| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 4,243,892 | 4,283,766 | +39,874 | 0.05 | 0.05 | -0.00 | buy |
| VANGUARD GROUP INC | 2,432,779 | 2,869,136 | +436,357 | 0.01 | 0.01 | +0.00 | buy |
| Avoro Capital Advisors LLC | 2,555,555 | 2,433,000 | -122,555 | 5.30 | 5.95 | +0.65 | sell |
| STATE STREET CORP | 944,547 | 1,332,875 | +388,328 | 0.01 | 0.01 | +0.00 | buy |
| Redmile Group, LLC | 1,508,250 | 1,021,078 | -487,172 | 9.85 | 11.34 | +1.49 | sell |
| Frazier Life Sciences Management, L.P. | 988,460 | 988,460 | 0 | 7.42 | 8.49 | +1.07 | hold |
| Capital World Investors | 97,147 | 878,158 | +781,011 | 0.00 | 0.03 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 658,618 | 600,145 | -58,473 | 0.01 | 0.01 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 572,915 | 580,452 | +7,537 | 0.03 | 0.03 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 525,745 | 580,220 | +54,475 | 0.01 | 0.01 | +0.00 | buy |
| Hood River Capital Management LLC | 495,586 | 521,093 | +25,507 | 1.97 | 1.98 | +0.02 | buy |
| JENNISON ASSOCIATES LLC | 670,735 | 520,390 | -150,345 | 0.08 | 0.06 | -0.02 | sell |
| GOLDMAN SACHS GROUP INC | 434,574 | 422,331 | -12,243 | 0.02 | 0.02 | -0.00 | sell |
| LORD, ABBETT & CO. LLC | 492,232 | 392,238 | -99,994 | 0.28 | 0.24 | -0.05 | sell |
| MORGAN STANLEY | 218,829 | 318,327 | +99,498 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 275,455 | 291,918 | +16,463 | 0.45 | 0.51 | +0.06 | buy |
| Invesco Ltd. | 89,628 | 275,077 | +185,449 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 18,261 | 251,762 | +233,501 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 188,903 | 220,439 | +31,536 | 0.01 | 0.01 | -0.00 | buy |
| NORTHERN TRUST CORP | 205,078 | 218,461 | +13,383 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 89,839 | 193,767 | +103,928 | 0.00 | 0.01 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 217,747 | 191,515 | -26,232 | 0.19 | 0.17 | -0.02 | sell |
| FRANKLIN RESOURCES INC | 131,465 | 181,582 | +50,117 | 0.01 | 0.01 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 158,425 | 176,446 | +18,021 | 0.04 | 0.05 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 169,934 | 169,934 | 0 | 0.38 | 0.40 | +0.02 | hold |
| JPMORGAN CHASE & CO | 175,126 | 163,824 | -11,302 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 134,820 | 143,865 | +9,045 | 0.02 | 0.03 | +0.00 | buy |
| Pictet Asset Management Holding SA | 142,960 | 137,433 | -5,527 | 0.03 | 0.03 | +0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 136,485 | 136,485 | 0 | 0.38 | 0.43 | +0.05 | hold |
| C WorldWide Group Holding A/S | 135,809 | 135,809 | 0 | 0.28 | 0.27 | -0.01 | hold |
| Soleus Capital Management, L.P. | 84,100 | 126,000 | +41,900 | 1.31 | 2.04 | +0.73 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 5,959 | 123,469 | +117,510 | 0.00 | 0.01 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 110,199 | 118,746 | +8,547 | 0.20 | 0.21 | +0.02 | buy |
| First Turn Management, LLC | 130,850 | 109,222 | -21,628 | 3.48 | 3.26 | -0.22 | sell |
| BRAIDWELL LP | 177,089 | 107,179 | -69,910 | 1.02 | 0.62 | -0.40 | sell |
| Handelsbanken Fonder AB | 105,200 | 106,500 | +1,300 | 0.08 | 0.09 | +0.00 | buy |
| Rock Springs Capital Management LP | 103,969 | 105,569 | +1,600 | 0.47 | 0.59 | +0.11 | buy |
| AMERIPRISE FINANCIAL INC | 43,391 | 101,996 | +58,605 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 75,844 | 93,629 | +17,785 | 0.00 | 0.00 | +0.00 | buy |
| S Squared Technology, LLC | 90,215 | 85,215 | -5,000 | 7.37 | 6.91 | -0.46 | sell |
| Integral Health Asset Management, LLC | 80,000 | 85,000 | +5,000 | 1.40 | 1.55 | +0.16 | buy |
| TimesSquare Capital Management, LLC | 97,161 | 83,039 | -14,122 | 0.25 | 0.24 | -0.01 | sell |
| JANE STREET GROUP, LLC | 93,745 | 77,832 | -15,913 | 0.02 | 0.02 | -0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 60,725 | 74,752 | +14,027 | 0.01 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 32,099 | 71,685 | +39,586 | 0.01 | 0.01 | +0.01 | buy |
| Man Group plc | 95,858 | 69,250 | -26,608 | 0.05 | 0.03 | -0.01 | sell |
| Decheng Capital LLC | 65,772 | 65,772 | 0 | 1.57 | 3.70 | +2.13 | hold |
| Corient Private Wealth LLC | 35,972 | 65,000 | +29,028 | 0.01 | 0.02 | +0.01 | buy |
| Legal & General Group Plc | 19,550 | 64,589 | +45,039 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 124,203 | 59,810 | -64,393 | 0.06 | 0.03 | -0.03 | sell |
| TD ASSET MANAGEMENT INC | 69,162 | 58,080 | -11,082 | 0.01 | 0.01 | -0.00 | sell |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 0 | 54,656 | +54,656 | 0.00 | 0.06 | +0.06 | buy |
| PRUDENTIAL FINANCIAL INC | 37,845 | 46,538 | +8,693 | 0.01 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 39,024 | 43,372 | +4,348 | 0.01 | 0.02 | +0.00 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 35,700 | 42,600 | +6,900 | 0.46 | 0.48 | +0.02 | buy |
| Rafferty Asset Management, LLC | 53,367 | 41,800 | -11,567 | 0.04 | 0.03 | -0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 41,298 | 41,015 | -283 | 0.01 | 0.01 | +0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 39,484 | 40,380 | +896 | 0.01 | 0.01 | -0.00 | buy |
| SEI INVESTMENTS CO | 33,752 | 40,115 | +6,363 | 0.01 | 0.01 | +0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 34,189 | 37,324 | +3,135 | 0.07 | 0.07 | +0.01 | buy |
| GW&K Investment Management, LLC | 37,528 | 37,126 | -402 | 0.06 | 0.06 | +0.00 | sell |
| Swiss National Bank | 36,200 | 36,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SEGALL BRYANT & HAMILL, LLC | 0 | 34,737 | +34,737 | 0.00 | 0.11 | +0.11 | buy |
| Janney Montgomery Scott LLC | 17,843 | 31,632 | +13,789 | 0.01 | 0.02 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 37,166 | 29,966 | -7,200 | 0.12 | 0.11 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 23,760 | 29,720 | +5,960 | 0.00 | 0.00 | +0.00 | buy |
| Global IMC LLC | 28,842 | 28,843 | +1 | 1.19 | 1.19 | +0.00 | buy |
| UBS Group AG | 51,028 | 28,556 | -22,472 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,028 | 28,381 | +10,353 | 0.00 | 0.01 | +0.00 | buy |
| CASTLEARK MANAGEMENT LLC | 28,520 | 28,280 | -240 | 0.21 | 0.21 | +0.00 | sell |
| CANADA LIFE ASSURANCE Co | 3,128 | 27,373 | +24,245 | 0.00 | 0.01 | +0.01 | buy |
| Informed Momentum Co LLC | 26,435 | 26,284 | -151 | 0.73 | 0.78 | +0.05 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 16,215 | 25,310 | +9,095 | 0.01 | 0.01 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 22,270 | +22,270 | 0.00 | 0.03 | +0.03 | buy |
| Hennion & Walsh Asset Management, Inc. | 33,154 | 21,650 | -11,504 | 0.32 | 0.20 | -0.11 | sell |
| CITIGROUP INC | 52,118 | 21,210 | -30,908 | 0.01 | 0.00 | -0.01 | sell |
| Hillsdale Investment Management Inc. | 0 | 21,000 | +21,000 | 0.00 | 0.30 | +0.30 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 20,625 | +20,625 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 21,614 | 19,088 | -2,526 | 0.00 | 0.00 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 19,000 | 19,000 | 0 | 0.32 | 0.33 | +0.01 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 18,660 | 18,425 | -235 | 0.00 | 0.00 | -0.00 | sell |
| Erste Asset Management GmbH | 18,200 | 18,200 | 0 | 0.04 | 0.04 | +0.00 | hold |
| Verition Fund Management LLC | 61,800 | 17,989 | -43,811 | 0.11 | 0.03 | -0.08 | sell |
| Nicholas Investment Partners, LP | 0 | 17,327 | +17,327 | 0.00 | 0.33 | +0.33 | buy |
| Fiera Capital Corp | 16,078 | 16,208 | +130 | 0.01 | 0.01 | +0.00 | buy |
| CWM, LLC | 23,850 | 15,618 | -8,232 | 0.02 | 0.01 | -0.01 | sell |
| DekaBank Deutsche Girozentrale | 15,503 | 15,503 | 0 | 0.01 | 0.01 | +0.00 | hold |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 0 | 14,900 | +14,900 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 18,272 | 14,892 | -3,380 | 0.04 | 0.03 | -0.01 | sell |
| State of Alaska, Department of Revenue | 0 | 14,587 | +14,587 | 0.00 | 0.03 | +0.03 | buy |
| WELLS FARGO & COMPANY/MN | 9,158 | 14,490 | +5,332 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 11,104 | 14,317 | +3,213 | 0.01 | 0.02 | +0.00 | buy |
| EFG Asset Management (North America) Corp. | 12,495 | 12,555 | +60 | 0.38 | 0.40 | +0.02 | buy |
| Louisiana State Employees Retirement System | 0 | 12,500 | +12,500 | 0.00 | 0.04 | +0.04 | buy |
| DEUTSCHE BANK AG\ | 12,809 | 12,270 | -539 | 0.00 | 0.00 | -0.00 | sell |
| State of New Jersey Common Pension Fund D | 17,759 | 12,010 | -5,749 | 0.01 | 0.01 | +0.00 | sell |
| NORGES BANK | 11,340 | 11,340 | 0 | 0.00 | 0.00 | -0.00 | hold |
| D. E. Shaw & Co., Inc. | 82,027 | 11,046 | -70,981 | 0.02 | 0.00 | -0.02 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 9,308 | 11,020 | +1,712 | 0.00 | 0.00 | +0.00 | buy |
| YOUSIF CAPITAL MANAGEMENT, LLC | 0 | 10,104 | +10,104 | 0.00 | 0.02 | +0.02 | buy |