| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 2,789,172 | 4,493,929 | +1,704,757 | 2.61 | 4.17 | +1.57 | buy |
| JANUS HENDERSON GROUP PLC | 4,558,519 | 4,983,940 | +425,421 | 0.06 | 0.07 | 0.00 | buy |
| BRAIDWELL LP | 1,958,310 | 2,332,196 | +373,886 | 1.48 | 1.85 | +0.36 | buy |
| PERCEPTIVE ADVISORS LLC | 2,330,294 | 2,685,537 | +355,243 | 1.32 | 1.98 | +0.66 | buy |
| Siren, L.L.C. | 404,113 | 734,343 | +330,230 | 0.54 | 0.87 | +0.33 | buy |
| BAKER BROS. ADVISORS LP | 5,840,059 | 6,155,940 | +315,881 | 1.62 | 1.76 | +0.14 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,781,006 | 2,078,509 | +297,503 | 0.71 | 1.05 | +0.34 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 21,509 | 240,000 | +218,491 | 0.00 | 0.01 | +0.01 | buy |
| MPM BioImpact LLC | 917,166 | 1,079,316 | +162,150 | 3.67 | 4.09 | +0.42 | buy |
| STEMPOINT CAPITAL LP | 19,900 | 132,706 | +112,806 | 0.16 | 0.89 | +0.73 | buy |
| J. Goldman & Co LP | 11,466 | 107,278 | +95,812 | 0.01 | 0.07 | +0.07 | buy |
| Artisan Partners Limited Partnership | 1,000,632 | 1,071,596 | +70,964 | 0.04 | 0.04 | +0.00 | buy |
| Woodline Partners LP | 527,839 | 567,218 | +39,379 | 0.12 | 0.10 | -0.02 | buy |
| MOODY ALDRICH PARTNERS LLC | 151,157 | 187,932 | +36,775 | 0.73 | 0.93 | +0.20 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 63,000 | 87,658 | +24,658 | 1.36 | 2.35 | +0.99 | buy |
| Exome Asset Management LLC | 59,900 | 81,473 | +21,573 | 1.08 | 1.64 | +0.56 | buy |
| Sofinnova Investments, Inc. | 384,767 | 402,773 | +18,006 | 0.82 | 0.78 | -0.03 | buy |
| Brevan Howard Capital Management LP | 11,251 | 25,346 | +14,095 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 227,023 | 236,642 | +9,619 | 0.13 | 0.14 | +0.01 | buy |
| ALPS ADVISORS INC | 68,906 | 76,567 | +7,661 | 0.01 | 0.01 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 29,293 | 33,164 | +3,871 | 0.06 | 0.08 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 18,035 | 20,077 | +2,042 | 0.05 | 0.05 | -0.00 | buy |
| Quarry LP | 3,500 | 2,000 | +1,500 | 0.03 | 0.01 | 0.00 | sell |
| PROFUND ADVISORS LLC | 15,245 | 14,945 | +300 | 0.02 | 0.01 | 0.00 | sell |
| Quantum Private Wealth, LLC | 73,424 | 73,524 | +100 | 0.66 | 0.63 | -0.04 | buy |
| BFSG, LLC | 600 | 300 | -300 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 5,145 | 2,526 | -2,619 | 0.06 | 0.03 | -0.04 | sell |
| HighVista Strategies LLC | 88,838 | 82,732 | -6,106 | 0.82 | 0.82 | +0.00 | sell |
| Crestline Management, LP | 26,981 | 13,268 | -13,713 | 0.04 | 0.01 | -0.03 | sell |
| Cinctive Capital Management LP | 46,249 | 14,093 | -32,156 | 0.07 | 0.02 | -0.05 | sell |
| Informed Momentum Co LLC | 125,184 | 91,333 | -33,851 | 0.50 | 0.35 | -0.15 | sell |
| DAFNA Capital Management LLC | 227,906 | 187,140 | -40,766 | 1.44 | 1.27 | -0.17 | sell |
| Opaleye Management Inc. | 522,500 | 480,000 | -42,500 | 2.33 | 2.24 | -0.08 | sell |
| Logos Global Management LP | 450,000 | 400,000 | -50,000 | 1.35 | 1.25 | -0.10 | sell |
| Candriam S.C.A. | 329,000 | 253,965 | -75,035 | 0.04 | 0.04 | +0.00 | sell |
| Aberdeen Group plc | 256,645 | 178,043 | -78,602 | 0.01 | 0.01 | -0.00 | sell |
| Polar Asset Management Partners Inc. | 157,579 | 64,279 | -93,300 | 0.09 | 0.02 | -0.07 | sell |
| Ally Bridge Group (NY) LLC | 187,695 | 83,176 | -104,519 | 2.68 | 1.90 | -0.78 | sell |
| Granahan Investment Management, LLC | 511,905 | 300,013 | -211,892 | 0.54 | 0.33 | -0.20 | sell |
| VIKING GLOBAL INVESTORS LP | 1,481,146 | 1,224,986 | -256,160 | 0.14 | 0.11 | -0.04 | sell |
| Parkman Healthcare Partners LLC | 657,070 | 381,173 | -275,897 | 2.24 | 1.36 | -0.88 | sell |
| Deep Track Capital, LP | 1,100,536 | 710,421 | -390,115 | 0.94 | 0.71 | -0.23 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,953,424 | 1,493,791 | -459,633 | 0.45 | 0.33 | -0.12 | sell |
| New Leaf Venture Partners, L.L.C. | 1,553,661 | 1,030,161 | -523,500 | 42.62 | 36.77 | -5.85 | sell |
| Novo Holdings A/S | 5,549,900 | 5,000,000 | -549,900 | 7.36 | 8.08 | +0.73 | sell |
| Frazier Life Sciences Management, L.P. | 2,832,867 | 1,271,245 | -1,561,622 | 3.03 | 1.41 | -1.62 | sell |