| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 1,049,699 | 3,112,786 | +2,063,087 | 0.03 | 0.39 | +0.35 | buy |
| Frazier Life Sciences Management, L.P. | 849,022 | 2,667,203 | +1,818,181 | 0.32 | 1.56 | +1.24 | buy |
| Parkman Healthcare Partners LLC | 473,312 | 651,625 | +178,313 | 0.50 | 1.01 | +0.51 | buy |
| Granahan Investment Management, LLC | 939,127 | 1,074,908 | +135,781 | 0.19 | 0.39 | +0.20 | buy |
| JANUS HENDERSON GROUP PLC | 1,120,767 | 1,215,013 | +94,246 | 0.00 | 0.01 | 0.00 | buy |
| Pale Fire Capital SE | 15,645 | 98,449 | +82,804 | 0.01 | 0.17 | +0.16 | buy |
| Woodline Partners LP | 360,093 | 404,212 | +44,119 | 0.02 | 0.05 | +0.02 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 139,858 | 114,685 | +25,173 | 0.02 | 0.09 | 0.00 | sell |
| Candriam S.C.A. | 298,000 | 308,000 | +10,000 | 0.01 | 0.02 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 1,634 | 7,338 | +5,704 | 0.00 | 0.02 | +0.01 | buy |
| Corton Capital Inc. | 17,044 | 20,218 | +3,174 | 0.05 | 0.07 | +0.02 | buy |
| Quantum Private Wealth, LLC | 61,719 | 63,219 | +1,500 | 0.17 | 0.29 | +0.12 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 61,394 | 61,384 | -10 | 0.01 | 0.01 | +0.01 | sell |
| ALPS ADVISORS INC | 46,874 | 43,226 | -3,648 | 0.00 | 0.00 | +0.00 | sell |
| DAFNA Capital Management LLC | 519,384 | 449,384 | -70,000 | 0.93 | 1.18 | +0.25 | sell |
| Opaleye Management Inc. | 875,405 | 699,000 | -176,405 | 1.63 | 2.03 | +0.40 | sell |
| Deep Track Capital, LP | 2,750,000 | 2,537,176 | -212,824 | 0.61 | 0.97 | +0.36 | sell |
| Cormorant Asset Management, LP | 2,946,887 | 2,551,989 | -394,898 | 0.98 | 1.33 | +0.35 | sell |