| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| AH Capital Management, L.L.C. | 3,233,170 | 3,233,170 | 0 | 2.79 | 4.38 | +1.59 | hold |
| Cormorant Asset Management, LP | 2,040,605 | 2,890,605 | +850,000 | 1.53 | 2.55 | +1.02 | buy |
| Sofinnova Investments, Inc. | 2,293,788 | 2,293,788 | 0 | 1.31 | 2.01 | +0.70 | hold |
| BlackRock, Inc. | 1,527,541 | 2,267,756 | +740,215 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 409,207 | 2,094,270 | +1,685,063 | 0.00 | 0.02 | +0.02 | buy |
| Octagon Capital Advisors LP | 1,598,000 | 1,748,000 | +150,000 | 2.65 | 3.38 | +0.74 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,650,648 | +1,650,648 | 0.00 | 0.31 | +0.31 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 1,327,545 | +1,327,545 | 0.00 | 0.05 | +0.05 | buy |
| BRAIDWELL LP | 0 | 1,200,587 | +1,200,587 | 0.00 | 0.70 | +0.70 | buy |
| Polar Capital Holdings Plc | 0 | 1,132,640 | +1,132,640 | 0.00 | 0.09 | +0.09 | buy |
| STATE STREET CORP | 422,846 | 850,894 | +428,048 | 0.00 | 0.00 | +0.00 | buy |
| Sands Capital Alternatives, LLC | 786,353 | 786,353 | 0 | 2.01 | 3.27 | +1.26 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 591,377 | 749,266 | +157,889 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 790,901 | 711,811 | -79,090 | 0.21 | 0.27 | +0.06 | sell |
| D. E. Shaw & Co., Inc. | 339,909 | 699,190 | +359,281 | 0.00 | 0.01 | +0.01 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 653,374 | 653,374 | 0 | 3.34 | 4.08 | +0.74 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,050,000 | 500,000 | -550,000 | 0.02 | 0.01 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 228,414 | 430,463 | +202,049 | 0.00 | 0.01 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 334,126 | 420,123 | +85,997 | 0.02 | 0.03 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 277,957 | 392,346 | +114,389 | 0.01 | 0.01 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 338,654 | +338,654 | 0.00 | 1.14 | +1.14 | buy |
| Comprehensive Financial Management LLC | 271,842 | 271,842 | 0 | 0.11 | 0.16 | +0.05 | hold |
| FRANKLIN RESOURCES INC | 0 | 265,373 | +265,373 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 311,659 | 259,869 | -51,790 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 219,842 | 247,276 | +27,434 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 167,452 | 224,129 | +56,677 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 214,546 | +214,546 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 201,337 | +201,337 | 0.00 | 0.07 | +0.07 | buy |
| MARSHALL WACE, LLP | 222,948 | 190,472 | -32,476 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 117,703 | 190,298 | +72,595 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 228,673 | 176,110 | -52,563 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 22,029 | 173,570 | +151,541 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 166,224 | +166,224 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 126,238 | 156,438 | +30,200 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 134,795 | 151,674 | +16,879 | 0.01 | 0.02 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 18,400 | 138,588 | +120,188 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 135,560 | 135,560 | 0 | 0.13 | 0.14 | +0.01 | hold |
| Burkehill Global Management, LP | 0 | 100,000 | +100,000 | 0.00 | 0.09 | +0.09 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 87,881 | +87,881 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 243,035 | 86,518 | -156,517 | 0.67 | 0.26 | -0.41 | sell |
| Bank of New York Mellon Corp | 61,560 | 75,568 | +14,008 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 75,000 | +75,000 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 29,879 | 69,482 | +39,603 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 51,918 | 69,334 | +17,416 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 67,681 | +67,681 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 196,048 | 64,226 | -131,822 | 0.04 | 0.02 | -0.02 | sell |
| Russell Investments Group, Ltd. | 41,308 | 63,256 | +21,948 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 62,385 | +62,385 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 188,683 | 61,508 | -127,175 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 39,334 | 60,572 | +21,238 | 0.00 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 52,439 | 60,089 | +7,650 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 271,164 | 60,000 | -211,164 | 2.14 | 0.43 | -1.70 | sell |
| AMERIPRISE FINANCIAL INC | 82,963 | 59,133 | -23,830 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 77,600 | 57,600 | -20,000 | 0.02 | 0.02 | -0.00 | sell |
| Squarepoint Ops LLC | 51,273 | 55,520 | +4,247 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 45,000 | 50,000 | +5,000 | 0.47 | 0.77 | +0.30 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.06 | +0.06 | buy |
| Nuveen, LLC | 30,794 | 48,688 | +17,894 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 42,151 | 46,951 | +4,800 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 36,727 | 46,878 | +10,151 | 0.01 | 0.01 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 36,506 | +36,506 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 29,527 | 35,320 | +5,793 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 34,809 | +34,809 | 0.00 | 0.07 | +0.07 | buy |
| Jump Financial, LLC | 42,800 | 33,900 | -8,900 | 0.01 | 0.01 | +0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 40,388 | 33,899 | -6,489 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 111,789 | 31,558 | -80,231 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 29,302 | +29,302 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 29,000 | +29,000 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 28,903 | +28,903 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 37,780 | 28,240 | -9,540 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 27,788 | 27,788 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WEXFORD CAPITAL LP | 0 | 25,765 | +25,765 | 0.00 | 0.07 | +0.07 | buy |
| Creative Planning | 0 | 25,321 | +25,321 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 15,796 | 23,096 | +7,300 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 0 | 23,087 | +23,087 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 22,782 | +22,782 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 22,500 | 22,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 14,808 | 21,418 | +6,610 | 0.00 | 0.00 | +0.00 | buy |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 0 | 20,796 | +20,796 | 0.00 | 0.53 | +0.53 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 18,055 | +18,055 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 14,437 | 16,725 | +2,288 | 0.00 | 0.00 | +0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 16,199 | 15,932 | -267 | 0.00 | 0.00 | +0.00 | sell |
| Persistent Asset Partners Ltd | 72,774 | 15,167 | -57,607 | 0.46 | 0.10 | -0.36 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11,009 | 14,155 | +3,146 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,538 | 13,384 | +11,846 | 0.00 | 0.00 | +0.00 | buy |
| Valor Management LLC | 13,105 | 13,105 | 0 | 0.31 | 0.13 | -0.19 | hold |
| NISA INVESTMENT ADVISORS, LLC | 10,237 | 12,737 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (US) LLC | 0 | 11,688 | +11,688 | 0.00 | 0.03 | +0.03 | buy |
| WELLS FARGO & COMPANY/MN | 26,597 | 11,406 | -15,191 | 0.00 | 0.00 | -0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 18,034 | 10,850 | -7,184 | 0.04 | 0.03 | -0.01 | sell |
| BANK OF NOVA SCOTIA | 0 | 10,300 | +10,300 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 10,165 | +10,165 | 0.00 | 0.01 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 6,577 | 8,387 | +1,810 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 5,843 | 7,707 | +1,864 | 0.01 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,100 | 5,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CWM, LLC | 3,693 | 3,678 | -15 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,124 | 2,872 | +1,748 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 2,152 | 2,655 | +503 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,269 | 2,470 | +1,201 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 2,860 | 2,322 | -538 | 0.00 | 0.00 | +0.00 | sell |