 | buy |
| Allianz Asset Management GmbH | 473,991 | 539,063 | +65,072 | 0.03 | 0.03 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 226,584 | 182,786 | +43,798 | 0.03 | 0.02 | -0.01 | sell |
| Long Corridor Asset Management Ltd | 16,000 | 31,000 | +15,000 | 0.48 | 0.66 | +0.18 | buy |
| Rock Springs Capital Management LP | 1,222,423 | 1,237,023 | +14,600 | 0.81 | 0.81 | -0.00 | buy |
| Clearbridge Investments, LLC | 811,314 | 822,888 | +11,574 | 0.02 | 0.02 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 11,794 | 22,355 | +10,561 | 0.02 | 0.03 | +0.02 | buy |
| Vivo Capital, LLC | 445,505 | 454,606 | +9,101 | 0.85 | 1.21 | +0.36 | buy |
| ALPS ADVISORS INC | 70,579 | 72,842 | +2,263 | 0.02 | 0.01 | -0.00 | buy |
| WealthPlan Investment Management, LLC | 37,393 | 39,393 | +2,000 | 0.31 | 0.17 | -0.14 | buy |
| AVIVA PLC | 55,370 | 56,770 | +1,400 | 0.01 | 0.01 | -0.00 | buy |
| PROFUND ADVISORS LLC | 18,848 | 19,777 | +929 | 0.03 | 0.03 | -0.00 | buy |
| SHELL ASSET MANAGEMENT CO | 7,823 | 8,475 | +652 | 0.01 | 0.01 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 814 | 1,371 | +557 | 0.01 | 0.01 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 12,423 | 10,998 | -1,425 | 0.20 | 0.16 | -0.04 | sell |
| Headlands Technologies LLC | 3,506 | 33 | -3,473 | 0.03 | 0.00 | -0.03 | sell |
| Capital World Investors | 5,223,568 | 5,218,843 | -4,725 | 0.03 | 0.03 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 8,000 | 3,000 | -5,000 | 0.04 | 0.01 | -0.02 | sell |
| RBF Capital, LLC | 15,000 | 10,000 | -5,000 | 0.03 | 0.02 | -0.01 | sell |
| ABN AMRO INVESTMENT SOLUTIONS | 56,843 | 51,069 | -5,774 | 0.03 | 0.02 | -0.01 | sell |
| Capital International Sarl | 65,173 | 17,328 | -47,845 | 0.08 | 0.02 | -0.06 | sell |
| Polar Capital Holdings Plc | 181,283 | 114,536 | -66,747 | 0.03 | 0.02 | -0.01 | sell |
| GILDER GAGNON HOWE & CO LLC | 100,637 | 10,138 | -90,499 | 0.04 | 0.00 | -0.03 | sell |
| Atika Capital Management LLC | 145,000 | 32,000 | -113,000 | 0.51 | 0.11 | -0.39 | sell |
| Capital International Investors | 966,853 | 845,353 | -121,500 | 0.01 | 0.01 | -0.00 | sell |
| Robeco Institutional Asset Management B.V. | 196,686 | 58,998 | -137,688 | 0.01 | 0.00 | -0.01 | sell |
| VIKING GLOBAL INVESTORS LP | 2,629,445 | 2,491,003 | -138,442 | 0.30 | 0.25 | -0.05 | sell |
| Legal & General Group Plc | 934,602 | 694,625 | -239,977 | 0.01 | 0.01 | -0.00 | sell |
| Genesis Investment Management, LLP | 1,352,222 | 1,032,166 | -320,056 | 4.06 | 3.50 | -0.55 | sell |
| Capital International, Inc./CA/ | 439,918 | 90,813 | -349,105 | 0.22 | 0.04 | -0.18 | sell |