| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 15,021,721 | 15,518,492 | +496,771 | 7.94 | 5.12 | -2.82 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 8,909,091 | 9,902,633 | +993,542 | 3.27 | 2.19 | -1.09 | buy |
| BAKER BROS. ADVISORS LP | 6,155,940 | 7,305,940 | +1,150,000 | 1.50 | 0.93 | -0.57 | buy |
| BlackRock, Inc. | 6,485,008 | 6,781,046 | +296,038 | 0.00 | 0.00 | -0.00 | buy |
| Paradigm Biocapital Advisors LP | 4,394,556 | 6,142,344 | +1,747,788 | 4.45 | 3.44 | -1.01 | buy |
| JANUS HENDERSON GROUP PLC | 5,282,154 | 5,503,349 | +221,195 | 0.07 | 0.04 | -0.03 | buy |
| Novo Holdings A/S | 5,350,000 | 5,350,000 | 0 | 8.95 | 4.95 | -4.00 | hold |
| BRAIDWELL LP | 2,458,808 | 5,210,831 | +2,752,023 | 1.90 | 2.34 | +0.43 | buy |
| VANGUARD GROUP INC | 4,294,404 | 4,841,500 | +547,096 | 0.00 | 0.00 | -0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 6,547,328 | 4,639,949 | -1,907,379 | 5.11 | 2.28 | -2.83 | sell |
| Cormorant Asset Management, LP | 4,101,992 | 4,251,992 | +150,000 | 6.83 | 4.15 | -2.68 | buy |
| Siren, L.L.C. | 1,696,444 | 3,160,298 | +1,463,854 | 2.11 | 2.14 | +0.04 | buy |
| Bellevue Group AG | 1,428,929 | 2,775,997 | +1,347,068 | 0.70 | 0.80 | +0.10 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,375,742 | 2,101,781 | +726,039 | 0.29 | 0.22 | -0.07 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,078,509 | 2,067,320 | -11,189 | 0.91 | 0.49 | -0.41 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,655,664 | 1,797,215 | +141,551 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 1,717,724 | 1,781,501 | +63,777 | 0.00 | 0.00 | -0.00 | buy |
| MPM BioImpact LLC | 1,105,444 | 1,720,741 | +615,297 | 4.18 | 3.91 | -0.27 | buy |
| First Light Asset Management, LLC | 1,852,290 | 1,714,019 | -138,271 | 4.65 | 2.91 | -1.74 | sell |
| Artisan Partners Limited Partnership | 917,222 | 1,379,068 | +461,846 | 0.03 | 0.03 | -0.01 | buy |
| Woodline Partners LP | 1,096,809 | 1,096,863 | +54 | 0.16 | 0.08 | -0.08 | buy |
| DIMENSIONAL FUND ADVISORS LP | 667,499 | 1,048,936 | +381,437 | 0.00 | 0.00 | -0.00 | buy |
| New Leaf Venture Partners, L.L.C. | 1,030,161 | 1,030,161 | 0 | 50.47 | 25.51 | -24.97 | hold |
| Integral Health Asset Management, LLC | 675,000 | 1,000,000 | +325,000 | 1.65 | 1.22 | -0.42 | buy |
| Polar Capital Holdings Plc | 250,000 | 975,000 | +725,000 | 0.03 | 0.07 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 615,118 | 921,965 | +306,847 | 0.01 | 0.01 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 779,766 | 783,166 | +3,400 | 0.01 | 0.01 | -0.00 | buy |
| MORGAN STANLEY | 408,997 | 727,714 | +318,717 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 74,307 | 724,899 | +650,592 | 0.00 | 0.01 | +0.01 | buy |
| Sofinnova Investments, Inc. | 342,218 | 716,873 | +374,655 | 0.57 | 0.64 | +0.07 | buy |
| Parkman Healthcare Partners LLC | 425,407 | 647,331 | +221,924 | 1.11 | 0.98 | -0.13 | buy |
| GOLDMAN SACHS GROUP INC | 366,644 | 631,743 | +265,099 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 606,692 | 602,898 | -3,794 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 140,548 | 595,432 | +454,884 | 0.00 | 0.01 | +0.00 | buy |
| Foresite Capital Management VI LLC | 585,000 | 585,000 | 0 | 7.05 | 4.31 | -2.74 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 521,261 | 579,104 | +57,843 | 0.00 | 0.00 | -0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 568,310 | 568,310 | 0 | 0.25 | 0.13 | -0.12 | hold |
| Sio Capital Management, LLC | 0 | 539,730 | +539,730 | 0.00 | 2.84 | +2.84 | buy |
| Qube Research & Technologies Ltd | 397,573 | 499,917 | +102,344 | 0.01 | 0.01 | -0.00 | buy |
| Opaleye Management Inc. | 395,000 | 490,000 | +95,000 | 1.93 | 1.30 | -0.63 | buy |
| FMR LLC | 186,023 | 470,717 | +284,694 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 313,025 | 443,319 | +130,294 | 0.01 | 0.01 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 442,837 | +442,837 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 300,000 | 431,300 | +131,300 | 0.37 | 0.29 | -0.08 | buy |
| Granahan Investment Management, LLC | 217,667 | 405,478 | +187,811 | 0.24 | 0.22 | -0.02 | buy |
| Eversept Partners, LP | 0 | 392,739 | +392,739 | 0.00 | 0.52 | +0.52 | buy |
| CITADEL ADVISORS LLC | 97,278 | 325,249 | +227,971 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 202,580 | 317,173 | +114,593 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 80 | 316,500 | +316,420 | 0.00 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 284,551 | +284,551 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 108,562 | 281,250 | +172,688 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 695,426 | 254,429 | -440,997 | 0.00 | 0.00 | -0.00 | sell |
| Kynam Capital Management, LP | 0 | 253,979 | +253,979 | 0.00 | 0.36 | +0.36 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 224,700 | 252,524 | +27,824 | 0.12 | 0.08 | -0.04 | buy |
| DAFNA Capital Management LLC | 183,140 | 238,140 | +55,000 | 1.14 | 0.86 | -0.28 | buy |
| Candriam S.C.A. | 225,796 | 223,990 | -1,806 | 0.03 | 0.02 | -0.01 | sell |
| Bank of New York Mellon Corp | 210,735 | 212,858 | +2,123 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 272,857 | 191,606 | -81,251 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 243,896 | 170,982 | -72,914 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 278,973 | 167,340 | -111,633 | 0.04 | 0.02 | -0.02 | sell |
| Neuberger Berman Group LLC | 102,181 | 165,535 | +63,354 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 79,151 | 151,062 | +71,911 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 376,060 | 147,525 | -228,535 | 0.00 | 0.00 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 89,425 | 132,178 | +42,753 | 0.00 | 0.00 | -0.00 | buy |
| Exome Asset Management LLC | 71,438 | 124,470 | +53,032 | 1.41 | 1.35 | -0.06 | buy |
| Jump Financial, LLC | 0 | 121,705 | +121,705 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 176,666 | 115,270 | -61,396 | 0.01 | 0.00 | -0.00 | sell |
| Campbell & CO Investment Adviser LLC | 0 | 114,181 | +114,181 | 0.00 | 0.09 | +0.09 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 113,303 | 112,570 | -733 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 108,837 | 112,483 | +3,646 | 0.00 | 0.00 | -0.00 | buy |
| Quantum Private Wealth, LLC | 90,724 | 100,774 | +10,050 | 0.75 | 0.43 | -0.33 | buy |
| MOODY ALDRICH PARTNERS LLC | 182,095 | 99,848 | -82,247 | 0.84 | 0.25 | -0.59 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 71,450 | 93,808 | +22,358 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 82,600 | 90,000 | +7,400 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 16,178 | 86,882 | +70,704 | 0.00 | 0.01 | +0.01 | buy |
| DekaBank Deutsche Girozentrale | 80,000 | 80,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TWINBEECH CAPITAL LP | 100,826 | 78,280 | -22,546 | 0.04 | 0.02 | -0.02 | sell |
| JPMORGAN CHASE & CO | 91,368 | 77,616 | -13,752 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 77,260 | 77,260 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Soleus Capital Management, L.P. | 72,300 | 76,493 | +4,193 | 0.12 | 0.07 | -0.06 | buy |
| HighVista Strategies LLC | 91,207 | 69,723 | -21,484 | 0.77 | 0.34 | -0.44 | sell |
| XTX Topco Ltd | 0 | 60,739 | +60,739 | 0.00 | 0.03 | +0.03 | buy |
| ALPS ADVISORS INC | 67,975 | 56,798 | -11,177 | 0.01 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 48,130 | 56,158 | +8,028 | 0.00 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 40,014 | 55,292 | +15,278 | 0.02 | 0.02 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 71,132 | 54,019 | -17,113 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 50,348 | 52,307 | +1,959 | 0.00 | 0.00 | -0.00 | buy |
| HighMark Wealth Management LLC | 165 | 52,065 | +51,900 | 0.00 | 0.33 | +0.33 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 294,881 | 50,682 | -244,199 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 14,758 | 50,185 | +35,427 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 47,755 | 47,755 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FRANKLIN RESOURCES INC | 46,287 | 45,806 | -481 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 45,255 | +45,255 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 34,719 | 44,069 | +9,350 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 46,208 | 44,065 | -2,143 | 0.01 | 0.01 | -0.01 | sell |
| MetLife Investment Management, LLC | 43,883 | 43,883 | 0 | 0.01 | 0.00 | -0.00 | hold |
| SEI INVESTMENTS CO | 42,962 | 43,638 | +676 | 0.00 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 46,804 | 41,663 | -5,141 | 0.01 | 0.00 | -0.01 | sell |
| Quantbot Technologies LP | 0 | 41,463 | +41,463 | 0.00 | 0.01 | +0.01 | buy |
| Graham Capital Management, L.P. | 17,047 | 40,364 | +23,317 | 0.01 | 0.02 | +0.00 | buy |