| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NORDEA INVESTMENT MANAGEMENT AB | 139,840 | 704,377 | +564,537 | 0.00 | 0.00 | +0.00 | buy |
| Clarius Group, LLC | 57,193 | 617,535 | +560,342 | 0.02 | 0.18 | +0.16 | buy |
| Aberdeen Group plc | 693,192 | 1,006,891 | +313,699 | 0.01 | 0.01 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 2,248,249 | 2,380,715 | +132,466 | 0.35 | 0.30 | -0.05 | buy |
| Tejara Capital Ltd | 229,672 | 258,600 | +28,928 | 0.73 | 0.60 | -0.13 | buy |
| ALPS ADVISORS INC | 102,828 | 74,550 | +28,278 | 0.00 | 0.00 | 0.00 | sell |
| LMR Partners LLP | 147,800 | 167,800 | +20,000 | 0.02 | 0.01 | -0.01 | buy |
| AXQ CAPITAL, LP | 13,299 | 23,820 | +10,521 | 0.03 | 0.04 | +0.00 | buy |
| Alta Partners Management Company, L.P. | 501,917 | 509,917 | +8,000 | 7.78 | 6.18 | -1.61 | buy |
| Sio Capital Management, LLC | 473,607 | 478,343 | +4,736 | 0.91 | 0.92 | +0.01 | buy |
| Cinctive Capital Management LP | 84,398 | 88,171 | +3,773 | 0.04 | 0.02 | -0.02 | buy |
| Ballentine Partners, LLC | 10,775 | 11,743 | +968 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 27,509 | 27,765 | +256 | 0.02 | 0.01 | -0.00 | buy |
| E Fund Management Co., Ltd. | 15,993 | 14,698 | -1,295 | 0.00 | 0.00 | -0.00 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 61,168 | 57,268 | -3,900 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 22,093 | 18,014 | -4,079 | 0.04 | 0.03 | -0.01 | sell |
| PROFUND ADVISORS LLC | 37,925 | 30,176 | -7,749 | 0.01 | 0.01 | -0.01 | sell |
| Stonepine Capital Management, LLC | 144,628 | 130,000 | -14,628 | 0.91 | 0.64 | -0.27 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 331,801 | 300,357 | -31,444 | 0.03 | 0.04 | +0.01 | sell |
| Rafferty Asset Management, LLC | 171,133 | 132,021 | -39,112 | 0.00 | 0.00 | -0.00 | sell |
| Catalio Capital Management, LP | 611,608 | 388,303 | -223,305 | 0.98 | 0.41 | -0.57 | sell |