| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 17,998,329 | 20,678,283 | +2,679,954 | 0.00 | 0.00 | +0.00 | buy |
| ARCH Venture Management, LLC | 12,916,663 | 12,694,163 | -222,500 | 17.09 | 11.76 | -5.34 | sell |
| SB INVESTMENT ADVISERS (UK) LTD | 10,948,093 | 10,948,093 | 0 | 1.27 | 1.46 | +0.19 | hold |
| STATE STREET CORP | 7,141,094 | 9,964,151 | +2,823,057 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 1,952,234 | 5,666,821 | +3,714,587 | 0.03 | 0.09 | +0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,657,843 | 3,348,366 | +690,523 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,579,678 | 3,119,421 | +539,743 | 0.00 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 2,744,714 | 2,456,677 | -288,037 | 1.48 | 1.18 | -0.30 | sell |
| GOLDMAN SACHS GROUP INC | 3,250,227 | 2,365,219 | -885,008 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 2,071,848 | 2,318,294 | +246,446 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 2,854,205 | 2,211,077 | -643,128 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 1,018,964 | 1,982,942 | +963,978 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,480,828 | 1,953,316 | +472,488 | 0.01 | 0.02 | +0.01 | buy |
| Boxer Capital Management, LLC | 1,866,000 | 1,866,000 | 0 | 2.20 | 1.43 | -0.76 | hold |
| NORTHERN TRUST CORP | 985,435 | 1,432,165 | +446,730 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 1,469,510 | 1,364,000 | -105,510 | 0.08 | 0.07 | -0.01 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 1,323,185 | +1,323,185 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,171,684 | 1,323,185 | +151,501 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 965,814 | 1,142,539 | +176,725 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,439,494 | 1,110,227 | -329,267 | 0.01 | 0.01 | -0.00 | sell |
| Sio Capital Management, LLC | 1,498,620 | 1,075,274 | -423,346 | 1.94 | 1.88 | -0.06 | sell |
| Savvy Advisors, Inc. | 0 | 1,040,665 | +1,040,665 | 0.00 | 0.23 | +0.23 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 761,364 | 1,016,864 | +255,500 | 0.01 | 0.01 | +0.00 | buy |
| Soleus Capital Management, L.P. | 2,002,000 | 1,000,000 | -1,002,000 | 0.73 | 0.35 | -0.38 | sell |
| CITADEL ADVISORS LLC | 2,098,476 | 991,337 | -1,107,139 | 0.01 | 0.01 | -0.01 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 730,548 | 853,685 | +123,137 | 4.68 | 5.49 | +0.82 | buy |
| Ensign Peak Advisors, Inc | 1,070,812 | 833,779 | -237,033 | 0.02 | 0.01 | -0.00 | sell |
| ALGERT GLOBAL LLC | 489,008 | 804,977 | +315,969 | 0.07 | 0.10 | +0.03 | buy |
| JPMORGAN CHASE & CO | 1,117,516 | 802,597 | -314,919 | 0.00 | 0.00 | -0.00 | sell |
| Saturn V Capital Management LP | 0 | 770,643 | +770,643 | 0.00 | 1.13 | +1.13 | buy |
| Bank of New York Mellon Corp | 584,047 | 694,374 | +110,327 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,078,020 | 653,692 | -424,328 | 0.01 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 1,248,669 | 641,486 | -607,183 | 0.02 | 0.01 | -0.01 | sell |
| Candriam S.C.A. | 1,135,763 | 626,690 | -509,073 | 0.05 | 0.03 | -0.02 | sell |
| Clearstead Advisors, LLC | 1,216,400 | 608,234 | -608,166 | 0.10 | 0.06 | -0.04 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 580,755 | 593,776 | +13,021 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 547,753 | 586,898 | +39,145 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 566,009 | 581,416 | +15,407 | 0.00 | 0.00 | -0.00 | buy |
| Weiss Asset Management LP | 0 | 555,541 | +555,541 | 0.00 | 0.06 | +0.06 | buy |
| Avidity Partners Management LP | 950,000 | 519,300 | -430,700 | 1.72 | 0.85 | -0.88 | sell |
| Walleye Capital LLC | 665,584 | 514,251 | -151,333 | 0.04 | 0.02 | -0.01 | sell |
| Alta Partners Management Company, L.P. | 509,917 | 509,917 | 0 | 3.03 | 4.08 | +1.06 | hold |
| Invesco Ltd. | 421,332 | 475,545 | +54,213 | 0.00 | 0.00 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 500,000 | 475,279 | -24,721 | 0.46 | 0.50 | +0.03 | sell |
| UBS Group AG | 744,142 | 461,334 | -282,808 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 122,066 | 458,671 | +336,605 | 0.02 | 0.04 | +0.03 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 403,795 | 417,209 | +13,414 | 0.01 | 0.01 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 817,685 | 416,403 | -401,282 | 0.01 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 375,354 | 374,265 | -1,089 | 0.01 | 0.01 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 296,824 | 349,020 | +52,196 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 353,663 | 345,541 | -8,122 | 0.05 | 0.06 | +0.01 | sell |
| Corient Private Wealth LLC | 293,688 | 311,002 | +17,314 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 308,104 | +308,104 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 232,550 | 285,154 | +52,604 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 256,749 | 270,875 | +14,126 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 231,500 | 234,500 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 0 | 220,000 | +220,000 | 0.00 | 1.05 | +1.05 | buy |
| CITIGROUP INC | 256,140 | 218,419 | -37,721 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 134,547 | 214,529 | +79,982 | 0.02 | 0.04 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 395,038 | 205,204 | -189,834 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 113,338 | 196,778 | +83,440 | 0.00 | 0.00 | +0.00 | buy |
| Hillsdale Investment Management Inc. | 161,096 | 187,196 | +26,100 | 0.04 | 0.04 | +0.00 | buy |
| Erste Asset Management GmbH | 180,800 | 180,800 | 0 | 0.01 | 0.01 | +0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 130,503 | 164,147 | +33,644 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 250,000 | 156,636 | -93,364 | 0.15 | 0.09 | -0.06 | sell |
| WINTON GROUP Ltd | 367,883 | 153,491 | -214,392 | 0.12 | 0.05 | -0.06 | sell |
| Man Group plc | 177,924 | 150,688 | -27,236 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 134,413 | 137,469 | +3,056 | 0.00 | 0.00 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,442,336 | 136,335 | -1,306,001 | 0.05 | 0.00 | -0.05 | sell |
| ALLIANCEBERNSTEIN L.P. | 107,850 | 135,990 | +28,140 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 87,375 | 135,840 | +48,465 | 0.00 | 0.00 | +0.00 | buy |
| Edgestream Partners, L.P. | 0 | 134,321 | +134,321 | 0.00 | 0.04 | +0.04 | buy |
| DEUTSCHE BANK AG\ | 90,733 | 134,258 | +43,525 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 113,593 | 132,338 | +18,745 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 96,145 | 129,789 | +33,644 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 250,391 | 128,427 | -121,964 | 0.03 | 0.02 | -0.01 | sell |
| Quantinno Capital Management LP | 95,927 | 127,925 | +31,998 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 122,900 | 126,458 | +3,558 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 26,013 | 126,141 | +100,128 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 115,402 | 125,712 | +10,310 | 0.00 | 0.00 | +0.00 | buy |
| Raiffeisen Bank International AG | 125,000 | 120,000 | -5,000 | 0.02 | 0.01 | -0.00 | sell |
| BARCLAYS PLC | 134,796 | 116,276 | -18,520 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 41,561 | 114,269 | +72,708 | 0.00 | 0.00 | +0.00 | buy |
| Empyrean Capital Partners, LP | 527,800 | 114,000 | -413,800 | 0.16 | 0.04 | -0.12 | sell |
| Creative Planning | 100,511 | 100,889 | +378 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 35,202 | 93,333 | +58,131 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 88,507 | +88,507 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 94,767 | 85,350 | -9,417 | 0.01 | 0.01 | -0.00 | sell |
| THOMPSON SIEGEL & WALMSLEY LLC | 92,000 | 83,000 | -9,000 | 0.01 | 0.02 | +0.00 | sell |
| BIT Capital GmbH | 30,000 | 80,000 | +50,000 | 0.02 | 0.03 | +0.01 | buy |
| Russell Investments Group, Ltd. | 82,213 | 79,015 | -3,198 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 370,128 | 73,914 | -296,214 | 0.03 | 0.00 | -0.02 | sell |
| PROFUND ADVISORS LLC | 63,866 | 73,077 | +9,211 | 0.02 | 0.02 | -0.00 | buy |
| MetLife Investment Management, LLC | 50,546 | 71,822 | +21,276 | 0.00 | 0.00 | +0.00 | buy |
| Quinn Opportunity Partners LLC | 70,976 | 70,976 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Illinois Municipal Retirement Fund | 0 | 68,943 | +68,943 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 61,725 | 68,270 | +6,545 | 0.01 | 0.01 | +0.00 | buy |
| LMR Partners LLP | 67,800 | 67,800 | 0 | 0.01 | 0.01 | -0.00 | hold |
| IEQ CAPITAL, LLC | 96,010 | 66,567 | -29,443 | 0.00 | 0.00 | -0.00 | sell |
| Headlands Technologies LLC | 103,247 | 64,299 | -38,948 | 0.11 | 0.07 | -0.04 | sell |