| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SB INVESTMENT ADVISERS (UK) LTD | 16,684,041 | 16,684,041 | 0 | 0.67 | 0.72 | +0.05 | hold |
| BlackRock, Inc. | 16,153,190 | 15,967,656 | -185,534 | 0.00 | 0.00 | +0.00 | sell |
| ARCH Venture Management, LLC | 12,916,663 | 12,916,663 | 0 | 21.76 | 14.98 | -6.78 | hold |
| VANGUARD GROUP INC | 13,227,066 | 12,799,381 | -427,685 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 5,254,712 | 5,241,293 | -13,419 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 3,558,655 | 3,637,130 | +78,475 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 3,007,955 | 2,978,871 | -29,084 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 1,633,690 | 2,689,118 | +1,055,428 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 2,380,715 | 2,380,715 | 0 | 0.30 | 0.33 | +0.02 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 2,252,420 | 2,246,222 | -6,198 | 0.00 | 0.00 | +0.00 | sell |
| Aberdeen Group plc | 1,006,891 | 1,526,265 | +519,374 | 0.01 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,290,138 | 1,521,802 | +231,664 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 609,292 | 1,396,504 | +787,212 | 0.00 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,064,500 | 1,167,100 | +102,600 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,293,016 | 1,142,879 | -150,137 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 696,000 | 911,882 | +215,882 | 0.02 | 0.03 | +0.01 | buy |
| NORTHERN TRUST CORP | 928,240 | 907,126 | -21,114 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 3,464,917 | 799,034 | -2,665,883 | 0.02 | 0.00 | -0.01 | sell |
| ROYAL BANK OF CANADA | 707,226 | 716,388 | +9,162 | 0.00 | 0.00 | +0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 704,377 | 714,561 | +10,184 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 369,615 | 649,300 | +279,685 | 0.00 | 0.01 | +0.00 | buy |
| Clarius Group, LLC | 617,535 | 619,312 | +1,777 | 0.18 | 0.21 | +0.03 | buy |
| Ikarian Capital, LLC | 1,068,062 | 593,374 | -474,688 | 1.78 | 0.69 | -1.10 | sell |
| Bank of New York Mellon Corp | 612,470 | 557,018 | -55,452 | 0.00 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 582,981 | 554,981 | -28,000 | 0.01 | 0.01 | +0.00 | sell |
| BAKER BROS. ADVISORS LP | 542,539 | 542,539 | 0 | 0.03 | 0.02 | -0.00 | hold |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 789,506 | 516,628 | -272,878 | 0.01 | 0.01 | -0.00 | sell |
| Alta Partners Management Company, L.P. | 509,917 | 509,917 | 0 | 6.18 | 4.85 | -1.32 | hold |
| TWO SIGMA ADVISERS, LP | 314,900 | 504,000 | +189,100 | 0.00 | 0.01 | +0.00 | buy |
| Sio Capital Management, LLC | 478,343 | 478,343 | 0 | 0.97 | 0.69 | -0.28 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 840,433 | 456,292 | -384,141 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 459,038 | 455,700 | -3,338 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 443,375 | 449,518 | +6,143 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 404,852 | 417,956 | +13,104 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 473,658 | 410,406 | -63,252 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 425,701 | 400,983 | -24,718 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 314,176 | 367,264 | +53,088 | 0.01 | 0.01 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 97,327 | 360,417 | +263,090 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 415,951 | 323,525 | -92,426 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 273,708 | 296,017 | +22,309 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 327,700 | 284,227 | -43,473 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 206,401 | 277,703 | +71,302 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 107,360 | 277,315 | +169,955 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 440,005 | 272,170 | -167,835 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 300,357 | 263,897 | -36,460 | 0.04 | 0.06 | +0.02 | sell |
| Corient Private Wealth LLC | 259,342 | 259,696 | +354 | 0.00 | 0.00 | +0.00 | buy |
| Tejara Capital Ltd | 258,600 | 256,939 | -1,661 | 0.60 | 0.80 | +0.20 | sell |
| PRUDENTIAL FINANCIAL INC | 610,452 | 252,334 | -358,118 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 248,726 | 244,971 | -3,755 | 0.00 | 0.00 | +0.00 | sell |
| Eagle Health Investments LP | 240,500 | 240,500 | 0 | 0.30 | 0.36 | +0.06 | hold |
| RHUMBLINE ADVISERS | 228,949 | 226,799 | -2,150 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 315,167 | 214,762 | -100,405 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 252,714 | 205,994 | -46,720 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 205,480 | 205,480 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 195,495 | 203,104 | +7,609 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 211,388 | 194,269 | -17,119 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 182,529 | 176,784 | -5,745 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 170,200 | 170,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LMR Partners LLP | 167,800 | 167,800 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Stonepine Capital Management, LLC | 130,000 | 160,000 | +30,000 | 0.65 | 0.74 | +0.10 | buy |
| ExodusPoint Capital Management, LP | 52,993 | 159,867 | +106,874 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 306,545 | 158,123 | -148,422 | 0.05 | 0.02 | -0.02 | sell |
| AQR CAPITAL MANAGEMENT LLC | 448,805 | 152,138 | -296,667 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 150,312 | +150,312 | 0.00 | 0.85 | +0.85 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 294,383 | 143,938 | -150,445 | 0.00 | 0.00 | -0.00 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 143,068 | +143,068 | 0.00 | 0.02 | +0.02 | buy |
| XTX Topco Ltd | 0 | 139,896 | +139,896 | 0.00 | 0.04 | +0.04 | buy |
| Walleye Capital LLC | 183,930 | 138,830 | -45,100 | 0.01 | 0.01 | -0.00 | sell |
| Rafferty Asset Management, LLC | 132,021 | 114,785 | -17,236 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 109,620 | 109,620 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 83,197 | 108,315 | +25,118 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 105,965 | +105,965 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 145,298 | 96,717 | -48,581 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 94,801 | +94,801 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 82,258 | 82,758 | +500 | 0.00 | 0.00 | +0.00 | buy |
| Connective Capital Management, LLC | 0 | 75,470 | +75,470 | 0.00 | 0.40 | +0.40 | buy |
| WELLS FARGO & COMPANY/MN | 62,167 | 75,445 | +13,278 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 72,240 | +72,240 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 256,918 | 70,477 | -186,441 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 37,475 | 69,028 | +31,553 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 68,105 | 68,149 | +44 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 74,550 | 66,109 | -8,441 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 66,045 | 65,741 | -304 | 0.00 | 0.00 | +0.00 | sell |
| WINTON GROUP Ltd | 0 | 57,751 | +57,751 | 0.00 | 0.01 | +0.01 | buy |
| HSBC HOLDINGS PLC | 44,326 | 57,595 | +13,269 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 57,268 | 55,968 | -1,300 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 54,480 | 52,929 | -1,551 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 37,759 | 52,676 | +14,917 | 0.00 | 0.00 | +0.00 | buy |
| Quinn Opportunity Partners LLC | 50,976 | 50,976 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Mitsubishi UFJ Asset Management Co., Ltd. | 49,910 | 50,009 | +99 | 0.00 | 0.00 | +0.00 | buy |
| State of Alaska, Department of Revenue | 55,076 | 47,531 | -7,545 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 47,432 | 47,432 | 0 | 0.01 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 42,935 | 47,136 | +4,201 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 47,014 | 47,014 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Louisiana State Employees Retirement System | 43,300 | 43,400 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Sender Co & Partners, Inc. | 0 | 43,175 | +43,175 | 0.00 | 0.10 | +0.10 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 12,570 | 41,210 | +28,640 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 48,999 | 40,726 | -8,273 | 0.00 | 0.00 | -0.00 | sell |
| State of Tennessee, Department of Treasury | 40,547 | 40,547 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 40,668 | 40,530 | -138 | 0.00 | 0.00 | +0.00 | sell |