| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DAFNA Capital Management LLC | 112,236 | 226,819 | +114,583 | 0.80 | 1.76 | +0.95 | buy |
| First Light Asset Management, LLC | 1,001,846 | 1,095,171 | +93,325 | 2.83 | 2.70 | -0.12 | buy |
| Knights of Columbus Asset Advisors LLC | 38,414 | 38,641 | +227 | 0.07 | 0.08 | +0.01 | buy |
| HighVista Strategies LLC | 91,931 | 90,996 | -935 | 0.80 | 0.84 | +0.04 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 7,976 | 6,014 | -1,962 | 0.04 | 0.04 | -0.00 | sell |
| Sofinnova Investments, Inc. | 386,498 | 380,923 | -5,575 | 0.46 | 0.80 | +0.34 | sell |
| China Universal Asset Management Co., Ltd. | 25,436 | 18,373 | -7,063 | 0.06 | 0.04 | -0.02 | sell |
| Granahan Investment Management, LLC | 200,843 | 193,778 | -7,065 | 0.31 | 0.28 | -0.03 | sell |
| MOODY ALDRICH PARTNERS LLC | 114,141 | 104,952 | -9,189 | 0.65 | 0.77 | +0.12 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 208,672 | 198,570 | -10,102 | 0.24 | 0.26 | +0.02 | sell |
| Longaeva Partners L.P. | 36,931 | 18,790 | -18,141 | 0.04 | 0.02 | -0.03 | sell |
| MPM BioImpact LLC | 1,660,696 | 1,620,780 | -39,916 | 4.04 | 4.02 | -0.02 | sell |
| PERCEPTIVE ADVISORS LLC | 4,423,974 | 4,373,974 | -50,000 | 2.72 | 2.67 | -0.06 | sell |
| J. Goldman & Co LP | 61,421 | 10,183 | -51,238 | 0.06 | 0.01 | -0.05 | sell |
| Artisan Partners Limited Partnership | 659,067 | 574,925 | -84,142 | 0.03 | 0.04 | +0.00 | sell |
| Cormorant Asset Management, LP | 3,260,000 | 2,510,000 | -750,000 | 5.16 | 5.23 | +0.07 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 10,428,437 | 8,392,730 | -2,035,707 | 3.48 | 2.96 | -0.52 | sell |
| BAKER BROS. ADVISORS LP | 6,575,940 | 3,701,719 | -2,874,221 | 1.19 | 0.75 | -0.44 | sell |