| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 14,567,176 | 15,021,721 | +454,545 | 3.19 | 5.03 | +1.84 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 8,909,091 | +8,909,091 | 0.00 | 2.07 | +2.07 | buy |
| FMR LLC | 6,492,513 | 6,365,724 | -126,789 | 0.01 | 0.01 | +0.00 | sell |
| BAKER BROS. ADVISORS LP | 3,112,786 | 5,840,059 | +2,727,273 | 0.39 | 1.34 | +0.95 | buy |
| VANGUARD GROUP INC | 2,125,380 | 4,017,433 | +1,892,053 | 0.00 | 0.00 | +0.00 | buy |
| VIKING GLOBAL INVESTORS LP | 6,159,146 | 3,339,146 | -2,820,000 | 0.25 | 0.23 | -0.02 | sell |
| Frazier Life Sciences Management, L.P. | 2,667,203 | 3,303,567 | +636,364 | 1.56 | 2.54 | +0.98 | buy |
| Cormorant Asset Management, LP | 2,551,989 | 3,006,534 | +454,545 | 1.34 | 2.42 | +1.08 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,933,137 | 2,874,586 | -1,058,551 | 0.79 | 0.91 | +0.12 | sell |
| CITADEL ADVISORS LLC | 2,585,930 | 2,719,291 | +133,361 | 0.03 | 0.05 | +0.02 | buy |
| Paradigm Biocapital Advisors LP | 0 | 2,446,373 | +2,446,373 | 0.00 | 1.57 | +1.57 | buy |
| PERCEPTIVE ADVISORS LLC | 555,555 | 2,319,646 | +1,764,091 | 0.14 | 0.75 | +0.61 | buy |
| TCG Crossover Management, LLC | 0 | 2,272,728 | +2,272,728 | 0.00 | 3.28 | +3.28 | buy |
| VR Adviser, LLC | 0 | 1,818,182 | +1,818,182 | 0.00 | 1.58 | +1.58 | buy |
| JANUS HENDERSON GROUP PLC | 1,215,013 | 1,805,312 | +590,299 | 0.01 | 0.02 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 881,896 | 1,747,844 | +865,948 | 0.00 | 0.01 | +0.00 | buy |
| New Leaf Venture Partners, L.L.C. | 1,553,661 | 1,553,661 | 0 | 13.69 | 24.80 | +11.11 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 947,046 | 1,369,897 | +422,851 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 395,069 | 1,267,819 | +872,750 | 0.05 | 0.23 | +0.18 | buy |
| EcoR1 Capital, LLC | 3,493,194 | 1,250,385 | -2,242,809 | 0.99 | 0.58 | -0.41 | sell |
| STATE STREET CORP | 892,709 | 1,211,476 | +318,767 | 0.00 | 0.00 | +0.00 | buy |
| Artal Group S.A. | 0 | 811,718 | +811,718 | 0.00 | 0.38 | +0.38 | buy |
| Opaleye Management Inc. | 699,000 | 665,000 | -34,000 | 2.03 | 2.64 | +0.61 | sell |
| Parkman Healthcare Partners LLC | 651,625 | 653,653 | +2,028 | 1.01 | 1.46 | +0.45 | buy |
| Granahan Investment Management, LLC | 1,074,908 | 608,012 | -466,896 | 0.39 | 0.39 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 770,452 | 559,334 | -211,118 | 0.01 | 0.01 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 131,355 | 532,255 | +400,900 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 363,243 | 499,520 | +136,277 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 331,059 | 497,162 | +166,103 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 31,950 | 473,680 | +441,730 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 340,906 | 472,903 | +131,997 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 0 | 441,259 | +441,259 | 0.00 | 1.29 | +1.29 | buy |
| Woodline Partners LP | 404,212 | 405,132 | +920 | 0.05 | 0.07 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 169,542 | 392,735 | +223,193 | 0.00 | 0.02 | +0.01 | buy |
| MORGAN STANLEY | 225,179 | 374,718 | +149,539 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 308,000 | 329,000 | +21,000 | 0.02 | 0.04 | +0.02 | buy |
| DAFNA Capital Management LLC | 449,384 | 306,197 | -143,187 | 1.18 | 1.27 | +0.09 | sell |
| DIMENSIONAL FUND ADVISORS LP | 262,238 | 299,288 | +37,050 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 342,864 | 293,265 | -49,599 | 0.08 | 0.11 | +0.03 | sell |
| Schonfeld Strategic Advisors LLC | 319,100 | 284,600 | -34,500 | 0.03 | 0.04 | +0.01 | sell |
| Bank of New York Mellon Corp | 146,170 | 212,265 | +66,095 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 180,911 | +180,911 | 0.00 | 0.90 | +0.90 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 175,901 | +175,901 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 55,591 | 126,332 | +70,741 | 0.01 | 0.05 | +0.03 | buy |
| Cubist Systematic Strategies, LLC | 1,729 | 103,208 | +101,479 | 0.00 | 0.02 | +0.02 | buy |
| TWO SIGMA ADVISERS, LP | 40,900 | 92,400 | +51,500 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 778,916 | 87,244 | -691,672 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 64,333 | 84,228 | +19,895 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 80,000 | 80,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 114,685 | 75,097 | -39,588 | 0.04 | 0.04 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 52,660 | 74,511 | +21,851 | 0.05 | 0.11 | +0.06 | buy |
| UBS Group AG | 0 | 74,118 | +74,118 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 70,693 | 68,698 | -1,995 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 50,100 | 67,300 | +17,200 | 0.00 | 0.00 | +0.00 | buy |
| Quantum Private Wealth, LLC | 63,219 | 66,674 | +3,455 | 0.29 | 0.45 | +0.16 | buy |
| ALPS ADVISORS INC | 43,226 | 65,672 | +22,446 | 0.00 | 0.01 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 60,881 | +60,881 | 0.00 | 0.05 | +0.05 | buy |
| ALLIANCEBERNSTEIN L.P. | 37,420 | 56,100 | +18,680 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 54,617 | +54,617 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 62,268 | 53,763 | -8,505 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 64,700 | 45,400 | -19,300 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 40,063 | 42,833 | +2,770 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 7,261 | 36,944 | +29,683 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 29,620 | 36,467 | +6,847 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 23,613 | 32,413 | +8,800 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 17,258 | 30,580 | +13,322 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 23,355 | 29,935 | +6,580 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 16,657 | 28,491 | +11,834 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 21,267 | 28,418 | +7,151 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 44,139 | 27,146 | -16,993 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 54,436 | 26,870 | -27,566 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 0 | 26,842 | +26,842 | 0.00 | 0.01 | +0.01 | buy |
| PDT Partners, LLC | 29,259 | 26,359 | -2,900 | 0.04 | 0.05 | +0.01 | sell |
| DEUTSCHE BANK AG\ | 20,410 | 25,274 | +4,864 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 11,610 | 24,854 | +13,244 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 16,528 | 21,146 | +4,618 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 13,176 | 20,431 | +7,255 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 20,005 | +20,005 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 19,601 | +19,601 | 0.00 | 0.00 | +0.00 | buy |
| DENALI ADVISORS LLC | 0 | 19,200 | +19,200 | 0.00 | 0.10 | +0.10 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 18,185 | 18,296 | +111 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,338 | 17,881 | +10,543 | 0.02 | 0.04 | +0.03 | buy |
| Mirae Asset Global Investments Co., Ltd. | 20,833 | 17,321 | -3,512 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 11,137 | 16,885 | +5,748 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 16,400 | 16,765 | +365 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 16,870 | 16,650 | -220 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 126,071 | 16,424 | -109,647 | 0.00 | 0.00 | -0.00 | sell |
| Castleview Partners, LLC | 0 | 16,204 | +16,204 | 0.00 | 0.17 | +0.17 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 14,903 | +14,903 | 0.00 | 0.02 | +0.02 | buy |
| EntryPoint Capital, LLC | 13,720 | 14,216 | +496 | 0.14 | 0.23 | +0.09 | buy |
| XTX Topco Ltd | 17,143 | 14,049 | -3,094 | 0.04 | 0.03 | -0.01 | sell |
| OXFORD ASSET MANAGEMENT LLP | 0 | 13,615 | +13,615 | 0.00 | 0.31 | +0.31 | buy |
| Nantahala Capital Management, LLC | 0 | 13,371 | +13,371 | 0.00 | 0.02 | +0.02 | buy |
| Corton Capital Inc. | 20,218 | 13,042 | -7,176 | 0.07 | 0.09 | +0.02 | sell |
| Entropy Technologies, LP | 0 | 12,665 | +12,665 | 0.00 | 0.02 | +0.02 | buy |
| STRS OHIO | 0 | 12,600 | +12,600 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 10,814 | +10,814 | 0.00 | 0.04 | +0.04 | buy |
| SFMG, LLC | 10,000 | 10,000 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Qube Research & Technologies Ltd | 2,026 | 9,002 | +6,976 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 29,826 | 8,467 | -21,359 | 0.00 | 0.00 | -0.00 | sell |