| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 4,566,850 | 5,915,556 | +1,348,706 | 0.05 | 0.09 | +0.04 | buy |
| Paradigm Biocapital Advisors LP | 6,541,210 | 7,365,038 | +823,828 | 4.35 | 4.74 | +0.39 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,036,170 | 1,722,169 | +685,999 | 0.01 | 0.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 910,000 | 1,449,915 | +539,915 | 0.96 | 1.85 | +0.89 | buy |
| Qube Research & Technologies Ltd | 296,208 | 825,910 | +529,702 | 0.01 | 0.04 | +0.03 | buy |
| FMR LLC | 692,955 | 1,017,052 | +324,097 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 123,097 | 429,032 | +305,935 | 0.00 | 0.01 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,191,193 | 4,477,942 | +286,749 | 0.71 | 1.04 | +0.33 | buy |
| MILLENNIUM MANAGEMENT LLC | 126,436 | 342,867 | +216,431 | 0.00 | 0.01 | +0.01 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 0 | 208,672 | +208,672 | 0.00 | 0.24 | +0.24 | buy |
| Nuveen, LLC | 169,466 | 335,783 | +166,317 | 0.00 | 0.00 | +0.00 | buy |
| Freestone Grove Partners LP | 0 | 148,426 | +148,426 | 0.00 | 0.03 | +0.03 | buy |
| Integral Health Asset Management, LLC | 1,500,000 | 1,600,000 | +100,000 | 1.89 | 2.67 | +0.78 | buy |
| MOODY ALDRICH PARTNERS LLC | 43,134 | 114,141 | +71,007 | 0.20 | 0.65 | +0.45 | buy |
| Artia Global Partners LP | 0 | 65,500 | +65,500 | 0.00 | 0.47 | +0.47 | buy |
| Invesco Ltd. | 75,438 | 138,399 | +62,961 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 61,421 | +61,421 | 0.00 | 0.09 | +0.09 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,746,222 | 1,789,819 | +43,597 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 746,562 | 789,043 | +42,481 | 0.01 | 0.02 | +0.01 | buy |
| Neuberger Berman Group LLC | 127,136 | 168,678 | +41,542 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 59,326 | 99,075 | +39,749 | 0.01 | 0.03 | +0.02 | buy |
| Caption Management, LLC | 0 | 38,675 | +38,675 | 0.00 | 0.06 | +0.06 | buy |
| Longaeva Partners L.P. | 0 | 36,931 | +36,931 | 0.00 | 0.06 | +0.06 | buy |
| JANE STREET GROUP, LLC | 0 | 35,578 | +35,578 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 32,520 | +32,520 | 0.00 | 0.02 | +0.02 | buy |
| Sio Capital Management, LLC | 237,481 | 268,986 | +31,505 | 0.98 | 1.22 | +0.24 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 29,889 | +29,889 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 50,392 | 73,419 | +23,027 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 241,509 | 264,204 | +22,695 | 0.13 | 0.18 | +0.05 | buy |
| SEI INVESTMENTS CO | 31,250 | 49,082 | +17,832 | 0.00 | 0.00 | +0.00 | buy |
| Eleva Capital SAS | 0 | 17,460 | +17,460 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 559,649 | 576,556 | +16,907 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 98,063 | 114,720 | +16,657 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 16,221 | +16,221 | 0.00 | 0.02 | +0.02 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 15,730 | +15,730 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 0 | 13,767 | +13,767 | 0.00 | 0.05 | +0.05 | buy |
| Hudson Bay Capital Management LP | 0 | 12,930 | +12,930 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 57,315 | 69,427 | +12,112 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 271,385 | 283,312 | +11,927 | 0.01 | 0.02 | +0.00 | buy |
| Bridgefront Capital, LLC | 0 | 11,809 | +11,809 | 0.00 | 0.09 | +0.09 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 10,605 | +10,605 | 0.00 | 0.00 | +0.00 | buy |
| Quantum Private Wealth, LLC | 106,024 | 116,624 | +10,600 | 0.77 | 1.13 | +0.37 | buy |
| Atom Investors LP | 0 | 9,941 | +9,941 | 0.00 | 0.02 | +0.02 | buy |
| AXQ CAPITAL, LP | 0 | 9,513 | +9,513 | 0.00 | 0.04 | +0.04 | buy |
| FIRST TRUST ADVISORS LP | 0 | 9,129 | +9,129 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 8,483 | +8,483 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 17,251 | 25,436 | +8,185 | 0.03 | 0.06 | +0.03 | buy |
| Pictet Asset Management Holding SA | 0 | 7,623 | +7,623 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 0 | 7,454 | +7,454 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 214,769 | 221,868 | +7,099 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 6,900 | +6,900 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 17,061 | 23,911 | +6,850 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 24,468 | 31,268 | +6,800 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 6,719 | +6,719 | 0.00 | 0.00 | +0.00 | buy |
| Orion Porfolio Solutions, LLC | 0 | 6,449 | +6,449 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,213,657 | 1,219,717 | +6,060 | 0.01 | 0.01 | +0.00 | buy |
| MPM BioImpact LLC | 1,655,256 | 1,660,696 | +5,440 | 4.70 | 4.04 | -0.66 | buy |
| Aberdeen Group plc | 821,940 | 826,059 | +4,119 | 0.03 | 0.04 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 1,613 | 5,473 | +3,860 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 710 | 4,278 | +3,568 | 0.00 | 0.02 | +0.02 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 11,265 | 14,739 | +3,474 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 0 | 1,560 | +1,560 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 146,038 | 147,573 | +1,535 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 1,564 | 2,973 | +1,409 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,731 | 2,737 | +1,006 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 10,571 | 11,524 | +953 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 1,354 | 2,289 | +935 | 0.00 | 0.00 | +0.00 | buy |
| Kemnay Advisory Services Inc. | 0 | 756 | +756 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 678 | +678 | 0.00 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 42,052 | 42,615 | +563 | 0.15 | 0.16 | +0.01 | buy |
| Rockefeller Capital Management L.P. | 182 | 732 | +550 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,162 | 1,677 | +515 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 5,145 | 5,595 | +450 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 626 | 1,032 | +406 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 86,929 | 87,326 | +397 | 0.01 | 0.01 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,079 | 2,378 | +299 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 11,263 | 11,544 | +281 | 0.08 | 0.10 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 31,369 | 31,614 | +245 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 728 | 972 | +244 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 5,800 | 6,000 | +200 | 0.02 | 0.04 | +0.01 | buy |
| Aster Capital Management (DIFC) Ltd | 152 | 310 | +158 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 151 | +151 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 17,978 | 18,091 | +113 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 161 | 261 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 224,192 | 224,290 | +98 | 0.02 | 0.03 | +0.01 | buy |
| Russell Investments Group, Ltd. | 6,494 | 6,574 | +80 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 279 | 351 | +72 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH THIRD BANCORP | 0 | 33 | +33 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 56 | 84 | +28 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 156 | 175 | +19 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 9 | +9 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| GHP Investment Advisors, Inc. | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Hughes Financial Services, LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 2,350 | 2,350 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ORBIMED ADVISORS LLC | 15,518,492 | 15,518,492 | 0 | 7.88 | 10.66 | +2.78 | hold |
| Ameritas Investment Partners, Inc. | 5,638 | 5,638 | 0 | 0.00 | 0.01 | +0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 145,286 | 145,286 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 294 | 294 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EASTERN BANK | 223 | 223 | 0 | 0.00 | 0.00 | +0.00 | hold |