| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 4,349,628 | 4,373,987 | +24,359 | 0.05 | 0.06 | +0.00 | buy |
| BlackRock, Inc. | 3,937,817 | 3,940,456 | +2,639 | 0.02 | 0.02 | +0.00 | buy |
| Avoro Capital Advisors LLC | 2,888,888 | 2,888,888 | 0 | 7.00 | 7.35 | +0.35 | hold |
| STATE STREET CORP | 1,342,303 | 1,314,434 | -27,869 | 0.01 | 0.01 | +0.00 | sell |
| Soleus Capital Management, L.P. | 941,059 | 1,153,087 | +212,028 | 9.84 | 12.06 | +2.22 | buy |
| Capital World Investors | 809,500 | 824,720 | +15,220 | 0.03 | 0.03 | +0.00 | buy |
| Redmile Group, LLC | 677,705 | 673,505 | -4,200 | 12.30 | 11.52 | -0.78 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 611,878 | 643,975 | +32,097 | 0.01 | 0.01 | +0.00 | buy |
| Hood River Capital Management LLC | 613,302 | 619,586 | +6,284 | 1.66 | 1.60 | -0.05 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 529,955 | 485,074 | -44,881 | 0.01 | 0.01 | +0.00 | sell |
| Bellevue Group AG | 410,323 | 481,785 | +71,462 | 1.92 | 2.96 | +1.04 | buy |
| Frazier Life Sciences Management, L.P. | 488,460 | 481,307 | -7,153 | 3.23 | 3.20 | -0.04 | sell |
| DIMENSIONAL FUND ADVISORS LP | 492,968 | 468,990 | -23,978 | 0.03 | 0.03 | -0.00 | sell |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 376,340 | 407,178 | +30,838 | 0.26 | 0.35 | +0.09 | buy |
| FIRST TRUST ADVISORS LP | 245,276 | 350,521 | +105,245 | 0.04 | 0.06 | +0.02 | buy |
| JANUS HENDERSON GROUP PLC | 219,440 | 266,659 | +47,219 | 0.02 | 0.03 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 190,807 | 260,647 | +69,840 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 247,443 | 252,463 | +5,020 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 60,008 | 251,373 | +191,365 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 242,774 | 241,986 | -788 | 0.01 | 0.01 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 293,525 | 214,949 | -78,576 | 0.01 | 0.01 | -0.00 | sell |
| MORGAN STANLEY | 221,481 | 209,082 | -12,399 | 0.00 | 0.00 | -0.00 | sell |
| BRAIDWELL LP | 202,101 | 182,425 | -19,676 | 1.59 | 1.57 | -0.02 | sell |
| FRANKLIN RESOURCES INC | 125,675 | 179,265 | +53,590 | 0.01 | 0.01 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 165,074 | 162,070 | -3,004 | 0.02 | 0.02 | +0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 76,538 | 156,064 | +79,526 | 0.01 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 150,616 | 150,616 | 0 | 0.14 | 0.15 | +0.00 | hold |
| Bank of New York Mellon Corp | 151,313 | 149,307 | -2,006 | 0.01 | 0.01 | +0.00 | sell |
| UBS Group AG | 159,595 | 143,525 | -16,070 | 0.01 | 0.01 | -0.00 | sell |
| Nuveen, LLC | 189,094 | 143,368 | -45,726 | 0.01 | 0.01 | -0.00 | sell |
| TimesSquare Capital Management, LLC | 97,400 | 112,342 | +14,942 | 0.36 | 0.49 | +0.13 | buy |
| Pictet Asset Management Holding SA | 156,568 | 110,665 | -45,903 | 0.04 | 0.03 | -0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 103,261 | 108,397 | +5,136 | 0.03 | 0.03 | +0.00 | buy |
| JPMORGAN CHASE & CO | 134,624 | 99,105 | -35,519 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 53,911 | 93,031 | +39,120 | 0.01 | 0.02 | +0.01 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 89,362 | 92,286 | +2,924 | 0.07 | 0.07 | +0.00 | buy |
| Handelsbanken Fonder AB | 105,800 | 91,400 | -14,400 | 0.08 | 0.08 | -0.00 | sell |
| S Squared Technology, LLC | 96,215 | 86,215 | -10,000 | 9.19 | 8.43 | -0.76 | sell |
| SEGALL BRYANT & HAMILL, LLC | 83,246 | 79,497 | -3,749 | 0.28 | 0.21 | -0.07 | sell |
| Biondo Investment Advisors, LLC | 68,130 | 72,045 | +3,915 | 2.03 | 2.39 | +0.36 | buy |
| ORBIMED ADVISORS LLC | 119,800 | 69,100 | -50,700 | 0.60 | 0.39 | -0.22 | sell |
| MARSHALL WACE, LLP | 183,754 | 68,343 | -115,411 | 0.04 | 0.02 | -0.02 | sell |
| RHUMBLINE ADVISERS | 66,436 | 68,099 | +1,663 | 0.01 | 0.02 | +0.00 | buy |
| C WorldWide Group Holding A/S | 85,809 | 67,809 | -18,000 | 0.37 | 0.38 | +0.01 | sell |
| Legal & General Group Plc | 63,361 | 59,050 | -4,311 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 52,345 | 49,837 | -2,508 | 0.00 | 0.00 | +0.00 | sell |
| SEI INVESTMENTS CO | 32,310 | 46,570 | +14,260 | 0.01 | 0.01 | +0.00 | buy |
| Bridgewater Associates, LP | 10,015 | 46,367 | +36,352 | 0.01 | 0.05 | +0.04 | buy |
| Palisades Investment Partners, LLC | 42,765 | 45,405 | +2,640 | 3.98 | 4.60 | +0.62 | buy |
| TD ASSET MANAGEMENT INC | 54,142 | 43,318 | -10,824 | 0.01 | 0.01 | -0.00 | sell |
| Swiss National Bank | 42,900 | 43,000 | +100 | 0.01 | 0.01 | +0.00 | buy |
| 1832 Asset Management L.P. | 17,600 | 42,600 | +25,000 | 0.01 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 26,461 | 40,715 | +14,254 | 0.00 | 0.01 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 40,128 | +40,128 | 0.00 | 0.12 | +0.12 | buy |
| Atle Fund Management AB | 33,853 | 37,579 | +3,726 | 2.66 | 2.19 | -0.47 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 33,617 | 36,937 | +3,320 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 40,629 | 36,069 | -4,560 | 0.01 | 0.01 | -0.00 | sell |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 37,269 | 35,859 | -1,410 | 0.10 | 0.11 | +0.01 | sell |
| FEDERATED HERMES, INC. | 34,541 | 35,495 | +954 | 0.01 | 0.01 | +0.00 | buy |
| Neuberger Berman Group LLC | 1,033 | 33,084 | +32,051 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 31,529 | 31,929 | +400 | 0.00 | 0.00 | +0.00 | buy |
| CASTLEARK MANAGEMENT LLC | 29,260 | 31,630 | +2,370 | 0.21 | 0.27 | +0.06 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 31,342 | 31,342 | 0 | 0.01 | 0.01 | +0.00 | hold |
| CITIGROUP INC | 29,943 | 31,172 | +1,229 | 0.01 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 39,360 | 30,155 | -9,205 | 0.02 | 0.01 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 27,015 | 29,638 | +2,623 | 0.01 | 0.01 | +0.00 | buy |
| Fisher Asset Management, LLC | 3,786 | 27,784 | +23,998 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 28,954 | 26,210 | -2,744 | 0.01 | 0.01 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 20,583 | 26,186 | +5,603 | 0.01 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 22,450 | 24,831 | +2,381 | 0.00 | 0.00 | +0.00 | buy |
| Granite Investment Partners, LLC | 25,760 | 24,284 | -1,476 | 0.38 | 0.39 | +0.01 | sell |
| Fiera Capital Corp | 18,857 | 24,146 | +5,289 | 0.01 | 0.02 | +0.01 | buy |
| CANADA LIFE ASSURANCE Co | 22,087 | 21,413 | -674 | 0.01 | 0.01 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 14,466 | 20,691 | +6,225 | 0.01 | 0.01 | +0.00 | buy |
| BESSEMER GROUP INC | 20,260 | 20,285 | +25 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 20,014 | 20,014 | 0 | 0.37 | 0.31 | -0.06 | hold |
| TFG Asset Management GP Ltd | 11,814 | 19,668 | +7,854 | 0.61 | 1.00 | +0.38 | buy |
| GW&K Investment Management, LLC | 19,581 | 19,245 | -336 | 0.04 | 0.04 | +0.00 | sell |
| Lisanti Capital Growth, LLC | 0 | 18,515 | +18,515 | 0.00 | 1.21 | +1.21 | buy |
| ZACKS INVESTMENT MANAGEMENT | 0 | 17,919 | +17,919 | 0.00 | 0.04 | +0.04 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 17,795 | +17,795 | 0.00 | 0.26 | +0.26 | buy |
| Rafferty Asset Management, LLC | 24,268 | 17,687 | -6,581 | 0.02 | 0.02 | -0.00 | sell |
| State of Alaska, Department of Revenue | 17,902 | 17,484 | -418 | 0.05 | 0.05 | +0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 17,734 | 17,226 | -508 | 0.01 | 0.01 | +0.00 | sell |
| Rhenman & Partners Asset Management AB | 25,000 | 16,675 | -8,325 | 0.58 | 0.53 | -0.04 | sell |
| Informed Momentum Co LLC | 24,667 | 16,483 | -8,184 | 0.68 | 0.49 | -0.19 | sell |
| Creative Planning | 13,881 | 15,937 | +2,056 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 15,756 | 15,756 | 0 | 0.01 | 0.01 | +0.00 | hold |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 15,650 | 15,637 | -13 | 0.01 | 0.01 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 12,954 | 15,121 | +2,167 | 0.00 | 0.01 | +0.00 | buy |
| CIM, LLC | 0 | 14,990 | +14,990 | 0.00 | 0.56 | +0.56 | buy |
| WELLS FARGO & COMPANY/MN | 31,572 | 14,988 | -16,584 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 1,375 | 14,476 | +13,101 | 0.00 | 0.02 | +0.02 | buy |
| Illinois Municipal Retirement Fund | 12,699 | 14,151 | +1,452 | 0.04 | 0.05 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 14,157 | 14,114 | -43 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 13,844 | 13,542 | -302 | 0.02 | 0.02 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 9,751 | 13,520 | +3,769 | 0.02 | 0.03 | +0.01 | buy |
| Evolutionary Tree Capital Management, LLC | 16,811 | 12,314 | -4,497 | 4.81 | 5.98 | +1.17 | sell |
| NATIXIS ADVISORS, LLC | 11,682 | 12,125 | +443 | 0.00 | 0.00 | +0.00 | buy |
| Bridge City Capital, LLC | 12,135 | 12,045 | -90 | 0.88 | 0.86 | -0.02 | sell |