| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 3,112,786 | 5,840,059 | +2,727,273 | 0.39 | 1.34 | +0.95 | buy |
| PERCEPTIVE ADVISORS LLC | 555,555 | 2,319,646 | +1,764,091 | 0.14 | 0.74 | +0.60 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 395,069 | 1,267,819 | +872,750 | 0.05 | 0.23 | +0.18 | buy |
| Frazier Life Sciences Management, L.P. | 2,667,203 | 3,303,567 | +636,364 | 1.56 | 2.54 | +0.98 | buy |
| JANUS HENDERSON GROUP PLC | 1,215,013 | 1,805,312 | +590,299 | 0.01 | 0.02 | 0.00 | buy |
| ORBIMED ADVISORS LLC | 14,567,176 | 15,021,721 | +454,545 | 3.19 | 5.03 | +1.84 | buy |
| Cormorant Asset Management, LP | 2,551,989 | 3,006,534 | +454,545 | 1.33 | 2.41 | +1.07 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 114,685 | 75,097 | +39,588 | 0.09 | 0.10 | 0.00 | sell |
| ALPS ADVISORS INC | 43,226 | 65,672 | +22,446 | 0.00 | 0.01 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 52,660 | 74,511 | +21,851 | 0.05 | 0.12 | 0.00 | buy |
| Candriam S.C.A. | 308,000 | 329,000 | +21,000 | 0.02 | 0.04 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 7,338 | 17,881 | +10,543 | 0.02 | 0.04 | +0.03 | buy |
| Quantum Private Wealth, LLC | 63,219 | 66,674 | +3,455 | 0.29 | 0.45 | +0.16 | buy |
| Parkman Healthcare Partners LLC | 651,625 | 653,653 | +2,028 | 1.00 | 1.46 | +0.46 | buy |
| Woodline Partners LP | 404,212 | 405,132 | +920 | 0.05 | 0.07 | +0.02 | buy |
| PDT Partners, LLC | 29,259 | 26,359 | -2,900 | 0.04 | 0.05 | +0.01 | sell |
| Corton Capital Inc. | 20,218 | 13,042 | -7,176 | 0.07 | 0.09 | +0.02 | sell |
| Opaleye Management Inc. | 699,000 | 665,000 | -34,000 | 2.03 | 2.64 | +0.61 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 342,864 | 293,265 | -49,599 | 0.08 | 0.11 | +0.03 | sell |
| DAFNA Capital Management LLC | 449,384 | 306,197 | -143,187 | 1.18 | 1.27 | +0.09 | sell |
| Granahan Investment Management, LLC | 1,074,908 | 608,012 | -466,896 | 0.39 | 0.39 | +0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,933,137 | 2,874,586 | -1,058,551 | 0.79 | 0.91 | +0.12 | sell |
| EcoR1 Capital, LLC | 3,493,194 | 1,250,385 | -2,242,809 | 0.99 | 0.58 | -0.42 | sell |
| VIKING GLOBAL INVESTORS LP | 6,159,146 | 3,339,146 | -2,820,000 | 0.25 | 0.23 | -0.02 | sell |