| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 2,291,372 | 6,959,032 | +4,667,660 | 0.96 | 1.23 | +0.27 | buy |
| Frazier Life Sciences Management, L.P. | 1,627,320 | 1,902,320 | +275,000 | 1.65 | 0.90 | -0.75 | buy |
| Clearbridge Investments, LLC | 3,519,337 | 1,808,035 | -1,711,302 | 0.09 | 0.03 | -0.06 | sell |
| UBS Group AG | 306,554 | 1,782,252 | +1,475,698 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 987,043 | 1,687,846 | +700,803 | 0.03 | 0.02 | -0.01 | buy |
| FMR LLC | 4,701,711 | 1,440,406 | -3,261,305 | 0.01 | 0.00 | -0.01 | sell |
| BAMCO INC /NY/ | 1,371,243 | 1,418,005 | +46,762 | 0.12 | 0.07 | -0.06 | buy |
| ADAR1 Capital Management, LLC | 868,780 | 1,246,520 | +377,740 | 2.92 | 1.64 | -1.27 | buy |
| Rock Springs Capital Management LP | 791,193 | 811,546 | +20,353 | 1.57 | 0.73 | -0.83 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,718,455 | 752,858 | -965,597 | 0.01 | 0.00 | -0.01 | sell |
| BlackRock, Inc. | 473,563 | 635,213 | +161,650 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 948,671 | 602,954 | -345,717 | 0.00 | 0.00 | -0.00 | sell |
| C WorldWide Group Holding A/S | 510,000 | 510,000 | 0 | 0.27 | 0.16 | -0.11 | hold |
| B Group, Inc. | 400,000 | 400,000 | 0 | 12.96 | 5.23 | -7.73 | hold |
| BANK OF AMERICA CORP /DE/ | 142,374 | 388,769 | +246,395 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 382,459 | 387,800 | +5,341 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 382,062 | +382,062 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 0 | 373,399 | +373,399 | 0.00 | 0.04 | +0.04 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 157,061 | 299,844 | +142,783 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 9,407 | 293,703 | +284,296 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 119,880 | 289,705 | +169,825 | 0.00 | 0.00 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 269,975 | 269,975 | 0 | 0.91 | 0.38 | -0.54 | hold |
| D. E. Shaw & Co., Inc. | 34,290 | 238,609 | +204,319 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 61,402 | 231,802 | +170,400 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 160,037 | 204,982 | +44,945 | 0.20 | 0.12 | -0.07 | buy |
| XY Capital Ltd | 0 | 202,304 | +202,304 | 0.00 | 3.63 | +3.63 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 200,628 | 196,853 | -3,775 | 6.70 | 1.86 | -4.84 | sell |
| AMERIPRISE FINANCIAL INC | 0 | 181,133 | +181,133 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 46,685 | 173,946 | +127,261 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 170,117 | +170,117 | 0.00 | 0.14 | +0.14 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 252,030 | 151,318 | -100,712 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 82,181 | 149,434 | +67,253 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 136,338 | 136,428 | +90 | 0.00 | 0.00 | -0.00 | buy |
| Privium Fund Management B.V. | 132,189 | 132,189 | 0 | 0.81 | 0.43 | -0.38 | hold |
| Qube Research & Technologies Ltd | 0 | 107,651 | +107,651 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 105,099 | 103,118 | -1,981 | 0.01 | 0.01 | -0.01 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 104,285 | 101,782 | -2,503 | 0.00 | 0.00 | -0.00 | sell |
| DCF Advisers, LLC | 92,000 | 97,500 | +5,500 | 1.18 | 0.57 | -0.61 | buy |
| NORTHERN TRUST CORP | 146,003 | 96,442 | -49,561 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 175,132 | 93,140 | -81,992 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 184,766 | 92,837 | -91,929 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 52,616 | 92,107 | +39,491 | 0.01 | 0.01 | -0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 90,000 | +90,000 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 121,528 | 86,640 | -34,888 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 26,768 | 83,793 | +57,025 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 62,067 | 75,165 | +13,098 | 0.02 | 0.01 | -0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 65,814 | +65,814 | 0.00 | 0.00 | +0.00 | buy |
| Long Corridor Asset Management Ltd | 65,800 | 65,800 | 0 | 0.91 | 0.08 | -0.84 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 56,895 | +56,895 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 69,155 | 46,935 | -22,220 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 40,005 | +40,005 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 10,328 | 38,457 | +28,129 | 0.10 | 0.18 | +0.08 | buy |
| WealthPlan Investment Management, LLC | 36,761 | 36,761 | 0 | 0.08 | 0.04 | -0.04 | hold |
| DekaBank Deutsche Girozentrale | 36,648 | 36,648 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MML INVESTORS SERVICES, LLC | 45,484 | 34,421 | -11,063 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 85,110 | 31,114 | -53,996 | 0.00 | 0.00 | -0.00 | sell |
| DRW Securities, LLC | 0 | 30,862 | +30,862 | 0.00 | 0.04 | +0.04 | buy |
| Invesco Ltd. | 38,554 | 30,594 | -7,960 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 0 | 29,523 | +29,523 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 50,576 | 23,879 | -26,697 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 32,039 | 22,099 | -9,940 | 0.00 | 0.00 | -0.00 | sell |
| Orion Porfolio Solutions, LLC | 48,517 | 20,849 | -27,668 | 0.01 | 0.00 | -0.01 | sell |
| GROUP ONE TRADING LLC | 0 | 19,032 | +19,032 | 0.00 | 0.01 | +0.01 | buy |
| US BANCORP \DE\ | 24,762 | 17,771 | -6,991 | 0.00 | 0.00 | -0.00 | sell |
| Marks Group Wealth Management, Inc | 16,523 | 16,278 | -245 | 0.05 | 0.03 | -0.02 | sell |
| Legacy Wealth Asset Management, LLC | 22,140 | 15,903 | -6,237 | 0.18 | 0.07 | -0.11 | sell |
| Headlands Technologies LLC | 0 | 15,846 | +15,846 | 0.00 | 0.02 | +0.02 | buy |
| Erste Asset Management GmbH | 15,100 | 15,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IvyRock Asset Management (HK) Ltd | 94,879 | 14,979 | -79,900 | 1.38 | 0.14 | -1.24 | sell |
| ROYAL BANK OF CANADA | 21,371 | 14,757 | -6,614 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 13,618 | +13,618 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 12,339 | +12,339 | 0.00 | 0.10 | +0.10 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 21,734 | 10,608 | -11,126 | 0.01 | 0.00 | -0.01 | sell |
| Virtu Financial LLC | 0 | 10,551 | +10,551 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 9,754 | 10,396 | +642 | 0.00 | 0.00 | -0.00 | buy |
| LMR Partners LLP | 132,668 | 10,320 | -122,348 | 0.06 | 0.00 | -0.06 | sell |
| Quantinno Capital Management LP | 8,633 | 10,085 | +1,452 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 8,380 | 6,380 | -2,000 | 0.02 | 0.01 | -0.01 | sell |
| CITIGROUP INC | 8,266 | 5,151 | -3,115 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 576 | 1,329 | +753 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 442 | 979 | +537 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 797 | 884 | +87 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 151 | 804 | +653 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,029 | 768 | -261 | 0.00 | 0.00 | -0.00 | sell |
| Horizon Investments, LLC | 1,086 | 735 | -351 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 0 | 409 | +409 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 182 | 331 | +149 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 325 | +325 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 34,738 | 317 | -34,421 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 291 | 281 | -10 | 0.00 | 0.00 | -0.00 | sell |
| ASSETMARK, INC | 7 | 233 | +226 | 0.00 | 0.00 | +0.00 | buy |
| Quent Capital, LLC | 230 | 230 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parkside Financial Bank & Trust | 0 | 213 | +213 | 0.00 | 0.00 | +0.00 | buy |
| PRIVATE TRUST CO NA | 206 | 206 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 176 | 203 | +27 | 0.00 | 0.00 | -0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 202 | 202 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Pinnacle Wealth Planning Services, Inc. | 0 | 201 | +201 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 173 | +173 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 135 | 159 | +24 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 157 | +157 | 0.00 | 0.00 | +0.00 | buy |