| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| STIFEL FINANCIAL CORP | 0 | 319,990 | +319,990 | 0.00 | 0.00 | +0.00 | buy |
| CANNELL CAPITAL LLC | 381,323 | 691,367 | +310,044 | 1.04 | 3.03 | +1.98 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 192,326 | 448,804 | +256,478 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 138,887 | 355,929 | +217,042 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 248,505 | 402,428 | +153,923 | 0.01 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 0 | 147,332 | +147,332 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 24,242 | 169,436 | +145,194 | 0.03 | 0.22 | +0.19 | buy |
| EcoR1 Capital, LLC | 1,829,603 | 1,939,288 | +109,685 | 0.97 | 1.49 | +0.52 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 193,100 | 274,000 | +80,900 | 0.00 | 0.01 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 11,043 | 78,213 | +67,170 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 64,795 | +64,795 | 0.00 | 0.00 | +0.00 | buy |
| THOMPSON SIEGEL & WALMSLEY LLC | 128,039 | 189,863 | +61,824 | 0.03 | 0.04 | +0.02 | buy |
| JPMORGAN CHASE & CO | 51,961 | 113,113 | +61,152 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 43,239 | 103,200 | +59,961 | 0.01 | 0.02 | +0.01 | buy |
| Nantahala Capital Management, LLC | 1,118,483 | 1,175,951 | +57,468 | 1.04 | 1.26 | +0.22 | buy |
| HRT FINANCIAL LP | 0 | 57,235 | +57,235 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 54,275 | +54,275 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 129,879 | 175,220 | +45,341 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 350 | 39,317 | +38,967 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 11,850 | 50,205 | +38,355 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,063,707 | 1,100,963 | +37,256 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 64,323 | 95,919 | +31,596 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 268,646 | 298,248 | +29,602 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 317,625 | 345,360 | +27,735 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 26,443 | +26,443 | 0.00 | 0.05 | +0.05 | buy |
| PDT Partners, LLC | 0 | 25,755 | +25,755 | 0.00 | 0.02 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 25,283 | +25,283 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 24,492 | +24,492 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 22,404 | +22,404 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 22,401 | +22,401 | 0.00 | 0.01 | +0.01 | buy |
| Diametric Capital, LP | 0 | 19,597 | +19,597 | 0.00 | 0.30 | +0.30 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 214,878 | 232,532 | +17,654 | 0.01 | 0.01 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 17,102 | +17,102 | 0.00 | 0.00 | +0.00 | buy |
| Quantessence Capital LLC | 0 | 16,590 | +16,590 | 0.00 | 0.05 | +0.05 | buy |
| State of Tennessee, Department of Treasury | 0 | 13,950 | +13,950 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 13,574 | +13,574 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 13,400 | +13,400 | 0.00 | 0.01 | +0.01 | buy |
| Cannon Global Investment Management, LLC | 0 | 11,400 | +11,400 | 0.00 | 0.41 | +0.41 | buy |
| Brevan Howard Capital Management LP | 0 | 10,693 | +10,693 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 10,189 | +10,189 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 105,336 | 114,236 | +8,900 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 7,794 | +7,794 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 7,499 | +7,499 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 4,118 | +4,118 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 49,700 | 53,100 | +3,400 | 0.00 | 0.00 | +0.00 | buy |
| Hillsdale Investment Management Inc. | 17,003 | 18,983 | +1,980 | 0.01 | 0.01 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 1,500 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 634 | +634 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 1,441 | 1,800 | +359 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 10,561 | 10,795 | +234 | 0.04 | 0.04 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 77 | +77 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 13,239 | 13,247 | +8 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 74,246 | 74,246 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Aristides Capital LLC | 241,587 | 241,587 | 0 | 1.01 | 1.16 | +0.16 | hold |
| Opaleye Management Inc. | 2,852,070 | 2,852,070 | 0 | 6.65 | 8.24 | +1.59 | hold |
| CHICAGO TRUST Co NA | 16,700 | 16,700 | 0 | 0.04 | 0.04 | -0.00 | hold |
| Truvestments Capital LLC | 1,183 | 1,183 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quantum Private Wealth, LLC | 11,500 | 11,500 | 0 | 0.05 | 0.06 | +0.01 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| BLAIR WILLIAM & CO/IL | 34,900 | 34,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jefferies Financial Group Inc. | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 141 | 100 | -41 | 0.00 | 0.00 | -0.00 | sell |
| ANCHOR CAPITAL ADVISORS LLC | 60,432 | 60,179 | -253 | 0.02 | 0.02 | +0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 17,740 | 17,316 | -424 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 1,392 | 686 | -706 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 1,031 | 0 | -1,031 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 86,957 | 84,450 | -2,507 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 37,900 | 35,300 | -2,600 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 14,655 | 11,797 | -2,858 | 0.02 | 0.01 | -0.01 | sell |
| Tower Research Capital LLC (TRC) | 6,433 | 2,971 | -3,462 | 0.00 | 0.00 | -0.00 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 24,442 | 20,419 | -4,023 | 0.06 | 0.06 | -0.00 | sell |
| Qube Research & Technologies Ltd | 94,181 | 86,848 | -7,333 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 24,710 | 16,303 | -8,407 | 0.01 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 54,886 | 44,661 | -10,225 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 12,068 | 0 | -12,068 | 0.02 | 0.00 | -0.02 | sell |
| Engineers Gate Manager LP | 12,589 | 0 | -12,589 | 0.00 | 0.00 | -0.00 | sell |
| Informed Momentum Co LLC | 95,019 | 77,833 | -17,186 | 0.18 | 0.17 | -0.00 | sell |
| CITIGROUP INC | 21,977 | 1 | -21,976 | 0.00 | 0.00 | -0.00 | sell |
| Baader Bank Aktiengesellschaft | 28,000 | 0 | -28,000 | 0.03 | 0.00 | -0.03 | sell |
| TWO SIGMA INVESTMENTS, LP | 112,458 | 82,355 | -30,103 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 36,376 | 4,472 | -31,904 | 0.01 | 0.00 | -0.01 | sell |
| MARSHALL WACE, LLP | 36,182 | 0 | -36,182 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 135,352 | 95,748 | -39,604 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 89,664 | 24,213 | -65,451 | 0.01 | 0.00 | -0.01 | sell |
| 683 Capital Management, LLC | 69,000 | 0 | -69,000 | 0.09 | 0.00 | -0.09 | sell |
| Westside Investment Management, Inc. | 575,222 | 493,650 | -81,572 | 1.61 | 1.36 | -0.25 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 238,962 | 135,270 | -103,692 | 0.07 | 0.04 | -0.03 | sell |
| Acuitas Investments, LLC | 185,824 | 0 | -185,824 | 2.03 | 0.00 | -2.03 | sell |
| PARADIGM CAPITAL MANAGEMENT INC/NY | 200,000 | 0 | -200,000 | 0.12 | 0.00 | -0.12 | sell |
| WASATCH ADVISORS LP | 231,328 | 0 | -231,328 | 0.02 | 0.00 | -0.02 | sell |
| Parkman Healthcare Partners LLC | 276,890 | 0 | -276,890 | 0.49 | 0.00 | -0.49 | sell |
| Mink Brook Asset Management LLC | 455,805 | 141,488 | -314,317 | 5.81 | 1.93 | -3.88 | sell |