| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 15,021,721 | 15,021,721 | 0 | 5.38 | 7.34 | +1.96 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 8,909,091 | 8,909,091 | 0 | 2.12 | 2.74 | +0.62 | hold |
| BAKER BROS. ADVISORS LP | 5,840,059 | 5,840,059 | 0 | 1.34 | 1.62 | +0.27 | hold |
| Novo Holdings A/S | 6,344,430 | 5,549,900 | -794,530 | 6.16 | 7.36 | +1.20 | sell |
| JANUS HENDERSON GROUP PLC | 2,607,299 | 4,558,519 | +1,951,220 | 0.03 | 0.06 | +0.04 | buy |
| VANGUARD GROUP INC | 4,508,166 | 4,516,063 | +7,897 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 3,006,534 | 3,406,534 | +400,000 | 3.15 | 4.82 | +1.67 | buy |
| Frazier Life Sciences Management, L.P. | 3,731,067 | 2,832,867 | -898,200 | 3.14 | 3.03 | -0.11 | sell |
| Paradigm Biocapital Advisors LP | 2,325,449 | 2,789,172 | +463,723 | 1.60 | 2.61 | +1.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,856,417 | 2,330,294 | +473,877 | 0.81 | 1.33 | +0.53 | buy |
| TCG Crossover Management, LLC | 2,272,728 | 2,112,984 | -159,744 | 4.27 | 4.78 | +0.51 | sell |
| BRAIDWELL LP | 0 | 1,958,310 | +1,958,310 | 0.00 | 1.48 | +1.48 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,260,392 | 1,953,424 | +693,032 | 0.22 | 0.45 | +0.23 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,874,586 | 1,781,006 | -1,093,580 | 0.86 | 0.71 | -0.15 | sell |
| STATE STREET CORP | 1,665,095 | 1,685,115 | +20,020 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,672,653 | 1,599,535 | -73,118 | 0.00 | 0.00 | +0.00 | sell |
| New Leaf Venture Partners, L.L.C. | 1,553,661 | 1,553,661 | 0 | 34.03 | 42.62 | +8.59 | hold |
| VIKING GLOBAL INVESTORS LP | 1,481,146 | 1,481,146 | 0 | 0.10 | 0.14 | +0.04 | hold |
| Bellevue Group AG | 1,428,929 | 1,428,929 | 0 | 0.42 | 0.62 | +0.20 | hold |
| EcoR1 Capital, LLC | 1,250,385 | 1,250,385 | 0 | 0.69 | 1.14 | +0.45 | hold |
| Deep Track Capital, LP | 186,386 | 1,100,536 | +914,150 | 0.10 | 0.94 | +0.84 | buy |
| Artisan Partners Limited Partnership | 0 | 1,000,632 | +1,000,632 | 0.00 | 0.04 | +0.04 | buy |
| VR Adviser, LLC | 1,818,182 | 1,000,000 | -818,182 | 2.09 | 1.40 | -0.69 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,145,506 | 987,030 | -158,476 | 0.02 | 0.02 | +0.01 | sell |
| AMERICAN CENTURY COMPANIES INC | 860,067 | 934,387 | +74,320 | 0.01 | 0.01 | +0.01 | buy |
| MPM BioImpact LLC | 740,661 | 917,166 | +176,505 | 2.07 | 3.67 | +1.60 | buy |
| DIMENSIONAL FUND ADVISORS LP | 467,507 | 726,871 | +259,364 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 574,517 | 657,070 | +82,553 | 1.41 | 2.24 | +0.83 | buy |
| FMR LLC | 4,780,563 | 653,208 | -4,127,355 | 0.01 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 415,720 | 577,565 | +161,845 | 0.01 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 508,691 | 575,880 | +67,189 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 78,134 | 545,546 | +467,412 | 0.01 | 0.12 | +0.11 | buy |
| CITADEL ADVISORS LLC | 2,349,174 | 538,249 | -1,810,925 | 0.04 | 0.01 | -0.03 | sell |
| Woodline Partners LP | 421,604 | 527,839 | +106,235 | 0.07 | 0.12 | +0.05 | buy |
| Opaleye Management Inc. | 580,000 | 522,500 | -57,500 | 2.39 | 2.33 | -0.06 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 571,197 | 522,086 | -49,111 | 0.00 | 0.00 | +0.00 | sell |
| Granahan Investment Management, LLC | 710,723 | 511,905 | -198,818 | 0.51 | 0.54 | +0.03 | sell |
| GOLDMAN SACHS GROUP INC | 1,622,741 | 482,225 | -1,140,516 | 0.01 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 311,476 | 455,348 | +143,872 | 0.01 | 0.02 | +0.01 | buy |
| Logos Global Management LP | 0 | 450,000 | +450,000 | 0.00 | 1.35 | +1.35 | buy |
| MORGAN STANLEY | 249,974 | 418,131 | +168,157 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 475,691 | 384,767 | -90,924 | 0.54 | 0.85 | +0.31 | sell |
| BANK OF AMERICA CORP /DE/ | 272,794 | 308,051 | +35,257 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 24,321 | 307,842 | +283,521 | 0.00 | 0.01 | +0.01 | buy |
| Candriam S.C.A. | 329,000 | 294,624 | -34,376 | 0.04 | 0.05 | +0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 362,576 | 261,458 | -101,118 | 0.02 | 0.02 | +0.00 | sell |
| Aberdeen Group plc | 0 | 256,645 | +256,645 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 0 | 242,251 | +242,251 | 0.00 | 0.07 | +0.07 | buy |
| DAFNA Capital Management LLC | 290,197 | 227,906 | -62,291 | 1.25 | 1.44 | +0.19 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 272,071 | 227,023 | -45,048 | 0.10 | 0.13 | +0.03 | sell |
| DEUTSCHE BANK AG\ | 31,114 | 217,882 | +186,768 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 268,712 | 210,772 | -57,940 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 493,847 | 205,321 | -288,526 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16,776 | 200,500 | +183,724 | 0.00 | 0.01 | +0.01 | buy |
| Ally Bridge Group (NY) LLC | 0 | 187,695 | +187,695 | 0.00 | 2.68 | +2.68 | buy |
| JPMORGAN CHASE & CO | 64,359 | 158,506 | +94,147 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 187,500 | 157,579 | -29,921 | 0.09 | 0.10 | +0.01 | sell |
| MOODY ALDRICH PARTNERS LLC | 0 | 151,157 | +151,157 | 0.00 | 0.73 | +0.73 | buy |
| Amundi | 0 | 150,420 | +150,420 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 28,845 | 131,892 | +103,047 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 131,806 | +131,806 | 0.00 | 0.07 | +0.07 | buy |
| Informed Momentum Co LLC | 0 | 125,184 | +125,184 | 0.00 | 0.50 | +0.50 | buy |
| BARCLAYS PLC | 30,524 | 119,350 | +88,826 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 98,269 | 100,872 | +2,603 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 96,409 | +96,409 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 0 | 88,838 | +88,838 | 0.00 | 0.82 | +0.82 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 79,868 | 84,294 | +4,426 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 80,000 | 80,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 80,360 | 75,960 | -4,400 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 23,053 | 75,841 | +52,788 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 60,510 | 75,305 | +14,795 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 75,000 | +75,000 | 0.00 | 0.22 | +0.22 | buy |
| BRIDGER MANAGEMENT, LLC | 0 | 74,700 | +74,700 | 0.00 | 1.00 | +1.00 | buy |
| SIMPLEX TRADING, LLC | 2,734 | 74,030 | +71,296 | 0.00 | 0.07 | +0.07 | buy |
| Swiss National Bank | 73,600 | 73,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Quantum Private Wealth, LLC | 66,774 | 73,424 | +6,650 | 0.43 | 0.66 | +0.24 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 51,339 | 71,784 | +20,445 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 72,843 | 68,906 | -3,937 | 0.01 | 0.01 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 29,846 | 67,082 | +37,236 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 22,244 | 64,776 | +42,532 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 63,000 | +63,000 | 0.00 | 1.36 | +1.36 | buy |
| Exome Asset Management LLC | 0 | 59,900 | +59,900 | 0.00 | 1.08 | +1.08 | buy |
| SEI INVESTMENTS CO | 0 | 52,610 | +52,610 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 64,487 | 50,370 | -14,117 | 0.00 | 0.00 | +0.00 | sell |
| NORGES BANK | 0 | 47,755 | +47,755 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 46,249 | +46,249 | 0.00 | 0.07 | +0.07 | buy |
| TWO SIGMA ADVISERS, LP | 96,000 | 45,400 | -50,600 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 24,549 | 45,223 | +20,674 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 39,252 | 43,657 | +4,405 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 42,271 | 42,271 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Hudson Bay Capital Management LP | 0 | 39,937 | +39,937 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 29,286 | 39,718 | +10,432 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 39,054 | 38,814 | -240 | 0.00 | 0.01 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 38,366 | 38,410 | +44 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 39,110 | 37,927 | -1,183 | 0.00 | 0.00 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 26,410 | 35,613 | +9,203 | 0.01 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 64,173 | 29,629 | -34,544 | 0.01 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 29,293 | +29,293 | 0.00 | 0.06 | +0.06 | buy |
| XTX Topco Ltd | 0 | 28,303 | +28,303 | 0.00 | 0.05 | +0.05 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 27,465 | +27,465 | 0.00 | 0.00 | +0.00 | buy |