| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 869,678 | 2,910,881 | +2,041,203 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 114,128 | 2,117,073 | +2,002,945 | 0.00 | 0.01 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,228,285 | 4,191,193 | +1,962,908 | 0.26 | 0.71 | +0.45 | buy |
| BANK OF AMERICA CORP /DE/ | 321,132 | 1,474,797 | +1,153,665 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 77,260 | 1,036,170 | +958,910 | 0.00 | 0.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 0 | 910,000 | +910,000 | 0.00 | 0.96 | +0.96 | buy |
| NORGES BANK | 0 | 751,355 | +751,355 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 681,921 | +681,921 | 0.00 | 0.02 | +0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 3,795,894 | 4,457,974 | +662,080 | 1.78 | 2.03 | +0.25 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 640,400 | +640,400 | 0.00 | 0.03 | +0.03 | buy |
| Siren, L.L.C. | 3,897,099 | 4,529,990 | +632,891 | 2.47 | 3.35 | +0.88 | buy |
| FMR LLC | 253,325 | 692,955 | +439,630 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 6,170,131 | 6,541,210 | +371,079 | 2.96 | 4.35 | +1.38 | buy |
| STEMPOINT CAPITAL LP | 0 | 360,876 | +360,876 | 0.00 | 1.54 | +1.54 | buy |
| Candriam S.C.A. | 221,159 | 501,214 | +280,055 | 0.02 | 0.06 | +0.04 | buy |
| BlackRock, Inc. | 6,351,487 | 6,630,576 | +279,089 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 498,646 | 746,562 | +247,916 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 202,297 | +202,297 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 619,878 | 821,940 | +202,062 | 0.02 | 0.03 | +0.02 | buy |
| Ally Bridge Group (NY) LLC | 0 | 195,000 | +195,000 | 0.00 | 7.68 | +7.68 | buy |
| GOLDMAN SACHS GROUP INC | 527,827 | 718,372 | +190,545 | 0.00 | 0.00 | +0.00 | buy |
| First Light Asset Management, LLC | 1,414,994 | 1,573,701 | +158,707 | 2.16 | 2.99 | +0.82 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 151,905 | +151,905 | 0.00 | 0.01 | +0.01 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 132,503 | 271,385 | +138,882 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 234,650 | 372,738 | +138,088 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 113,856 | +113,856 | 0.00 | 0.03 | +0.03 | buy |
| CITADEL ADVISORS LLC | 22,317 | 123,097 | +100,780 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,095,473 | 1,186,467 | +90,994 | 0.01 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 9,881 | 88,723 | +78,842 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 68,720 | 146,038 | +77,318 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 4,803,941 | 4,871,624 | +67,683 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 154,896 | 214,769 | +59,873 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 55,620 | +55,620 | 0.00 | 0.04 | +0.04 | buy |
| ADAR1 Capital Management, LLC | 40,000 | 90,999 | +50,999 | 0.06 | 0.17 | +0.10 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 42,052 | +42,052 | 0.00 | 0.15 | +0.15 | buy |
| Knights of Columbus Asset Advisors LLC | 0 | 38,676 | +38,676 | 0.00 | 0.05 | +0.05 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 0 | 38,343 | +38,343 | 0.00 | 0.62 | +0.62 | buy |
| ALPS ADVISORS INC | 51,112 | 86,929 | +35,817 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 0 | 33,591 | +33,591 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 42,196 | 75,442 | +33,246 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,183,136 | 1,213,657 | +30,521 | 0.00 | 0.01 | +0.00 | buy |
| DIADEMA PARTNERS LP | 0 | 30,000 | +30,000 | 0.00 | 0.44 | +0.44 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,717,641 | 1,746,222 | +28,581 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 12,417 | 39,648 | +27,231 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 26,266 | 50,848 | +24,582 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 45,635 | 70,196 | +24,561 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 59,256 | 82,096 | +22,840 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 21,204 | +21,204 | 0.00 | 0.25 | +0.25 | buy |
| LMR Partners LLP | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 17,978 | +17,978 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,699,909 | 1,717,343 | +17,434 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 14,184 | +14,184 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 597,603 | 611,384 | +13,781 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 13,746 | +13,746 | 0.00 | 0.00 | +0.00 | buy |
| Centiva Capital, LP | 0 | 12,500 | +12,500 | 0.00 | 0.02 | +0.02 | buy |
| GUGGENHEIM CAPITAL LLC | 0 | 10,571 | +10,571 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 9,849 | +9,849 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 66,056 | 75,438 | +9,382 | 0.00 | 0.00 | +0.00 | buy |
| Lion Point Capital, LP | 0 | 9,100 | +9,100 | 0.00 | 1.17 | +1.17 | buy |
| RAYMOND JAMES FINANCIAL INC | 13,379 | 21,609 | +8,230 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 8,177 | +8,177 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 51,989 | 59,326 | +7,337 | 0.01 | 0.01 | +0.00 | buy |
| Creative Planning | 18,036 | 24,468 | +6,432 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 51,386 | 57,315 | +5,929 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 5,800 | +5,800 | 0.00 | 0.02 | +0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 83,437 | 88,937 | +5,500 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 6,863 | 11,265 | +4,402 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 7,380 | 11,263 | +3,883 | 0.03 | 0.08 | +0.04 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 36,619 | 39,997 | +3,378 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 14,297 | 17,061 | +2,764 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 101,900 | 103,900 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 1,731 | +1,731 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 15,291 | 16,976 | +1,685 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 7,590 | 9,069 | +1,479 | 0.00 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35,538 | 36,759 | +1,221 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 29,179 | 30,389 | +1,210 | 0.00 | 0.01 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 4,073 | 5,145 | +1,072 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 774 | +774 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 710 | +710 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 10,600 | 11,300 | +700 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 2,304 | 2,854 | +550 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 95 | 626 | +531 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 489 | +489 | 0.00 | 0.00 | +0.00 | buy |
| Optimize Financial Inc | 27,283 | 27,679 | +396 | 0.23 | 0.35 | +0.12 | buy |
| NISA INVESTMENT ADVISORS, LLC | 874 | 1,162 | +288 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 163 | 448 | +285 | 0.00 | 0.00 | +0.00 | buy |
| EASTERN BANK | 0 | 223 | +223 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 521 | 728 | +207 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 1,158 | 1,354 | +196 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 182 | +182 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 152 | +152 | 0.00 | 0.00 | +0.00 | buy |
| Quantum Private Wealth, LLC | 105,874 | 106,024 | +150 | 0.50 | 0.77 | +0.27 | buy |
| CWM, LLC | 132 | 279 | +147 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 27 | 173 | +146 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 558 | 659 | +101 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 135 | 225 | +90 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 33 | 56 | +23 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 31,350 | 31,369 | +19 | 0.00 | 0.00 | +0.00 | buy |
| Bare Financial Services, Inc | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |