| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 2,607,299 | 4,558,519 | +1,951,220 | 0.03 | 0.06 | 0.00 | buy |
| Deep Track Capital, LP | 186,386 | 1,100,536 | +914,150 | 0.10 | 0.94 | +0.84 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,260,392 | 1,953,424 | +693,032 | 0.22 | 0.45 | +0.23 | buy |
| PERCEPTIVE ADVISORS LLC | 1,856,417 | 2,330,294 | +473,877 | 0.81 | 1.32 | +0.51 | buy |
| Paradigm Biocapital Advisors LP | 2,325,449 | 2,789,172 | +463,723 | 1.60 | 2.61 | +1.00 | buy |
| Cormorant Asset Management, LP | 3,006,534 | 3,406,534 | +400,000 | 3.13 | 4.82 | +1.69 | buy |
| MPM BioImpact LLC | 740,661 | 917,166 | +176,505 | 2.07 | 3.67 | +1.60 | buy |
| Woodline Partners LP | 421,604 | 527,839 | +106,235 | 0.07 | 0.12 | +0.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 362,576 | 261,458 | +101,118 | 0.02 | 0.02 | 0.00 | sell |
| Parkman Healthcare Partners LLC | 574,517 | 657,070 | +82,553 | 1.41 | 2.24 | +0.83 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 85,008 | 20,000 | +65,008 | 0.10 | 0.04 | 0.00 | sell |
| Quarry LP | 14,000 | 3,500 | +10,500 | 0.11 | 0.03 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 10,973 | 18,035 | +7,062 | 0.03 | 0.05 | +0.03 | buy |
| Quantum Private Wealth, LLC | 66,774 | 73,424 | +6,650 | 0.43 | 0.66 | +0.24 | buy |
| PROFUND ADVISORS LLC | 11,405 | 15,245 | +3,840 | 0.01 | 0.02 | 0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 1,946 | 3,307 | +1,361 | 0.00 | 0.01 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 5,054 | 5,145 | +91 | 0.04 | 0.06 | +0.02 | buy |
| ALPS ADVISORS INC | 72,843 | 68,906 | -3,937 | 0.01 | 0.01 | +0.00 | sell |
| PDT Partners, LLC | 26,287 | 20,551 | -5,736 | 0.04 | 0.05 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 49,597 | 21,509 | -28,088 | 0.00 | 0.00 | -0.00 | sell |
| Polar Asset Management Partners Inc. | 187,500 | 157,579 | -29,921 | 0.07 | 0.09 | +0.02 | sell |
| Candriam S.C.A. | 329,000 | 294,624 | -34,376 | 0.04 | 0.05 | +0.01 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 272,071 | 227,023 | -45,048 | 0.10 | 0.13 | +0.03 | sell |
| Opaleye Management Inc. | 580,000 | 522,500 | -57,500 | 2.39 | 2.33 | -0.06 | sell |
| DAFNA Capital Management LLC | 290,197 | 227,906 | -62,291 | 1.25 | 1.44 | +0.19 | sell |
| Sofinnova Investments, Inc. | 475,691 | 384,767 | -90,924 | 0.45 | 0.82 | +0.37 | sell |
| TCG Crossover Management, LLC | 2,272,728 | 2,112,984 | -159,744 | 4.27 | 4.78 | +0.51 | sell |
| Granahan Investment Management, LLC | 710,723 | 511,905 | -198,818 | 0.51 | 0.54 | +0.03 | sell |
| STEMPOINT CAPITAL LP | 271,057 | 19,900 | -251,157 | 1.44 | 0.16 | -1.28 | sell |
| ADAR1 Capital Management, LLC | 436,608 | 18,178 | -418,430 | 1.58 | 0.08 | -1.50 | sell |
| Novo Holdings A/S | 6,344,430 | 5,549,900 | -794,530 | 6.16 | 7.36 | +1.20 | sell |
| VR Adviser, LLC | 1,818,182 | 1,000,000 | -818,182 | 2.09 | 1.40 | -0.69 | sell |
| Frazier Life Sciences Management, L.P. | 3,731,067 | 2,832,867 | -898,200 | 3.14 | 3.03 | -0.11 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,874,586 | 1,781,006 | -1,093,580 | 0.86 | 0.71 | -0.15 | sell |