| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 15,518,492 | 15,518,492 | 0 | 6.04 | 7.88 | +1.84 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 10,428,437 | 10,428,437 | 0 | 2.08 | 2.65 | +0.57 | hold |
| BlackRock, Inc. | 6,351,487 | 6,630,576 | +279,089 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 7,305,940 | 6,575,940 | -730,000 | 0.86 | 0.96 | +0.10 | sell |
| Paradigm Biocapital Advisors LP | 6,170,131 | 6,541,210 | +371,079 | 2.96 | 4.35 | +1.38 | buy |
| Novo Holdings A/S | 5,350,000 | 5,350,000 | 0 | 5.59 | 10.31 | +4.72 | hold |
| BRAIDWELL LP | 5,210,831 | 5,210,831 | 0 | 2.51 | 4.14 | +1.63 | hold |
| VANGUARD GROUP INC | 4,803,941 | 4,871,624 | +67,683 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 4,979,331 | 4,566,850 | -412,481 | 0.04 | 0.05 | +0.01 | sell |
| Siren, L.L.C. | 3,897,099 | 4,529,990 | +632,891 | 2.47 | 3.35 | +0.88 | buy |
| PERCEPTIVE ADVISORS LLC | 3,795,894 | 4,457,974 | +662,080 | 1.78 | 2.03 | +0.25 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,228,285 | 4,191,193 | +1,962,908 | 0.26 | 0.71 | +0.45 | buy |
| Cormorant Asset Management, LP | 4,010,000 | 3,285,000 | -725,000 | 4.49 | 4.62 | +0.13 | sell |
| MORGAN STANLEY | 869,678 | 2,910,881 | +2,041,203 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 114,128 | 2,117,073 | +2,002,945 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,717,641 | 1,746,222 | +28,581 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,699,909 | 1,717,343 | +17,434 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 1,720,741 | 1,655,256 | -65,485 | 4.57 | 4.70 | +0.13 | sell |
| First Light Asset Management, LLC | 1,414,994 | 1,573,701 | +158,707 | 2.16 | 2.99 | +0.82 | buy |
| Bellevue Group AG | 2,775,997 | 1,528,518 | -1,247,479 | 0.94 | 0.72 | -0.22 | sell |
| Integral Health Asset Management, LLC | 1,500,000 | 1,500,000 | 0 | 1.77 | 1.89 | +0.11 | hold |
| BANK OF AMERICA CORP /DE/ | 321,132 | 1,474,797 | +1,153,665 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,183,136 | 1,213,657 | +30,521 | 0.00 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,095,473 | 1,186,467 | +90,994 | 0.01 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 77,260 | 1,036,170 | +958,910 | 0.00 | 0.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 0 | 910,000 | +910,000 | 0.00 | 0.96 | +0.96 | buy |
| Aberdeen Group plc | 619,878 | 821,940 | +202,062 | 0.02 | 0.03 | +0.02 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 765,694 | 765,694 | 0 | 0.19 | 0.24 | +0.05 | hold |
| NORGES BANK | 0 | 751,355 | +751,355 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 498,646 | 746,562 | +247,916 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 527,827 | 718,372 | +190,545 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 718,175 | 704,077 | -14,098 | 0.02 | 0.03 | +0.01 | sell |
| FMR LLC | 253,325 | 692,955 | +439,630 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 681,921 | +681,921 | 0.00 | 0.02 | +0.02 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 640,400 | +640,400 | 0.00 | 0.03 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 597,603 | 611,384 | +13,781 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 568,310 | 568,310 | 0 | 0.15 | 0.22 | +0.07 | hold |
| NORTHERN TRUST CORP | 587,882 | 559,649 | -28,233 | 0.00 | 0.00 | +0.00 | sell |
| Candriam S.C.A. | 221,159 | 501,214 | +280,055 | 0.02 | 0.06 | +0.04 | buy |
| Opaleye Management Inc. | 500,000 | 500,000 | 0 | 1.15 | 1.64 | +0.49 | hold |
| Sofinnova Investments, Inc. | 520,240 | 437,819 | -82,421 | 0.52 | 0.47 | -0.05 | sell |
| Parkman Healthcare Partners LLC | 550,173 | 427,690 | -122,483 | 0.98 | 1.01 | +0.03 | sell |
| D. E. Shaw & Co., Inc. | 677,561 | 394,695 | -282,866 | 0.01 | 0.01 | -0.00 | sell |
| BARCLAYS PLC | 234,650 | 372,738 | +138,088 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 360,876 | +360,876 | 0.00 | 1.54 | +1.54 | buy |
| Eversept Partners, LP | 502,234 | 337,340 | -164,894 | 0.62 | 0.47 | -0.15 | sell |
| Qube Research & Technologies Ltd | 555,713 | 296,208 | -259,505 | 0.01 | 0.01 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 132,503 | 271,385 | +138,882 | 0.00 | 0.01 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 250,622 | 241,509 | -9,113 | 0.09 | 0.13 | +0.04 | sell |
| Sio Capital Management, LLC | 307,181 | 237,481 | -69,700 | 1.26 | 0.98 | -0.28 | sell |
| Granahan Investment Management, LLC | 339,617 | 232,295 | -107,322 | 0.23 | 0.25 | +0.02 | sell |
| Woodline Partners LP | 224,190 | 224,192 | +2 | 0.02 | 0.02 | +0.00 | buy |
| CITIGROUP INC | 538,453 | 223,294 | -315,159 | 0.01 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 154,896 | 214,769 | +59,873 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 202,297 | +202,297 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 204,242 | 198,614 | -5,628 | 0.00 | 0.00 | +0.00 | sell |
| Ally Bridge Group (NY) LLC | 0 | 195,000 | +195,000 | 0.00 | 7.68 | +7.68 | buy |
| HighVista Strategies LLC | 208,101 | 171,137 | -36,964 | 0.83 | 1.09 | +0.27 | sell |
| Nuveen, LLC | 172,707 | 169,466 | -3,241 | 0.00 | 0.00 | +0.00 | sell |
| DAFNA Capital Management LLC | 213,736 | 159,736 | -54,000 | 0.86 | 0.92 | +0.06 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 151,905 | +151,905 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 68,720 | 146,038 | +77,318 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 151,062 | 145,286 | -5,776 | 0.00 | 0.00 | +0.00 | sell |
| Neuberger Berman Group LLC | 219,646 | 127,136 | -92,510 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 725,425 | 126,436 | -598,989 | 0.01 | 0.00 | -0.01 | sell |
| CITADEL ADVISORS LLC | 22,317 | 123,097 | +100,780 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 113,856 | +113,856 | 0.00 | 0.03 | +0.03 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 114,531 | 111,387 | -3,144 | 0.00 | 0.00 | +0.00 | sell |
| Quantum Private Wealth, LLC | 105,874 | 106,024 | +150 | 0.50 | 0.77 | +0.27 | buy |
| Swiss National Bank | 101,900 | 103,900 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 173,439 | 100,046 | -73,393 | 1.86 | 1.23 | -0.63 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 139,112 | 98,063 | -41,049 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 40,000 | 90,999 | +50,999 | 0.06 | 0.17 | +0.10 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 83,437 | 88,937 | +5,500 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 9,881 | 88,723 | +78,842 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 51,112 | 86,929 | +35,817 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 104,829 | 85,075 | -19,754 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 59,256 | 82,096 | +22,840 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 80,000 | 80,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jump Financial, LLC | 80,825 | 79,915 | -910 | 0.02 | 0.02 | +0.01 | sell |
| WELLS FARGO & COMPANY/MN | 42,196 | 75,442 | +33,246 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 66,056 | 75,438 | +9,382 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 45,635 | 70,196 | +24,561 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 51,989 | 59,326 | +7,337 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 51,386 | 57,315 | +5,929 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 55,620 | +55,620 | 0.00 | 0.04 | +0.04 | buy |
| HighMark Wealth Management LLC | 53,179 | 53,179 | 0 | 0.38 | 0.54 | +0.16 | hold |
| Legal & General Group Plc | 55,941 | 52,747 | -3,194 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 26,266 | 50,848 | +24,582 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 50,793 | 50,392 | -401 | 0.00 | 0.00 | +0.00 | sell |
| FRANKLIN RESOURCES INC | 48,220 | 43,145 | -5,075 | 0.00 | 0.00 | +0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 82,941 | 43,134 | -39,807 | 0.26 | 0.20 | -0.06 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 42,052 | +42,052 | 0.00 | 0.15 | +0.15 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 49,205 | 41,584 | -7,621 | 0.06 | 0.08 | +0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 36,619 | 39,997 | +3,378 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 12,417 | 39,648 | +27,231 | 0.00 | 0.00 | +0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 0 | 38,676 | +38,676 | 0.00 | 0.05 | +0.05 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 0 | 38,343 | +38,343 | 0.00 | 0.62 | +0.62 | buy |
| MetLife Investment Management, LLC | 43,883 | 38,291 | -5,592 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35,538 | 36,759 | +1,221 | 0.00 | 0.00 | +0.00 | buy |