| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 15,518,492 | 15,518,492 | 0 | 5.12 | 6.04 | +0.92 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 9,902,633 | 10,428,437 | +525,804 | 2.19 | 2.08 | -0.10 | buy |
| BAKER BROS. ADVISORS LP | 7,305,940 | 7,305,940 | 0 | 0.93 | 0.86 | -0.07 | hold |
| BlackRock, Inc. | 6,781,046 | 6,351,487 | -429,559 | 0.00 | 0.00 | +0.00 | sell |
| Paradigm Biocapital Advisors LP | 6,142,344 | 6,170,131 | +27,787 | 3.44 | 2.96 | -0.48 | buy |
| Novo Holdings A/S | 5,350,000 | 5,350,000 | 0 | 4.95 | 5.59 | +0.64 | hold |
| BRAIDWELL LP | 5,210,831 | 5,210,831 | 0 | 2.34 | 2.51 | +0.17 | hold |
| JANUS HENDERSON GROUP PLC | 5,503,349 | 4,979,331 | -524,018 | 0.04 | 0.04 | +0.00 | sell |
| VANGUARD GROUP INC | 4,841,500 | 4,803,941 | -37,559 | 0.00 | 0.00 | +0.00 | sell |
| Cormorant Asset Management, LP | 4,251,992 | 4,010,000 | -241,992 | 4.15 | 4.49 | +0.34 | sell |
| Siren, L.L.C. | 3,160,298 | 3,897,099 | +736,801 | 2.14 | 2.47 | +0.33 | buy |
| PERCEPTIVE ADVISORS LLC | 4,639,949 | 3,795,894 | -844,055 | 2.28 | 1.78 | -0.50 | sell |
| Bellevue Group AG | 2,775,997 | 2,775,997 | 0 | 0.80 | 0.94 | +0.13 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,101,781 | 2,228,285 | +126,504 | 0.22 | 0.26 | +0.04 | buy |
| MPM BioImpact LLC | 1,720,741 | 1,720,741 | 0 | 3.91 | 4.57 | +0.66 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,797,215 | 1,717,641 | -79,574 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 1,781,501 | 1,699,909 | -81,592 | 0.00 | 0.00 | +0.00 | sell |
| Integral Health Asset Management, LLC | 1,000,000 | 1,500,000 | +500,000 | 1.22 | 1.77 | +0.55 | buy |
| First Light Asset Management, LLC | 1,714,019 | 1,414,994 | -299,025 | 2.91 | 2.16 | -0.75 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,048,936 | 1,183,136 | +134,200 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 783,166 | 1,095,473 | +312,307 | 0.01 | 0.01 | +0.00 | buy |
| New Leaf Venture Partners, L.L.C. | 1,030,161 | 1,030,161 | 0 | 25.51 | 38.82 | +13.31 | hold |
| MORGAN STANLEY | 727,714 | 869,678 | +141,964 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,067,320 | 765,694 | -1,301,626 | 0.49 | 0.19 | -0.30 | sell |
| MILLENNIUM MANAGEMENT LLC | 921,965 | 725,425 | -196,540 | 0.01 | 0.01 | -0.00 | sell |
| Artisan Partners Limited Partnership | 1,379,068 | 718,175 | -660,893 | 0.03 | 0.02 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 595,432 | 677,561 | +82,129 | 0.01 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 443,319 | 619,878 | +176,559 | 0.01 | 0.02 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 579,104 | 597,603 | +18,499 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 602,898 | 587,882 | -15,016 | 0.00 | 0.00 | +0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 568,310 | 568,310 | 0 | 0.13 | 0.15 | +0.02 | hold |
| Qube Research & Technologies Ltd | 499,917 | 555,713 | +55,796 | 0.01 | 0.01 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 647,331 | 550,173 | -97,158 | 0.98 | 0.98 | -0.00 | sell |
| CITIGROUP INC | 724,899 | 538,453 | -186,446 | 0.01 | 0.01 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 631,743 | 527,827 | -103,916 | 0.00 | 0.00 | -0.00 | sell |
| Sofinnova Investments, Inc. | 716,873 | 520,240 | -196,633 | 0.64 | 0.52 | -0.12 | sell |
| Eversept Partners, LP | 392,739 | 502,234 | +109,495 | 0.52 | 0.62 | +0.11 | buy |
| Opaleye Management Inc. | 490,000 | 500,000 | +10,000 | 1.30 | 1.15 | -0.15 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 442,837 | 498,646 | +55,809 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 431,300 | 431,300 | 0 | 0.29 | 0.27 | -0.02 | hold |
| Granahan Investment Management, LLC | 405,478 | 339,617 | -65,861 | 0.22 | 0.23 | +0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 254,429 | 321,132 | +66,703 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 539,730 | 307,181 | -232,549 | 2.84 | 1.26 | -1.58 | sell |
| Kynam Capital Management, LP | 253,979 | 253,979 | 0 | 0.36 | 0.31 | -0.05 | hold |
| FMR LLC | 470,717 | 253,325 | -217,392 | 0.00 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 252,524 | 250,622 | -1,902 | 0.08 | 0.09 | +0.01 | sell |
| BARCLAYS PLC | 281,250 | 234,650 | -46,600 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 1,096,863 | 224,190 | -872,673 | 0.08 | 0.02 | -0.06 | sell |
| Candriam S.C.A. | 223,990 | 221,159 | -2,831 | 0.02 | 0.02 | +0.00 | sell |
| Neuberger Berman Group LLC | 165,535 | 219,646 | +54,111 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 238,140 | 213,736 | -24,404 | 0.86 | 0.86 | -0.01 | sell |
| HighVista Strategies LLC | 69,723 | 208,101 | +138,378 | 0.34 | 0.83 | +0.49 | buy |
| Bank of New York Mellon Corp | 212,858 | 204,242 | -8,616 | 0.00 | 0.00 | +0.00 | sell |
| Exome Asset Management LLC | 124,470 | 173,439 | +48,969 | 1.35 | 1.86 | +0.51 | buy |
| Nuveen, LLC | 317,173 | 172,707 | -144,466 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 147,525 | 154,896 | +7,371 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 151,062 | 151,062 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 191,606 | 139,112 | -52,494 | 0.00 | 0.00 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 132,178 | 132,503 | +325 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 112,570 | 114,531 | +1,961 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 170,982 | 114,128 | -56,854 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 27,276 | 113,243 | +85,967 | 0.03 | 0.15 | +0.13 | buy |
| Quantum Private Wealth, LLC | 100,774 | 105,874 | +5,100 | 0.43 | 0.50 | +0.07 | buy |
| RHUMBLINE ADVISERS | 112,483 | 104,829 | -7,654 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 90,000 | 101,900 | +11,900 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 93,808 | 83,437 | -10,371 | 0.00 | 0.00 | +0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 99,848 | 82,941 | -16,907 | 0.25 | 0.26 | +0.00 | sell |
| Jump Financial, LLC | 121,705 | 80,825 | -40,880 | 0.02 | 0.02 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 80,000 | 80,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 77,260 | 77,260 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Squarepoint Ops LLC | 0 | 75,276 | +75,276 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 50,185 | 69,998 | +19,813 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 77,616 | 68,720 | -8,896 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 56,158 | 66,056 | +9,898 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 316,500 | 59,256 | -257,244 | 0.01 | 0.00 | -0.01 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 57,300 | +57,300 | 0.00 | 0.02 | +0.02 | buy |
| Legal & General Group Plc | 52,307 | 55,941 | +3,634 | 0.00 | 0.00 | +0.00 | buy |
| HighMark Wealth Management LLC | 52,065 | 53,179 | +1,114 | 0.33 | 0.38 | +0.05 | buy |
| HRT FINANCIAL LP | 0 | 52,203 | +52,203 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 167,340 | 51,989 | -115,351 | 0.02 | 0.01 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 50,682 | 51,386 | +704 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 56,798 | 51,112 | -5,686 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 36,878 | 50,793 | +13,915 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 38,809 | 49,205 | +10,396 | 0.05 | 0.06 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 45,806 | 48,220 | +2,414 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 115,270 | 45,635 | -69,635 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 43,883 | 43,883 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 38,384 | 42,196 | +3,812 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 34,723 | 40,963 | +6,240 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 40,000 | 40,000 | 0 | 0.09 | 0.06 | -0.02 | hold |
| SEI INVESTMENTS CO | 43,638 | 39,095 | -4,543 | 0.00 | 0.00 | +0.00 | sell |
| Handelsbanken Fonder AB | 28,700 | 38,400 | +9,700 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 54,019 | 36,619 | -17,400 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 38,328 | 35,538 | -2,790 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 39,978 | 31,350 | -8,628 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 44,065 | 29,179 | -14,886 | 0.01 | 0.00 | -0.00 | sell |
| Optimize Financial Inc | 0 | 27,283 | +27,283 | 0.00 | 0.23 | +0.23 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 26,266 | +26,266 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 22,625 | +22,625 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 325,249 | 22,317 | -302,932 | 0.00 | 0.00 | -0.00 | sell |