| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 15,518,492 | 15,518,492 | 0 | 10.66 | 11.94 | +1.28 | hold |
| Paradigm Biocapital Advisors LP | 7,365,038 | 10,215,455 | +2,850,417 | 4.74 | 7.77 | +3.03 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 10,428,437 | 8,392,730 | -2,035,707 | 3.48 | 2.96 | -0.52 | sell |
| BlackRock, Inc. | 6,472,991 | 6,606,336 | +133,345 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,017,052 | 5,489,135 | +4,472,083 | 0.00 | 0.01 | +0.01 | buy |
| Novo Holdings A/S | 5,350,000 | 5,350,000 | 0 | 13.65 | 12.62 | -1.03 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,477,942 | 4,728,623 | +250,681 | 1.04 | 1.11 | +0.08 | buy |
| PERCEPTIVE ADVISORS LLC | 4,423,974 | 4,373,974 | -50,000 | 2.75 | 2.76 | +0.01 | sell |
| BAKER BROS. ADVISORS LP | 6,575,940 | 3,701,719 | -2,874,221 | 1.19 | 0.75 | -0.44 | sell |
| Siren, L.L.C. | 4,430,263 | 3,184,629 | -1,245,634 | 3.87 | 2.63 | -1.24 | sell |
| Cormorant Asset Management, LP | 3,260,000 | 2,510,000 | -750,000 | 5.18 | 5.23 | +0.05 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,789,819 | 2,174,051 | +384,232 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,722,169 | 2,119,024 | +396,855 | 0.01 | 0.02 | +0.01 | buy |
| Integral Health Asset Management, LLC | 1,600,000 | 2,000,000 | +400,000 | 2.67 | 3.33 | +0.67 | buy |
| BRAIDWELL LP | 2,347,583 | 1,996,965 | -350,618 | 2.47 | 3.00 | +0.53 | sell |
| MORGAN STANLEY | 2,246,028 | 1,948,597 | -297,431 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 1,716,823 | 1,827,927 | +111,104 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 1,660,696 | 1,620,780 | -39,916 | 4.04 | 4.02 | -0.02 | sell |
| BANK OF AMERICA CORP /DE/ | 1,327,360 | 1,558,260 | +230,900 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 825,910 | 1,252,507 | +426,597 | 0.04 | 0.06 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,219,717 | 1,139,726 | -79,991 | 0.01 | 0.01 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 1,147,176 | 1,127,078 | -20,098 | 0.02 | 0.02 | +0.00 | sell |
| First Light Asset Management, LLC | 1,001,846 | 1,095,171 | +93,325 | 2.83 | 2.70 | -0.12 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 789,043 | 902,870 | +113,827 | 0.02 | 0.02 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 69,427 | 816,518 | +747,091 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 576,556 | 671,270 | +94,714 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 826,059 | 647,926 | -178,133 | 0.04 | 0.04 | -0.01 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 620,532 | +620,532 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 596,310 | 620,532 | +24,222 | 0.00 | 0.00 | +0.00 | buy |
| Tyro Capital Management LLC | 0 | 612,965 | +612,965 | 0.00 | 5.59 | +5.59 | buy |
| GOLDMAN SACHS GROUP INC | 629,820 | 599,469 | -30,351 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 322,828 | 577,036 | +254,208 | 1.05 | 2.41 | +1.35 | buy |
| Artisan Partners Limited Partnership | 659,067 | 574,925 | -84,142 | 0.03 | 0.04 | +0.00 | sell |
| NORGES BANK | 0 | 510,140 | +510,140 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 500,000 | 500,000 | 0 | 2.07 | 1.84 | -0.23 | hold |
| CITADEL ADVISORS LLC | 429,032 | 469,707 | +40,675 | 0.01 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 462,000 | +462,000 | 0.00 | 0.03 | +0.03 | buy |
| Soleus Capital Management, L.P. | 1,449,915 | 450,889 | -999,026 | 1.85 | 0.63 | -1.22 | sell |
| Nuveen, LLC | 335,783 | 414,706 | +78,923 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 386,498 | 380,923 | -5,575 | 0.61 | 0.83 | +0.22 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 404,200 | 334,014 | -70,186 | 0.02 | 0.02 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 19,678 | 317,565 | +297,887 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 283,312 | 283,333 | +21 | 0.02 | 0.02 | +0.00 | buy |
| DIADEMA PARTNERS LP | 0 | 272,214 | +272,214 | 0.00 | 3.91 | +3.91 | buy |
| PRUDENTIAL FINANCIAL INC | 10,605 | 260,725 | +250,120 | 0.00 | 0.01 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 264,204 | 256,608 | -7,596 | 0.18 | 0.18 | +0.01 | sell |
| Schonfeld Strategic Advisors LLC | 99,075 | 255,202 | +156,127 | 0.03 | 0.05 | +0.03 | buy |
| DEUTSCHE BANK AG\ | 221,868 | 244,995 | +23,127 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 112,236 | 226,819 | +114,583 | 0.80 | 1.76 | +0.95 | buy |
| Woodline Partners LP | 224,290 | 224,290 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Bank of New York Mellon Corp | 192,434 | 212,347 | +19,913 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 147,573 | 203,151 | +55,578 | 0.00 | 0.00 | +0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 208,672 | 198,570 | -10,102 | 0.24 | 0.26 | +0.02 | sell |
| Granahan Investment Management, LLC | 200,843 | 193,778 | -7,065 | 0.31 | 0.28 | -0.03 | sell |
| Neuberger Berman Group LLC | 168,678 | 191,195 | +22,517 | 0.00 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 177,244 | 190,205 | +12,961 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 104,863 | 189,115 | +84,252 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 1,311,125 | 174,967 | -1,136,158 | 0.01 | 0.00 | -0.01 | sell |
| ADAR1 Capital Management, LLC | 90,599 | 143,199 | +52,600 | 0.17 | 0.27 | +0.10 | buy |
| Invesco Ltd. | 138,399 | 120,932 | -17,467 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 114,720 | 118,209 | +3,489 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 117,262 | +117,262 | 0.00 | 0.01 | +0.01 | buy |
| Quantum Private Wealth, LLC | 116,624 | 113,380 | -3,244 | 1.13 | 1.18 | +0.05 | sell |
| ALPS ADVISORS INC | 87,326 | 108,795 | +21,469 | 0.01 | 0.02 | +0.01 | buy |
| MOODY ALDRICH PARTNERS LLC | 114,141 | 104,952 | -9,189 | 0.65 | 0.77 | +0.12 | sell |
| Artia Global Partners LP | 65,500 | 98,800 | +33,300 | 0.47 | 0.76 | +0.30 | buy |
| Swiss National Bank | 103,900 | 96,800 | -7,100 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 39,153 | 94,671 | +55,518 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 91,638 | +91,638 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 91,931 | 90,996 | -935 | 0.80 | 0.84 | +0.04 | sell |
| RHUMBLINE ADVISERS | 83,540 | 90,232 | +6,692 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 85,000 | +85,000 | 0.00 | 0.01 | +0.01 | buy |
| Ally Bridge Group (NY) LLC | 161,000 | 83,300 | -77,700 | 5.04 | 4.36 | -0.68 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 82,734 | +82,734 | 0.00 | 0.06 | +0.06 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 88,937 | 80,197 | -8,740 | 0.00 | 0.00 | +0.00 | sell |
| DekaBank Deutsche Girozentrale | 80,000 | 80,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 25,244 | 78,898 | +53,654 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 6,574 | 77,594 | +71,020 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 71,389 | +71,389 | 0.00 | 0.03 | +0.03 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 73,419 | 71,306 | -2,113 | 0.00 | 0.00 | +0.00 | sell |
| Persistent Asset Partners Ltd | 10,053 | 69,441 | +59,388 | 0.12 | 0.89 | +0.77 | buy |
| CITIGROUP INC | 18,517 | 59,563 | +41,046 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 29,889 | 56,934 | +27,045 | 0.01 | 0.01 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 32,896 | 56,910 | +24,014 | 0.00 | 0.00 | +0.00 | buy |
| HighMark Wealth Management LLC | 53,179 | 53,179 | 0 | 0.68 | 0.72 | +0.04 | hold |
| TWO SIGMA INVESTMENTS, LP | 50,848 | 49,548 | -1,300 | 0.00 | 0.00 | +0.00 | sell |
| SEI INVESTMENTS CO | 49,082 | 47,543 | -1,539 | 0.00 | 0.00 | +0.00 | sell |
| ALGERT GLOBAL LLC | 32,520 | 47,240 | +14,720 | 0.02 | 0.02 | +0.01 | buy |
| XTX Topco Ltd | 19,108 | 45,832 | +26,724 | 0.01 | 0.02 | +0.01 | buy |
| Legal & General Group Plc | 42,537 | 44,688 | +2,151 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 44,466 | +44,466 | 0.00 | 0.11 | +0.11 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 23,911 | 43,587 | +19,676 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 38,084 | 41,804 | +3,720 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35,450 | 40,757 | +5,307 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 40,379 | +40,379 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 31,268 | 39,198 | +7,930 | 0.00 | 0.00 | +0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 38,414 | 38,641 | +227 | 0.07 | 0.08 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 41,726 | 37,605 | -4,121 | 0.00 | 0.00 | +0.00 | sell |
| Aquatic Capital Management LLC | 0 | 36,918 | +36,918 | 0.00 | 0.05 | +0.05 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 31,614 | 32,939 | +1,325 | 0.00 | 0.00 | +0.00 | buy |