| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SB INVESTMENT ADVISERS (UK) LTD | 16,684,041 | 16,684,041 | 0 | 1.03 | 1.08 | +0.05 | hold |
| BlackRock, Inc. | 16,375,806 | 16,462,717 | +86,911 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 13,135,956 | 13,130,635 | -5,321 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 5,625,533 | 5,074,731 | -550,802 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 3,573,000 | 3,218,617 | -354,383 | 0.49 | 0.49 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,188,774 | 2,196,601 | +7,827 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,212,105 | 1,915,465 | +703,360 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 1,086,327 | 1,807,017 | +720,690 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,104,716 | 1,715,083 | +610,367 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,134,276 | 1,252,655 | +118,379 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,182,300 | 1,237,600 | +55,300 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 1,236,919 | 1,123,806 | -113,113 | 0.00 | 0.00 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 0 | 1,084,539 | +1,084,539 | 0.00 | 0.09 | +0.09 | buy |
| Sio Capital Management, LLC | 0 | 1,054,651 | +1,054,651 | 0.00 | 2.18 | +2.18 | buy |
| NORTHERN TRUST CORP | 878,924 | 930,454 | +51,530 | 0.00 | 0.00 | -0.00 | buy |
| Artisan Partners Limited Partnership | 0 | 918,529 | +918,529 | 0.00 | 0.01 | +0.01 | buy |
| Ikarian Capital, LLC | 0 | 897,862 | +897,862 | 0.00 | 1.88 | +1.88 | buy |
| Hudson Bay Capital Management LP | 528,242 | 849,873 | +321,631 | 0.03 | 0.04 | +0.01 | buy |
| Point72 Asset Management, L.P. | 5,215 | 848,454 | +843,239 | 0.00 | 0.02 | +0.02 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 975,300 | 769,725 | -205,575 | 0.03 | 0.02 | -0.01 | sell |
| Bank of New York Mellon Corp | 642,283 | 604,067 | -38,216 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 93,329 | 581,829 | +488,500 | 0.11 | 0.79 | +0.67 | buy |
| GOLDMAN SACHS GROUP INC | 832,683 | 517,130 | -315,553 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 930,655 | 502,000 | -428,655 | 0.01 | 0.00 | -0.01 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 431,411 | 447,313 | +15,902 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 23,776 | 434,460 | +410,684 | 0.00 | 0.03 | +0.03 | buy |
| Invesco Ltd. | 396,198 | 398,772 | +2,574 | 0.00 | 0.00 | -0.00 | buy |
| Aberdeen Group plc | 0 | 363,161 | +363,161 | 0.00 | 0.01 | +0.01 | buy |
| Empowered Funds, LLC | 329,781 | 290,626 | -39,155 | 0.04 | 0.03 | -0.01 | sell |
| CITADEL ADVISORS LLC | 268,972 | 271,264 | +2,292 | 0.00 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 329,781 | 263,243 | -66,538 | 0.05 | 0.04 | -0.01 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 260,371 | +260,371 | 0.00 | 0.06 | +0.06 | buy |
| Corient Private Wealth LLC | 283,065 | 257,520 | -25,545 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 246,833 | +246,833 | 0.00 | 0.02 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 276,024 | 245,876 | -30,148 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 425,369 | 244,569 | -180,800 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 383,188 | 240,113 | -143,075 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 235,393 | 236,681 | +1,288 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 245,804 | 231,983 | -13,821 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 206,889 | 230,724 | +23,835 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 194,208 | 229,294 | +35,086 | 0.01 | 0.01 | -0.00 | buy |
| BARCLAYS PLC | 550,186 | 221,178 | -329,008 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 267,414 | 219,172 | -48,242 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 189,219 | 216,734 | +27,515 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 103,700 | 214,263 | +110,563 | 0.00 | 0.00 | +0.00 | buy |
| State of Alaska, Department of Revenue | 152,242 | 202,441 | +50,199 | 0.01 | 0.02 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 15,200 | 201,185 | +185,985 | 0.00 | 0.02 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 189,670 | 196,780 | +7,110 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 336,593 | 193,650 | -142,943 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 114,418 | 184,317 | +69,899 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 140,371 | 181,325 | +40,954 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 179,262 | +179,262 | 0.00 | 0.04 | +0.04 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 88,608 | 178,138 | +89,530 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 185,200 | 174,700 | -10,500 | 0.00 | 0.00 | -0.00 | sell |
| Allianz Asset Management GmbH | 72,356 | 171,949 | +99,593 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 164,106 | +164,106 | 0.00 | 0.97 | +0.97 | buy |
| Qube Research & Technologies Ltd | 358,086 | 154,909 | -203,177 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 52,794 | 145,873 | +93,079 | 0.00 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 130,347 | 143,077 | +12,730 | 0.00 | 0.00 | +0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 423,087 | 136,487 | -286,600 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 0 | 135,036 | +135,036 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 173,852 | 120,723 | -53,129 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 174,740 | 119,985 | -54,755 | 0.02 | 0.01 | -0.01 | sell |
| SIMPLEX TRADING, LLC | 4,273 | 116,627 | +112,354 | 0.00 | 0.02 | +0.02 | buy |
| Sofinnova Investments, Inc. | 129,246 | 114,131 | -15,115 | 0.08 | 0.06 | -0.02 | sell |
| ALPS ADVISORS INC | 0 | 111,360 | +111,360 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 109,620 | 109,620 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DAFNA Capital Management LLC | 0 | 100,000 | +100,000 | 0.00 | 0.19 | +0.19 | buy |
| WINTON GROUP Ltd | 130,965 | 92,235 | -38,730 | 0.07 | 0.04 | -0.02 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 81,269 | 88,776 | +7,507 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 49,022 | 84,049 | +35,027 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 89,630 | 83,197 | -6,433 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 81,858 | 81,858 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Graham Capital Management, L.P. | 35,915 | 81,250 | +45,335 | 0.01 | 0.02 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 42,800 | 74,800 | +32,000 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 67,826 | 71,332 | +3,506 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 71,892 | 71,322 | -570 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 68,835 | 67,366 | -1,469 | 0.00 | 0.00 | -0.00 | sell |
| Quinn Opportunity Partners LLC | 0 | 65,976 | +65,976 | 0.00 | 0.03 | +0.03 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 24,606 | 64,906 | +40,300 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 319,185 | 64,067 | -255,118 | 0.40 | 0.10 | -0.30 | sell |
| Ensign Peak Advisors, Inc | 63,874 | 63,874 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 15,013 | 61,391 | +46,378 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 61,281 | 59,104 | -2,177 | 0.00 | 0.00 | -0.00 | sell |
| Clarius Group, LLC | 57,193 | 57,193 | 0 | 0.03 | 0.03 | -0.00 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 26,433 | 56,784 | +30,351 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 50,735 | 55,493 | +4,758 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 57,446 | 55,241 | -2,205 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 251,757 | 52,661 | -199,096 | 0.00 | 0.00 | -0.00 | sell |
| Tejara Capital Ltd | 0 | 51,967 | +51,967 | 0.00 | 0.25 | +0.25 | buy |
| Avantax Planning Partners, Inc. | 51,359 | 50,486 | -873 | 0.01 | 0.01 | -0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 49,651 | +49,651 | 0.00 | 0.07 | +0.07 | buy |
| Corebridge Financial, Inc. | 51,477 | 47,772 | -3,705 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 48,291 | 47,265 | -1,026 | 0.00 | 0.00 | -0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 47,026 | 47,014 | -12 | 0.01 | 0.01 | +0.00 | sell |
| Amundi | 14,373 | 46,614 | +32,241 | 0.00 | 0.00 | +0.00 | buy |
| Louisiana State Employees Retirement System | 44,300 | 44,600 | +300 | 0.01 | 0.01 | +0.00 | buy |
| State of Tennessee, Department of Treasury | 38,041 | 39,268 | +1,227 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 37,057 | 37,057 | 0 | 0.00 | 0.00 | -0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 25,522 | 37,008 | +11,486 | 0.00 | 0.00 | +0.00 | buy |