| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP | 8,436,606 | 6,657,735 | -1,778,871 | 0.04 | 0.03 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 8,760,074 | 6,567,892 | -2,192,182 | 0.11 | 0.09 | -0.02 | sell |
| Capital World Investors | 6,435,383 | 6,433,424 | -1,959 | 0.02 | 0.03 | +0.00 | sell |
| FMR LLC | 644,859 | 5,475,505 | +4,830,646 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 1,714,357 | 3,166,946 | +1,452,589 | 0.00 | 0.01 | +0.00 | buy |
| RTW INVESTMENTS, LP | 0 | 2,509,119 | +2,509,119 | 0.00 | 0.99 | +0.99 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,805,647 | 2,354,025 | +548,378 | 0.01 | 0.01 | +0.00 | buy |
| BAMCO INC /NY/ | 1,906,520 | 1,909,088 | +2,568 | 0.12 | 0.13 | +0.01 | buy |
| Clearbridge Investments, LLC | 873,178 | 1,862,842 | +989,664 | 0.02 | 0.04 | +0.02 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 1,762,954 | +1,762,954 | 0.00 | 0.03 | +0.03 | buy |
| Woodline Partners LP | 1,607,962 | 1,759,797 | +151,835 | 0.33 | 0.31 | -0.02 | buy |
| Allianz Asset Management GmbH | 521,825 | 1,505,866 | +984,041 | 0.02 | 0.06 | +0.04 | buy |
| Rock Springs Capital Management LP | 1,315,673 | 1,305,337 | -10,336 | 1.03 | 1.30 | +0.27 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,295,040 | +1,295,040 | 0.00 | 0.45 | +0.45 | buy |
| ADAR1 Capital Management, LLC | 532,454 | 1,045,837 | +513,383 | 2.15 | 5.65 | +3.49 | buy |
| UBS Group AG | 18,258 | 878,802 | +860,544 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 604,153 | 841,735 | +237,582 | 0.07 | 0.10 | +0.03 | buy |
| MPM BioImpact LLC | 0 | 800,000 | +800,000 | 0.00 | 2.97 | +2.97 | buy |
| BlackRock, Inc. | 648,714 | 579,528 | -69,186 | 0.00 | 0.00 | -0.00 | sell |
| C WorldWide Group Holding A/S | 500,000 | 500,000 | 0 | 0.13 | 0.16 | +0.03 | hold |
| SUPERSTRING CAPITAL MANAGEMENT LP | 626,932 | 403,630 | -223,302 | 13.53 | 9.28 | -4.25 | sell |
| Candriam S.C.A. | 390,023 | 375,479 | -14,544 | 0.05 | 0.06 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 224,728 | 309,128 | +84,400 | 0.00 | 0.01 | +0.00 | buy |
| Vestal Point Capital, LP | 0 | 300,000 | +300,000 | 0.00 | 0.47 | +0.47 | buy |
| MARSHALL WACE, LLP | 0 | 288,992 | +288,992 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 13,464 | 283,600 | +270,136 | 0.00 | 0.02 | +0.02 | buy |
| Capital International Investors | 144,986 | 264,986 | +120,000 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 235,000 | 235,000 | 0 | 4.89 | 5.26 | +0.38 | hold |
| Alberta Investment Management Corp | 162,553 | 232,293 | +69,740 | 0.03 | 0.04 | +0.01 | buy |
| Russell Investments Group, Ltd. | 257,632 | 231,694 | -25,938 | 0.01 | 0.01 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 251,507 | 230,928 | -20,579 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 88,300 | 187,800 | +99,500 | 0.00 | 0.01 | +0.00 | buy |
| Privium Fund Management B.V. | 215,624 | 185,062 | -30,562 | 1.29 | 1.10 | -0.20 | sell |
| Hennion & Walsh Asset Management, Inc. | 142,189 | 183,317 | +41,128 | 0.16 | 0.22 | +0.06 | buy |
| CITADEL ADVISORS LLC | 1,336,372 | 180,052 | -1,156,320 | 0.03 | 0.00 | -0.03 | sell |
| JPMORGAN CHASE & CO | 138,125 | 161,635 | +23,510 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 121,084 | 160,378 | +39,294 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 153,455 | 140,809 | -12,646 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 126,202 | +126,202 | 0.00 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 138,410 | 123,387 | -15,023 | 0.00 | 0.00 | -0.00 | sell |
| FIL Ltd | 125,941 | 111,713 | -14,228 | 0.00 | 0.00 | -0.00 | sell |
| Eversept Partners, LP | 135,219 | 102,930 | -32,289 | 0.25 | 0.28 | +0.03 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 238,867 | 91,504 | -147,363 | 0.01 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 74,665 | 88,395 | +13,730 | 0.01 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 102,350 | 82,727 | -19,623 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 8,849 | 73,412 | +64,563 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 96,350 | 72,619 | -23,731 | 0.04 | 0.03 | -0.00 | sell |
| CITIGROUP INC | 69,747 | 70,954 | +1,207 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 65,814 | 65,814 | 0 | 0.00 | 0.01 | +0.00 | hold |
| DCF Advisers, LLC | 42,250 | 64,750 | +22,500 | 0.53 | 0.86 | +0.33 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 63,909 | +63,909 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 101,678 | 62,114 | -39,564 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 55,914 | 57,114 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 43,626 | 55,520 | +11,894 | 0.00 | 0.00 | +0.00 | buy |
| Robeco Institutional Asset Management B.V. | 52,035 | 52,035 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHERN TRUST CORP | 22,665 | 49,365 | +26,700 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 72,870 | 44,800 | -28,070 | 1.04 | 0.78 | -0.26 | sell |
| Invesco Ltd. | 42,550 | 44,340 | +1,790 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 43,178 | +43,178 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 12,910 | 42,163 | +29,253 | 0.01 | 0.02 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 40,954 | +40,954 | 0.00 | 0.00 | +0.00 | buy |
| WealthPlan Investment Management, LLC | 39,393 | 39,393 | 0 | 0.10 | 0.10 | +0.01 | hold |
| BAROMETER CAPITAL MANAGEMENT INC. | 12,500 | 39,100 | +26,600 | 0.09 | 0.37 | +0.28 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 37,278 | +37,278 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 36,648 | 36,648 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 68,012 | 29,757 | -38,255 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 0 | 27,961 | +27,961 | 0.00 | 0.00 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 27,039 | +27,039 | 0.00 | 0.01 | +0.01 | buy |
| M&T BANK CORP | 25,188 | 25,123 | -65 | 0.00 | 0.00 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 256,611 | 23,508 | -233,103 | 0.02 | 0.00 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 23,208 | +23,208 | 0.00 | 0.00 | +0.00 | buy |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | 0 | 20,000 | +20,000 | 0.00 | 0.37 | +0.37 | buy |
| LMR Partners LLP | 0 | 19,840 | +19,840 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,283 | 19,755 | +18,472 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 19,502 | +19,502 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 18,840 | +18,840 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 15,301 | 18,480 | +3,179 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 14,000 | 18,200 | +4,200 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 13,900 | 16,893 | +2,993 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 15,555 | 15,555 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bayesian Capital Management, LP | 0 | 15,469 | +15,469 | 0.00 | 0.05 | +0.05 | buy |
| Erste Asset Management GmbH | 15,100 | 15,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 13,946 | +13,946 | 0.00 | 0.07 | +0.07 | buy |
| Daiwa Securities Group Inc. | 9,557 | 13,833 | +4,276 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 31,618 | 13,487 | -18,131 | 0.06 | 0.03 | -0.03 | sell |
| VIRTUS ADVISERS, LLC | 16,727 | 13,086 | -3,641 | 0.19 | 0.14 | -0.05 | sell |
| Bellevue Group AG | 0 | 13,000 | +13,000 | 0.00 | 0.01 | +0.01 | buy |
| Orion Porfolio Solutions, LLC | 0 | 11,956 | +11,956 | 0.00 | 0.00 | +0.00 | buy |
| Bridgefront Capital, LLC | 0 | 11,303 | +11,303 | 0.00 | 0.10 | +0.10 | buy |
| NJ State Employees Deferred Compensation Plan | 11,300 | 11,300 | 0 | 0.03 | 0.04 | +0.00 | hold |
| Jefferies Financial Group Inc. | 28,458 | 11,300 | -17,158 | 0.01 | 0.00 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 9,559 | 11,061 | +1,502 | 0.03 | 0.03 | +0.00 | buy |
| JANE STREET GROUP, LLC | 36,475 | 10,881 | -25,594 | 0.00 | 0.00 | -0.00 | sell |
| TOWNSQUARE CAPITAL LLC | 0 | 9,290 | +9,290 | 0.00 | 0.00 | +0.00 | buy |
| Kingsview Wealth Management, LLC | 9,349 | 8,794 | -555 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 9,631 | 8,760 | -871 | 0.00 | 0.00 | -0.00 | sell |
| Jasper Ridge Partners, L.P. | 0 | 8,024 | +8,024 | 0.00 | 0.01 | +0.01 | buy |
| US BANCORP \DE\ | 331 | 5,865 | +5,534 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 4,084 | 5,030 | +946 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 4,517 | 4,603 | +86 | 0.00 | 0.00 | +0.00 | buy |