| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 2,789,172 | 4,493,929 | +1,704,757 | 2.61 | 4.17 | +1.57 | buy |
| First Light Asset Management, LLC | 0 | 780,639 | +780,639 | 0.00 | 1.99 | +1.99 | buy |
| Integral Health Asset Management, LLC | 0 | 550,000 | +550,000 | 0.00 | 1.30 | +1.30 | buy |
| JANUS HENDERSON GROUP PLC | 4,558,519 | 4,983,940 | +425,421 | 0.06 | 0.07 | +0.01 | buy |
| BRAIDWELL LP | 1,958,310 | 2,332,196 | +373,886 | 1.48 | 1.85 | +0.36 | buy |
| PERCEPTIVE ADVISORS LLC | 2,330,294 | 2,685,537 | +355,243 | 1.33 | 2.00 | +0.66 | buy |
| Siren, L.L.C. | 404,113 | 734,343 | +330,230 | 0.54 | 0.87 | +0.33 | buy |
| BAKER BROS. ADVISORS LP | 5,840,059 | 6,155,940 | +315,881 | 1.62 | 1.76 | +0.14 | buy |
| Pictet Asset Management Holding SA | 0 | 301,241 | +301,241 | 0.00 | 0.01 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 300,000 | +300,000 | 0.00 | 0.53 | +0.53 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,781,006 | 2,078,509 | +297,503 | 0.71 | 1.06 | +0.35 | buy |
| Qube Research & Technologies Ltd | 131,892 | 369,442 | +237,550 | 0.01 | 0.02 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 455,348 | 686,371 | +231,023 | 0.02 | 0.02 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 219,549 | +219,549 | 0.00 | 0.10 | +0.10 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 21,509 | 240,000 | +218,491 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 84,294 | 279,125 | +194,831 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 150,420 | 341,687 | +191,267 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 183,300 | +183,300 | 0.00 | 0.37 | +0.37 | buy |
| MPM BioImpact LLC | 917,166 | 1,079,316 | +162,150 | 3.67 | 4.09 | +0.42 | buy |
| STEMPOINT CAPITAL LP | 19,900 | 132,706 | +112,806 | 0.16 | 0.89 | +0.73 | buy |
| Point72 Asset Management, L.P. | 0 | 106,562 | +106,562 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 9,400 | 110,259 | +100,859 | 0.01 | 0.07 | +0.06 | buy |
| J. Goldman & Co LP | 11,466 | 107,278 | +95,812 | 0.01 | 0.10 | +0.09 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 93,061 | +93,061 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 6,393,567 | 6,479,015 | +85,448 | 0.00 | 0.00 | -0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 80,509 | +80,509 | 0.00 | 0.00 | +0.00 | buy |
| Harvest Investment Services, LLC | 0 | 79,381 | +79,381 | 0.00 | 0.52 | +0.52 | buy |
| Trexquant Investment LP | 0 | 74,781 | +74,781 | 0.00 | 0.02 | +0.02 | buy |
| Artisan Partners Limited Partnership | 1,000,632 | 1,071,596 | +70,964 | 0.04 | 0.04 | +0.00 | buy |
| BAMCO INC /NY/ | 0 | 60,000 | +60,000 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 217,882 | 275,837 | +57,955 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 46,391 | +46,391 | 0.00 | 0.01 | +0.01 | buy |
| EFG Asset Management (North America) Corp. | 0 | 41,338 | +41,338 | 0.00 | 0.15 | +0.15 | buy |
| Woodline Partners LP | 527,839 | 567,218 | +39,379 | 0.12 | 0.10 | -0.02 | buy |
| MOODY ALDRICH PARTNERS LLC | 151,157 | 187,932 | +36,775 | 0.73 | 0.93 | +0.20 | buy |
| NORTHERN TRUST CORP | 575,880 | 611,306 | +35,426 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 33,082 | +33,082 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 33,079 | +33,079 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,685,115 | 1,715,545 | +30,430 | 0.00 | 0.00 | -0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 63,000 | 87,658 | +24,658 | 1.36 | 2.35 | +0.99 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 23,364 | +23,364 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 22,584 | +22,584 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 0 | 21,800 | +21,800 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 59,900 | 81,473 | +21,573 | 1.08 | 1.64 | +0.56 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 21,568 | +21,568 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 21,362 | +21,362 | 0.00 | 0.02 | +0.02 | buy |
| MORGAN STANLEY | 418,131 | 436,430 | +18,299 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 384,767 | 402,773 | +18,006 | 0.85 | 0.79 | -0.06 | buy |
| UBS Group AG | 75,305 | 92,066 | +16,761 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 522,086 | 537,359 | +15,273 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 19,900 | 34,844 | +14,944 | 0.01 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 119,350 | 133,657 | +14,307 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 11,251 | 25,346 | +14,095 | 0.01 | 0.02 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 11,593 | +11,593 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 22,357 | 33,918 | +11,561 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 16,629 | 26,358 | +9,729 | 0.00 | 0.00 | +0.00 | buy |
| Neo Ivy Capital Management | 0 | 9,720 | +9,720 | 0.00 | 0.05 | +0.05 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 227,023 | 236,642 | +9,619 | 0.13 | 0.14 | +0.01 | buy |
| BI Asset Management Fondsmaeglerselskab A/S | 0 | 8,853 | +8,853 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 35,613 | 43,809 | +8,196 | 0.01 | 0.01 | +0.00 | buy |
| ALPS ADVISORS INC | 68,906 | 76,567 | +7,661 | 0.01 | 0.01 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 6,889 | +6,889 | 0.00 | 0.02 | +0.02 | buy |
| Legal & General Group Plc | 43,657 | 50,292 | +6,635 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 19,259 | 24,928 | +5,669 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 23,808 | 29,050 | +5,242 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 67,082 | 71,366 | +4,284 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 29,293 | 33,164 | +3,871 | 0.06 | 0.07 | +0.01 | buy |
| Quantbot Technologies LP | 0 | 3,855 | +3,855 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 11,117 | 14,678 | +3,561 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 307 | 3,676 | +3,369 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 726,871 | 729,923 | +3,052 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 2,894 | +2,894 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 75,841 | 78,497 | +2,656 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 15,899 | 18,415 | +2,516 | 0.01 | 0.02 | +0.00 | buy |
| MetLife Investment Management, LLC | 42,271 | 44,612 | +2,341 | 0.01 | 0.01 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 18,035 | 20,077 | +2,042 | 0.05 | 0.05 | -0.00 | buy |
| HSBC HOLDINGS PLC | 8,728 | 10,759 | +2,031 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 9,371 | 11,143 | +1,772 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 38,410 | 40,170 | +1,760 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 39,718 | 41,313 | +1,595 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 100,872 | 102,397 | +1,525 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 75,960 | 77,260 | +1,300 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,599,535 | 1,600,571 | +1,036 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 7,112 | 7,594 | +482 | 0.01 | 0.01 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 476 | +476 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 8,946 | 9,366 | +420 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 210,772 | 211,056 | +284 | 0.00 | 0.00 | -0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 229 | +229 | 0.00 | 0.00 | +0.00 | buy |
| Bleakley Financial Group, LLC | 9,899 | 10,080 | +181 | 0.01 | 0.01 | +0.00 | buy |
| HighMark Wealth Management LLC | 0 | 165 | +165 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 108 | +108 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 10,758 | 10,863 | +105 | 0.00 | 0.00 | -0.00 | buy |
| Quantum Private Wealth, LLC | 73,424 | 73,524 | +100 | 0.66 | 0.63 | -0.04 | buy |
| NISA INVESTMENT ADVISORS, LLC | 982 | 1,049 | +67 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 1,288 | 1,321 | +33 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 70 | 90 | +20 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 20 | 26 | +6 | 0.00 | 0.00 | -0.00 | buy |
| Parallel Advisors, LLC | 133 | 136 | +3 | 0.00 | 0.00 | -0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 1 | 3 | +2 | 0.00 | 0.00 | +0.00 | buy |