| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 15,021,721 | 15,021,721 | 0 | 7.34 | 8.33 | +0.99 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 8,909,091 | 8,909,091 | 0 | 2.74 | 3.17 | +0.42 | hold |
| BlackRock, Inc. | 6,393,567 | 6,479,015 | +85,448 | 0.00 | 0.00 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 5,840,059 | 6,155,940 | +315,881 | 1.62 | 1.76 | +0.14 | buy |
| Novo Holdings A/S | 5,549,900 | 5,000,000 | -549,900 | 7.36 | 8.08 | +0.73 | sell |
| JANUS HENDERSON GROUP PLC | 4,558,519 | 4,983,940 | +425,421 | 0.06 | 0.07 | +0.01 | buy |
| Paradigm Biocapital Advisors LP | 2,789,172 | 4,493,929 | +1,704,757 | 2.61 | 4.17 | +1.57 | buy |
| VANGUARD GROUP INC | 4,516,063 | 4,466,849 | -49,214 | 0.00 | 0.00 | -0.00 | sell |
| Cormorant Asset Management, LP | 3,406,534 | 3,406,534 | 0 | 4.82 | 5.00 | +0.17 | hold |
| PERCEPTIVE ADVISORS LLC | 2,330,294 | 2,685,537 | +355,243 | 1.33 | 2.00 | +0.66 | buy |
| BRAIDWELL LP | 1,958,310 | 2,332,196 | +373,886 | 1.48 | 1.85 | +0.36 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,781,006 | 2,078,509 | +297,503 | 0.71 | 1.06 | +0.35 | buy |
| STATE STREET CORP | 1,685,115 | 1,715,545 | +30,430 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,599,535 | 1,600,571 | +1,036 | 0.00 | 0.00 | -0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,953,424 | 1,493,791 | -459,633 | 0.45 | 0.33 | -0.12 | sell |
| Bellevue Group AG | 1,428,929 | 1,428,929 | 0 | 0.62 | 0.73 | +0.12 | hold |
| Frazier Life Sciences Management, L.P. | 2,832,867 | 1,271,245 | -1,561,622 | 3.03 | 1.41 | -1.62 | sell |
| VIKING GLOBAL INVESTORS LP | 1,481,146 | 1,224,986 | -256,160 | 0.14 | 0.11 | -0.04 | sell |
| MPM BioImpact LLC | 917,166 | 1,079,316 | +162,150 | 3.67 | 4.09 | +0.42 | buy |
| Artisan Partners Limited Partnership | 1,000,632 | 1,071,596 | +70,964 | 0.04 | 0.04 | +0.00 | buy |
| New Leaf Venture Partners, L.L.C. | 1,553,661 | 1,030,161 | -523,500 | 42.62 | 36.77 | -5.85 | sell |
| MILLENNIUM MANAGEMENT LLC | 987,030 | 888,968 | -98,062 | 0.02 | 0.02 | -0.00 | sell |
| First Light Asset Management, LLC | 0 | 780,639 | +780,639 | 0.00 | 1.99 | +1.99 | buy |
| AMERICAN CENTURY COMPANIES INC | 934,387 | 770,353 | -164,034 | 0.01 | 0.01 | -0.00 | sell |
| Siren, L.L.C. | 404,113 | 734,343 | +330,230 | 0.54 | 0.87 | +0.33 | buy |
| DIMENSIONAL FUND ADVISORS LP | 726,871 | 729,923 | +3,052 | 0.00 | 0.00 | -0.00 | buy |
| Deep Track Capital, LP | 1,100,536 | 710,421 | -390,115 | 0.94 | 0.71 | -0.23 | sell |
| D. E. Shaw & Co., Inc. | 455,348 | 686,371 | +231,023 | 0.02 | 0.02 | +0.00 | buy |
| NORTHERN TRUST CORP | 575,880 | 611,306 | +35,426 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 527,839 | 567,218 | +39,379 | 0.12 | 0.10 | -0.02 | buy |
| Integral Health Asset Management, LLC | 0 | 550,000 | +550,000 | 0.00 | 1.30 | +1.30 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 522,086 | 537,359 | +15,273 | 0.00 | 0.00 | -0.00 | buy |
| Opaleye Management Inc. | 522,500 | 480,000 | -42,500 | 2.33 | 2.24 | -0.08 | sell |
| CITADEL ADVISORS LLC | 538,249 | 469,451 | -68,798 | 0.01 | 0.01 | -0.00 | sell |
| MORGAN STANLEY | 418,131 | 436,430 | +18,299 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 384,767 | 402,773 | +18,006 | 0.85 | 0.79 | -0.06 | buy |
| Logos Global Management LP | 450,000 | 400,000 | -50,000 | 1.35 | 1.25 | -0.10 | sell |
| Parkman Healthcare Partners LLC | 657,070 | 381,173 | -275,897 | 2.24 | 1.36 | -0.88 | sell |
| Qube Research & Technologies Ltd | 131,892 | 369,442 | +237,550 | 0.01 | 0.02 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 482,225 | 346,891 | -135,334 | 0.00 | 0.00 | -0.00 | sell |
| Amundi | 150,420 | 341,687 | +191,267 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 301,241 | +301,241 | 0.00 | 0.01 | +0.01 | buy |
| Granahan Investment Management, LLC | 511,905 | 300,013 | -211,892 | 0.54 | 0.33 | -0.20 | sell |
| TANG CAPITAL MANAGEMENT LLC | 0 | 300,000 | +300,000 | 0.00 | 0.53 | +0.53 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 307,842 | 284,148 | -23,694 | 0.01 | 0.01 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 84,294 | 279,125 | +194,831 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 217,882 | 275,837 | +57,955 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 545,546 | 268,509 | -277,037 | 0.12 | 0.05 | -0.07 | sell |
| Candriam S.C.A. | 294,624 | 253,965 | -40,659 | 0.05 | 0.04 | -0.01 | sell |
| FMR LLC | 653,208 | 248,036 | -405,172 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 21,509 | 240,000 | +218,491 | 0.00 | 0.01 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 227,023 | 236,642 | +9,619 | 0.13 | 0.14 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 219,549 | +219,549 | 0.00 | 0.10 | +0.10 | buy |
| Bank of New York Mellon Corp | 210,772 | 211,056 | +284 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 205,321 | 202,893 | -2,428 | 0.00 | 0.00 | +0.00 | sell |
| Walleye Capital LLC | 242,251 | 198,662 | -43,589 | 0.07 | 0.05 | -0.02 | sell |
| MOODY ALDRICH PARTNERS LLC | 151,157 | 187,932 | +36,775 | 0.73 | 0.93 | +0.20 | buy |
| DAFNA Capital Management LLC | 227,906 | 187,140 | -40,766 | 1.44 | 1.27 | -0.17 | sell |
| Soleus Capital Management, L.P. | 0 | 183,300 | +183,300 | 0.00 | 0.37 | +0.37 | buy |
| Aberdeen Group plc | 256,645 | 178,043 | -78,602 | 0.01 | 0.01 | -0.00 | sell |
| BARCLAYS PLC | 119,350 | 133,657 | +14,307 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 19,900 | 132,706 | +112,806 | 0.16 | 0.89 | +0.73 | buy |
| TWO SIGMA INVESTMENTS, LP | 261,458 | 131,667 | -129,791 | 0.02 | 0.01 | -0.01 | sell |
| JPMORGAN CHASE & CO | 158,506 | 124,435 | -34,071 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 9,400 | 110,259 | +100,859 | 0.01 | 0.07 | +0.06 | buy |
| J. Goldman & Co LP | 11,466 | 107,278 | +95,812 | 0.01 | 0.10 | +0.09 | buy |
| Point72 Asset Management, L.P. | 0 | 106,562 | +106,562 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 100,872 | 102,397 | +1,525 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 93,061 | +93,061 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 75,305 | 92,066 | +16,761 | 0.00 | 0.00 | -0.00 | buy |
| Informed Momentum Co LLC | 125,184 | 91,333 | -33,851 | 0.50 | 0.35 | -0.15 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 63,000 | 87,658 | +24,658 | 1.36 | 2.35 | +0.99 | buy |
| Ally Bridge Group (NY) LLC | 187,695 | 83,176 | -104,519 | 2.68 | 1.90 | -0.78 | sell |
| HighVista Strategies LLC | 88,838 | 82,732 | -6,106 | 0.82 | 0.82 | +0.00 | sell |
| Exome Asset Management LLC | 59,900 | 81,473 | +21,573 | 1.08 | 1.64 | +0.56 | buy |
| Ensign Peak Advisors, Inc | 0 | 80,509 | +80,509 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 80,000 | 80,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Harvest Investment Services, LLC | 0 | 79,381 | +79,381 | 0.00 | 0.52 | +0.52 | buy |
| CITIGROUP INC | 75,841 | 78,497 | +2,656 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 75,960 | 77,260 | +1,300 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 68,906 | 76,567 | +7,661 | 0.01 | 0.01 | +0.00 | buy |
| Trexquant Investment LP | 0 | 74,781 | +74,781 | 0.00 | 0.02 | +0.02 | buy |
| BRIDGER MANAGEMENT, LLC | 74,700 | 74,700 | 0 | 1.00 | 1.07 | +0.07 | hold |
| Swiss National Bank | 73,600 | 73,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Quantum Private Wealth, LLC | 73,424 | 73,524 | +100 | 0.66 | 0.63 | -0.04 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 67,082 | 71,366 | +4,284 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 157,579 | 64,279 | -93,300 | 0.10 | 0.03 | -0.08 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 71,784 | 61,521 | -10,263 | 0.00 | 0.00 | -0.00 | sell |
| BAMCO INC /NY/ | 0 | 60,000 | +60,000 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 131,806 | 55,178 | -76,628 | 0.07 | 0.03 | -0.04 | sell |
| SEI INVESTMENTS CO | 52,610 | 52,178 | -432 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 43,657 | 50,292 | +6,635 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 74,030 | 50,130 | -23,900 | 0.07 | 0.04 | -0.03 | sell |
| BANK OF AMERICA CORP /DE/ | 308,051 | 48,907 | -259,144 | 0.00 | 0.00 | -0.00 | sell |
| NORGES BANK | 47,755 | 47,755 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Verition Fund Management LLC | 0 | 46,391 | +46,391 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 42,271 | 44,612 | +2,341 | 0.01 | 0.01 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 35,613 | 43,809 | +8,196 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 64,776 | 43,435 | -21,341 | 0.00 | 0.00 | -0.00 | sell |
| EFG Asset Management (North America) Corp. | 0 | 41,338 | +41,338 | 0.00 | 0.15 | +0.15 | buy |