| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 1,049,699 | 3,112,786 | +2,063,087 | 0.03 | 0.39 | +0.35 | buy |
| Frazier Life Sciences Management, L.P. | 849,022 | 2,667,203 | +1,818,181 | 0.32 | 1.56 | +1.24 | buy |
| Hudson Bay Capital Management LP | 0 | 1,187,880 | +1,187,880 | 0.00 | 0.11 | +0.11 | buy |
| Logos Global Management LP | 0 | 950,000 | +950,000 | 0.00 | 1.16 | +1.16 | buy |
| BARCLAYS PLC | 18,279 | 778,916 | +760,637 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 555,555 | +555,555 | 0.00 | 0.14 | +0.14 | buy |
| Point72 Asset Management, L.P. | 0 | 501,256 | +501,256 | 0.00 | 0.02 | +0.02 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 395,069 | +395,069 | 0.00 | 0.05 | +0.05 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 342,864 | +342,864 | 0.00 | 0.08 | +0.08 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 327,801 | +327,801 | 0.00 | 1.54 | +1.54 | buy |
| Vontobel Holding Ltd. | 0 | 327,801 | +327,801 | 0.00 | 0.03 | +0.03 | buy |
| Ikarian Capital, LLC | 0 | 270,000 | +270,000 | 0.00 | 0.81 | +0.81 | buy |
| AMERICAN CENTURY COMPANIES INC | 527,839 | 770,452 | +242,613 | 0.00 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 0 | 225,179 | +225,179 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 116,900 | 319,100 | +202,200 | 0.01 | 0.03 | +0.02 | buy |
| Parkman Healthcare Partners LLC | 473,312 | 651,625 | +178,313 | 0.50 | 1.01 | +0.51 | buy |
| Aberdeen Group plc | 0 | 150,418 | +150,418 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 939,127 | 1,074,908 | +135,781 | 0.19 | 0.39 | +0.20 | buy |
| TWO SIGMA INVESTMENTS, LP | 57,564 | 169,542 | +111,978 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 788,260 | 892,709 | +104,449 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 35,893 | 131,355 | +95,462 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,120,767 | 1,215,013 | +94,246 | 0.00 | 0.01 | +0.00 | buy |
| FMR LLC | 6,402,847 | 6,492,513 | +89,666 | 0.00 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 174,921 | 262,238 | +87,317 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 15,645 | 98,449 | +82,804 | 0.01 | 0.17 | +0.16 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 72,117 | +72,117 | 0.00 | 0.03 | +0.03 | buy |
| VANGUARD GROUP INC | 2,064,421 | 2,125,380 | +60,959 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 55,591 | +55,591 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 891,768 | 947,046 | +55,278 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 54,436 | +54,436 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 50,100 | +50,100 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 47,100 | +47,100 | 0.00 | 0.02 | +0.02 | buy |
| JANE STREET GROUP, LLC | 0 | 44,139 | +44,139 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 360,093 | 404,212 | +44,119 | 0.02 | 0.05 | +0.02 | buy |
| HRT FINANCIAL LP | 0 | 38,788 | +38,788 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 31,950 | +31,950 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 10,200 | 40,900 | +30,700 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 0 | 29,259 | +29,259 | 0.00 | 0.04 | +0.04 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 43,871 | 70,693 | +26,822 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 24,037 | +24,037 | 0.00 | 0.02 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 23,613 | +23,613 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 41,226 | 62,268 | +21,042 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 9,441 | 29,620 | +20,179 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 344,916 | 363,243 | +18,327 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 14,084 | +14,084 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 3,530 | 16,657 | +13,127 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 6,056 | 18,237 | +12,181 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 11,610 | +11,610 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 11,137 | +11,137 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 18,698 | 29,826 | +11,128 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 298,000 | 308,000 | +10,000 | 0.01 | 0.02 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 43,964 | 52,660 | +8,696 | 0.02 | 0.05 | +0.03 | buy |
| NATIXIS | 0 | 7,500 | +7,500 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,178 | 7,261 | +6,083 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,634 | 7,338 | +5,704 | 0.00 | 0.02 | +0.01 | buy |
| XTX Topco Ltd | 11,952 | 17,143 | +5,191 | 0.01 | 0.04 | +0.03 | buy |
| Mirae Asset Global Investments Co., Ltd. | 16,048 | 20,833 | +4,785 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 17,044 | 20,218 | +3,174 | 0.05 | 0.07 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 10,574 | 13,176 | +2,602 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 35,100 | 37,420 | +2,320 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 2,026 | +2,026 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 1,729 | +1,729 | 0.00 | 0.00 | +0.00 | buy |
| Quantum Private Wealth, LLC | 61,719 | 63,219 | +1,500 | 0.17 | 0.29 | +0.12 | buy |
| RHUMBLINE ADVISERS | 63,610 | 64,333 | +723 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 125,704 | 126,071 | +367 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 146 | 434 | +288 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 330,859 | 331,059 | +200 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 95 | +95 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 45 | +45 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,933,137 | 3,933,137 | 0 | 0.50 | 0.79 | +0.30 | hold |
| ORBIMED ADVISORS LLC | 14,567,176 | 14,567,176 | 0 | 1.79 | 3.19 | +1.40 | hold |
| Ameritas Investment Partners, Inc. | 4,190 | 4,190 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 18,185 | 18,185 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VIKING GLOBAL INVESTORS LP | 6,159,146 | 6,159,146 | 0 | 0.14 | 0.25 | +0.10 | hold |
| Novo Holdings A/S | 6,071,703 | 6,071,703 | 0 | 2.57 | 4.10 | +1.53 | hold |
| DekaBank Deutsche Girozentrale | 80,000 | 80,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 254 | 254 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SFMG, LLC | 10,000 | 10,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MetLife Investment Management, LLC | 23,355 | 23,355 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EcoR1 Capital, LLC | 3,493,194 | 3,493,194 | 0 | 0.68 | 0.99 | +0.31 | hold |
| New Leaf Venture Partners, L.L.C. | 1,553,661 | 1,553,661 | 0 | 11.43 | 13.69 | +2.26 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 2,617 | 2,617 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 340,906 | 340,906 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 16,870 | 16,870 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARTINGALE ASSET MANAGEMENT L P | 61,394 | 61,384 | -10 | 0.01 | 0.01 | +0.01 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 21,353 | 21,267 | -86 | 0.00 | 0.00 | +0.00 | sell |
| MassMutual Private Wealth & Trust, FSB | 102 | 0 | -102 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 146,284 | 146,170 | -114 | 0.00 | 0.00 | +0.00 | sell |
| US BANCORP \DE\ | 180 | 0 | -180 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 355 | 0 | -355 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 371 | 0 | -371 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 3,943 | 3,547 | -396 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 40,504 | 40,063 | -441 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 17,920 | 17,258 | -662 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 21,097 | 20,410 | -687 | 0.00 | 0.00 | +0.00 | sell |
| Quantbot Technologies LP | 2,700 | 1,925 | -775 | 0.00 | 0.00 | +0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 17,561 | 16,400 | -1,161 | 0.00 | 0.00 | +0.00 | sell |