| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Woodline Partners LP | 135,036 | 466,737 | +331,701 | 0.01 | 0.02 | +0.01 | buy |
| Aberdeen Group plc | 363,161 | 693,192 | +330,031 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 64,067 | 250,000 | +185,933 | 0.10 | 0.31 | +0.21 | buy |
| Tejara Capital Ltd | 51,967 | 229,672 | +177,705 | 0.25 | 0.73 | +0.48 | buy |
| Ikarian Capital, LLC | 897,862 | 1,068,062 | +170,200 | 1.88 | 2.25 | +0.37 | buy |
| Rafferty Asset Management, LLC | 120,723 | 171,133 | +50,410 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (US) LLC | 13,790 | 43,142 | +29,352 | 0.03 | 0.08 | +0.05 | buy |
| Alta Partners Management Company, L.P. | 489,485 | 501,917 | +12,432 | 5.67 | 7.78 | +2.12 | buy |
| PROFUND ADVISORS LLC | 27,510 | 37,925 | +10,415 | 0.01 | 0.01 | +0.00 | buy |
| Nebula Research & Development LLC | 11,445 | 21,226 | +9,781 | 0.01 | 0.01 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 56,900 | 61,168 | +4,268 | 0.01 | 0.00 | 0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 136,487 | 139,840 | +3,353 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,892 | 3,526 | +634 | 0.00 | 0.00 | +0.00 | buy |
| Ballentine Partners, LLC | 10,934 | 10,775 | -159 | 0.00 | 0.00 | -0.00 | sell |
| Teza Capital Management LLC | 11,786 | 10,277 | -1,509 | 0.01 | 0.03 | +0.02 | sell |
| China Universal Asset Management Co., Ltd. | 29,202 | 27,509 | -1,693 | 0.02 | 0.02 | -0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 49,651 | 46,089 | -3,562 | 0.07 | 0.05 | -0.02 | sell |
| ALPS ADVISORS INC | 111,360 | 102,828 | -8,532 | 0.01 | 0.00 | -0.00 | sell |
| Quinn Opportunity Partners LLC | 65,976 | 50,976 | -15,000 | 0.03 | 0.02 | -0.01 | sell |
| Stonepine Capital Management, LLC | 164,106 | 144,628 | -19,478 | 0.97 | 0.91 | -0.06 | sell |
| Sofinnova Investments, Inc. | 114,131 | 83,010 | -31,121 | 0.06 | 0.04 | -0.03 | sell |
| WINTON GROUP Ltd | 92,235 | 35,384 | -56,851 | 0.04 | 0.01 | -0.03 | sell |
| Artisan Partners Limited Partnership | 918,529 | 791,611 | -126,918 | 0.01 | 0.01 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 581,829 | 90,855 | -490,974 | 0.77 | 0.14 | -0.64 | sell |
| BAKER BROS. ADVISORS LP | 1,084,539 | 542,539 | -542,000 | 0.09 | 0.04 | -0.05 | sell |
| Sio Capital Management, LLC | 1,054,651 | 473,607 | -581,044 | 2.18 | 0.91 | -1.26 | sell |
| ORBIMED ADVISORS LLC | 3,218,617 | 2,248,249 | -970,368 | 0.49 | 0.35 | -0.14 | sell |