| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 2,385,898 | 4,243,892 | +1,857,994 | 0.02 | 0.05 | +0.03 | buy |
| Avoro Capital Advisors LLC | 2,565,555 | 2,555,555 | -10,000 | 4.40 | 5.30 | +0.91 | sell |
| VANGUARD GROUP INC | 2,435,774 | 2,432,779 | -2,995 | 0.01 | 0.01 | +0.00 | sell |
| Redmile Group, LLC | 1,733,189 | 1,508,250 | -224,939 | 7.69 | 9.85 | +2.16 | sell |
| Frazier Life Sciences Management, L.P. | 988,460 | 988,460 | 0 | 6.56 | 7.42 | +0.86 | hold |
| STATE STREET CORP | 1,237,497 | 944,547 | -292,950 | 0.01 | 0.01 | +0.00 | sell |
| JENNISON ASSOCIATES LLC | 724,344 | 670,735 | -53,609 | 0.07 | 0.08 | +0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 427,363 | 658,618 | +231,255 | 0.01 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 550,806 | 572,915 | +22,109 | 0.02 | 0.03 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 511,246 | 525,745 | +14,499 | 0.01 | 0.01 | +0.00 | buy |
| Hood River Capital Management LLC | 458,513 | 495,586 | +37,073 | 1.56 | 1.97 | +0.40 | buy |
| LORD, ABBETT & CO. LLC | 618,458 | 492,232 | -126,226 | 0.27 | 0.28 | +0.01 | sell |
| GOLDMAN SACHS GROUP INC | 228,053 | 434,574 | +206,521 | 0.01 | 0.02 | +0.01 | buy |
| Woodline Partners LP | 481,979 | 275,455 | -206,524 | 0.65 | 0.45 | -0.20 | sell |
| MORGAN STANLEY | 319,721 | 218,829 | -100,892 | 0.00 | 0.00 | -0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 244,061 | 217,747 | -26,314 | 0.18 | 0.19 | +0.01 | sell |
| NORTHERN TRUST CORP | 209,199 | 205,078 | -4,121 | 0.00 | 0.01 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 185,038 | 188,903 | +3,865 | 0.01 | 0.01 | +0.00 | buy |
| BRAIDWELL LP | 196,200 | 177,089 | -19,111 | 0.89 | 1.02 | +0.12 | sell |
| JPMORGAN CHASE & CO | 213,519 | 175,126 | -38,393 | 0.00 | 0.00 | +0.00 | sell |
| BAKER BROS. ADVISORS LP | 169,934 | 169,934 | 0 | 0.24 | 0.38 | +0.14 | hold |
| Allspring Global Investments Holdings, LLC | 59,324 | 158,425 | +99,101 | 0.01 | 0.04 | +0.03 | buy |
| Pictet Asset Management Holding SA | 192,875 | 142,960 | -49,915 | 0.03 | 0.03 | +0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 136,485 | 136,485 | 0 | 0.28 | 0.38 | +0.10 | hold |
| C WorldWide Group Holding A/S | 185,809 | 135,809 | -50,000 | 0.31 | 0.28 | -0.03 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 172,879 | 134,820 | -38,059 | 0.02 | 0.02 | +0.00 | sell |
| FRANKLIN RESOURCES INC | 26,546 | 131,465 | +104,919 | 0.00 | 0.01 | +0.01 | buy |
| First Turn Management, LLC | 242,185 | 130,850 | -111,335 | 4.31 | 3.48 | -0.83 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 256,604 | 124,203 | -132,401 | 0.09 | 0.06 | -0.03 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 196,386 | 110,199 | -86,187 | 0.29 | 0.20 | -0.10 | sell |
| Handelsbanken Fonder AB | 123,200 | 105,200 | -18,000 | 0.07 | 0.08 | +0.01 | sell |
| Rock Springs Capital Management LP | 103,969 | 103,969 | 0 | 0.32 | 0.47 | +0.15 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 8,042 | 101,557 | +93,515 | 0.00 | 0.03 | +0.03 | buy |
| TimesSquare Capital Management, LLC | 250,470 | 97,161 | -153,309 | 0.46 | 0.25 | -0.21 | sell |
| Capital World Investors | 0 | 97,147 | +97,147 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 50,836 | 95,858 | +45,022 | 0.02 | 0.05 | +0.03 | buy |
| JANE STREET GROUP, LLC | 50,618 | 93,745 | +43,127 | 0.01 | 0.02 | +0.01 | buy |
| S Squared Technology, LLC | 110,215 | 90,215 | -20,000 | 6.64 | 7.37 | +0.73 | sell |
| Bank of New York Mellon Corp | 98,651 | 89,839 | -8,812 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 54,229 | 89,628 | +35,399 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 40,000 | 84,100 | +44,100 | 0.55 | 1.31 | +0.76 | buy |
| D. E. Shaw & Co., Inc. | 67,141 | 82,027 | +14,886 | 0.01 | 0.02 | +0.01 | buy |
| Integral Health Asset Management, LLC | 85,000 | 80,000 | -5,000 | 1.52 | 1.40 | -0.13 | sell |
| BANK OF AMERICA CORP /DE/ | 91,193 | 75,844 | -15,349 | 0.00 | 0.00 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 40,962 | 69,162 | +28,200 | 0.00 | 0.01 | +0.01 | buy |
| Decheng Capital LLC | 65,772 | 65,772 | 0 | 2.28 | 1.57 | -0.71 | hold |
| Verition Fund Management LLC | 95,958 | 61,800 | -34,158 | 0.12 | 0.11 | -0.02 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 47,597 | 60,725 | +13,128 | 0.01 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 8,521 | 56,635 | +48,114 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 84,021 | 53,367 | -30,654 | 0.04 | 0.04 | -0.01 | sell |
| CITIGROUP INC | 36,566 | 52,118 | +15,552 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 30,760 | 51,028 | +20,268 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 0 | 45,000 | +45,000 | 0.00 | 0.66 | +0.66 | buy |
| AMERIPRISE FINANCIAL INC | 15,939 | 43,391 | +27,452 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 29,250 | 41,298 | +12,048 | 0.00 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 74,945 | 39,484 | -35,461 | 0.01 | 0.01 | -0.00 | sell |
| Aberdeen Group plc | 0 | 39,024 | +39,024 | 0.00 | 0.01 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 39,556 | 37,845 | -1,711 | 0.01 | 0.01 | +0.00 | sell |
| GW&K Investment Management, LLC | 0 | 37,528 | +37,528 | 0.00 | 0.06 | +0.06 | buy |
| ORBIMED ADVISORS LLC | 103,700 | 37,166 | -66,534 | 0.26 | 0.12 | -0.14 | sell |
| Swiss National Bank | 35,900 | 36,200 | +300 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 35,972 | +35,972 | 0.00 | 0.01 | +0.01 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 0 | 35,700 | +35,700 | 0.00 | 0.46 | +0.46 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 36,388 | 34,189 | -2,199 | 0.05 | 0.07 | +0.01 | sell |
| SEI INVESTMENTS CO | 14,784 | 33,752 | +18,968 | 0.00 | 0.01 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 31,398 | 33,154 | +1,756 | 0.22 | 0.32 | +0.09 | buy |
| RHUMBLINE ADVISERS | 31,785 | 32,099 | +314 | 0.00 | 0.01 | +0.00 | buy |
| Global IMC LLC | 0 | 28,842 | +28,842 | 0.00 | 1.19 | +1.19 | buy |
| CASTLEARK MANAGEMENT LLC | 32,350 | 28,520 | -3,830 | 0.18 | 0.21 | +0.03 | sell |
| Affinity Asset Advisors, LLC | 25,000 | 26,746 | +1,746 | 0.62 | 0.77 | +0.16 | buy |
| Informed Momentum Co LLC | 0 | 26,435 | +26,435 | 0.00 | 0.73 | +0.73 | buy |
| CITADEL ADVISORS LLC | 8,199 | 25,014 | +16,815 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 24,700 | +24,700 | 0.00 | 0.01 | +0.01 | buy |
| CWM, LLC | 30,569 | 23,850 | -6,719 | 0.02 | 0.02 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 25,900 | 23,760 | -2,140 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 64,179 | 21,614 | -42,565 | 0.00 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 5,408 | 20,963 | +15,555 | 0.04 | 0.17 | +0.13 | buy |
| Ensign Peak Advisors, Inc | 6,900 | 20,917 | +14,017 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 19,092 | 19,550 | +458 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 0 | 19,000 | +19,000 | 0.00 | 0.32 | +0.32 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 19,769 | 18,660 | -1,109 | 0.00 | 0.00 | +0.00 | sell |
| Eversept Partners, LP | 80,798 | 18,557 | -62,241 | 0.98 | 0.25 | -0.74 | sell |
| ExodusPoint Capital Management, LP | 42,502 | 18,272 | -24,230 | 0.07 | 0.04 | -0.03 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 20,426 | 18,261 | -2,165 | 0.00 | 0.00 | +0.00 | sell |
| Erste Asset Management GmbH | 18,200 | 18,200 | 0 | 0.03 | 0.04 | +0.01 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 14,993 | 18,028 | +3,035 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 0 | 17,843 | +17,843 | 0.00 | 0.01 | +0.01 | buy |
| State of New Jersey Common Pension Fund D | 24,804 | 17,759 | -7,045 | 0.01 | 0.01 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 39,072 | 16,778 | -22,294 | 0.01 | 0.00 | -0.01 | sell |
| Trek Financial, LLC | 0 | 16,684 | +16,684 | 0.00 | 0.24 | +0.24 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 14,896 | 16,215 | +1,319 | 0.01 | 0.01 | +0.00 | buy |
| Fiera Capital Corp | 15,900 | 16,078 | +178 | 0.01 | 0.01 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 15,503 | 15,503 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Exome Asset Management LLC | 0 | 14,700 | +14,700 | 0.00 | 2.24 | +2.24 | buy |
| Brevan Howard Capital Management LP | 0 | 14,127 | +14,127 | 0.00 | 0.23 | +0.23 | buy |
| Trexquant Investment LP | 0 | 13,293 | +13,293 | 0.00 | 0.05 | +0.05 | buy |
| DEUTSCHE BANK AG\ | 18,830 | 12,809 | -6,021 | 0.00 | 0.00 | -0.00 | sell |
| EFG Asset Management (North America) Corp. | 10,196 | 12,495 | +2,299 | 0.24 | 0.38 | +0.14 | buy |
| Mirae Asset Global Investments Co., Ltd. | 13,484 | 12,001 | -1,483 | 0.00 | 0.00 | -0.00 | sell |
| NORGES BANK | 11,340 | 11,340 | 0 | 0.00 | 0.00 | +0.00 | hold |