| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 1,017,052 | 5,489,135 | +4,472,083 | 0.00 | 0.01 | +0.01 | buy |
| Paradigm Biocapital Advisors LP | 7,365,038 | 10,215,455 | +2,850,417 | 4.74 | 7.77 | +3.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 69,427 | 816,518 | +747,091 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 620,532 | +620,532 | 0.00 | 0.00 | +0.00 | buy |
| Tyro Capital Management LLC | 0 | 612,965 | +612,965 | 0.00 | 5.59 | +5.59 | buy |
| NORGES BANK | 0 | 510,140 | +510,140 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 462,000 | +462,000 | 0.00 | 0.03 | +0.03 | buy |
| Qube Research & Technologies Ltd | 825,910 | 1,252,507 | +426,597 | 0.04 | 0.06 | +0.02 | buy |
| Integral Health Asset Management, LLC | 1,600,000 | 2,000,000 | +400,000 | 2.67 | 3.33 | +0.67 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,722,169 | 2,119,024 | +396,855 | 0.01 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,789,819 | 2,174,051 | +384,232 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 19,678 | 317,565 | +297,887 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 0 | 272,214 | +272,214 | 0.00 | 3.91 | +3.91 | buy |
| Parkman Healthcare Partners LLC | 322,828 | 577,036 | +254,208 | 1.05 | 2.41 | +1.35 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,477,942 | 4,728,623 | +250,681 | 1.04 | 1.11 | +0.08 | buy |
| PRUDENTIAL FINANCIAL INC | 10,605 | 260,725 | +250,120 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 1,327,360 | 1,558,260 | +230,900 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 99,075 | 255,202 | +156,127 | 0.03 | 0.05 | +0.03 | buy |
| BlackRock, Inc. | 6,472,991 | 6,606,336 | +133,345 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 117,262 | +117,262 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 112,236 | 226,819 | +114,583 | 0.80 | 1.76 | +0.95 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 789,043 | 902,870 | +113,827 | 0.02 | 0.02 | +0.00 | buy |
| STATE STREET CORP | 1,716,823 | 1,827,927 | +111,104 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 576,556 | 671,270 | +94,714 | 0.00 | 0.00 | +0.00 | buy |
| First Light Asset Management, LLC | 1,001,846 | 1,095,171 | +93,325 | 2.83 | 2.70 | -0.12 | buy |
| HSBC HOLDINGS PLC | 0 | 91,638 | +91,638 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 85,000 | +85,000 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 104,863 | 189,115 | +84,252 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 82,734 | +82,734 | 0.00 | 0.06 | +0.06 | buy |
| Nuveen, LLC | 335,783 | 414,706 | +78,923 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 71,389 | +71,389 | 0.00 | 0.03 | +0.03 | buy |
| Russell Investments Group, Ltd. | 6,574 | 77,594 | +71,020 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 10,053 | 69,441 | +59,388 | 0.12 | 0.89 | +0.77 | buy |
| JPMORGAN CHASE & CO | 147,573 | 203,151 | +55,578 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 39,153 | 94,671 | +55,518 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 25,244 | 78,898 | +53,654 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 90,599 | 143,199 | +52,600 | 0.17 | 0.27 | +0.10 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 44,466 | +44,466 | 0.00 | 0.11 | +0.11 | buy |
| CITIGROUP INC | 18,517 | 59,563 | +41,046 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 429,032 | 469,707 | +40,675 | 0.01 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 40,379 | +40,379 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 36,918 | +36,918 | 0.00 | 0.05 | +0.05 | buy |
| Artia Global Partners LP | 65,500 | 98,800 | +33,300 | 0.47 | 0.76 | +0.30 | buy |
| TUDOR INVESTMENT CORP ET AL | 29,889 | 56,934 | +27,045 | 0.01 | 0.01 | +0.00 | buy |
| XTX Topco Ltd | 19,108 | 45,832 | +26,724 | 0.01 | 0.02 | +0.01 | buy |
| Brevan Howard Capital Management LP | 0 | 26,566 | +26,566 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 596,310 | 620,532 | +24,222 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 32,896 | 56,910 | +24,014 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 23,829 | +23,829 | 0.00 | 0.05 | +0.05 | buy |
| DEUTSCHE BANK AG\ | 221,868 | 244,995 | +23,127 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 168,678 | 191,195 | +22,517 | 0.00 | 0.01 | +0.00 | buy |
| ALPS ADVISORS INC | 87,326 | 108,795 | +21,469 | 0.01 | 0.02 | +0.01 | buy |
| Bank of New York Mellon Corp | 192,434 | 212,347 | +19,913 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 23,911 | 43,587 | +19,676 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 0 | 16,288 | +16,288 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 14,738 | +14,738 | 0.00 | 0.02 | +0.02 | buy |
| ALGERT GLOBAL LLC | 32,520 | 47,240 | +14,720 | 0.02 | 0.02 | +0.01 | buy |
| STRS OHIO | 6,900 | 21,100 | +14,200 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 177,244 | 190,205 | +12,961 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 12,913 | +12,913 | 0.00 | 0.05 | +0.05 | buy |
| Quantinno Capital Management LP | 7,454 | 20,299 | +12,845 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 12,365 | +12,365 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 151 | 12,209 | +12,058 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 8,539 | 18,456 | +9,917 | 0.00 | 0.00 | +0.00 | buy |
| Private Advisor Group, LLC | 0 | 9,341 | +9,341 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 0 | 9,100 | +9,100 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 31,268 | 39,198 | +7,930 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 0 | 7,027 | +7,027 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 15,730 | 22,685 | +6,955 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 83,540 | 90,232 | +6,692 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 6,670 | +6,670 | 0.00 | 0.00 | +0.00 | buy |
| Marex Group plc | 0 | 6,274 | +6,274 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 6,035 | +6,035 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0 | 5,900 | +5,900 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 5,655 | +5,655 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 5,470 | +5,470 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 5,466 | +5,466 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35,450 | 40,757 | +5,307 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 4,477 | +4,477 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 38,084 | 41,804 | +3,720 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 114,720 | 118,209 | +3,489 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 18,865 | 21,096 | +2,231 | 0.01 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 42,537 | 44,688 | +2,151 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 11,524 | 13,649 | +2,125 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 1,812 | +1,812 | 0.00 | 0.00 | +0.00 | buy |
| BI Asset Management Fondsmaeglerselskab A/S | 0 | 1,439 | +1,439 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 31,614 | 32,939 | +1,325 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,638 | 6,491 | +853 | 0.01 | 0.01 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 9,129 | 9,877 | +748 | 0.00 | 0.00 | +0.00 | buy |
| Centiva Capital, LP | 539 | 1,217 | +678 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 14,739 | 15,288 | +549 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 8,683 | 9,164 | +481 | 0.01 | 0.01 | +0.00 | buy |
| Orion Porfolio Solutions, LLC | 6,449 | 6,930 | +481 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 1,032 | 1,513 | +481 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 2,973 | 3,386 | +413 | 0.00 | 0.00 | +0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 38,414 | 38,641 | +227 | 0.07 | 0.08 | +0.01 | buy |
| OSAIC HOLDINGS, INC. | 8,483 | 8,694 | +211 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH THIRD BANCORP | 33 | 193 | +160 | 0.00 | 0.00 | +0.00 | buy |
| Hurley Capital, LLC | 0 | 149 | +149 | 0.00 | 0.00 | +0.00 | buy |