| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 36,073 | 306,552 | +270,479 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 120,929 | +120,929 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 453,455 | 562,731 | +109,276 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,557,553 | 1,651,247 | +93,694 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 120,312 | 191,383 | +71,071 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 24,792 | 89,678 | +64,886 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 89,296 | 143,000 | +53,704 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 151,085 | 188,571 | +37,486 | 0.61 | 0.90 | +0.29 | buy |
| STATE STREET CORP | 160,849 | 198,111 | +37,262 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 67,398 | 104,281 | +36,883 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 36,848 | +36,848 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 64,601 | 99,669 | +35,068 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 153,009 | 186,568 | +33,559 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 30,723 | +30,723 | 0.00 | 0.02 | +0.02 | buy |
| R Squared Ltd | 0 | 26,159 | +26,159 | 0.00 | 0.07 | +0.07 | buy |
| TWO SIGMA ADVISERS, LP | 62,501 | 87,700 | +25,199 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,935 | 25,735 | +23,800 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 19,888 | +19,888 | 0.00 | 0.00 | +0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 19,295 | +19,295 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 77,555 | 91,118 | +13,563 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 11,891 | +11,891 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 10,734 | +10,734 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 2,938 | 10,676 | +7,738 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 4,529 | +4,529 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 109,605 | 114,063 | +4,458 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 31,552 | 35,746 | +4,194 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 53,970 | 57,998 | +4,028 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 11,000 | 15,000 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 640 | 1,637 | +997 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 474 | +474 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 2,428 | 2,640 | +212 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 120 | +120 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 9 | 110 | +101 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 101 | +101 | 0.00 | 0.00 | +0.00 | buy |
| Cornerstone Planning Group LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 0 | 41 | +41 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,480 | 1,482 | +2 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 13,760 | 13,760 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 1,269 | 1,269 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 52,600 | 52,600 | 0 | 0.01 | 0.01 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,600,000 | 1,600,000 | 0 | 0.33 | 0.36 | +0.03 | hold |
| ALGERT GLOBAL LLC | 11,152 | 11,152 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AH Capital Management, L.L.C. | 3,233,170 | 3,233,170 | 0 | 4.27 | 1.36 | -2.90 | hold |
| Cormorant Asset Management, LP | 2,140,605 | 2,140,605 | 0 | 0.66 | 0.87 | +0.21 | hold |
| Redpoint Management, LLC | 383,254 | 383,254 | 0 | 0.93 | 1.36 | +0.42 | hold |
| Parallel Advisors, LLC | 300 | 300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Woodline Partners LP | 31,565 | 31,565 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Comprehensive Financial Management LLC | 271,842 | 271,842 | 0 | 0.03 | 0.04 | +0.01 | hold |
| Militia Capital Partners, LP | 40,300 | 40,300 | 0 | 0.08 | 0.11 | +0.03 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 653,374 | 653,374 | 0 | 1.67 | 2.22 | +0.55 | hold |
| Valor Management LLC | 13,105 | 13,105 | 0 | 0.02 | 0.11 | +0.09 | hold |
| Sands Capital Alternatives, LLC | 786,353 | 786,353 | 0 | 0.64 | 1.01 | +0.37 | hold |
| Nuveen, LLC | 30,794 | 30,794 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ulland Investment Advisors, LLC | 20 | 20 | 0 | 0.00 | 0.00 | 0.00 | hold |
| True Wealth Design, LLC | 80 | 80 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD Waterhouse Canada Inc. | 256 | 256 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Siren, L.L.C. | 382,406 | 382,406 | 0 | 0.08 | 0.09 | +0.01 | hold |
| Police & Firemen's Retirement System of New Jersey | 6,577 | 6,577 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 2,152 | 2,152 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,100 | 5,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Clearstead Advisors, LLC | 18 | 18 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 55 | 55 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 414 | 414 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 237 | 237 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 25,325 | 25,325 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 545 | 45 | -500 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,305 | 2,595 | -710 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 998 | 184 | -814 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 30,136 | 28,652 | -1,484 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 12,955 | 11,136 | -1,819 | 0.00 | 0.00 | +0.00 | sell |
| Walleye Capital LLC | 15,493 | 12,893 | -2,600 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 14,567 | 11,829 | -2,738 | 0.00 | 0.00 | +0.00 | sell |
| STRS OHIO | 21,100 | 17,800 | -3,300 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 39,961 | 34,558 | -5,403 | 0.00 | 0.00 | +0.00 | sell |
| BlackRock, Inc. | 1,287,417 | 1,279,621 | -7,796 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 11,158 | 276 | -10,882 | 0.00 | 0.00 | -0.00 | sell |
| Sofinnova Investments, Inc. | 2,304,901 | 2,293,788 | -11,113 | 0.65 | 0.83 | +0.18 | sell |
| AMERIPRISE FINANCIAL INC | 44,034 | 30,463 | -13,571 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 15,281 | 1,405 | -13,876 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 14,911 | 0 | -14,911 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 53,139 | 37,193 | -15,946 | 0.02 | 0.02 | -0.00 | sell |
| Jefferies Financial Group Inc. | 50,000 | 0 | -50,000 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 226,789 | 174,196 | -52,593 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 1,937,123 | 1,880,073 | -57,050 | 1.30 | 1.09 | -0.20 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 273,452 | 213,088 | -60,364 | 0.00 | 0.00 | +0.00 | sell |
| ORBIMED ADVISORS LLC | 921,959 | 790,901 | -131,058 | 0.10 | 0.11 | +0.02 | sell |
| CANTOR FITZGERALD, L. P. | 200,000 | 0 | -200,000 | 0.02 | 0.00 | -0.02 | sell |