| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 0 | 1,958,310 | +1,958,310 | 0.00 | 1.48 | +1.48 | buy |
| JANUS HENDERSON GROUP PLC | 2,607,299 | 4,558,519 | +1,951,220 | 0.03 | 0.06 | +0.04 | buy |
| Artisan Partners Limited Partnership | 0 | 1,000,632 | +1,000,632 | 0.00 | 0.04 | +0.04 | buy |
| Deep Track Capital, LP | 186,386 | 1,100,536 | +914,150 | 0.10 | 0.94 | +0.84 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,260,392 | 1,953,424 | +693,032 | 0.22 | 0.45 | +0.23 | buy |
| PERCEPTIVE ADVISORS LLC | 1,856,417 | 2,330,294 | +473,877 | 0.81 | 1.33 | +0.53 | buy |
| Schonfeld Strategic Advisors LLC | 78,134 | 545,546 | +467,412 | 0.01 | 0.12 | +0.11 | buy |
| Paradigm Biocapital Advisors LP | 2,325,449 | 2,789,172 | +463,723 | 1.60 | 2.61 | +1.00 | buy |
| Logos Global Management LP | 0 | 450,000 | +450,000 | 0.00 | 1.35 | +1.35 | buy |
| Cormorant Asset Management, LP | 3,006,534 | 3,406,534 | +400,000 | 3.15 | 4.82 | +1.67 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 24,321 | 307,842 | +283,521 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 467,507 | 726,871 | +259,364 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 256,645 | +256,645 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 0 | 242,251 | +242,251 | 0.00 | 0.07 | +0.07 | buy |
| Ally Bridge Group (NY) LLC | 0 | 187,695 | +187,695 | 0.00 | 2.68 | +2.68 | buy |
| DEUTSCHE BANK AG\ | 31,114 | 217,882 | +186,768 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16,776 | 200,500 | +183,724 | 0.00 | 0.01 | +0.01 | buy |
| MPM BioImpact LLC | 740,661 | 917,166 | +176,505 | 2.07 | 3.67 | +1.60 | buy |
| MORGAN STANLEY | 249,974 | 418,131 | +168,157 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 415,720 | 577,565 | +161,845 | 0.01 | 0.02 | +0.01 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 151,157 | +151,157 | 0.00 | 0.73 | +0.73 | buy |
| Amundi | 0 | 150,420 | +150,420 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 311,476 | 455,348 | +143,872 | 0.01 | 0.02 | +0.01 | buy |
| Jump Financial, LLC | 0 | 131,806 | +131,806 | 0.00 | 0.07 | +0.07 | buy |
| Informed Momentum Co LLC | 0 | 125,184 | +125,184 | 0.00 | 0.50 | +0.50 | buy |
| Woodline Partners LP | 421,604 | 527,839 | +106,235 | 0.07 | 0.12 | +0.05 | buy |
| Qube Research & Technologies Ltd | 28,845 | 131,892 | +103,047 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 0 | 96,409 | +96,409 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 64,359 | 158,506 | +94,147 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 88,838 | +88,838 | 0.00 | 0.82 | +0.82 | buy |
| BARCLAYS PLC | 30,524 | 119,350 | +88,826 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 574,517 | 657,070 | +82,553 | 1.41 | 2.24 | +0.83 | buy |
| Monashee Investment Management LLC | 0 | 75,000 | +75,000 | 0.00 | 0.22 | +0.22 | buy |
| BRIDGER MANAGEMENT, LLC | 0 | 74,700 | +74,700 | 0.00 | 1.00 | +1.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 860,067 | 934,387 | +74,320 | 0.01 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 2,734 | 74,030 | +71,296 | 0.00 | 0.07 | +0.07 | buy |
| NORTHERN TRUST CORP | 508,691 | 575,880 | +67,189 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 63,000 | +63,000 | 0.00 | 1.36 | +1.36 | buy |
| Exome Asset Management LLC | 0 | 59,900 | +59,900 | 0.00 | 1.08 | +1.08 | buy |
| CITIGROUP INC | 23,053 | 75,841 | +52,788 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 52,610 | +52,610 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 47,755 | +47,755 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 46,249 | +46,249 | 0.00 | 0.07 | +0.07 | buy |
| Invesco Ltd. | 22,244 | 64,776 | +42,532 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 39,937 | +39,937 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 29,846 | 67,082 | +37,236 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 272,794 | 308,051 | +35,257 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 29,293 | +29,293 | 0.00 | 0.06 | +0.06 | buy |
| XTX Topco Ltd | 0 | 28,303 | +28,303 | 0.00 | 0.05 | +0.05 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 27,465 | +27,465 | 0.00 | 0.00 | +0.00 | buy |
| Crestline Management, LP | 0 | 26,981 | +26,981 | 0.00 | 0.04 | +0.04 | buy |
| NEOS Investment Management LLC | 0 | 23,359 | +23,359 | 0.00 | 0.02 | +0.02 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 21,128 | +21,128 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 24,549 | 45,223 | +20,674 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 51,339 | 71,784 | +20,445 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,665,095 | 1,685,115 | +20,020 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 19,900 | +19,900 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 60,510 | 75,305 | +14,795 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 13,335 | +13,335 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 13,244 | +13,244 | 0.00 | 0.00 | +0.00 | buy |
| Orion Porfolio Solutions, LLC | 0 | 13,011 | +13,011 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 11,466 | +11,466 | 0.00 | 0.01 | +0.01 | buy |
| Brevan Howard Capital Management LP | 0 | 11,251 | +11,251 | 0.00 | 0.01 | +0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 11,117 | +11,117 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 29,286 | 39,718 | +10,432 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 9,400 | +9,400 | 0.00 | 0.01 | +0.01 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 9,371 | +9,371 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 26,410 | 35,613 | +9,203 | 0.01 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 8,946 | +8,946 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 8,728 | +8,728 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 68 | 8,536 | +8,468 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 4,508,166 | 4,516,063 | +7,897 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 0 | 7,686 | +7,686 | 0.00 | 0.03 | +0.03 | buy |
| AlphaQuest LLC | 1,742 | 9,035 | +7,293 | 0.00 | 0.02 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 10,973 | 18,035 | +7,062 | 0.03 | 0.05 | +0.03 | buy |
| Quantum Private Wealth, LLC | 66,774 | 73,424 | +6,650 | 0.43 | 0.66 | +0.24 | buy |
| Chicago Partners Investment Group LLC | 0 | 6,018 | +6,018 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 13,490 | 19,259 | +5,769 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 79,868 | 84,294 | +4,426 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 39,252 | 43,657 | +4,405 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 11,405 | 15,245 | +3,840 | 0.01 | 0.02 | +0.01 | buy |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 0 | 2,849 | +2,849 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 98,269 | 100,872 | +2,603 | 0.00 | 0.00 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 1,946 | 3,307 | +1,361 | 0.00 | 0.01 | +0.00 | buy |
| ROYAL BANK OF CANADA | 7,573 | 8,914 | +1,341 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 1,200 | +1,200 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 23,086 | 23,808 | +722 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,788 | 3,392 | +604 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 10,459 | 10,758 | +299 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 1,187 | 1,288 | +101 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 886 | 982 | +96 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 5,054 | 5,145 | +91 | 0.04 | 0.06 | +0.02 | buy |
| SIGNATUREFD, LLC | 455 | 537 | +82 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 0 | 47 | +47 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 38,366 | 38,410 | +44 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 35 | 70 | +35 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 0 | 27 | +27 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 5 | 20 | +15 | 0.00 | 0.00 | +0.00 | buy |