| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 566,075 | 1,829,603 | +1,263,528 | 0.12 | 0.92 | +0.81 | buy |
| Nantahala Capital Management, LLC | 998,733 | 1,118,483 | +119,750 | 0.30 | 0.64 | +0.34 | buy |
| Opaleye Management Inc. | 2,780,000 | 2,852,070 | +72,070 | 2.78 | 6.65 | +3.87 | buy |
| Aristides Capital LLC | 200,000 | 241,587 | +41,587 | 0.37 | 0.66 | +0.29 | buy |
| Parkman Healthcare Partners LLC | 260,226 | 276,890 | +16,664 | 0.20 | 0.49 | +0.29 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 253,362 | 238,962 | +14,400 | 0.03 | 0.07 | 0.00 | sell |
| THOMPSON SIEGEL & WALMSLEY LLC | 115,030 | 128,039 | +13,009 | 0.01 | 0.03 | +0.02 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 8,927 | 10,561 | +1,634 | 0.01 | 0.04 | +0.03 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 27,252 | 24,442 | -2,810 | 0.03 | 0.06 | +0.03 | sell |
| WASATCH ADVISORS LP | 238,565 | 231,328 | -7,237 | 0.01 | 0.02 | +0.01 | sell |
| Informed Momentum Co LLC | 128,276 | 95,019 | -33,257 | 0.12 | 0.18 | +0.06 | sell |
| PARADIGM CAPITAL MANAGEMENT INC/NY | 300,000 | 200,000 | -100,000 | 0.08 | 0.12 | +0.04 | sell |
| Acuitas Investments, LLC | 579,960 | 185,824 | -394,136 | 1.55 | 2.03 | +0.48 | sell |