| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 3,112,786 | 5,840,059 | +2,727,273 | 0.39 | 1.34 | 0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,805,312 | 2,607,299 | +801,987 | 0.02 | 0.03 | 0.00 | buy |
| Frazier Life Sciences Management, L.P. | 3,303,567 | 3,731,067 | +427,500 | 2.54 | 3.14 | +0.60 | buy |
| MPM BioImpact LLC | 441,259 | 740,661 | +299,402 | 1.29 | 2.07 | +0.78 | buy |
| ADAR1 Capital Management, LLC | 180,911 | 436,608 | +255,697 | 0.90 | 1.58 | +0.68 | buy |
| Granahan Investment Management, LLC | 608,012 | 710,723 | +102,711 | 0.39 | 0.51 | +0.12 | buy |
| TWO SIGMA INVESTMENTS, LP | 392,735 | 362,576 | +30,159 | 0.02 | 0.02 | 0.00 | sell |
| Woodline Partners LP | 405,132 | 421,604 | +16,472 | 0.07 | 0.07 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 75,097 | 85,008 | +9,911 | 0.10 | 0.10 | 0.00 | buy |
| ALPS ADVISORS INC | 65,672 | 72,843 | +7,171 | 0.01 | 0.01 | +0.00 | buy |
| Quantum Private Wealth, LLC | 66,674 | 66,774 | +100 | 0.45 | 0.43 | -0.02 | buy |
| PDT Partners, LLC | 26,359 | 26,287 | -72 | 0.05 | 0.04 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 17,881 | 10,973 | -6,908 | 0.04 | 0.03 | -0.01 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,267,819 | 1,260,392 | -7,427 | 0.23 | 0.22 | -0.01 | sell |
| DAFNA Capital Management LLC | 306,197 | 290,197 | -16,000 | 1.27 | 1.25 | -0.02 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 293,265 | 272,071 | -21,194 | 0.11 | 0.10 | -0.01 | sell |
| Parkman Healthcare Partners LLC | 653,653 | 574,517 | -79,136 | 1.46 | 1.41 | -0.05 | sell |
| Opaleye Management Inc. | 665,000 | 580,000 | -85,000 | 2.64 | 2.39 | -0.26 | sell |
| Paradigm Biocapital Advisors LP | 2,446,373 | 2,325,449 | -120,924 | 1.57 | 1.60 | +0.03 | sell |
| PERCEPTIVE ADVISORS LLC | 2,319,646 | 1,856,417 | -463,229 | 0.74 | 0.81 | +0.07 | sell |
| VIKING GLOBAL INVESTORS LP | 3,339,146 | 1,481,146 | -1,858,000 | 0.23 | 0.10 | -0.12 | sell |