| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SB INVESTMENT ADVISERS (UK) LTD | 16,684,041 | 16,684,041 | 0 | 0.99 | 0.67 | -0.32 | hold |
| BlackRock, Inc. | 16,541,330 | 16,153,190 | -388,140 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 12,807,508 | 13,227,066 | +419,558 | 0.00 | 0.00 | -0.00 | buy |
| ARCH Venture Management, LLC | 0 | 12,916,663 | +12,916,663 | 0.00 | 21.76 | +21.76 | buy |
| STATE STREET CORP | 5,727,163 | 5,254,712 | -472,451 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 2,216,434 | 3,558,655 | +1,342,221 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,617,228 | 3,464,917 | +1,847,689 | 0.01 | 0.02 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,684,415 | 3,007,955 | +323,540 | 0.00 | 0.00 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 2,248,249 | 2,380,715 | +132,466 | 0.35 | 0.30 | -0.05 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,295,031 | 2,252,420 | -42,611 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 1,424,345 | 1,633,690 | +209,345 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,374,874 | 1,293,016 | -81,858 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 742,674 | 1,290,138 | +547,464 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 1,068,062 | 1,068,062 | 0 | 2.25 | 1.78 | -0.47 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 1,120,400 | 1,064,500 | -55,900 | 0.01 | 0.01 | -0.00 | sell |
| Aberdeen Group plc | 693,192 | 1,006,891 | +313,699 | 0.01 | 0.01 | -0.00 | buy |
| NORTHERN TRUST CORP | 930,320 | 928,240 | -2,080 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 840,433 | 840,433 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Artisan Partners Limited Partnership | 791,611 | 791,611 | 0 | 0.01 | 0.01 | -0.00 | hold |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,060,155 | 789,506 | -270,649 | 0.03 | 0.01 | -0.01 | sell |
| ROYAL BANK OF CANADA | 23,362 | 707,226 | +683,864 | 0.00 | 0.00 | +0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 139,840 | 704,377 | +564,537 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 591,420 | 696,000 | +104,580 | 0.02 | 0.02 | -0.00 | buy |
| Clarius Group, LLC | 57,193 | 617,535 | +560,342 | 0.02 | 0.18 | +0.16 | buy |
| Bank of New York Mellon Corp | 596,519 | 612,470 | +15,951 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 668,789 | 610,452 | -58,337 | 0.01 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 433,378 | 609,292 | +175,914 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 63,874 | 582,981 | +519,107 | 0.00 | 0.01 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 542,539 | 542,539 | 0 | 0.04 | 0.03 | -0.01 | hold |
| Alta Partners Management Company, L.P. | 501,917 | 509,917 | +8,000 | 7.78 | 6.18 | -1.61 | buy |
| Sio Capital Management, LLC | 473,607 | 478,343 | +4,736 | 0.93 | 0.97 | +0.04 | buy |
| BARCLAYS PLC | 211,623 | 473,658 | +262,035 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 459,337 | 459,038 | -299 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 268,297 | 448,805 | +180,508 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 439,306 | 443,375 | +4,069 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 290,676 | 440,005 | +149,329 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 470,707 | 425,701 | -45,006 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 260,518 | 415,951 | +155,433 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 405,580 | 404,852 | -728 | 0.00 | 0.00 | -0.00 | sell |
| Catalio Capital Management, LP | 611,608 | 388,303 | -223,305 | 0.98 | 0.41 | -0.57 | sell |
| TWO SIGMA INVESTMENTS, LP | 272,535 | 369,615 | +97,080 | 0.00 | 0.00 | -0.00 | buy |
| Allianz Asset Management GmbH | 308,700 | 327,700 | +19,000 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 477,396 | 315,167 | -162,229 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 112,700 | 314,900 | +202,200 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 292,578 | 314,176 | +21,598 | 0.01 | 0.01 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 306,545 | 306,545 | 0 | 0.07 | 0.05 | -0.02 | hold |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 331,801 | 300,357 | -31,444 | 0.04 | 0.04 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 199,063 | 294,383 | +95,320 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 257,620 | 273,708 | +16,088 | 0.00 | 0.00 | -0.00 | buy |
| Corient Private Wealth LLC | 258,376 | 259,342 | +966 | 0.00 | 0.00 | -0.00 | buy |
| Tejara Capital Ltd | 229,672 | 258,600 | +28,928 | 0.73 | 0.60 | -0.13 | buy |
| Man Group plc | 92,191 | 256,918 | +164,727 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 208,734 | 252,714 | +43,980 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 250,000 | 250,000 | 0 | 0.31 | 0.20 | -0.11 | hold |
| Legal & General Group Plc | 234,850 | 248,726 | +13,876 | 0.00 | 0.00 | -0.00 | buy |
| Eagle Health Investments LP | 240,500 | 240,500 | 0 | 0.40 | 0.30 | -0.11 | hold |
| Graham Capital Management, L.P. | 115,115 | 234,614 | +119,499 | 0.02 | 0.04 | +0.01 | buy |
| RHUMBLINE ADVISERS | 226,649 | 228,949 | +2,300 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 0 | 217,355 | +217,355 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 213,735 | 211,388 | -2,347 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 209,661 | 206,401 | -3,260 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 358,575 | 205,480 | -153,095 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 208,290 | 195,495 | -12,795 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 250,966 | 183,930 | -67,036 | 0.02 | 0.01 | -0.01 | sell |
| HRT FINANCIAL LP | 15,583 | 182,529 | +166,946 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 174,700 | 170,200 | -4,500 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 147,800 | 167,800 | +20,000 | 0.02 | 0.01 | -0.01 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 55,452 | 145,298 | +89,846 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 171,133 | 132,021 | -39,112 | 0.00 | 0.00 | -0.00 | sell |
| Stonepine Capital Management, LLC | 144,628 | 130,000 | -14,628 | 0.91 | 0.65 | -0.27 | sell |
| ALLIANCEBERNSTEIN L.P. | 109,620 | 109,620 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Squarepoint Ops LLC | 53,698 | 107,360 | +53,662 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 97,327 | +97,327 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 84,398 | 88,171 | +3,773 | 0.04 | 0.02 | -0.02 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 83,197 | 83,197 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 81,858 | 82,258 | +400 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 102,828 | 74,550 | -28,278 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 64,839 | 71,881 | +7,042 | 0.00 | 0.00 | -0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 67,776 | 68,105 | +329 | 0.00 | 0.00 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 18,399 | 67,808 | +49,409 | 0.01 | 0.02 | +0.01 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 67,083 | 66,045 | -1,038 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 64,906 | 64,906 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WELLS FARGO & COMPANY/MN | 56,432 | 62,167 | +5,735 | 0.00 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 0 | 59,670 | +59,670 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 61,168 | 57,268 | -3,900 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 133,630 | 56,730 | -76,900 | 0.01 | 0.00 | -0.01 | sell |
| State of Alaska, Department of Revenue | 51,128 | 55,076 | +3,948 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 54,480 | 54,480 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ExodusPoint Capital Management, LP | 0 | 52,993 | +52,993 | 0.00 | 0.00 | +0.00 | buy |
| TEXAS PERMANENT SCHOOL FUND CORP | 52,841 | 52,841 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quinn Opportunity Partners LLC | 50,976 | 50,976 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Mitsubishi UFJ Asset Management Co., Ltd. | 38,290 | 49,910 | +11,620 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 62,641 | 48,999 | -13,642 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 0 | 47,432 | +47,432 | 0.00 | 0.01 | +0.01 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 47,014 | 47,014 | 0 | 0.01 | 0.01 | -0.00 | hold |
| IEQ CAPITAL, LLC | 35,446 | 46,363 | +10,917 | 0.00 | 0.00 | -0.00 | buy |
| Vontobel Holding Ltd. | 48,369 | 45,356 | -3,013 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 48,172 | 45,144 | -3,028 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 14,249 | 44,326 | +30,077 | 0.00 | 0.00 | +0.00 | buy |
| Louisiana State Employees Retirement System | 43,500 | 43,300 | -200 | 0.01 | 0.00 | -0.00 | sell |