| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| AH Capital Management, L.L.C. | 3,233,170 | 3,233,170 | 0 | 4.38 | 0.56 | -3.82 | hold |
| BlackRock, Inc. | 2,267,756 | 2,849,077 | +581,321 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 2,890,605 | 2,390,605 | -500,000 | 2.55 | 3.00 | +0.45 | sell |
| Sofinnova Investments, Inc. | 2,293,788 | 2,293,788 | 0 | 2.01 | 3.00 | +0.99 | hold |
| Octagon Capital Advisors LP | 1,748,000 | 1,748,000 | 0 | 3.38 | 3.93 | +0.55 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 1,650,648 | 1,671,648 | +21,000 | 0.31 | 0.36 | +0.05 | buy |
| MPM BioImpact LLC | 0 | 1,667,661 | +1,667,661 | 0.00 | 2.49 | +2.49 | buy |
| Polar Capital Holdings Plc | 1,132,640 | 1,072,344 | -60,296 | 0.09 | 0.07 | -0.01 | sell |
| BRAIDWELL LP | 1,200,587 | 1,033,129 | -167,458 | 0.70 | 0.94 | +0.24 | sell |
| STATE STREET CORP | 850,894 | 1,021,464 | +170,570 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 749,266 | 1,004,264 | +254,998 | 0.00 | 0.00 | +0.00 | buy |
| Sands Capital Alternatives, LLC | 786,353 | 786,353 | 0 | 3.27 | 3.14 | -0.12 | hold |
| ORBIMED ADVISORS LLC | 711,811 | 752,153 | +40,342 | 0.27 | 0.35 | +0.08 | buy |
| D. E. Shaw & Co., Inc. | 699,190 | 742,761 | +43,571 | 0.01 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,327,545 | 702,858 | -624,687 | 0.05 | 0.03 | -0.01 | sell |
| Pivotal bioVenture Partners Investment Advisor LLC | 653,374 | 653,374 | 0 | 4.08 | 5.20 | +1.12 | hold |
| STEMPOINT CAPITAL LP | 338,654 | 464,171 | +125,517 | 1.14 | 1.97 | +0.83 | buy |
| DIMENSIONAL FUND ADVISORS LP | 214,546 | 394,138 | +179,592 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 420,123 | 377,085 | -43,038 | 0.03 | 0.03 | +0.00 | sell |
| Walleye Capital LLC | 151,674 | 354,395 | +202,721 | 0.02 | 0.04 | +0.02 | buy |
| Nuveen, LLC | 48,688 | 349,142 | +300,454 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 224,129 | 343,166 | +119,037 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000 | 300,000 | -200,000 | 0.01 | 0.01 | -0.00 | sell |
| Integral Health Asset Management, LLC | 0 | 300,000 | +300,000 | 0.00 | 0.30 | +0.30 | buy |
| MORGAN STANLEY | 259,869 | 282,386 | +22,517 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 265,373 | 281,967 | +16,594 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 273,371 | +273,371 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 247,276 | 273,371 | +26,095 | 0.00 | 0.00 | +0.00 | buy |
| Comprehensive Financial Management LLC | 271,842 | 271,842 | 0 | 0.16 | 0.22 | +0.06 | hold |
| GOLDMAN SACHS GROUP INC | 156,438 | 270,769 | +114,331 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 61,508 | 257,855 | +196,347 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 173,570 | 233,979 | +60,409 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 392,346 | 224,453 | -167,893 | 0.01 | 0.01 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 430,463 | 222,621 | -207,842 | 0.01 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 86,518 | 213,671 | +127,153 | 0.26 | 0.75 | +0.49 | buy |
| Ikarian Capital, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.80 | +0.80 | buy |
| FMR LLC | 190,298 | 183,563 | -6,735 | 0.00 | 0.00 | +0.00 | sell |
| Yiheng Capital Management, L.P. | 0 | 170,532 | +170,532 | 0.00 | 1.78 | +1.78 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 138,588 | 165,700 | +27,112 | 0.00 | 0.01 | +0.00 | buy |
| DIADEMA PARTNERS LP | 60,000 | 146,334 | +86,334 | 0.43 | 1.27 | +0.83 | buy |
| Ensign Peak Advisors, Inc | 166,224 | 141,698 | -24,526 | 0.01 | 0.01 | +0.00 | sell |
| Invesco Ltd. | 176,110 | 127,420 | -48,690 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 75,568 | 107,332 | +31,764 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 69,482 | 102,926 | +33,444 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 100,000 | 100,000 | 0 | 0.09 | 0.09 | +0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 67,681 | 94,656 | +26,975 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 78,365 | +78,365 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 63,256 | 73,387 | +10,131 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 31,558 | 71,487 | +39,929 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 0 | 69,000 | +69,000 | 0.00 | 0.79 | +0.79 | buy |
| Squarepoint Ops LLC | 55,520 | 68,436 | +12,916 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 46,951 | 61,394 | +14,443 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 61,380 | +61,380 | 0.00 | 0.03 | +0.03 | buy |
| AMERIPRISE FINANCIAL INC | 59,133 | 59,198 | +65 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 60,089 | 58,025 | -2,064 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 28,903 | 54,780 | +25,877 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 69,334 | 51,188 | -18,146 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 23,087 | 51,188 | +28,101 | 0.00 | 0.00 | +0.00 | buy |
| SEVEN GRAND MANAGERS, LLC | 50,000 | 50,000 | 0 | 0.06 | 0.05 | -0.01 | hold |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 87,881 | 49,545 | -38,336 | 0.00 | 0.00 | -0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 0 | 47,491 | +47,491 | 0.00 | 0.21 | +0.21 | buy |
| SIMPLEX TRADING, LLC | 2,322 | 47,280 | +44,958 | 0.00 | 0.03 | +0.03 | buy |
| ALLIANCEBERNSTEIN L.P. | 29,000 | 45,700 | +16,700 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 35,320 | 43,904 | +8,584 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 57,600 | 42,000 | -15,600 | 0.02 | 0.02 | -0.00 | sell |
| Corient Private Wealth LLC | 22,782 | 40,258 | +17,476 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 15,167 | 37,253 | +22,086 | 0.10 | 0.29 | +0.19 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 36,506 | 35,340 | -1,166 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 23,096 | 34,298 | +11,202 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 190,472 | 31,743 | -158,729 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 13,384 | 30,472 | +17,088 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 11,406 | 29,694 | +18,288 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 21,418 | 29,247 | +7,829 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 29,302 | 28,147 | -1,155 | 0.00 | 0.00 | +0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 27,788 | 27,788 | 0 | 0.00 | 0.00 | +0.00 | hold |
| XTX Topco Ltd | 46,878 | 26,793 | -20,085 | 0.01 | 0.01 | -0.01 | sell |
| WEXFORD CAPITAL LP | 25,765 | 25,765 | 0 | 0.07 | 0.09 | +0.01 | hold |
| BARCLAYS PLC | 28,240 | 25,620 | -2,620 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 24,089 | +24,089 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 23,240 | +23,240 | 0.00 | 0.02 | +0.02 | buy |
| STRS OHIO | 22,500 | 22,000 | -500 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 16,725 | 20,889 | +4,164 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 50,000 | 20,000 | -30,000 | 0.77 | 0.37 | -0.40 | sell |
| BANK OF NOVA SCOTIA | 10,300 | 20,000 | +9,700 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 25,321 | 18,535 | -6,786 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 0 | 18,147 | +18,147 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 18,137 | +18,137 | 0.00 | 0.10 | +0.10 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 18,055 | 18,090 | +35 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 14,155 | 16,187 | +2,032 | 0.00 | 0.00 | +0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 15,932 | 15,932 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Y-Intercept (Hong Kong) Ltd | 201,337 | 15,240 | -186,097 | 0.07 | 0.01 | -0.06 | sell |
| Engineers Gate Manager LP | 0 | 14,015 | +14,015 | 0.00 | 0.00 | +0.00 | buy |
| Valor Management LLC | 13,105 | 13,105 | 0 | 0.13 | 0.00 | -0.13 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,100 | 12,400 | +7,300 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 12,737 | 11,977 | -760 | 0.00 | 0.00 | +0.00 | sell |
| PROFUND ADVISORS LLC | 0 | 10,880 | +10,880 | 0.00 | 0.01 | +0.01 | buy |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 20,796 | 10,472 | -10,324 | 0.53 | 0.08 | -0.45 | sell |
| Police & Firemen's Retirement System of New Jersey | 8,387 | 10,367 | +1,980 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 9,529 | +9,529 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 9,480 | +9,480 | 0.00 | 0.00 | +0.00 | buy |