| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 0 | 566,075 | +566,075 | 0.00 | 0.12 | +0.12 | buy |
| Opaleye Management Inc. | 2,395,000 | 2,780,000 | +385,000 | 1.80 | 2.78 | +0.98 | buy |
| WASATCH ADVISORS LP | 0 | 238,565 | +238,565 | 0.00 | 0.01 | +0.01 | buy |
| Informed Momentum Co LLC | 0 | 128,276 | +128,276 | 0.00 | 0.12 | +0.12 | buy |
| Nantahala Capital Management, LLC | 940,733 | 998,733 | +58,000 | 0.31 | 0.50 | +0.19 | buy |
| Westside Investment Management, Inc. | 585,400 | 618,675 | +33,275 | 0.44 | 0.79 | +0.35 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 240,331 | 272,696 | +32,365 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 4 | 32,342 | +32,338 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 34,847 | 65,014 | +30,167 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 26,495 | +26,495 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 20,637 | +20,637 | 0.00 | 0.00 | +0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 12,170 | +12,170 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 8,927 | +8,927 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 8,269 | +8,269 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 253,197 | 260,226 | +7,029 | 0.11 | 0.20 | +0.09 | buy |
| NORTHERN TRUST CORP | 59,849 | 64,130 | +4,281 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 0 | 1,183 | +1,183 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 722 | +722 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,027,688 | 1,027,688 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PARADIGM CAPITAL MANAGEMENT INC/NY | 300,000 | 300,000 | 0 | 0.04 | 0.08 | +0.03 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 253,362 | 253,362 | 0 | 0.02 | 0.03 | +0.01 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 350 | 350 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bank of New York Mellon Corp | 74,491 | 74,491 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Plante Moran Financial Advisors, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Acuitas Investments, LLC | 579,960 | 579,960 | 0 | 1.02 | 1.55 | +0.53 | hold |
| Aristides Capital LLC | 200,000 | 200,000 | 0 | 0.27 | 0.50 | +0.22 | hold |
| CHICAGO TRUST Co NA | 16,700 | 16,700 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Quantum Private Wealth, LLC | 11,500 | 11,500 | 0 | 0.01 | 0.02 | +0.01 | hold |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 27,252 | 27,252 | 0 | 0.02 | 0.03 | +0.01 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 13,239 | 13,239 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BLAIR WILLIAM & CO/IL | 34,500 | 34,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 81,403 | 81,403 | 0 | 0.00 | 0.00 | +0.00 | hold |
| XTX Topco Ltd | 11,739 | 11,304 | -435 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 1,200 | 0 | -1,200 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,638 | 0 | -3,638 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 10,564 | 0 | -10,564 | 0.00 | 0.00 | -0.00 | sell |
| THOMPSON SIEGEL & WALMSLEY LLC | 127,724 | 115,030 | -12,694 | 0.01 | 0.01 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 120,574 | 105,954 | -14,620 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 134,288 | 119,347 | -14,941 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 16,485 | 0 | -16,485 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 106,500 | 83,400 | -23,100 | 0.00 | 0.00 | +0.00 | sell |
| Schonfeld Strategic Advisors LLC | 50,917 | 17,200 | -33,717 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 41,255 | 0 | -41,255 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 57,503 | 0 | -57,503 | 0.00 | 0.00 | -0.00 | sell |
| Stonepine Capital Management, LLC | 110,000 | 0 | -110,000 | 0.33 | 0.00 | -0.33 | sell |