| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 644,859 | 5,475,505 | +4,830,646 | 0.00 | 0.01 | +0.01 | buy |
| RTW INVESTMENTS, LP | 0 | 2,509,119 | +2,509,119 | 0.00 | 0.99 | +0.99 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 1,762,954 | +1,762,954 | 0.00 | 0.03 | +0.03 | buy |
| MORGAN STANLEY | 1,714,357 | 3,166,946 | +1,452,589 | 0.00 | 0.01 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,295,040 | +1,295,040 | 0.00 | 0.45 | +0.45 | buy |
| Clearbridge Investments, LLC | 873,178 | 1,862,842 | +989,664 | 0.02 | 0.04 | +0.02 | buy |
| Allianz Asset Management GmbH | 521,825 | 1,505,866 | +984,041 | 0.02 | 0.06 | +0.04 | buy |
| UBS Group AG | 18,258 | 878,802 | +860,544 | 0.00 | 0.01 | +0.01 | buy |
| MPM BioImpact LLC | 0 | 800,000 | +800,000 | 0.00 | 2.97 | +2.97 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,805,647 | 2,354,025 | +548,378 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 532,454 | 1,045,837 | +513,383 | 2.15 | 5.65 | +3.49 | buy |
| Vestal Point Capital, LP | 0 | 300,000 | +300,000 | 0.00 | 0.47 | +0.47 | buy |
| MARSHALL WACE, LLP | 0 | 288,992 | +288,992 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 13,464 | 283,600 | +270,136 | 0.00 | 0.02 | +0.02 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 604,153 | 841,735 | +237,582 | 0.07 | 0.10 | +0.03 | buy |
| Woodline Partners LP | 1,607,962 | 1,759,797 | +151,835 | 0.33 | 0.31 | -0.02 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 126,202 | +126,202 | 0.00 | 0.02 | +0.02 | buy |
| Capital International Investors | 144,986 | 264,986 | +120,000 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 88,300 | 187,800 | +99,500 | 0.00 | 0.01 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 224,728 | 309,128 | +84,400 | 0.00 | 0.01 | +0.00 | buy |
| Alberta Investment Management Corp | 162,553 | 232,293 | +69,740 | 0.03 | 0.04 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 8,849 | 73,412 | +64,563 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 63,909 | +63,909 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 43,178 | +43,178 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 142,189 | 183,317 | +41,128 | 0.16 | 0.22 | +0.06 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 40,954 | +40,954 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 121,084 | 160,378 | +39,294 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 37,278 | +37,278 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 12,910 | 42,163 | +29,253 | 0.01 | 0.02 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 27,961 | +27,961 | 0.00 | 0.00 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 27,039 | +27,039 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 22,665 | 49,365 | +26,700 | 0.00 | 0.00 | +0.00 | buy |
| BAROMETER CAPITAL MANAGEMENT INC. | 12,500 | 39,100 | +26,600 | 0.09 | 0.37 | +0.28 | buy |
| JPMORGAN CHASE & CO | 138,125 | 161,635 | +23,510 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 23,208 | +23,208 | 0.00 | 0.00 | +0.00 | buy |
| DCF Advisers, LLC | 42,250 | 64,750 | +22,500 | 0.53 | 0.86 | +0.33 | buy |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | 0 | 20,000 | +20,000 | 0.00 | 0.37 | +0.37 | buy |
| LMR Partners LLP | 0 | 19,840 | +19,840 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 0 | 19,502 | +19,502 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 18,840 | +18,840 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,283 | 19,755 | +18,472 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 15,469 | +15,469 | 0.00 | 0.05 | +0.05 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 13,946 | +13,946 | 0.00 | 0.07 | +0.07 | buy |
| ALPS ADVISORS INC | 74,665 | 88,395 | +13,730 | 0.01 | 0.01 | +0.00 | buy |
| Bellevue Group AG | 0 | 13,000 | +13,000 | 0.00 | 0.01 | +0.01 | buy |
| Orion Porfolio Solutions, LLC | 0 | 11,956 | +11,956 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 43,626 | 55,520 | +11,894 | 0.00 | 0.00 | +0.00 | buy |
| Bridgefront Capital, LLC | 0 | 11,303 | +11,303 | 0.00 | 0.10 | +0.10 | buy |
| TOWNSQUARE CAPITAL LLC | 0 | 9,290 | +9,290 | 0.00 | 0.00 | +0.00 | buy |
| Jasper Ridge Partners, L.P. | 0 | 8,024 | +8,024 | 0.00 | 0.01 | +0.01 | buy |
| US BANCORP \DE\ | 331 | 5,865 | +5,534 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 4,381 | +4,381 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 9,557 | 13,833 | +4,276 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 14,000 | 18,200 | +4,200 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 15,301 | 18,480 | +3,179 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 13,900 | 16,893 | +2,993 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 846 | 3,702 | +2,856 | 0.00 | 0.00 | +0.00 | buy |
| BAMCO INC /NY/ | 1,906,520 | 1,909,088 | +2,568 | 0.12 | 0.13 | +0.01 | buy |
| Invesco Ltd. | 42,550 | 44,340 | +1,790 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 9,559 | 11,061 | +1,502 | 0.03 | 0.03 | +0.00 | buy |
| CITIGROUP INC | 69,747 | 70,954 | +1,207 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 1,200 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 55,914 | 57,114 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 4,084 | 5,030 | +946 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 5 | 290 | +285 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 0 | 210 | +210 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 241 | 382 | +141 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 4,517 | 4,603 | +86 | 0.00 | 0.00 | +0.00 | buy |
| WHITTIER TRUST CO OF NEVADA INC | 0 | 80 | +80 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 134 | 181 | +47 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 2,215 | 2,240 | +25 | 0.00 | 0.00 | +0.00 | buy |
| PRIVATE TRUST CO NA | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 41 | 52 | +11 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 0 | 9 | +9 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 95 | 98 | +3 | 0.00 | 0.00 | -0.00 | buy |
| Robeco Institutional Asset Management B.V. | 52,035 | 52,035 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 36,648 | 36,648 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NJ State Employees Deferred Compensation Plan | 11,300 | 11,300 | 0 | 0.03 | 0.04 | +0.00 | hold |
| C WorldWide Group Holding A/S | 500,000 | 500,000 | 0 | 0.13 | 0.16 | +0.03 | hold |
| QUADRANT CAPITAL GROUP LLC | 31 | 31 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Parallel Advisors, LLC | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Nan Fung Group Holdings Ltd | 235,000 | 235,000 | 0 | 4.89 | 5.26 | +0.38 | hold |
| Quent Capital, LLC | 230 | 230 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WealthPlan Investment Management, LLC | 39,393 | 39,393 | 0 | 0.10 | 0.10 | +0.01 | hold |
| Erste Asset Management GmbH | 15,100 | 15,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 15,555 | 15,555 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PNC FINANCIAL SERVICES GROUP, INC. | 1,303 | 1,303 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AXA S.A. | 65,814 | 65,814 | 0 | 0.00 | 0.01 | +0.00 | hold |
| CWM, LLC | 446 | 413 | -33 | 0.00 | 0.00 | -0.00 | sell |
| M&T BANK CORP | 25,188 | 25,123 | -65 | 0.00 | 0.00 | +0.00 | sell |
| Smartleaf Asset Management LLC | 132 | 0 | -132 | 0.00 | 0.00 | -0.00 | sell |
| SHELL ASSET MANAGEMENT CO | 191 | 0 | -191 | 0.00 | 0.00 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 430 | 0 | -430 | 0.00 | 0.00 | -0.00 | sell |
| Kingsview Wealth Management, LLC | 9,349 | 8,794 | -555 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 975 | 332 | -643 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 9,631 | 8,760 | -871 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,748 | 366 | -1,382 | 0.00 | 0.00 | -0.00 | sell |
| Capital World Investors | 6,435,383 | 6,433,424 | -1,959 | 0.02 | 0.03 | +0.00 | sell |
| Walleye Capital LLC | 3,448 | 438 | -3,010 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 16,727 | 13,086 | -3,641 | 0.19 | 0.14 | -0.05 | sell |