| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAR1 Capital Management, LLC | 123,037 | 971,100 | +848,063 | 0.15 | 0.70 | +0.56 | buy |
| VANGUARD GROUP INC | 356,798 | 697,667 | +340,869 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,318,361 | 1,600,000 | +281,639 | 0.51 | 0.33 | -0.17 | buy |
| FMR LLC | 0 | 72,307 | +72,307 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 47,409 | 104,830 | +57,421 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 53,401 | +53,401 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,125 | 54,182 | +52,057 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.18 | +0.18 | buy |
| STRS OHIO | 0 | 34,100 | +34,100 | 0.00 | 0.00 | +0.00 | buy |
| BAILARD, INC. | 0 | 25,700 | +25,700 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 256,995 | 282,029 | +25,034 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 21,603 | +21,603 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 15,145 | +15,145 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 14,222 | +14,222 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 0 | 11,000 | +11,000 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 7,254 | +7,254 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 14,685 | 21,534 | +6,849 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 3,858 | 9,800 | +5,942 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 84,867 | 89,977 | +5,110 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 5,100 | +5,100 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 712,394 | 715,841 | +3,447 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 87,243 | 89,568 | +2,325 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 443 | 2,277 | +1,834 | 0.00 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 6,667 | 6,979 | +312 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 178 | +178 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 36 | +36 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 921,959 | 921,959 | 0 | 0.11 | 0.08 | -0.03 | hold |
| Ameritas Investment Partners, Inc. | 1,269 | 1,269 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 929 | 929 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RTW INVESTMENTS, LP | 786,353 | 786,353 | 0 | 0.07 | 0.05 | -0.02 | hold |
| AH Capital Management, L.L.C. | 3,233,170 | 3,233,170 | 0 | 2.51 | 1.73 | -0.78 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,452,336 | 1,452,336 | 0 | 0.31 | 0.22 | -0.09 | hold |
| Cormorant Asset Management, LP | 2,629,529 | 2,629,529 | 0 | 0.84 | 0.75 | -0.09 | hold |
| Sofinnova Investments, Inc. | 2,304,901 | 2,304,901 | 0 | 0.98 | 0.65 | -0.32 | hold |
| Parallel Advisors, LLC | 731 | 731 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Comprehensive Financial Management LLC | 271,842 | 271,842 | 0 | 0.04 | 0.03 | -0.01 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 653,374 | 653,374 | 0 | 2.55 | 1.99 | -0.57 | hold |
| Valor Management LLC | 13,105 | 13,105 | 0 | 0.03 | 0.02 | -0.01 | hold |
| Sands Capital Alternatives, LLC | 786,353 | 786,353 | 0 | 0.99 | 0.72 | -0.27 | hold |
| Ulland Investment Advisors, LLC | 20 | 20 | 0 | 0.00 | 0.00 | 0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Legal & General Group Plc | 1,320 | 1,320 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HOWARD HUGHES MEDICAL INSTITUTE | 113,765 | 113,765 | 0 | 0.12 | 0.21 | +0.10 | hold |
| AMALGAMATED BANK | 414 | 414 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Redpoint Management, LLC | 383,255 | 383,254 | -1 | 0.70 | 0.52 | -0.18 | sell |
| Mendota Financial Group, LLC | 10 | 0 | -10 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 184 | 108 | -76 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 6,032 | 5,945 | -87 | 0.00 | 0.00 | -0.00 | sell |
| TD Waterhouse Canada Inc. | 386 | 256 | -130 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 9,555 | 8,537 | -1,018 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,678 | 2,404 | -1,274 | 0.00 | 0.00 | -0.00 | sell |
| NATIONAL BANK OF CANADA /FI/ | 2,045 | 545 | -1,500 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 19,800 | 17,500 | -2,300 | 0.01 | 0.01 | -0.00 | sell |
| Siren, L.L.C. | 388,000 | 382,406 | -5,594 | 0.10 | 0.08 | -0.02 | sell |
| BARCLAYS PLC | 18,791 | 12,727 | -6,064 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 10,132 | 0 | -10,132 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 10,174 | 0 | -10,174 | 0.00 | 0.00 | -0.00 | sell |
| WEALTHEDGE INVESTMENT ADVISORS, LLC | 10,585 | 0 | -10,585 | 0.03 | 0.00 | -0.03 | sell |
| GSA CAPITAL PARTNERS LLP | 12,146 | 0 | -12,146 | 0.01 | 0.00 | -0.01 | sell |
| Squarepoint Ops LLC | 12,263 | 0 | -12,263 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 14,965 | 0 | -14,965 | 0.00 | 0.00 | -0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 19,074 | 0 | -19,074 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 24,416 | 0 | -24,416 | 0.00 | 0.00 | -0.00 | sell |
| NORGES BANK | 27,829 | 0 | -27,829 | 0.00 | 0.00 | -0.00 | sell |
| MYDA Advisors LLC | 30,000 | 0 | -30,000 | 0.05 | 0.00 | -0.05 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 39,974 | 0 | -39,974 | 0.05 | 0.00 | -0.05 | sell |
| Woodline Partners LP | 88,368 | 31,565 | -56,803 | 0.00 | 0.00 | -0.00 | sell |
| FIL Ltd | 146,215 | 82,991 | -63,224 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 75,908 | 0 | -75,908 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 103,891 | 0 | -103,891 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 195,967 | 26,759 | -169,208 | 0.00 | 0.00 | -0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 1,310,589 | 1,052,494 | -258,095 | 0.10 | 0.07 | -0.03 | sell |
| MORGAN STANLEY | 442,953 | 0 | -442,953 | 0.00 | 0.00 | -0.00 | sell |