| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 0 | 1,318,361 | +1,318,361 | 0.00 | 0.51 | +0.51 | buy |
| Cormorant Asset Management, LP | 1,629,529 | 2,629,529 | +1,000,000 | 1.80 | 0.84 | -0.96 | buy |
| BlackRock, Inc. | 0 | 712,394 | +712,394 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 442,953 | +442,953 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 40,000 | 356,798 | +316,798 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 256,995 | +256,995 | 0.00 | 0.00 | +0.00 | buy |
| AH Capital Management, L.L.C. | 3,013,975 | 3,233,170 | +219,195 | 5.51 | 2.51 | -3.00 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 527,647 | 653,374 | +125,727 | 6.51 | 2.55 | -3.96 | buy |
| ADAR1 Capital Management, LLC | 0 | 123,037 | +123,037 | 0.00 | 0.15 | +0.15 | buy |
| UBS Group AG | 0 | 103,891 | +103,891 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 300,000 | 388,000 | +88,000 | 0.31 | 0.10 | -0.21 | buy |
| GOLDMAN SACHS GROUP INC | 108,616 | 195,967 | +87,351 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 0 | 87,243 | +87,243 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 84,867 | +84,867 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 75,908 | +75,908 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 47,409 | +47,409 | 0.00 | 0.00 | +0.00 | buy |
| MYDA Advisors LLC | 0 | 30,000 | +30,000 | 0.00 | 0.05 | +0.05 | buy |
| Engineers Gate Manager LP | 0 | 24,416 | +24,416 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 19,800 | +19,800 | 0.00 | 0.01 | +0.01 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 19,074 | +19,074 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 14,685 | +14,685 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 12,146 | +12,146 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 0 | 10,174 | +10,174 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 10,132 | +10,132 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 9,555 | +9,555 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 11,900 | 18,791 | +6,891 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 6,667 | +6,667 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 0 | 6,032 | +6,032 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 3,858 | +3,858 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 3,678 | +3,678 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 2,125 | +2,125 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 2,045 | +2,045 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 1,320 | +1,320 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 1,269 | +1,269 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 929 | +929 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 414 | +414 | 0.00 | 0.00 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 0 | 386 | +386 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 184 | +184 | 0.00 | 0.00 | +0.00 | buy |
| Ulland Investment Advisors, LLC | 0 | 20 | +20 | 0.00 | 0.00 | 0.00 | buy |
| Mendota Financial Group, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 786,353 | 786,353 | 0 | 0.24 | 0.07 | -0.17 | hold |
| Sofinnova Investments, Inc. | 2,304,901 | 2,304,901 | 0 | 3.97 | 0.98 | -2.99 | hold |
| Redpoint Management, LLC | 383,255 | 383,255 | 0 | 1.49 | 0.70 | -0.79 | hold |
| Parallel Advisors, LLC | 731 | 731 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Comprehensive Financial Management LLC | 271,842 | 271,842 | 0 | 0.16 | 0.04 | -0.11 | hold |
| Valor Management LLC | 13,105 | 13,105 | 0 | 0.06 | 0.03 | -0.03 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| HOWARD HUGHES MEDICAL INSTITUTE | 113,765 | 113,765 | 0 | 0.38 | 0.12 | -0.26 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,455,000 | 1,452,336 | -2,664 | 1.09 | 0.31 | -0.77 | sell |
| Point72 Asset Management, L.P. | 2,700 | 0 | -2,700 | 0.00 | 0.00 | -0.00 | sell |
| Aster Capital Management (DIFC) Ltd | 6,988 | 0 | -6,988 | 0.03 | 0.00 | -0.03 | sell |
| HRT FINANCIAL LP | 9,813 | 0 | -9,813 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 11,500 | 0 | -11,500 | 0.00 | 0.00 | -0.00 | sell |
| NORGES BANK | 40,000 | 27,829 | -12,171 | 0.00 | 0.00 | -0.00 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 12,643 | 0 | -12,643 | 0.03 | 0.00 | -0.03 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 20,000 | 0 | -20,000 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 36,314 | 12,263 | -24,051 | 0.00 | 0.00 | -0.00 | sell |
| Maven Securities LTD | 25,000 | 0 | -25,000 | 0.06 | 0.00 | -0.06 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 26,677 | 0 | -26,677 | 0.00 | 0.00 | -0.00 | sell |
| Ghisallo Capital Management LLC | 30,000 | 0 | -30,000 | 0.03 | 0.00 | -0.03 | sell |
| Woodline Partners LP | 124,950 | 88,368 | -36,582 | 0.02 | 0.00 | -0.02 | sell |
| JANE STREET GROUP, LLC | 43,073 | 0 | -43,073 | 0.00 | 0.00 | -0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 50,000 | 0 | -50,000 | 0.05 | 0.00 | -0.05 | sell |
| FIL Ltd | 200,000 | 146,215 | -53,785 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 55,080 | 0 | -55,080 | 0.09 | 0.00 | -0.09 | sell |
| TD ASSET MANAGEMENT INC | 59,678 | 0 | -59,678 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 100,000 | 39,974 | -60,026 | 0.47 | 0.05 | -0.42 | sell |
| Walleye Capital LLC | 76,875 | 0 | -76,875 | 0.02 | 0.00 | -0.02 | sell |
| Monashee Investment Management LLC | 95,000 | 0 | -95,000 | 0.21 | 0.00 | -0.21 | sell |
| SOROS FUND MANAGEMENT LLC | 100,000 | 0 | -100,000 | 0.04 | 0.00 | -0.04 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 120,000 | 0 | -120,000 | 0.01 | 0.00 | -0.01 | sell |
| Zimmer Partners, LP | 125,000 | 0 | -125,000 | 0.05 | 0.00 | -0.05 | sell |
| Alyeska Investment Group, L.P. | 150,000 | 0 | -150,000 | 0.02 | 0.00 | -0.02 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 150,000 | 0 | -150,000 | 0.01 | 0.00 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 166,022 | 14,965 | -151,057 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 200,000 | 0 | -200,000 | 0.01 | 0.00 | -0.01 | sell |
| JPMORGAN CHASE & CO | 200,000 | 0 | -200,000 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 213,718 | 0 | -213,718 | 0.00 | 0.00 | -0.00 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 229,431 | 0 | -229,431 | 0.25 | 0.00 | -0.25 | sell |
| WASATCH ADVISORS LP | 254,907 | 0 | -254,907 | 0.03 | 0.00 | -0.03 | sell |
| EMERALD ADVISERS, LLC | 281,317 | 0 | -281,317 | 0.23 | 0.00 | -0.23 | sell |
| Sands Capital Alternatives, LLC | 1,086,353 | 786,353 | -300,000 | 6.35 | 0.99 | -5.36 | sell |
| BROWN ADVISORY INC | 334,915 | 0 | -334,915 | 0.01 | 0.00 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 449,837 | 0 | -449,837 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 1,423,470 | 921,959 | -501,511 | 0.54 | 0.11 | -0.43 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 2,210,589 | 1,310,589 | -900,000 | 0.53 | 0.10 | -0.43 | sell |
| ALLIANCEBERNSTEIN L.P. | 994,315 | 0 | -994,315 | 0.01 | 0.00 | -0.01 | sell |