| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital World Investors | 6,036,185 | 6,077,666 | +41,481 | 0.03 | 0.03 | -0.00 | buy |
| FMR LLC | 6,197,423 | 4,701,711 | -1,495,712 | 0.01 | 0.01 | -0.00 | sell |
| Clearbridge Investments, LLC | 4,011,956 | 3,519,337 | -492,619 | 0.11 | 0.09 | -0.02 | sell |
| RTW INVESTMENTS, LP | 5,536,876 | 2,291,372 | -3,245,504 | 2.76 | 0.96 | -1.80 | sell |
| JANUS HENDERSON GROUP PLC | 2,197,860 | 2,049,537 | -148,323 | 0.04 | 0.03 | -0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,376,963 | 1,718,455 | +341,492 | 0.01 | 0.01 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 1,308,138 | 1,627,320 | +319,182 | 1.83 | 1.65 | -0.18 | buy |
| BAMCO INC /NY/ | 1,587,814 | 1,371,243 | -216,571 | 0.15 | 0.12 | -0.03 | sell |
| CITADEL ADVISORS LLC | 366,213 | 987,043 | +620,830 | 0.01 | 0.03 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 153,037 | 948,671 | +795,634 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 850,437 | 868,780 | +18,343 | 4.83 | 2.92 | -1.91 | buy |
| Allianz Asset Management GmbH | 932,000 | 815,000 | -117,000 | 0.04 | 0.03 | -0.01 | sell |
| Rock Springs Capital Management LP | 871,392 | 791,193 | -80,199 | 1.90 | 1.57 | -0.33 | sell |
| MPM BioImpact LLC | 745,060 | 745,060 | 0 | 4.51 | 4.13 | -0.38 | hold |
| C WorldWide Group Holding A/S | 510,000 | 510,000 | 0 | 0.24 | 0.27 | +0.02 | hold |
| BlackRock, Inc. | 455,287 | 473,563 | +18,276 | 0.00 | 0.00 | -0.00 | buy |
| B Group, Inc. | 400,000 | 400,000 | 0 | 12.08 | 12.96 | +0.88 | hold |
| Legal & General Group Plc | 81,836 | 382,459 | +300,623 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 241,650 | 306,554 | +64,904 | 0.00 | 0.00 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 269,975 | 269,975 | 0 | 1.13 | 0.91 | -0.22 | hold |
| ENVESTNET ASSET MANAGEMENT INC | 239,247 | 252,030 | +12,783 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 134,895 | 200,628 | +65,733 | 5.88 | 6.70 | +0.82 | buy |
| Woodline Partners LP | 1,201,016 | 198,509 | -1,002,507 | 0.22 | 0.03 | -0.19 | sell |
| RAYMOND JAMES FINANCIAL INC | 189,913 | 184,766 | -5,147 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 174,480 | 175,132 | +652 | 0.00 | 0.00 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 168,090 | 160,037 | -8,053 | 0.24 | 0.20 | -0.04 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 22,699 | 157,061 | +134,362 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 146,017 | 146,003 | -14 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 149,744 | 142,374 | -7,370 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 138,724 | 136,338 | -2,386 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 44,070 | 132,668 | +88,598 | 0.02 | 0.06 | +0.03 | buy |
| Privium Fund Management B.V. | 132,189 | 132,189 | 0 | 1.00 | 0.81 | -0.20 | hold |
| TD ASSET MANAGEMENT INC | 24,128 | 121,528 | +97,400 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 289,101 | 119,880 | -169,221 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 77,857 | 105,099 | +27,242 | 0.01 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 30,771 | 104,349 | +73,578 | 0.00 | 0.01 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 104,513 | 104,285 | -228 | 0.00 | 0.00 | -0.00 | sell |
| IvyRock Asset Management (HK) Ltd | 0 | 94,879 | +94,879 | 0.00 | 1.38 | +1.38 | buy |
| DCF Advisers, LLC | 91,000 | 92,000 | +1,000 | 1.53 | 1.18 | -0.35 | buy |
| LPL Financial LLC | 31,864 | 85,110 | +53,246 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 144,322 | 82,181 | -62,141 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 20,364 | 69,155 | +48,791 | 0.00 | 0.00 | +0.00 | buy |
| Long Corridor Asset Management Ltd | 0 | 65,800 | +65,800 | 0.00 | 0.91 | +0.91 | buy |
| NEOS Investment Management LLC | 58,835 | 62,067 | +3,232 | 0.03 | 0.02 | -0.01 | buy |
| TEMA ETFS LLC | 58,835 | 62,067 | +3,232 | 0.55 | 0.17 | -0.37 | buy |
| MARSHALL WACE, LLP | 24,456 | 61,402 | +36,946 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 60,798 | 52,616 | -8,182 | 0.01 | 0.01 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 56,522 | 50,576 | -5,946 | 0.00 | 0.00 | -0.00 | sell |
| Orion Porfolio Solutions, LLC | 48,433 | 48,517 | +84 | 0.01 | 0.01 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 15,572 | 46,685 | +31,113 | 0.00 | 0.00 | +0.00 | buy |
| MML INVESTORS SERVICES, LLC | 43,679 | 45,484 | +1,805 | 0.00 | 0.00 | -0.00 | buy |
| BAROMETER CAPITAL MANAGEMENT INC. | 23,600 | 41,900 | +18,300 | 0.23 | 0.32 | +0.10 | buy |
| Invesco Ltd. | 47,599 | 38,554 | -9,045 | 0.00 | 0.00 | -0.00 | sell |
| WealthPlan Investment Management, LLC | 36,761 | 36,761 | 0 | 0.09 | 0.08 | -0.01 | hold |
| DekaBank Deutsche Girozentrale | 36,648 | 36,648 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 24,046 | 34,738 | +10,692 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 279,661 | 34,290 | -245,371 | 0.01 | 0.00 | -0.01 | sell |
| BANK OF MONTREAL /CAN/ | 29,782 | 32,039 | +2,257 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 21,705 | 26,768 | +5,063 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 24,438 | 24,762 | +324 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 22,166 | 22,166 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legacy Wealth Asset Management, LLC | 21,968 | 22,140 | +172 | 0.20 | 0.18 | -0.01 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 21,974 | 21,734 | -240 | 0.01 | 0.01 | -0.00 | sell |
| ROYAL BANK OF CANADA | 18,707 | 21,371 | +2,664 | 0.00 | 0.00 | +0.00 | buy |
| GTS SECURITIES LLC | 0 | 19,465 | +19,465 | 0.00 | 0.03 | +0.03 | buy |
| Marks Group Wealth Management, Inc | 14,253 | 16,523 | +2,270 | 0.05 | 0.05 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 85,247 | 16,514 | -68,733 | 0.00 | 0.00 | -0.00 | sell |
| Erste Asset Management GmbH | 15,100 | 15,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cerity Partners LLC | 14,268 | 14,283 | +15 | 0.00 | 0.00 | -0.00 | buy |
| Polymer Capital Management (HK) LTD | 0 | 13,902 | +13,902 | 0.00 | 0.07 | +0.07 | buy |
| GSA CAPITAL PARTNERS LLP | 27,545 | 13,033 | -14,512 | 0.07 | 0.04 | -0.03 | sell |
| SECTORAL ASSET MANAGEMENT INC | 15,840 | 12,590 | -3,250 | 0.37 | 0.26 | -0.10 | sell |
| Infini Capital Management Ltd | 0 | 12,480 | +12,480 | 0.00 | 0.41 | +0.41 | buy |
| OMERS ADMINISTRATION Corp | 0 | 11,600 | +11,600 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 11,586 | +11,586 | 0.00 | 0.01 | +0.01 | buy |
| NJ State Employees Deferred Compensation Plan | 11,300 | 11,300 | 0 | 0.05 | 0.04 | -0.00 | hold |
| STIFEL FINANCIAL CORP | 11,248 | 11,219 | -29 | 0.00 | 0.00 | -0.00 | sell |
| TRUIST FINANCIAL CORP | 10,389 | 11,132 | +743 | 0.00 | 0.00 | -0.00 | buy |
| ABC ARBITRAGE SA | 0 | 10,388 | +10,388 | 0.00 | 0.03 | +0.03 | buy |
| Virtus Investment Advisers, LLC | 10,328 | 10,328 | 0 | 0.12 | 0.10 | -0.02 | hold |
| SG Americas Securities, LLC | 0 | 9,754 | +9,754 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 9,791 | 9,407 | -384 | 0.00 | 0.00 | -0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 11,785 | 8,945 | -2,840 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 8,696 | 8,633 | -63 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 11,627 | 8,380 | -3,247 | 0.04 | 0.02 | -0.01 | sell |
| Bank of New York Mellon Corp | 7,527 | 8,365 | +838 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 8,512 | 8,266 | -246 | 0.00 | 0.00 | -0.00 | sell |
| Cetera Investment Advisers | 0 | 8,069 | +8,069 | 0.00 | 0.00 | +0.00 | buy |
| Jasper Ridge Partners, L.P. | 8,024 | 8,024 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Kingsview Wealth Management, LLC | 9,038 | 8,003 | -1,035 | 0.01 | 0.00 | -0.00 | sell |
| Atria Investments, Inc | 8,074 | 7,497 | -577 | 0.00 | 0.00 | -0.00 | sell |
| &PARTNERS | 6,469 | 7,100 | +631 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 6,767 | +6,767 | 0.00 | 0.01 | +0.01 | buy |
| PARK AVENUE SECURITIES LLC | 6,575 | 6,615 | +40 | 0.00 | 0.00 | -0.00 | buy |
| OneDigital Investment Advisors LLC | 6,327 | 6,367 | +40 | 0.00 | 0.00 | -0.00 | buy |
| PEAK6 LLC | 7,500 | 6,000 | -1,500 | 0.01 | 0.01 | -0.00 | sell |
| Jefferies Financial Group Inc. | 5,000 | 3,700 | -1,300 | 0.00 | 0.00 | -0.00 | sell |
| Icon Wealth Advisors, LLC | 3,186 | 3,229 | +43 | 0.01 | 0.01 | -0.00 | buy |
| Pictet Asset Management Holding SA | 2,700 | 2,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRINCIPAL SECURITIES, INC. | 1,373 | 1,270 | -103 | 0.00 | 0.00 | -0.00 | sell |