| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 2,685,537 | 6,547,328 | +3,861,791 | 1.98 | 5.09 | +3.11 | buy |
| First Light Asset Management, LLC | 780,639 | 1,852,290 | +1,071,651 | 1.99 | 4.65 | +2.66 | buy |
| Siren, L.L.C. | 734,343 | 1,696,444 | +962,101 | 0.87 | 2.11 | +1.24 | buy |
| Cormorant Asset Management, LP | 3,406,534 | 4,101,992 | +695,458 | 5.00 | 6.79 | +1.79 | buy |
| Deep Track Capital, LP | 710,421 | 1,400,000 | +689,579 | 0.71 | 1.00 | +0.29 | buy |
| Woodline Partners LP | 567,218 | 1,096,809 | +529,591 | 0.10 | 0.16 | +0.05 | buy |
| Novo Holdings A/S | 5,000,000 | 5,350,000 | +350,000 | 8.08 | 8.95 | +0.87 | buy |
| READYSTATE ASSET MANAGEMENT LP | 21,362 | 361,233 | +339,871 | 0.02 | 0.40 | +0.37 | buy |
| JANUS HENDERSON GROUP PLC | 4,983,940 | 5,282,154 | +298,214 | 0.07 | 0.07 | 0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 240,000 | 390,000 | +150,000 | 0.01 | 0.02 | +0.00 | buy |
| Aberdeen Group plc | 178,043 | 313,025 | +134,982 | 0.01 | 0.01 | +0.00 | buy |
| BRAIDWELL LP | 2,332,196 | 2,458,808 | +126,612 | 1.85 | 1.90 | +0.06 | buy |
| Integral Health Asset Management, LLC | 550,000 | 675,000 | +125,000 | 1.25 | 1.58 | +0.33 | buy |
| EFG Asset Management (North America) Corp. | 41,338 | 104,386 | +63,048 | 0.15 | 0.38 | +0.23 | buy |
| STEMPOINT CAPITAL LP | 132,706 | 180,255 | +47,549 | 0.89 | 1.27 | +0.38 | buy |
| Parkman Healthcare Partners LLC | 381,173 | 425,407 | +44,234 | 1.36 | 1.11 | -0.25 | buy |
| MPM BioImpact LLC | 1,079,316 | 1,105,444 | +26,128 | 4.09 | 4.18 | +0.09 | buy |
| Ally Bridge Group (NY) LLC | 83,176 | 102,650 | +19,474 | 1.90 | 2.04 | +0.13 | buy |
| Quantum Private Wealth, LLC | 73,524 | 90,724 | +17,200 | 0.63 | 0.75 | +0.13 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 33,164 | 49,995 | +16,831 | 0.08 | 0.11 | +0.04 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 93,061 | 79,151 | +13,910 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 82,732 | 91,207 | +8,475 | 0.82 | 0.77 | -0.05 | buy |
| PROFUND ADVISORS LLC | 14,945 | 15,687 | +742 | 0.01 | 0.01 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,988 | 2,424 | +436 | 0.00 | 0.00 | +0.00 | buy |
| BFSG, LLC | 300 | 100 | -200 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 20,077 | 18,993 | -1,084 | 0.05 | 0.04 | -0.01 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 87,658 | 85,454 | -2,204 | 2.35 | 2.18 | -0.17 | sell |
| DAFNA Capital Management LLC | 187,140 | 183,140 | -4,000 | 1.27 | 1.14 | -0.13 | sell |
| MOODY ALDRICH PARTNERS LLC | 187,932 | 182,095 | -5,837 | 0.93 | 0.84 | -0.09 | sell |
| BI Asset Management Fondsmaeglerselskab A/S | 8,853 | 1,163 | -7,690 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 76,567 | 67,975 | -8,592 | 0.01 | 0.01 | -0.00 | sell |
| Exome Asset Management LLC | 81,473 | 71,438 | -10,035 | 1.64 | 1.41 | -0.23 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 236,642 | 224,700 | -11,942 | 0.14 | 0.12 | -0.02 | sell |
| Candriam S.C.A. | 253,965 | 225,796 | -28,169 | 0.04 | 0.03 | -0.01 | sell |
| Sofinnova Investments, Inc. | 402,773 | 342,218 | -60,555 | 0.78 | 0.49 | -0.29 | sell |
| Granahan Investment Management, LLC | 300,013 | 217,667 | -82,346 | 0.33 | 0.24 | -0.10 | sell |
| Opaleye Management Inc. | 480,000 | 395,000 | -85,000 | 2.24 | 1.93 | -0.31 | sell |
| Paradigm Biocapital Advisors LP | 4,493,929 | 4,394,556 | -99,373 | 4.17 | 4.45 | +0.28 | sell |
| Soleus Capital Management, L.P. | 183,300 | 72,300 | -111,000 | 0.37 | 0.12 | -0.25 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,493,791 | 1,375,742 | -118,049 | 0.33 | 0.29 | -0.04 | sell |
| Artisan Partners Limited Partnership | 1,071,596 | 917,222 | -154,374 | 0.04 | 0.03 | -0.01 | sell |
| VIKING GLOBAL INVESTORS LP | 1,224,986 | 490,035 | -734,951 | 0.11 | 0.03 | -0.07 | sell |