| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| AH Capital Management, L.L.C. | 3,233,170 | 3,233,170 | 0 | 1.36 | 2.79 | +1.43 | hold |
| Sofinnova Investments, Inc. | 2,293,788 | 2,293,788 | 0 | 0.83 | 1.31 | +0.48 | hold |
| Cormorant Asset Management, LP | 2,140,605 | 2,040,605 | -100,000 | 0.87 | 1.53 | +0.66 | sell |
| Octagon Capital Advisors LP | 0 | 1,598,000 | +1,598,000 | 0.00 | 2.65 | +2.65 | buy |
| BlackRock, Inc. | 1,279,621 | 1,527,541 | +247,920 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,651,247 | 1,414,770 | -236,477 | 0.00 | 0.00 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,050,000 | +1,050,000 | 0.00 | 0.02 | +0.02 | buy |
| ORBIMED ADVISORS LLC | 790,901 | 790,901 | 0 | 0.11 | 0.21 | +0.10 | hold |
| Sands Capital Alternatives, LLC | 786,353 | 786,353 | 0 | 1.01 | 2.01 | +0.99 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 653,374 | 653,374 | 0 | 2.22 | 3.34 | +1.12 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 562,731 | 591,377 | +28,646 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 198,111 | 422,846 | +224,735 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 409,207 | +409,207 | 0.00 | 0.00 | +0.00 | buy |
| Redpoint Management, LLC | 383,254 | 383,254 | 0 | 1.36 | 3.73 | +2.37 | hold |
| D. E. Shaw & Co., Inc. | 104,281 | 339,909 | +235,628 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 213,088 | 334,126 | +121,038 | 0.00 | 0.02 | +0.01 | buy |
| MORGAN STANLEY | 0 | 311,659 | +311,659 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 10,676 | 277,957 | +267,281 | 0.00 | 0.01 | +0.01 | buy |
| Comprehensive Financial Management LLC | 271,842 | 271,842 | 0 | 0.04 | 0.11 | +0.06 | hold |
| DIADEMA PARTNERS LP | 0 | 271,164 | +271,164 | 0.00 | 2.14 | +2.14 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 243,035 | +243,035 | 0.00 | 0.67 | +0.67 | buy |
| CITADEL ADVISORS LLC | 114,063 | 230,543 | +116,480 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 228,673 | +228,673 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 306,552 | 228,414 | -78,138 | 0.00 | 0.00 | +0.00 | sell |
| MARSHALL WACE, LLP | 174,196 | 222,948 | +48,752 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 191,383 | 219,842 | +28,459 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 11,152 | 196,048 | +184,896 | 0.00 | 0.04 | +0.04 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 188,683 | +188,683 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 186,568 | 167,452 | -19,116 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 1,880,073 | 135,560 | -1,744,513 | 1.09 | 0.13 | -0.96 | sell |
| Walleye Capital LLC | 12,893 | 134,795 | +121,902 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 89,678 | 126,238 | +36,560 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 91,118 | 117,703 | +26,585 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 25,735 | 111,789 | +86,054 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 30,463 | 82,963 | +52,500 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 52,600 | 77,600 | +25,000 | 0.01 | 0.02 | +0.01 | buy |
| Persistent Asset Partners Ltd | 0 | 72,774 | +72,774 | 0.00 | 0.46 | +0.46 | buy |
| Bank of New York Mellon Corp | 57,998 | 61,560 | +3,562 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 52,439 | +52,439 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 35,746 | 51,918 | +16,172 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 51,366 | +51,366 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 51,273 | +51,273 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 188,571 | 45,000 | -143,571 | 0.90 | 0.47 | -0.43 | sell |
| Jump Financial, LLC | 0 | 42,800 | +42,800 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 99,669 | 42,151 | -57,518 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 4,529 | 41,308 | +36,779 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 41,180 | +41,180 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 120,929 | 40,388 | -80,541 | 0.00 | 0.00 | -0.00 | sell |
| Militia Capital Partners, LP | 40,300 | 40,300 | 0 | 0.11 | 0.20 | +0.09 | hold |
| Trexquant Investment LP | 0 | 39,334 | +39,334 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 34,558 | 37,780 | +3,222 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 36,727 | +36,727 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 31,565 | 31,565 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nuveen, LLC | 30,794 | 30,794 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UBS Group AG | 0 | 29,879 | +29,879 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 28,652 | 29,527 | +875 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 13,760 | 27,788 | +14,028 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 19,888 | 26,597 | +6,709 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 17,800 | 22,500 | +4,700 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 36,848 | 22,029 | -14,819 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 87,700 | 19,500 | -68,200 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 143,000 | 18,400 | -124,600 | 0.00 | 0.00 | -0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 18,034 | +18,034 | 0.00 | 0.04 | +0.04 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 19,295 | 17,735 | -1,560 | 0.01 | 0.02 | +0.00 | sell |
| Quadrature Capital Ltd | 10,734 | 16,769 | +6,035 | 0.00 | 0.00 | +0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 0 | 16,199 | +16,199 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 25,325 | 15,796 | -9,529 | 0.00 | 0.00 | +0.00 | sell |
| R Squared Ltd | 26,159 | 15,006 | -11,153 | 0.07 | 0.09 | +0.03 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11,891 | 14,808 | +2,917 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 14,437 | +14,437 | 0.00 | 0.00 | +0.00 | buy |
| Valor Management LLC | 13,105 | 13,105 | 0 | 0.11 | 0.31 | +0.20 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 11,829 | 12,192 | +363 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11,136 | 11,009 | -127 | 0.00 | 0.00 | +0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 237 | 10,237 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 6,577 | 6,577 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 6,300 | +6,300 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 5,843 | +5,843 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,100 | 5,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CWM, LLC | 2,640 | 3,693 | +1,053 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 1,405 | 2,860 | +1,455 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 2,183 | +2,183 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 2,152 | 2,152 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 0 | 1,742 | +1,742 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 276 | 1,538 | +1,262 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,482 | 1,461 | -21 | 0.00 | 0.00 | +0.00 | sell |
| Sterling Capital Management LLC | 1,637 | 1,367 | -270 | 0.00 | 0.00 | +0.00 | sell |
| Ameritas Investment Partners, Inc. | 1,269 | 1,269 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 2,595 | 1,124 | -1,471 | 0.00 | 0.00 | -0.00 | sell |
| Parallel Advisors, LLC | 300 | 867 | +567 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 414 | 745 | +331 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 0 | 704 | +704 | 0.00 | 0.00 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 256 | 256 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EverSource Wealth Advisors, LLC | 110 | 145 | +35 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 122 | +122 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 120 | 120 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 0 | 119 | +119 | 0.00 | 0.00 | +0.00 | buy |
| Cornerstone Planning Group LLC | 100 | 102 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 101 | 101 | 0 | 0.00 | 0.00 | +0.00 | hold |
| True Wealth Design, LLC | 80 | 80 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIGNATUREFD, LLC | 0 | 57 | +57 | 0.00 | 0.00 | +0.00 | buy |