| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 15,021,721 | 15,021,721 | 0 | 5.03 | 5.38 | +0.35 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 8,909,091 | 8,909,091 | 0 | 2.07 | 2.12 | +0.05 | hold |
| Novo Holdings A/S | 0 | 6,344,430 | +6,344,430 | 0.00 | 6.16 | +6.16 | buy |
| BAKER BROS. ADVISORS LP | 5,840,059 | 5,840,059 | 0 | 1.34 | 1.34 | +0.01 | hold |
| FMR LLC | 6,365,724 | 4,780,563 | -1,585,161 | 0.01 | 0.01 | -0.00 | sell |
| VANGUARD GROUP INC | 4,017,433 | 4,508,166 | +490,733 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 3,303,567 | 3,731,067 | +427,500 | 2.54 | 3.14 | +0.60 | buy |
| Cormorant Asset Management, LP | 3,006,534 | 3,006,534 | 0 | 2.42 | 3.15 | +0.73 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,874,586 | 2,874,586 | 0 | 0.91 | 0.86 | -0.05 | hold |
| JANUS HENDERSON GROUP PLC | 1,805,312 | 2,607,299 | +801,987 | 0.02 | 0.03 | +0.01 | buy |
| CITADEL ADVISORS LLC | 2,719,291 | 2,349,174 | -370,117 | 0.05 | 0.04 | -0.01 | sell |
| Paradigm Biocapital Advisors LP | 2,446,373 | 2,325,449 | -120,924 | 1.57 | 1.60 | +0.03 | sell |
| TCG Crossover Management, LLC | 2,272,728 | 2,272,728 | 0 | 3.28 | 4.27 | +0.99 | hold |
| PERCEPTIVE ADVISORS LLC | 2,319,646 | 1,856,417 | -463,229 | 0.75 | 0.81 | +0.06 | sell |
| VR Adviser, LLC | 1,818,182 | 1,818,182 | 0 | 1.58 | 2.09 | +0.51 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,369,897 | 1,672,653 | +302,756 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,211,476 | 1,665,095 | +453,619 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,747,844 | 1,622,741 | -125,103 | 0.01 | 0.01 | -0.00 | sell |
| New Leaf Venture Partners, L.L.C. | 1,553,661 | 1,553,661 | 0 | 24.80 | 34.03 | +9.22 | hold |
| VIKING GLOBAL INVESTORS LP | 3,339,146 | 1,481,146 | -1,858,000 | 0.23 | 0.10 | -0.12 | sell |
| Bellevue Group AG | 0 | 1,428,929 | +1,428,929 | 0.00 | 0.42 | +0.42 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,267,819 | 1,260,392 | -7,427 | 0.23 | 0.22 | -0.01 | sell |
| EcoR1 Capital, LLC | 1,250,385 | 1,250,385 | 0 | 0.58 | 0.69 | +0.11 | hold |
| MILLENNIUM MANAGEMENT LLC | 532,255 | 1,145,506 | +613,251 | 0.01 | 0.02 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 559,334 | 860,067 | +300,733 | 0.01 | 0.01 | +0.00 | buy |
| Artal Group S.A. | 811,718 | 811,718 | 0 | 0.38 | 0.38 | -0.01 | hold |
| MPM BioImpact LLC | 441,259 | 740,661 | +299,402 | 1.29 | 2.07 | +0.78 | buy |
| Granahan Investment Management, LLC | 608,012 | 710,723 | +102,711 | 0.39 | 0.51 | +0.12 | buy |
| Opaleye Management Inc. | 665,000 | 580,000 | -85,000 | 2.64 | 2.39 | -0.26 | sell |
| Parkman Healthcare Partners LLC | 653,653 | 574,517 | -79,136 | 1.46 | 1.41 | -0.05 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 497,162 | 571,197 | +74,035 | 0.00 | 0.00 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 528,594 | +528,594 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 499,520 | 508,691 | +9,171 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 472,903 | 493,847 | +20,944 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 0 | 475,691 | +475,691 | 0.00 | 0.54 | +0.54 | buy |
| DIMENSIONAL FUND ADVISORS LP | 299,288 | 467,507 | +168,219 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 180,911 | 436,608 | +255,697 | 0.90 | 1.58 | +0.68 | buy |
| Woodline Partners LP | 405,132 | 421,604 | +16,472 | 0.07 | 0.07 | +0.00 | buy |
| MARSHALL WACE, LLP | 54,617 | 415,720 | +361,103 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 392,735 | 362,576 | -30,159 | 0.02 | 0.02 | -0.00 | sell |
| Candriam S.C.A. | 329,000 | 329,000 | 0 | 0.04 | 0.04 | -0.00 | hold |
| D. E. Shaw & Co., Inc. | 473,680 | 311,476 | -162,204 | 0.01 | 0.01 | -0.00 | sell |
| DAFNA Capital Management LLC | 306,197 | 290,197 | -16,000 | 1.27 | 1.25 | -0.02 | sell |
| BANK OF AMERICA CORP /DE/ | 53,763 | 272,794 | +219,031 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 293,265 | 272,071 | -21,194 | 0.11 | 0.10 | -0.01 | sell |
| STEMPOINT CAPITAL LP | 0 | 271,057 | +271,057 | 0.00 | 1.44 | +1.44 | buy |
| Bank of New York Mellon Corp | 212,265 | 268,712 | +56,447 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 268,143 | +268,143 | 0.00 | 0.05 | +0.05 | buy |
| MORGAN STANLEY | 374,718 | 249,974 | -124,744 | 0.00 | 0.00 | -0.00 | sell |
| Polar Asset Management Partners Inc. | 0 | 187,500 | +187,500 | 0.00 | 0.09 | +0.09 | buy |
| Deep Track Capital, LP | 0 | 186,386 | +186,386 | 0.00 | 0.10 | +0.10 | buy |
| RHUMBLINE ADVISERS | 84,228 | 98,269 | +14,041 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 92,400 | 96,000 | +3,600 | 0.00 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 75,097 | 85,008 | +9,911 | 0.04 | 0.04 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 56,100 | 80,360 | +24,260 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 80,000 | 80,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 32,413 | 79,868 | +47,455 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 284,600 | 78,134 | -206,466 | 0.04 | 0.01 | -0.03 | sell |
| Swiss National Bank | 67,300 | 73,600 | +6,300 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 65,672 | 72,843 | +7,171 | 0.01 | 0.01 | +0.00 | buy |
| Quantum Private Wealth, LLC | 66,674 | 66,774 | +100 | 0.45 | 0.43 | -0.02 | buy |
| JANE STREET GROUP, LLC | 27,146 | 64,487 | +37,341 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 42,833 | 64,359 | +21,526 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 8,467 | 64,173 | +55,706 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 74,118 | 60,510 | -13,608 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 24,854 | 52,541 | +27,687 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 19,601 | 51,339 | +31,738 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 49,597 | +49,597 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 46,234 | +46,234 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 44,783 | +44,783 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 29,935 | 42,271 | +12,336 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 28,491 | 39,252 | +10,761 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 36,467 | 39,110 | +2,643 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 30,580 | 38,366 | +7,786 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 26,842 | 34,511 | +7,669 | 0.01 | 0.02 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 25,274 | 31,114 | +5,840 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 87,244 | 30,524 | -56,720 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 68,698 | 29,846 | -38,852 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 9,002 | 28,845 | +19,843 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 26,410 | +26,410 | 0.00 | 0.01 | +0.01 | buy |
| PDT Partners, LLC | 26,359 | 26,287 | -72 | 0.05 | 0.04 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 20,005 | 24,549 | +4,544 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 18,296 | 24,321 | +6,025 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 20,431 | 23,241 | +2,810 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 16,424 | 23,086 | +6,662 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 36,944 | 23,053 | -13,891 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 21,146 | 22,244 | +1,098 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 16,650 | 16,870 | +220 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,870 | 16,776 | -10,094 | 0.00 | 0.00 | -0.00 | sell |
| Bleakley Financial Group, LLC | 0 | 15,265 | +15,265 | 0.00 | 0.01 | +0.01 | buy |
| Simplicity Wealth,LLC | 0 | 15,218 | +15,218 | 0.00 | 0.01 | +0.01 | buy |
| STRS OHIO | 12,600 | 14,800 | +2,200 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 14,000 | +14,000 | 0.00 | 0.11 | +0.11 | buy |
| Alpine Global Management, LLC | 0 | 13,908 | +13,908 | 0.00 | 0.04 | +0.04 | buy |
| State of New Jersey Common Pension Fund D | 0 | 13,738 | +13,738 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 14,903 | 13,701 | -1,202 | 0.02 | 0.01 | -0.01 | sell |
| ProShare Advisors LLC | 16,885 | 13,490 | -3,395 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 13,371 | 13,371 | 0 | 0.02 | 0.02 | +0.00 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 16,765 | 13,084 | -3,681 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 0 | 11,405 | +11,405 | 0.00 | 0.01 | +0.01 | buy |