| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 566,075 | 1,829,603 | +1,263,528 | 0.12 | 0.97 | +0.86 | buy |
| CANNELL CAPITAL LLC | 0 | 381,323 | +381,323 | 0.00 | 1.04 | +1.04 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 65,014 | 214,878 | +149,864 | 0.00 | 0.01 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 105,954 | 248,505 | +142,551 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 138,887 | +138,887 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 135,352 | +135,352 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 129,879 | +129,879 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 998,733 | 1,118,483 | +119,750 | 0.50 | 1.04 | +0.54 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 112,458 | +112,458 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 83,400 | 193,100 | +109,700 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 119,347 | 192,326 | +72,979 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 17,200 | 89,664 | +72,464 | 0.00 | 0.01 | +0.01 | buy |
| Opaleye Management Inc. | 2,780,000 | 2,852,070 | +72,070 | 2.78 | 6.65 | +3.87 | buy |
| 683 Capital Management, LLC | 0 | 69,000 | +69,000 | 0.00 | 0.09 | +0.09 | buy |
| JANE STREET GROUP, LLC | 0 | 64,323 | +64,323 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 32,342 | 94,181 | +61,839 | 0.00 | 0.00 | +0.00 | buy |
| ANCHOR CAPITAL ADVISORS LLC | 0 | 60,432 | +60,432 | 0.00 | 0.02 | +0.02 | buy |
| BARCLAYS PLC | 0 | 54,886 | +54,886 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 51,961 | +51,961 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 49,700 | +49,700 | 0.00 | 0.00 | +0.00 | buy |
| Aristides Capital LLC | 200,000 | 241,587 | +41,587 | 0.50 | 1.01 | +0.51 | buy |
| OMERS ADMINISTRATION Corp | 0 | 37,900 | +37,900 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 36,376 | +36,376 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 1,027,688 | 1,063,707 | +36,019 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 8,269 | 43,239 | +34,970 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 284,855 | 317,625 | +32,770 | 0.00 | 0.00 | +0.00 | buy |
| Baader Bank Aktiengesellschaft | 0 | 28,000 | +28,000 | 0.00 | 0.03 | +0.03 | buy |
| Jump Financial, LLC | 0 | 24,710 | +24,710 | 0.00 | 0.01 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 24,242 | +24,242 | 0.00 | 0.03 | +0.03 | buy |
| STATE STREET CORP | 81,403 | 105,336 | +23,933 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 64,130 | 86,957 | +22,827 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 17,740 | +17,740 | 0.00 | 0.00 | +0.00 | buy |
| Hillsdale Investment Management Inc. | 0 | 17,003 | +17,003 | 0.00 | 0.01 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 260,226 | 276,890 | +16,664 | 0.20 | 0.49 | +0.29 | buy |
| MARSHALL WACE, LLP | 20,637 | 36,182 | +15,545 | 0.00 | 0.00 | +0.00 | buy |
| THOMPSON SIEGEL & WALMSLEY LLC | 115,030 | 128,039 | +13,009 | 0.01 | 0.03 | +0.02 | buy |
| Engineers Gate Manager LP | 0 | 12,589 | +12,589 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 12,068 | +12,068 | 0.00 | 0.02 | +0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 11,850 | +11,850 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 6,433 | +6,433 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 11,304 | 14,655 | +3,351 | 0.00 | 0.02 | +0.01 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 8,927 | 10,561 | +1,634 | 0.01 | 0.04 | +0.03 | buy |
| Point72 (DIFC) Ltd | 0 | 1,441 | +1,441 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 1,392 | +1,392 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 1,031 | +1,031 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 34,500 | 34,900 | +400 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 350 | 350 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHICAGO TRUST Co NA | 16,700 | 16,700 | 0 | 0.02 | 0.04 | +0.02 | hold |
| Truvestments Capital LLC | 1,183 | 1,183 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Quantum Private Wealth, LLC | 11,500 | 11,500 | 0 | 0.02 | 0.05 | +0.03 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 13,239 | 13,239 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bank of New York Mellon Corp | 74,491 | 74,246 | -245 | 0.00 | 0.00 | +0.00 | sell |
| GROUP ONE TRADING LLC | 722 | 0 | -722 | 0.00 | 0.00 | -0.00 | sell |
| Plante Moran Financial Advisors, LLC | 1,000 | 0 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 27,252 | 24,442 | -2,810 | 0.03 | 0.06 | +0.03 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 272,696 | 268,646 | -4,050 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 26,495 | 21,977 | -4,518 | 0.00 | 0.00 | +0.00 | sell |
| WASATCH ADVISORS LP | 238,565 | 231,328 | -7,237 | 0.01 | 0.02 | +0.01 | sell |
| Financial Advisors Network, Inc. | 10,633 | 0 | -10,633 | 0.01 | 0.00 | -0.01 | sell |
| OCCUDO QUANTITATIVE STRATEGIES LP | 12,170 | 0 | -12,170 | 0.01 | 0.00 | -0.01 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 253,362 | 238,962 | -14,400 | 0.03 | 0.07 | +0.04 | sell |
| Informed Momentum Co LLC | 128,276 | 95,019 | -33,257 | 0.12 | 0.18 | +0.06 | sell |
| Westside Investment Management, Inc. | 618,675 | 575,222 | -43,453 | 0.79 | 1.61 | +0.82 | sell |
| PARADIGM CAPITAL MANAGEMENT INC/NY | 300,000 | 200,000 | -100,000 | 0.08 | 0.12 | +0.04 | sell |
| Acuitas Investments, LLC | 579,960 | 185,824 | -394,136 | 1.55 | 2.03 | +0.48 | sell |