| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 15,518,492 | 15,518,492 | 0 | 7.88 | 10.66 | +2.78 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 10,428,437 | 10,428,437 | 0 | 2.65 | 3.48 | +0.83 | hold |
| Paradigm Biocapital Advisors LP | 6,541,210 | 7,365,038 | +823,828 | 4.35 | 4.74 | +0.39 | buy |
| BAKER BROS. ADVISORS LP | 6,575,940 | 6,575,940 | 0 | 0.96 | 1.19 | +0.23 | hold |
| BlackRock, Inc. | 6,630,576 | 6,472,991 | -157,585 | 0.00 | 0.00 | +0.00 | sell |
| JANUS HENDERSON GROUP PLC | 4,566,850 | 5,915,556 | +1,348,706 | 0.05 | 0.09 | +0.04 | buy |
| Novo Holdings A/S | 5,350,000 | 5,350,000 | 0 | 10.31 | 13.65 | +3.34 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,191,193 | 4,477,942 | +286,749 | 0.71 | 1.04 | +0.33 | buy |
| Siren, L.L.C. | 4,529,990 | 4,430,263 | -99,727 | 3.35 | 3.87 | +0.52 | sell |
| PERCEPTIVE ADVISORS LLC | 4,457,974 | 4,423,974 | -34,000 | 2.03 | 2.75 | +0.73 | sell |
| Cormorant Asset Management, LP | 3,285,000 | 3,260,000 | -25,000 | 4.62 | 5.18 | +0.56 | sell |
| BRAIDWELL LP | 5,210,831 | 2,347,583 | -2,863,248 | 4.14 | 2.47 | -1.67 | sell |
| MORGAN STANLEY | 2,910,881 | 2,246,028 | -664,853 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,746,222 | 1,789,819 | +43,597 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,036,170 | 1,722,169 | +685,999 | 0.01 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 1,717,343 | 1,716,823 | -520 | 0.00 | 0.00 | +0.00 | sell |
| MPM BioImpact LLC | 1,655,256 | 1,660,696 | +5,440 | 4.70 | 4.04 | -0.66 | buy |
| Integral Health Asset Management, LLC | 1,500,000 | 1,600,000 | +100,000 | 1.89 | 2.67 | +0.78 | buy |
| Bellevue Group AG | 1,528,518 | 1,528,518 | 0 | 0.72 | 1.15 | +0.43 | hold |
| Soleus Capital Management, L.P. | 910,000 | 1,449,915 | +539,915 | 0.96 | 1.85 | +0.89 | buy |
| BANK OF AMERICA CORP /DE/ | 1,474,797 | 1,327,360 | -147,437 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 2,117,073 | 1,311,125 | -805,948 | 0.01 | 0.01 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,213,657 | 1,219,717 | +6,060 | 0.01 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,186,467 | 1,147,176 | -39,291 | 0.01 | 0.02 | +0.00 | sell |
| FMR LLC | 692,955 | 1,017,052 | +324,097 | 0.00 | 0.00 | +0.00 | buy |
| First Light Asset Management, LLC | 1,573,701 | 1,001,846 | -571,855 | 2.99 | 2.83 | -0.16 | sell |
| Aberdeen Group plc | 821,940 | 826,059 | +4,119 | 0.03 | 0.04 | +0.01 | buy |
| Qube Research & Technologies Ltd | 296,208 | 825,910 | +529,702 | 0.01 | 0.04 | +0.03 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 746,562 | 789,043 | +42,481 | 0.01 | 0.02 | +0.01 | buy |
| Artisan Partners Limited Partnership | 704,077 | 659,067 | -45,010 | 0.03 | 0.03 | +0.01 | sell |
| MARSHALL WACE, LLP | 681,921 | 648,393 | -33,528 | 0.02 | 0.02 | +0.01 | sell |
| GOLDMAN SACHS GROUP INC | 718,372 | 629,820 | -88,552 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 611,384 | 596,310 | -15,074 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 559,649 | 576,556 | +16,907 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 500,000 | 500,000 | 0 | 1.64 | 2.07 | +0.44 | hold |
| Candriam S.C.A. | 501,214 | 447,416 | -53,798 | 0.06 | 0.07 | +0.01 | sell |
| CITADEL ADVISORS LLC | 123,097 | 429,032 | +305,935 | 0.00 | 0.01 | +0.01 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 640,400 | 404,200 | -236,200 | 0.03 | 0.02 | -0.01 | sell |
| Sofinnova Investments, Inc. | 437,819 | 386,498 | -51,321 | 0.47 | 0.61 | +0.14 | sell |
| MILLENNIUM MANAGEMENT LLC | 126,436 | 342,867 | +216,431 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 169,466 | 335,783 | +166,317 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 427,690 | 322,828 | -104,862 | 1.01 | 1.05 | +0.04 | sell |
| STEMPOINT CAPITAL LP | 360,876 | 290,864 | -70,012 | 1.54 | 1.76 | +0.22 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 271,385 | 283,312 | +11,927 | 0.01 | 0.02 | +0.00 | buy |
| Sio Capital Management, LLC | 237,481 | 268,986 | +31,505 | 0.98 | 1.22 | +0.24 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 241,509 | 264,204 | +22,695 | 0.13 | 0.18 | +0.05 | buy |
| Woodline Partners LP | 224,192 | 224,290 | +98 | 0.02 | 0.03 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 214,769 | 221,868 | +7,099 | 0.00 | 0.00 | +0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 0 | 208,672 | +208,672 | 0.00 | 0.24 | +0.24 | buy |
| Granahan Investment Management, LLC | 232,295 | 200,843 | -31,452 | 0.25 | 0.31 | +0.06 | sell |
| AMERIPRISE FINANCIAL INC | 202,297 | 200,661 | -1,636 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 198,614 | 192,434 | -6,180 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 372,738 | 177,244 | -195,494 | 0.00 | 0.00 | -0.00 | sell |
| Neuberger Berman Group LLC | 127,136 | 168,678 | +41,542 | 0.00 | 0.00 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 195,000 | 161,000 | -34,000 | 7.68 | 5.04 | -2.64 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 568,310 | 149,863 | -418,447 | 0.22 | 0.08 | -0.14 | sell |
| Freestone Grove Partners LP | 0 | 148,426 | +148,426 | 0.00 | 0.03 | +0.03 | buy |
| JPMORGAN CHASE & CO | 146,038 | 147,573 | +1,535 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 145,286 | 145,286 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Invesco Ltd. | 75,438 | 138,399 | +62,961 | 0.00 | 0.00 | +0.00 | buy |
| Quantum Private Wealth, LLC | 106,024 | 116,624 | +10,600 | 0.77 | 1.13 | +0.37 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 98,063 | 114,720 | +16,657 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 43,134 | 114,141 | +71,007 | 0.20 | 0.65 | +0.45 | buy |
| DAFNA Capital Management LLC | 159,736 | 112,236 | -47,500 | 0.92 | 0.80 | -0.12 | sell |
| D. E. Shaw & Co., Inc. | 394,695 | 104,863 | -289,832 | 0.01 | 0.00 | -0.00 | sell |
| Swiss National Bank | 103,900 | 103,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Schonfeld Strategic Advisors LLC | 59,326 | 99,075 | +39,749 | 0.01 | 0.03 | +0.02 | buy |
| HighVista Strategies LLC | 171,137 | 91,931 | -79,206 | 1.09 | 0.80 | -0.29 | sell |
| ADAR1 Capital Management, LLC | 90,999 | 90,599 | -400 | 0.17 | 0.17 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 88,937 | 88,937 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALPS ADVISORS INC | 86,929 | 87,326 | +397 | 0.01 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 85,075 | 83,540 | -1,535 | 0.00 | 0.00 | +0.00 | sell |
| DekaBank Deutsche Girozentrale | 80,000 | 80,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 50,392 | 73,419 | +23,027 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 57,315 | 69,427 | +12,112 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 0 | 65,500 | +65,500 | 0.00 | 0.47 | +0.47 | buy |
| J. Goldman & Co LP | 0 | 61,421 | +61,421 | 0.00 | 0.09 | +0.09 | buy |
| FEDERATED HERMES, INC. | 82,096 | 56,778 | -25,318 | 0.00 | 0.00 | -0.00 | sell |
| HighMark Wealth Management LLC | 53,179 | 53,179 | 0 | 0.54 | 0.68 | +0.14 | hold |
| TWO SIGMA INVESTMENTS, LP | 50,848 | 50,848 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SEI INVESTMENTS CO | 31,250 | 49,082 | +17,832 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 113,856 | 46,401 | -67,455 | 0.03 | 0.02 | -0.01 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 42,052 | 42,615 | +563 | 0.15 | 0.16 | +0.01 | buy |
| Legal & General Group Plc | 52,747 | 42,537 | -10,210 | 0.00 | 0.00 | +0.00 | sell |
| FRANKLIN RESOURCES INC | 43,145 | 41,726 | -1,419 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 39,648 | 39,153 | -495 | 0.00 | 0.00 | +0.00 | sell |
| Caption Management, LLC | 0 | 38,675 | +38,675 | 0.00 | 0.06 | +0.06 | buy |
| Knights of Columbus Asset Advisors LLC | 38,676 | 38,414 | -262 | 0.05 | 0.07 | +0.01 | sell |
| MetLife Investment Management, LLC | 38,291 | 38,084 | -207 | 0.00 | 0.01 | +0.00 | sell |
| Longaeva Partners L.P. | 0 | 36,931 | +36,931 | 0.00 | 0.06 | +0.06 | buy |
| JANE STREET GROUP, LLC | 0 | 35,578 | +35,578 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 36,759 | 35,450 | -1,309 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 39,997 | 32,896 | -7,101 | 0.00 | 0.00 | +0.00 | sell |
| ALGERT GLOBAL LLC | 0 | 32,520 | +32,520 | 0.00 | 0.02 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 31,369 | 31,614 | +245 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 24,468 | 31,268 | +6,800 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 31,100 | 31,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TUDOR INVESTMENT CORP ET AL | 0 | 29,889 | +29,889 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 111,387 | 27,409 | -83,978 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 70,196 | 26,674 | -43,522 | 0.00 | 0.00 | -0.00 | sell |