| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,228,285 | 4,191,193 | +1,962,908 | 0.26 | 0.71 | +0.45 | buy |
| PERCEPTIVE ADVISORS LLC | 3,795,894 | 4,457,974 | +662,080 | 1.78 | 1.97 | +0.19 | buy |
| Siren, L.L.C. | 3,897,099 | 4,529,990 | +632,891 | 2.47 | 3.35 | +0.88 | buy |
| Paradigm Biocapital Advisors LP | 6,170,131 | 6,541,210 | +371,079 | 2.96 | 4.35 | +1.38 | buy |
| Candriam S.C.A. | 221,159 | 501,214 | +280,055 | 0.02 | 0.06 | +0.04 | buy |
| Aberdeen Group plc | 619,878 | 821,940 | +202,062 | 0.02 | 0.03 | +0.02 | buy |
| First Light Asset Management, LLC | 1,414,994 | 1,573,701 | +158,707 | 2.16 | 2.99 | +0.82 | buy |
| ADAR1 Capital Management, LLC | 40,000 | 90,999 | +50,999 | 0.06 | 0.17 | +0.10 | buy |
| ALPS ADVISORS INC | 51,112 | 86,929 | +35,817 | 0.00 | 0.01 | 0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 151,062 | 145,286 | +5,776 | 0.00 | 0.00 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 7,380 | 11,263 | +3,883 | 0.03 | 0.08 | +0.04 | buy |
| Optimize Financial Inc | 27,283 | 27,679 | +396 | 0.23 | 0.35 | +0.12 | buy |
| Quantum Private Wealth, LLC | 105,874 | 106,024 | +150 | 0.50 | 0.77 | +0.27 | buy |
| PROFUND ADVISORS LLC | 11,809 | 11,825 | +16 | 0.01 | 0.01 | 0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,266 | 2,079 | -187 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 18,466 | 17,251 | -1,215 | 0.02 | 0.03 | +0.01 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 49,205 | 41,584 | -7,621 | 0.06 | 0.08 | +0.02 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 20,471 | 12,360 | -8,111 | 0.05 | 0.05 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 250,622 | 241,509 | -9,113 | 0.09 | 0.13 | +0.04 | sell |
| Artisan Partners Limited Partnership | 718,175 | 704,077 | -14,098 | 0.02 | 0.03 | +0.01 | sell |
| HighVista Strategies LLC | 208,101 | 171,137 | -36,964 | 0.83 | 1.09 | +0.27 | sell |
| MOODY ALDRICH PARTNERS LLC | 82,941 | 43,134 | -39,807 | 0.26 | 0.20 | -0.06 | sell |
| DAFNA Capital Management LLC | 213,736 | 159,736 | -54,000 | 0.86 | 0.92 | +0.06 | sell |
| MPM BioImpact LLC | 1,720,741 | 1,655,256 | -65,485 | 4.57 | 4.70 | +0.13 | sell |
| Sio Capital Management, LLC | 307,181 | 237,481 | -69,700 | 1.26 | 0.93 | -0.33 | sell |
| Exome Asset Management LLC | 173,439 | 100,046 | -73,393 | 1.86 | 1.23 | -0.63 | sell |
| Sofinnova Investments, Inc. | 520,240 | 437,819 | -82,421 | 0.46 | 0.47 | +0.01 | sell |
| Granahan Investment Management, LLC | 339,617 | 232,295 | -107,322 | 0.23 | 0.25 | +0.02 | sell |
| Parkman Healthcare Partners LLC | 550,173 | 427,690 | -122,483 | 0.98 | 1.01 | +0.03 | sell |
| Eversept Partners, LP | 502,234 | 337,340 | -164,894 | 0.56 | 0.42 | -0.14 | sell |
| Cormorant Asset Management, LP | 4,010,000 | 3,285,000 | -725,000 | 4.49 | 3.77 | -0.72 | sell |
| BAKER BROS. ADVISORS LP | 7,305,940 | 6,575,940 | -730,000 | 0.86 | 0.96 | +0.10 | sell |
| Bellevue Group AG | 2,775,997 | 1,528,518 | -1,247,479 | 0.94 | 0.72 | -0.22 | sell |