| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 200,500 | 400,744 | +200,244 | 0.93 | 2.54 | +1.61 | buy |
| Avoro Capital Advisors LLC | 2,628,822 | 2,731,000 | +102,178 | 5.83 | 7.69 | +1.86 | buy |
| Soleus Capital Management, L.P. | 358,379 | 441,758 | +83,379 | 4.25 | 6.25 | +2.00 | buy |
| Capital World Investors | 879,203 | 954,468 | +75,265 | 0.02 | 0.03 | +0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 9,884 | 24,929 | +15,045 | 0.01 | 0.02 | 0.00 | buy |
| Atle Fund Management AB | 9,202 | 23,491 | +14,289 | 0.70 | 1.87 | +1.17 | buy |
| PRUDENTIAL FINANCIAL INC | 41,193 | 27,311 | +13,882 | 0.01 | 0.01 | 0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 27,711 | 41,518 | +13,807 | 0.10 | 0.18 | +0.08 | buy |
| Hood River Capital Management LLC | 512,726 | 524,644 | +11,918 | 1.19 | 1.61 | +0.43 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 81,328 | 72,815 | +8,513 | 0.01 | 0.01 | +0.00 | sell |
| Integral Health Asset Management, LLC | 55,000 | 60,000 | +5,000 | 0.76 | 1.20 | +0.44 | buy |
| Nebula Research & Development LLC | 2,670 | 6,220 | +3,550 | 0.05 | 0.10 | +0.05 | buy |
| CIBC WORLD MARKETS CORP | 2,321 | 5,504 | +3,183 | 0.00 | 0.01 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 123,453 | 126,337 | +2,884 | 0.01 | 0.01 | 0.00 | buy |
| Evolutionary Tree Capital Management, LLC | 10,700 | 13,343 | +2,643 | 1.71 | 2.80 | +1.09 | buy |
| CANADA LIFE ASSURANCE Co | 26,754 | 24,609 | +2,145 | 0.01 | 0.01 | +0.00 | sell |
| S Squared Technology, LLC | 95,215 | 97,215 | +2,000 | 6.20 | 8.97 | +2.77 | buy |
| ProShare Advisors LLC | 8,848 | 7,151 | +1,697 | 0.00 | 0.00 | 0.00 | sell |
| Main Management ETF Advisors, LLC | 3,560 | 5,047 | +1,487 | 0.03 | 0.04 | +0.02 | buy |
| AlphaQuest LLC | 3,020 | 1,663 | +1,357 | 0.07 | 0.04 | 0.00 | sell |
| Summit Global Investments | 3,453 | 4,711 | +1,258 | 0.03 | 0.06 | +0.03 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 10,839 | 12,078 | +1,239 | 0.02 | 0.02 | +0.01 | buy |
| CERTUITY, LLC | 1,365 | 2,585 | +1,220 | 0.02 | 0.05 | +0.03 | buy |
| Woodline Partners LP | 221,102 | 222,043 | +941 | 0.23 | 0.26 | +0.03 | buy |
| GW&K Investment Management, LLC | 34,930 | 34,100 | +830 | 0.05 | 0.06 | +0.01 | sell |
| WINTON GROUP Ltd | 6,565 | 7,274 | +709 | 0.07 | 0.08 | +0.01 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 3,750 | 4,430 | +680 | 0.12 | 0.15 | +0.04 | buy |
| Avanza Fonder AB | 759 | 1,260 | +501 | 0.00 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 12,607 | 13,048 | +441 | 0.00 | 0.00 | +0.00 | buy |
| State of Alaska, Department of Revenue | 14,423 | 14,024 | +399 | 0.03 | 0.03 | 0.00 | sell |
| E Fund Management Co., Ltd. | 1,934 | 2,258 | +324 | 0.02 | 0.02 | +0.00 | buy |
| Cynosure Group, LLC | 3,630 | 3,902 | +272 | 0.08 | 0.10 | +0.01 | buy |
| DnB Asset Management AS | 1,537 | 1,779 | +242 | 0.00 | 0.00 | +0.00 | buy |
| Palisades Investment Partners, LLC | 40,479 | 40,696 | +217 | 2.68 | 3.68 | +1.01 | buy |
| YOUSIF CAPITAL MANAGEMENT, LLC | 9,777 | 9,570 | +207 | 0.02 | 0.02 | 0.00 | sell |
| Perigon Wealth Management, LLC | 8,289 | 8,491 | +202 | 0.03 | 0.04 | +0.01 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 2,161 | 2,354 | +193 | 0.06 | 0.07 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 9,761 | 9,952 | +191 | 0.02 | 0.02 | 0.00 | buy |
| OREGON PUBLIC EMPLOYEES RETIREMENT FUND | 5,975 | 5,802 | +173 | 0.02 | 0.02 | 0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 604 | 736 | +132 | 0.00 | 0.00 | +0.00 | buy |
| Sound View Wealth Advisors Group, LLC | 1,420 | 1,515 | +95 | 0.02 | 0.02 | +0.00 | buy |
| TRANSCEND CAPITAL ADVISORS, LLC | 1,382 | 1,383 | +1 | 0.02 | 0.02 | +0.00 | buy |
| Jackson Creek Investment Advisors LLC | 8,052 | 8,048 | -4 | 0.38 | 0.46 | +0.08 | sell |
| Ballentine Partners, LLC | 2,145 | 2,136 | -9 | 0.01 | 0.01 | +0.00 | sell |
| Rakuten Securities, Inc. | 20 | 5 | -15 | 0.00 | 0.00 | -0.00 | sell |
| Fiera Capital Corp | 15,673 | 15,645 | -28 | 0.01 | 0.01 | +0.00 | sell |
| Ameritas Investment Partners, Inc. | 2,595 | 2,509 | -86 | 0.01 | 0.02 | +0.00 | sell |
| Argent Trust Co | 1,899 | 1,692 | -207 | 0.01 | 0.01 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 6,098 | 5,778 | -320 | 0.09 | 0.10 | +0.01 | sell |
| EFG Asset Management (North America) Corp. | 17,714 | 17,371 | -343 | 0.38 | 0.52 | +0.14 | sell |
| PROFUND ADVISORS LLC | 6,321 | 5,963 | -358 | 0.04 | 0.05 | +0.01 | sell |
| STRS OHIO | 7,300 | 6,900 | -400 | 0.00 | 0.01 | +0.00 | sell |
| Entropy Technologies, LP | 3,500 | 2,300 | -1,200 | 0.06 | 0.04 | -0.02 | sell |
| Privium Fund Management B.V. | 9,250 | 7,510 | -1,740 | 0.33 | 0.35 | +0.03 | sell |
| Bellevue Group AG | 5,047 | 2,650 | -2,397 | 0.02 | 0.01 | -0.00 | sell |
| Rafferty Asset Management, LLC | 27,201 | 24,161 | -3,040 | 0.02 | 0.02 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 43,480 | 40,268 | -3,212 | 0.01 | 0.01 | +0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 13,678 | 10,205 | -3,473 | 0.10 | 0.08 | -0.02 | sell |
| SEGALL BRYANT & HAMILL, LLC | 149,309 | 145,337 | -3,972 | 0.32 | 0.40 | +0.08 | sell |
| Rhenman & Partners Asset Management AB | 23,750 | 17,750 | -6,000 | 0.38 | 0.37 | -0.01 | sell |
| Decheng Capital LLC | 76,772 | 65,000 | -11,772 | 2.58 | 3.29 | +0.71 | sell |
| Redmile Group, LLC | 753,175 | 737,675 | -15,500 | 8.22 | 12.57 | +4.35 | sell |
| TimesSquare Capital Management, LLC | 158,868 | 142,183 | -16,685 | 100.00 | 100.00 | 0.00 | sell |
| Aberdeen Group plc | 57,033 | 37,301 | -19,732 | 0.02 | 0.01 | -0.00 | sell |
| C WorldWide Group Holding A/S | 105,809 | 85,809 | -20,000 | 0.20 | 0.19 | -0.01 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 89,047 | 59,978 | -29,069 | 100.00 | 7.60 | -92.40 | sell |
| LORD, ABBETT & CO. LLC | 215,628 | 151,225 | -64,403 | 0.11 | 0.10 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 509,459 | 410,861 | -98,598 | 0.01 | 0.01 | -0.00 | sell |
| Frazier Life Sciences Management, L.P. | 788,460 | 688,460 | -100,000 | 5.13 | 5.67 | +0.55 | sell |
| JENNISON ASSOCIATES LLC | 303,521 | 33,594 | -269,927 | 0.03 | 0.00 | -0.02 | sell |