| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 500,000 | 1,049,699 | +549,699 | 0.02 | 0.03 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 580,748 | 1,120,767 | +540,019 | 0.00 | 0.00 | 0.00 | buy |
| Granahan Investment Management, LLC | 644,713 | 939,127 | +294,414 | 0.15 | 0.19 | +0.04 | buy |
| VIKING GLOBAL INVESTORS LP | 5,943,261 | 6,159,146 | +215,885 | 0.19 | 0.14 | -0.05 | buy |
| Frazier Life Sciences Management, L.P. | 749,022 | 849,022 | +100,000 | 0.35 | 0.32 | -0.02 | buy |
| Opaleye Management Inc. | 815,000 | 875,405 | +60,405 | 1.51 | 1.63 | +0.12 | buy |
| Parkman Healthcare Partners LLC | 454,247 | 473,312 | +19,065 | 0.61 | 0.50 | -0.11 | buy |
| BIT Capital GmbH | 18,663 | 23,715 | +5,052 | 0.02 | 0.02 | +0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 25,107 | 26,023 | +916 | 0.03 | 0.03 | -0.01 | buy |
| China Universal Asset Management Co., Ltd. | 829 | 1,634 | +805 | 0.00 | 0.00 | +0.00 | buy |
| Quantum Private Wealth, LLC | 61,219 | 61,719 | +500 | 0.22 | 0.17 | -0.05 | buy |
| ALPS ADVISORS INC | 46,513 | 46,874 | +361 | 0.00 | 0.00 | -0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 61,404 | 61,394 | -10 | 0.01 | 0.01 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 11,422 | 10,384 | -1,038 | 0.05 | 0.04 | -0.02 | sell |