| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 2,685,537 | 6,547,328 | +3,861,791 | 2.00 | 5.11 | +3.11 | buy |
| First Light Asset Management, LLC | 780,639 | 1,852,290 | +1,071,651 | 1.99 | 4.65 | +2.66 | buy |
| Siren, L.L.C. | 734,343 | 1,696,444 | +962,101 | 0.87 | 2.11 | +1.24 | buy |
| Cormorant Asset Management, LP | 3,406,534 | 4,101,992 | +695,458 | 5.00 | 6.83 | +1.84 | buy |
| Deep Track Capital, LP | 710,421 | 1,400,000 | +689,579 | 0.71 | 1.00 | +0.29 | buy |
| BANK OF AMERICA CORP /DE/ | 48,907 | 695,426 | +646,519 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 568,310 | +568,310 | 0.00 | 0.25 | +0.25 | buy |
| Woodline Partners LP | 567,218 | 1,096,809 | +529,591 | 0.10 | 0.16 | +0.05 | buy |
| Novo Holdings A/S | 5,000,000 | 5,350,000 | +350,000 | 8.08 | 8.95 | +0.87 | buy |
| READYSTATE ASSET MANAGEMENT LP | 21,362 | 361,233 | +339,871 | 0.02 | 0.40 | +0.37 | buy |
| JANUS HENDERSON GROUP PLC | 4,983,940 | 5,282,154 | +298,214 | 0.07 | 0.07 | -0.00 | buy |
| Ikarian Capital, LLC | 0 | 280,000 | +280,000 | 0.00 | 2.01 | +2.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 29,050 | 294,881 | +265,831 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 0 | 250,000 | +250,000 | 0.00 | 0.03 | +0.03 | buy |
| Caption Management, LLC | 0 | 204,500 | +204,500 | 0.00 | 0.21 | +0.21 | buy |
| UBS Group AG | 92,066 | 243,896 | +151,830 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 240,000 | 390,000 | +150,000 | 0.01 | 0.02 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 31,713 | 176,666 | +144,953 | 0.00 | 0.01 | +0.01 | buy |
| Aberdeen Group plc | 178,043 | 313,025 | +134,982 | 0.01 | 0.01 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 0 | 128,746 | +128,746 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 2,332,196 | 2,458,808 | +126,612 | 1.85 | 1.90 | +0.06 | buy |
| Integral Health Asset Management, LLC | 550,000 | 675,000 | +125,000 | 1.30 | 1.65 | +0.35 | buy |
| Neuberger Berman Group LLC | 0 | 102,181 | +102,181 | 0.00 | 0.00 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 100,826 | +100,826 | 0.00 | 0.04 | +0.04 | buy |
| DEUTSCHE BANK AG\ | 275,837 | 376,060 | +100,223 | 0.00 | 0.00 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 0 | 100,000 | +100,000 | 0.00 | 1.98 | +1.98 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 23,364 | 120,910 | +97,546 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 85,214 | +85,214 | 0.00 | 0.06 | +0.06 | buy |
| EFG Asset Management (North America) Corp. | 41,338 | 104,386 | +63,048 | 0.15 | 0.38 | +0.23 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,600,571 | 1,655,664 | +55,093 | 0.00 | 0.00 | -0.00 | buy |
| STEMPOINT CAPITAL LP | 132,706 | 180,255 | +47,549 | 0.89 | 1.27 | +0.38 | buy |
| Parkman Healthcare Partners LLC | 381,173 | 425,407 | +44,234 | 1.36 | 1.11 | -0.25 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 40,014 | +40,014 | 0.00 | 0.02 | +0.02 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 37,591 | +37,591 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 36,358 | +36,358 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 0 | 33,200 | +33,200 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 369,442 | 397,573 | +28,131 | 0.02 | 0.01 | -0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 27,635 | +27,635 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 1,079,316 | 1,105,444 | +26,128 | 4.09 | 4.18 | +0.09 | buy |
| ADAR1 Capital Management, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.08 | +0.08 | buy |
| GOLDMAN SACHS GROUP INC | 346,891 | 366,644 | +19,753 | 0.00 | 0.00 | -0.00 | buy |
| Ally Bridge Group (NY) LLC | 83,176 | 102,650 | +19,474 | 1.90 | 2.04 | +0.13 | buy |
| Squarepoint Ops LLC | 26,358 | 45,756 | +19,398 | 0.00 | 0.00 | +0.00 | buy |
| Quantum Private Wealth, LLC | 73,524 | 90,724 | +17,200 | 0.63 | 0.75 | +0.13 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 33,164 | 49,995 | +16,831 | 0.07 | 0.11 | +0.04 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 40,170 | 56,988 | +16,818 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 16,328 | +16,328 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 31,607 | 46,287 | +14,680 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 13,073 | +13,073 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 12,883 | +12,883 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 476 | 12,631 | +12,155 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 34,844 | 46,208 | +11,364 | 0.01 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 268,509 | 278,973 | +10,464 | 0.05 | 0.04 | -0.00 | buy |
| CONTRAVISORY INVESTMENT MANAGEMENT, INC. | 0 | 10,209 | +10,209 | 0.00 | 0.05 | +0.05 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 61,521 | 71,132 | +9,611 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 770,353 | 779,766 | +9,413 | 0.01 | 0.01 | -0.00 | buy |
| Tidal Investments LLC | 0 | 9,220 | +9,220 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 73,600 | 82,600 | +9,000 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 82,732 | 91,207 | +8,475 | 0.82 | 0.77 | -0.05 | buy |
| AlphaQuest LLC | 2,203 | 9,358 | +7,155 | 0.01 | 0.02 | +0.01 | buy |
| RHUMBLINE ADVISERS | 102,397 | 108,837 | +6,440 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 6,479,015 | 6,485,008 | +5,993 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 5,829 | +5,829 | 0.00 | 0.03 | +0.03 | buy |
| Invesco Ltd. | 43,435 | 48,130 | +4,695 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,676 | 7,960 | +4,284 | 0.00 | 0.01 | +0.00 | buy |
| Allostery Investments LP | 0 | 3,000 | +3,000 | 0.00 | 0.10 | +0.10 | buy |
| TUDOR INVESTMENT CORP ET AL | 43,809 | 46,804 | +2,995 | 0.01 | 0.01 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 41,313 | 43,776 | +2,463 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 3,324 | 5,729 | +2,405 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,715,545 | 1,717,724 | +2,179 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Trading LLC | 0 | 1,456 | +1,456 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 10,863 | 12,201 | +1,338 | 0.00 | 0.00 | -0.00 | buy |
| Pictet Asset Management Holding SA | 301,241 | 302,513 | +1,272 | 0.01 | 0.01 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 33,918 | 35,158 | +1,240 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 2,053 | 3,194 | +1,141 | 0.05 | 0.05 | -0.00 | buy |
| PROFUND ADVISORS LLC | 14,945 | 15,687 | +742 | 0.01 | 0.01 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 14,678 | 15,399 | +721 | 0.00 | 0.00 | -0.00 | buy |
| CROWLEY WEALTH MANAGEMENT, INC. | 0 | 560 | +560 | 0.00 | 0.01 | +0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,988 | 2,424 | +436 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 0 | 356 | +356 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 11,906 | 12,217 | +311 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 282 | +282 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 11,143 | 11,421 | +278 | 0.00 | 0.00 | -0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 198 | +198 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 1,321 | 1,407 | +86 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 71,366 | 71,450 | +84 | 0.00 | 0.00 | -0.00 | buy |
| TD PRIVATE CLIENT WEALTH LLC | 0 | 60 | +60 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 50,292 | 50,348 | +56 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 9,366 | 9,419 | +53 | 0.00 | 0.00 | -0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 26 | 61 | +35 | 0.00 | 0.00 | -0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 32 | +32 | 0.00 | 0.00 | +0.00 | buy |
| CREATIVE FINANCIAL DESIGNS INC /ADV | 0 | 31 | +31 | 0.00 | 0.00 | +0.00 | buy |
| Stephens Consulting, LLC | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 90 | 120 | +30 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 466 | 492 | +26 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,155 | 3,168 | +13 | 0.00 | 0.00 | -0.00 | buy |
| COMERICA BANK | 108 | 121 | +13 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 2,512 | 2,521 | +9 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,049 | 1,056 | +7 | 0.00 | 0.00 | +0.00 | buy |