| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Siren, L.L.C. | 3,160,298 | 3,897,099 | +736,801 | 2.14 | 2.47 | +0.33 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 9,902,633 | 10,428,437 | +525,804 | 2.19 | 2.08 | -0.10 | buy |
| Integral Health Asset Management, LLC | 1,000,000 | 1,500,000 | +500,000 | 1.22 | 1.77 | +0.55 | buy |
| AMERICAN CENTURY COMPANIES INC | 783,166 | 1,095,473 | +312,307 | 0.01 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 443,319 | 619,878 | +176,559 | 0.01 | 0.02 | +0.01 | buy |
| MORGAN STANLEY | 727,714 | 869,678 | +141,964 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 69,723 | 208,101 | +138,378 | 0.34 | 0.83 | +0.49 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,048,936 | 1,183,136 | +134,200 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,101,781 | 2,228,285 | +126,504 | 0.22 | 0.26 | +0.04 | buy |
| Eversept Partners, LP | 392,739 | 502,234 | +109,495 | 0.52 | 0.62 | +0.11 | buy |
| GSA CAPITAL PARTNERS LLP | 27,276 | 113,243 | +85,967 | 0.03 | 0.15 | +0.13 | buy |
| D. E. Shaw & Co., Inc. | 595,432 | 677,561 | +82,129 | 0.01 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 75,276 | +75,276 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 254,429 | 321,132 | +66,703 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 57,300 | +57,300 | 0.00 | 0.02 | +0.02 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 442,837 | 498,646 | +55,809 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 499,917 | 555,713 | +55,796 | 0.01 | 0.01 | +0.00 | buy |
| Neuberger Berman Group LLC | 165,535 | 219,646 | +54,111 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 52,203 | +52,203 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 124,470 | 173,439 | +48,969 | 1.35 | 1.86 | +0.51 | buy |
| Paradigm Biocapital Advisors LP | 6,142,344 | 6,170,131 | +27,787 | 3.44 | 2.96 | -0.48 | buy |
| Optimize Financial Inc | 0 | 27,283 | +27,283 | 0.00 | 0.23 | +0.23 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 26,266 | +26,266 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 22,625 | +22,625 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 20,471 | +20,471 | 0.00 | 0.05 | +0.05 | buy |
| JANE STREET GROUP, LLC | 50,185 | 69,998 | +19,813 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 579,104 | 597,603 | +18,499 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 15,695 | +15,695 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 36,878 | 50,793 | +13,915 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 13,379 | +13,379 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 90,000 | 101,900 | +11,900 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 10,837 | +10,837 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 38,809 | 49,205 | +10,396 | 0.05 | 0.06 | +0.01 | buy |
| Opaleye Management Inc. | 490,000 | 500,000 | +10,000 | 1.30 | 1.15 | -0.15 | buy |
| Invesco Ltd. | 56,158 | 66,056 | +9,898 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 9,881 | +9,881 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 28,700 | 38,400 | +9,700 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 147,525 | 154,896 | +7,371 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 24 | 7,190 | +7,166 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 34,723 | 40,963 | +6,240 | 0.01 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 8,193 | 14,297 | +6,104 | 0.00 | 0.00 | +0.00 | buy |
| Quantum Private Wealth, LLC | 100,774 | 105,874 | +5,100 | 0.43 | 0.50 | +0.07 | buy |
| WELLS FARGO & COMPANY/MN | 38,384 | 42,196 | +3,812 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 52,307 | 55,941 | +3,634 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 4,183 | 7,590 | +3,407 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 45,806 | 48,220 | +2,414 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 2,304 | +2,304 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 185 | 2,350 | +2,165 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 112,570 | 114,531 | +1,961 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 13,745 | 15,549 | +1,804 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 17,356 | 18,865 | +1,509 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 6,098 | 7,380 | +1,282 | 0.03 | 0.03 | +0.01 | buy |
| Creative Planning | 16,910 | 18,036 | +1,126 | 0.00 | 0.00 | +0.00 | buy |
| HighMark Wealth Management LLC | 52,065 | 53,179 | +1,114 | 0.33 | 0.38 | +0.05 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 3,400 | 4,500 | +1,100 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 50,682 | 51,386 | +704 | 0.00 | 0.00 | +0.00 | buy |
| KAYNE ANDERSON RUDNICK INVESTMENT MANAGEMENT LLC | 0 | 622 | +622 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 468 | +468 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 132,178 | 132,503 | +325 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 2,009 | 2,292 | +283 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 374 | 558 | +184 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 12,646 | 12,815 | +169 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 151 | +151 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 135 | +135 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 132 | +132 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 233 | 344 | +111 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 61 | 142 | +81 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 454 | 521 | +67 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 48 | 106 | +58 | 0.00 | 0.00 | -0.00 | buy |
| Allworth Financial LP | 0 | 33 | +33 | 0.00 | 0.00 | +0.00 | buy |
| MONTAG A & ASSOCIATES INC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 4,062 | 4,073 | +11 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 4 | +4 | 0.00 | 0.00 | -0.00 | buy |
| Clearstead Advisors, LLC | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 26 | 27 | +1 | 0.00 | 0.00 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 15,518,492 | 15,518,492 | 0 | 5.12 | 6.04 | +0.92 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 151,062 | 151,062 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 77,260 | 77,260 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 431,300 | 431,300 | 0 | 0.29 | 0.27 | -0.02 | hold |
| PRINCIPAL SECURITIES, INC. | 27 | 27 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 7,305,940 | 7,305,940 | 0 | 0.93 | 0.86 | -0.07 | hold |
| AMERICAN NATIONAL BANK & TRUST | 2 | 2 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Novo Holdings A/S | 5,350,000 | 5,350,000 | 0 | 4.95 | 5.59 | +0.64 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 568,310 | 568,310 | 0 | 0.13 | 0.15 | +0.02 | hold |
| Parkside Financial Bank & Trust | 35 | 35 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIGNATUREFD, LLC | 363 | 363 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 80,000 | 80,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 344 | 344 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SFMG, LLC | 10,000 | 10,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MetLife Investment Management, LLC | 43,883 | 43,883 | 0 | 0.00 | 0.00 | +0.00 | hold |
| New Leaf Venture Partners, L.L.C. | 1,030,161 | 1,030,161 | 0 | 25.51 | 38.82 | +13.31 | hold |
| Bellevue Group AG | 2,775,997 | 2,775,997 | 0 | 0.80 | 0.94 | +0.13 | hold |
| MPM BioImpact LLC | 1,720,741 | 1,720,741 | 0 | 3.91 | 4.57 | +0.66 | hold |
| Parallel Advisors, LLC | 95 | 95 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BFSG, LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| KLP KAPITALFORVALTNING AS | 10,600 | 10,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Versant Capital Management, Inc | 95 | 95 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 207 | 207 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Kynam Capital Management, LP | 253,979 | 253,979 | 0 | 0.36 | 0.31 | -0.05 | hold |
| Covestor Ltd | 8 | 8 | 0 | 0.00 | 0.00 | 0.00 | hold |