| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 16,330,103 | 17,998,329 | +1,668,226 | 0.00 | 0.00 | +0.00 | buy |
| ARCH Venture Management, LLC | 12,916,663 | 12,916,663 | 0 | 11.95 | 17.09 | +5.14 | hold |
| SB INVESTMENT ADVISERS (UK) LTD | 13,116,977 | 10,948,093 | -2,168,884 | 0.79 | 1.27 | +0.48 | sell |
| STATE STREET CORP | 6,229,555 | 7,141,094 | +911,539 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,568,904 | 3,250,227 | +1,681,323 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 2,679,145 | 2,854,205 | +175,060 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 2,744,714 | +2,744,714 | 0.00 | 1.48 | +1.48 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,328,207 | 2,657,843 | +329,636 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,536,277 | 2,579,678 | +43,401 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 489,226 | 2,098,476 | +1,609,250 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 3,158,416 | 2,071,848 | -1,086,568 | 0.00 | 0.00 | +0.00 | sell |
| Soleus Capital Management, L.P. | 0 | 2,002,000 | +2,002,000 | 0.00 | 0.73 | +0.73 | buy |
| Point72 Asset Management, L.P. | 195,718 | 1,952,234 | +1,756,516 | 0.00 | 0.03 | +0.03 | buy |
| Boxer Capital Management, LLC | 625,000 | 1,866,000 | +1,241,000 | 0.82 | 2.20 | +1.37 | buy |
| Sio Capital Management, LLC | 478,343 | 1,498,620 | +1,020,277 | 0.48 | 1.94 | +1.46 | buy |
| Pictet Asset Management Holding SA | 13,488 | 1,480,828 | +1,467,340 | 0.00 | 0.01 | +0.01 | buy |
| Hudson Bay Capital Management LP | 1,325,000 | 1,469,510 | +144,510 | 0.05 | 0.08 | +0.03 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 1,442,336 | +1,442,336 | 0.00 | 0.05 | +0.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 589,561 | 1,439,494 | +849,933 | 0.01 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 83,059 | 1,248,669 | +1,165,610 | 0.00 | 0.02 | +0.02 | buy |
| Clearstead Advisors, LLC | 0 | 1,216,400 | +1,216,400 | 0.00 | 0.10 | +0.10 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 904,480 | 1,171,684 | +267,204 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 1,031,663 | 1,135,763 | +104,100 | 0.03 | 0.05 | +0.02 | buy |
| JPMORGAN CHASE & CO | 418,603 | 1,117,516 | +698,913 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 279,676 | 1,078,020 | +798,344 | 0.00 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 531,431 | 1,070,812 | +539,381 | 0.01 | 0.02 | +0.01 | buy |
| Nuveen, LLC | 565,544 | 1,018,964 | +453,420 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 848,469 | 985,435 | +136,966 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 930,908 | 965,814 | +34,906 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 0 | 950,000 | +950,000 | 0.00 | 1.72 | +1.72 | buy |
| D. E. Shaw & Co., Inc. | 49,792 | 817,685 | +767,893 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 614,464 | 761,364 | +146,900 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 417,965 | 744,142 | +326,177 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 730,548 | +730,548 | 0.00 | 4.68 | +4.68 | buy |
| Walleye Capital LLC | 256,125 | 665,584 | +409,459 | 0.01 | 0.04 | +0.03 | buy |
| Bank of New York Mellon Corp | 545,557 | 584,047 | +38,490 | 0.00 | 0.00 | +0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 609,726 | 580,755 | -28,971 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 186,324 | 566,009 | +379,685 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 450,595 | 547,753 | +97,158 | 0.00 | 0.00 | +0.00 | buy |
| Empyrean Capital Partners, LP | 0 | 527,800 | +527,800 | 0.00 | 0.16 | +0.16 | buy |
| Alta Partners Management Company, L.P. | 509,917 | 509,917 | 0 | 2.97 | 3.03 | +0.06 | hold |
| Parkman Healthcare Partners LLC | 0 | 500,000 | +500,000 | 0.00 | 0.46 | +0.46 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,002,606 | 489,360 | -513,246 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 0 | 489,008 | +489,008 | 0.00 | 0.07 | +0.07 | buy |
| Invesco Ltd. | 405,698 | 421,332 | +15,634 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 326,172 | 403,795 | +77,623 | 0.01 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 731,307 | 395,038 | -336,269 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 371,291 | 375,354 | +4,063 | 0.01 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 370,128 | +370,128 | 0.00 | 0.03 | +0.03 | buy |
| WINTON GROUP Ltd | 189,306 | 367,883 | +178,577 | 0.04 | 0.12 | +0.08 | buy |
| Susquehanna Portfolio Strategies, LLC | 47,432 | 353,663 | +306,231 | 0.00 | 0.05 | +0.04 | buy |
| AMERICAN CENTURY COMPANIES INC | 295,391 | 296,824 | +1,433 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 260,702 | 293,688 | +32,986 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 575,712 | 293,258 | -282,454 | 0.45 | 0.38 | -0.07 | sell |
| Legal & General Group Plc | 240,643 | 256,749 | +16,106 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 311,287 | 256,140 | -55,147 | 0.00 | 0.00 | +0.00 | sell |
| Engineers Gate Manager LP | 0 | 250,391 | +250,391 | 0.00 | 0.03 | +0.03 | buy |
| Eversept Partners, LP | 0 | 250,000 | +250,000 | 0.00 | 0.15 | +0.15 | buy |
| RHUMBLINE ADVISERS | 208,359 | 232,550 | +24,191 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 178,000 | 231,500 | +53,500 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 390,058 | 195,561 | -194,497 | 0.00 | 0.00 | -0.00 | sell |
| Erste Asset Management GmbH | 28,800 | 180,800 | +152,000 | 0.00 | 0.01 | +0.01 | buy |
| Man Group plc | 0 | 177,924 | +177,924 | 0.00 | 0.00 | +0.00 | buy |
| Tejara Capital Ltd | 231,246 | 161,789 | -69,457 | 0.58 | 0.48 | -0.10 | sell |
| Hillsdale Investment Management Inc. | 0 | 161,096 | +161,096 | 0.00 | 0.04 | +0.04 | buy |
| ExodusPoint Capital Management, LP | 177,103 | 137,059 | -40,044 | 0.01 | 0.01 | +0.00 | sell |
| BARCLAYS PLC | 365,826 | 134,796 | -231,030 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 134,547 | +134,547 | 0.00 | 0.02 | +0.02 | buy |
| Rafferty Asset Management, LLC | 133,766 | 134,413 | +647 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 121,080 | 130,503 | +9,423 | 0.00 | 0.00 | +0.00 | buy |
| Raiffeisen Bank International AG | 0 | 125,000 | +125,000 | 0.00 | 0.02 | +0.02 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 126,058 | 122,900 | -3,158 | 0.00 | 0.00 | +0.00 | sell |
| Jump Financial, LLC | 0 | 122,066 | +122,066 | 0.00 | 0.02 | +0.02 | buy |
| PRUDENTIAL FINANCIAL INC | 281,542 | 115,402 | -166,140 | 0.00 | 0.00 | -0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 65,006 | 113,593 | +48,587 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 106,977 | 113,338 | +6,361 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 112,700 | +112,700 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 109,620 | 107,850 | -1,770 | 0.00 | 0.00 | +0.00 | sell |
| Headlands Technologies LLC | 22,556 | 103,247 | +80,691 | 0.01 | 0.11 | +0.09 | buy |
| Creative Planning | 79,696 | 100,511 | +20,815 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 100,000 | +100,000 | 0.00 | 0.49 | +0.49 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 81,611 | 96,145 | +14,534 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 96,010 | +96,010 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 39,272 | 95,927 | +56,655 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 94,767 | +94,767 | 0.00 | 0.01 | +0.01 | buy |
| THOMPSON SIEGEL & WALMSLEY LLC | 0 | 92,000 | +92,000 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 206,222 | 90,733 | -115,489 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 87,773 | 87,375 | -398 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 7,500 | 82,213 | +74,713 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 24,941 | 76,416 | +51,475 | 0.01 | 0.04 | +0.03 | buy |
| Quadrature Capital Ltd | 49,800 | 75,658 | +25,858 | 0.00 | 0.01 | +0.01 | buy |
| Aquatic Capital Management LLC | 0 | 75,301 | +75,301 | 0.00 | 0.02 | +0.02 | buy |
| TUDOR INVESTMENT CORP ET AL | 68,574 | 73,504 | +4,930 | 0.00 | 0.00 | +0.00 | buy |
| Quinn Opportunity Partners LLC | 50,976 | 70,976 | +20,000 | 0.01 | 0.03 | +0.02 | buy |
| LMR Partners LLP | 67,800 | 67,800 | 0 | 0.00 | 0.01 | +0.00 | hold |
| XTX Topco Ltd | 60,078 | 66,942 | +6,864 | 0.01 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 264,006 | 66,344 | -197,662 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 56,693 | 63,866 | +7,173 | 0.01 | 0.02 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 135,701 | 63,227 | -72,474 | 0.02 | 0.01 | -0.01 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 36,304 | 61,725 | +25,421 | 0.00 | 0.01 | +0.00 | buy |