| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,973,233 | +1,973,233 | 0.00 | 0.03 | +0.03 | buy |
| Ikarian Capital, LLC | 0 | 705,010 | +705,010 | 0.00 | 0.18 | +0.18 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 331,113 | +331,113 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 53,513 | 146,034 | +92,521 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 58,073 | 150,000 | +91,927 | 0.00 | 0.00 | +0.00 | buy |
| Concurrent Investment Advisors, LLC | 0 | 82,651 | +82,651 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 60,415 | +60,415 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 57,951 | +57,951 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 106,500 | 144,000 | +37,500 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 10,724 | 43,530 | +32,806 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 25,712 | +25,712 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKET INC. | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 1,400 | 2,200 | +800 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 750,984 | 751,267 | +283 | 0.00 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 158,058 | 158,058 | 0 | 0.01 | 0.00 | -0.00 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 6,483,910 | 6,483,910 | 0 | 0.27 | 0.19 | -0.07 | hold |
| Birchview Capital, LP | 50,000 | 50,000 | 0 | 0.04 | 0.04 | -0.01 | hold |
| CITIGROUP INC | 1,301 | 1,301 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Stonebridge Financial Group, LLC | 35 | 0 | -35 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 200 | 0 | -200 | 0.00 | 0.00 | -0.00 | sell |
| Steward Partners Investment Advisory, LLC | 550 | 0 | -550 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 21,100 | 17,600 | -3,500 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 48,136 | 43,672 | -4,464 | 0.00 | 0.00 | -0.00 | sell |
| Pacifica Partners Inc. | 20,585 | 14,210 | -6,375 | 0.01 | 0.00 | -0.01 | sell |
| Alyeska Investment Group, L.P. | 13,538 | 0 | -13,538 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 13,858 | 0 | -13,858 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 30,053 | 0 | -30,053 | 0.00 | 0.00 | -0.00 | sell |
| Eversept Partners, LP | 1,675,978 | 1,640,430 | -35,548 | 0.19 | 0.13 | -0.06 | sell |
| XTX Topco Ltd | 37,528 | 0 | -37,528 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 632,204 | 527,166 | -105,038 | 0.00 | 0.00 | -0.00 | sell |
| 683 Capital Management, LLC | 2,625,000 | 2,475,000 | -150,000 | 0.27 | 0.20 | -0.07 | sell |
| DAFNA Capital Management LLC | 450,000 | 200,000 | -250,000 | 0.13 | 0.04 | -0.09 | sell |
| CITADEL ADVISORS LLC | 432,822 | 0 | -432,822 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 618,903 | 0 | -618,903 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 725,019 | 0 | -725,019 | 0.24 | 0.00 | -0.24 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,161,567 | 0 | -1,161,567 | 0.25 | 0.00 | -0.25 | sell |
| MORGAN STANLEY | 1,261,652 | 0 | -1,261,652 | 0.00 | 0.00 | -0.00 | sell |