| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 2,458,808 | 5,210,831 | +2,752,023 | 1.90 | 2.34 | +0.43 | buy |
| Paradigm Biocapital Advisors LP | 4,394,556 | 6,142,344 | +1,747,788 | 4.45 | 3.44 | -1.01 | buy |
| Siren, L.L.C. | 1,696,444 | 3,160,298 | +1,463,854 | 2.11 | 2.14 | +0.04 | buy |
| Bellevue Group AG | 1,428,929 | 2,775,997 | +1,347,068 | 0.70 | 0.80 | +0.10 | buy |
| BAKER BROS. ADVISORS LP | 6,155,940 | 7,305,940 | +1,150,000 | 1.50 | 0.93 | -0.57 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 8,909,091 | 9,902,633 | +993,542 | 3.27 | 2.19 | -1.09 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,375,742 | 2,101,781 | +726,039 | 0.29 | 0.22 | -0.07 | buy |
| Polar Capital Holdings Plc | 250,000 | 975,000 | +725,000 | 0.03 | 0.07 | +0.03 | buy |
| MPM BioImpact LLC | 1,105,444 | 1,720,741 | +615,297 | 4.18 | 3.91 | -0.27 | buy |
| ORBIMED ADVISORS LLC | 15,021,721 | 15,518,492 | +496,771 | 7.94 | 5.12 | -2.82 | buy |
| Artisan Partners Limited Partnership | 917,222 | 1,379,068 | +461,846 | 0.03 | 0.03 | -0.01 | buy |
| Sofinnova Investments, Inc. | 342,218 | 716,873 | +374,655 | 0.49 | 0.57 | +0.08 | buy |
| Integral Health Asset Management, LLC | 675,000 | 1,000,000 | +325,000 | 1.65 | 1.22 | -0.42 | buy |
| Parkman Healthcare Partners LLC | 425,407 | 647,331 | +221,924 | 1.11 | 0.98 | -0.13 | buy |
| JANUS HENDERSON GROUP PLC | 5,282,154 | 5,503,349 | +221,195 | 0.07 | 0.04 | 0.00 | buy |
| Granahan Investment Management, LLC | 217,667 | 405,478 | +187,811 | 0.24 | 0.22 | -0.02 | buy |
| Cormorant Asset Management, LP | 4,101,992 | 4,251,992 | +150,000 | 6.79 | 4.15 | -2.63 | buy |
| TANG CAPITAL MANAGEMENT LLC | 300,000 | 431,300 | +131,300 | 0.37 | 0.29 | -0.08 | buy |
| Aberdeen Group plc | 313,025 | 443,319 | +130,294 | 0.01 | 0.01 | -0.00 | buy |
| Opaleye Management Inc. | 395,000 | 490,000 | +95,000 | 1.93 | 1.30 | -0.63 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 79,151 | 151,062 | +71,911 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 183,140 | 238,140 | +55,000 | 1.14 | 0.86 | -0.28 | buy |
| Exome Asset Management LLC | 71,438 | 124,470 | +53,032 | 1.41 | 1.35 | -0.06 | buy |
| HighMark Wealth Management LLC | 165 | 52,065 | +51,900 | 0.00 | 0.33 | +0.33 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 224,700 | 252,524 | +27,824 | 0.12 | 0.08 | -0.04 | buy |
| ADAR1 Capital Management, LLC | 20,000 | 40,000 | +20,000 | 0.08 | 0.09 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 40,014 | 55,292 | +15,278 | 0.07 | 0.04 | 0.00 | buy |
| AlphaQuest LLC | 9,358 | 21,390 | +12,032 | 0.02 | 0.03 | 0.00 | buy |
| SummitTX Capital, L.P. | 9,664 | 21,380 | +11,716 | 0.01 | 0.01 | +0.00 | buy |
| ALPS ADVISORS INC | 67,975 | 56,798 | +11,177 | 0.01 | 0.00 | 0.00 | sell |
| Quantum Private Wealth, LLC | 90,724 | 100,774 | +10,050 | 0.75 | 0.43 | -0.33 | buy |
| Soleus Capital Management, L.P. | 72,300 | 76,493 | +4,193 | 0.12 | 0.07 | -0.06 | buy |
| China Universal Asset Management Co., Ltd. | 18,993 | 21,120 | +2,127 | 0.04 | 0.03 | -0.01 | buy |
| Virtus Investment Advisers, LLC | 5,829 | 6,098 | +269 | 0.03 | 0.03 | -0.01 | buy |
| Woodline Partners LP | 1,096,809 | 1,096,863 | +54 | 0.16 | 0.08 | -0.08 | buy |
| PROFUND ADVISORS LLC | 15,687 | 15,085 | -602 | 0.01 | 0.01 | -0.01 | sell |
| Candriam S.C.A. | 225,796 | 223,990 | -1,806 | 0.03 | 0.02 | -0.01 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 49,995 | 38,809 | -11,186 | 0.08 | 0.05 | -0.03 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,078,509 | 2,067,320 | -11,189 | 0.90 | 0.49 | -0.41 | sell |
| HighVista Strategies LLC | 91,207 | 69,723 | -21,484 | 0.77 | 0.34 | -0.44 | sell |
| TWINBEECH CAPITAL LP | 100,826 | 78,280 | -22,546 | 0.04 | 0.02 | -0.02 | sell |
| MOODY ALDRICH PARTNERS LLC | 182,095 | 99,848 | -82,247 | 0.84 | 0.25 | -0.59 | sell |
| First Light Asset Management, LLC | 1,852,290 | 1,714,019 | -138,271 | 4.65 | 2.91 | -1.74 | sell |
| PERCEPTIVE ADVISORS LLC | 6,547,328 | 4,639,949 | -1,907,379 | 5.09 | 2.26 | -2.83 | sell |