| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| AH Capital Management, L.L.C. | 0 | 3,013,975 | +3,013,975 | 0.00 | 5.51 | +5.51 | buy |
| Sofinnova Investments, Inc. | 0 | 2,304,901 | +2,304,901 | 0.00 | 3.97 | +3.97 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 2,210,589 | +2,210,589 | 0.00 | 0.53 | +0.53 | buy |
| Cormorant Asset Management, LP | 0 | 1,629,529 | +1,629,529 | 0.00 | 1.80 | +1.80 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 1,455,000 | +1,455,000 | 0.00 | 1.09 | +1.09 | buy |
| ORBIMED ADVISORS LLC | 0 | 1,423,470 | +1,423,470 | 0.00 | 0.54 | +0.54 | buy |
| Sands Capital Alternatives, LLC | 0 | 1,086,353 | +1,086,353 | 0.00 | 6.35 | +6.35 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 994,315 | +994,315 | 0.00 | 0.01 | +0.01 | buy |
| RTW INVESTMENTS, LP | 0 | 786,353 | +786,353 | 0.00 | 0.24 | +0.24 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 0 | 527,647 | +527,647 | 0.00 | 6.51 | +6.51 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 449,837 | +449,837 | 0.00 | 0.00 | +0.00 | buy |
| Redpoint Management, LLC | 0 | 383,255 | +383,255 | 0.00 | 1.49 | +1.49 | buy |
| BROWN ADVISORY INC | 0 | 334,915 | +334,915 | 0.00 | 0.01 | +0.01 | buy |
| EMERALD ADVISERS, LLC | 0 | 281,317 | +281,317 | 0.00 | 0.23 | +0.23 | buy |
| Comprehensive Financial Management LLC | 0 | 271,842 | +271,842 | 0.00 | 0.16 | +0.16 | buy |
| WASATCH ADVISORS LP | 0 | 254,907 | +254,907 | 0.00 | 0.03 | +0.03 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 229,431 | +229,431 | 0.00 | 0.25 | +0.25 | buy |
| CITADEL ADVISORS LLC | 0 | 213,718 | +213,718 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 200,000 | +200,000 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 0 | 200,000 | +200,000 | 0.00 | 0.00 | +0.00 | buy |
| FIL Ltd | 0 | 200,000 | +200,000 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 166,022 | +166,022 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 150,000 | +150,000 | 0.00 | 0.02 | +0.02 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 150,000 | +150,000 | 0.00 | 0.01 | +0.01 | buy |
| Zimmer Partners, LP | 0 | 125,000 | +125,000 | 0.00 | 0.05 | +0.05 | buy |
| Woodline Partners LP | 0 | 124,950 | +124,950 | 0.00 | 0.02 | +0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 120,000 | +120,000 | 0.00 | 0.01 | +0.01 | buy |
| HOWARD HUGHES MEDICAL INSTITUTE | 0 | 113,765 | +113,765 | 0.00 | 0.38 | +0.38 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 108,616 | +108,616 | 0.00 | 0.00 | +0.00 | buy |
| SOROS FUND MANAGEMENT LLC | 0 | 100,000 | +100,000 | 0.00 | 0.04 | +0.04 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.47 | +0.47 | buy |
| Monashee Investment Management LLC | 0 | 95,000 | +95,000 | 0.00 | 0.21 | +0.21 | buy |
| Walleye Capital LLC | 0 | 76,875 | +76,875 | 0.00 | 0.02 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 0 | 59,678 | +59,678 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 55,080 | +55,080 | 0.00 | 0.09 | +0.09 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 0 | 50,000 | +50,000 | 0.00 | 0.05 | +0.05 | buy |
| JANE STREET GROUP, LLC | 0 | 43,073 | +43,073 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 0 | 40,000 | +40,000 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 40,000 | +40,000 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 36,314 | +36,314 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 30,000 | +30,000 | 0.00 | 0.03 | +0.03 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 26,677 | +26,677 | 0.00 | 0.00 | +0.00 | buy |
| Maven Securities LTD | 0 | 25,000 | +25,000 | 0.00 | 0.06 | +0.06 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| Valor Management LLC | 0 | 13,105 | +13,105 | 0.00 | 0.06 | +0.06 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 12,643 | +12,643 | 0.00 | 0.03 | +0.03 | buy |
| BARCLAYS PLC | 0 | 11,900 | +11,900 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 11,500 | +11,500 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 9,813 | +9,813 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 2,700 | +2,700 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 731 | +731 | 0.00 | 0.00 | +0.00 | buy |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |