| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 4,320,832 | 4,334,761 | +13,929 | 0.05 | 0.03 | -0.02 | buy |
| BlackRock, Inc. | 3,943,165 | 3,845,155 | -98,010 | 0.02 | 0.01 | -0.00 | sell |
| VANGUARD GROUP INC | 2,825,282 | 2,822,888 | -2,394 | 0.01 | 0.01 | -0.00 | sell |
| Avoro Capital Advisors LLC | 2,731,000 | 2,660,000 | -71,000 | 7.69 | 6.40 | -1.28 | sell |
| STATE STREET CORP | 1,226,707 | 1,355,346 | +128,639 | 0.01 | 0.01 | -0.00 | buy |
| Capital World Investors | 954,468 | 942,249 | -12,219 | 0.03 | 0.02 | -0.01 | sell |
| Soleus Capital Management, L.P. | 441,758 | 922,958 | +481,200 | 6.25 | 8.76 | +2.52 | buy |
| BRAIDWELL LP | 400,744 | 727,811 | +327,067 | 2.54 | 3.42 | +0.88 | buy |
| Frazier Life Sciences Management, L.P. | 688,460 | 688,460 | 0 | 5.67 | 3.78 | -1.89 | hold |
| Redmile Group, LLC | 737,675 | 663,471 | -74,204 | 12.57 | 9.71 | -2.86 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 612,353 | 619,547 | +7,194 | 0.01 | 0.01 | -0.00 | buy |
| Hood River Capital Management LLC | 524,644 | 533,023 | +8,379 | 1.61 | 1.02 | -0.59 | buy |
| GOLDMAN SACHS GROUP INC | 233,640 | 530,361 | +296,721 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 533,919 | 505,889 | -28,030 | 0.02 | 0.02 | -0.01 | sell |
| NORGES BANK | 273,209 | 282,706 | +9,497 | 0.01 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 410,861 | 261,383 | -149,478 | 0.01 | 0.00 | -0.01 | sell |
| NORTHERN TRUST CORP | 259,995 | 251,408 | -8,587 | 0.01 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 250,514 | 246,180 | -4,334 | 0.01 | 0.01 | -0.00 | sell |
| MORGAN STANLEY | 298,205 | 234,421 | -63,784 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 575,506 | 234,320 | -341,186 | 0.03 | 0.01 | -0.02 | sell |
| FIRST TRUST ADVISORS LP | 33,125 | 222,370 | +189,245 | 0.01 | 0.02 | +0.02 | buy |
| Nuveen, LLC | 234,180 | 188,019 | -46,161 | 0.01 | 0.01 | -0.01 | sell |
| Bank of New York Mellon Corp | 169,179 | 160,517 | -8,662 | 0.01 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 222,043 | 150,616 | -71,427 | 0.26 | 0.11 | -0.15 | sell |
| SEGALL BRYANT & HAMILL, LLC | 145,337 | 148,614 | +3,277 | 0.40 | 0.29 | -0.11 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 147,980 | +147,980 | 0.00 | 0.84 | +0.84 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 126,337 | 140,883 | +14,546 | 0.01 | 0.01 | -0.00 | buy |
| Pictet Asset Management Holding SA | 65,262 | 130,537 | +65,275 | 0.01 | 0.02 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 92,561 | 121,812 | +29,251 | 0.00 | 0.00 | -0.00 | buy |
| TimesSquare Capital Management, LLC | 142,183 | 114,204 | -27,979 | 0.41 | 0.23 | -0.19 | sell |
| MARSHALL WACE, LLP | 17,224 | 112,382 | +95,158 | 0.00 | 0.02 | +0.01 | buy |
| S Squared Technology, LLC | 97,215 | 109,215 | +12,000 | 8.97 | 6.33 | -2.64 | buy |
| Aberdeen Group plc | 37,301 | 108,518 | +71,217 | 0.01 | 0.03 | +0.01 | buy |
| Logos Global Management LP | 0 | 100,000 | +100,000 | 0.00 | 1.84 | +1.84 | buy |
| UBS Group AG | 81,119 | 97,240 | +16,121 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 44,997 | 92,871 | +47,874 | 0.00 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 100,774 | 91,153 | -9,621 | 0.00 | 0.00 | -0.00 | sell |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 0 | 91,099 | +91,099 | 0.00 | 0.03 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 11,200 | 89,800 | +78,600 | 0.00 | 0.02 | +0.01 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 80,264 | 86,688 | +6,424 | 0.06 | 0.05 | -0.01 | buy |
| C WorldWide Group Holding A/S | 85,809 | 85,809 | 0 | 0.19 | 0.16 | -0.03 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 72,815 | 80,123 | +7,308 | 0.01 | 0.01 | -0.01 | buy |
| Invesco Ltd. | 254,486 | 70,888 | -183,598 | 0.01 | 0.00 | -0.01 | sell |
| RHUMBLINE ADVISERS | 68,727 | 70,753 | +2,026 | 0.01 | 0.01 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 65,961 | 68,735 | +2,774 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 66,509 | 68,393 | +1,884 | 0.00 | 0.00 | -0.00 | buy |
| Handelsbanken Fonder AB | 74,300 | 66,800 | -7,500 | 0.06 | 0.03 | -0.02 | sell |
| Decheng Capital LLC | 65,000 | 66,000 | +1,000 | 3.29 | 2.29 | -1.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 64,601 | 63,993 | -608 | 0.01 | 0.01 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 60,508 | 62,835 | +2,327 | 0.00 | 0.00 | -0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 59,978 | 59,978 | 0 | 0.05 | 0.04 | -0.02 | hold |
| Alyeska Investment Group, L.P. | 0 | 53,934 | +53,934 | 0.00 | 0.03 | +0.03 | buy |
| CITIGROUP INC | 73,525 | 52,533 | -20,992 | 0.01 | 0.01 | -0.01 | sell |
| FEDERATED HERMES, INC. | 12,781 | 42,743 | +29,962 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 41,800 | 41,400 | -400 | 0.01 | 0.00 | -0.00 | sell |
| Corient Private Wealth LLC | 42,127 | 40,538 | -1,589 | 0.01 | 0.01 | -0.00 | sell |
| Palisades Investment Partners, LLC | 40,696 | 40,203 | -493 | 3.68 | 2.42 | -1.27 | sell |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 36,431 | 38,357 | +1,926 | 0.08 | 0.06 | -0.02 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 41,518 | 38,146 | -3,372 | 0.18 | 0.13 | -0.05 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 24,183 | 36,089 | +11,906 | 0.01 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 24,161 | 34,665 | +10,504 | 0.02 | 0.02 | -0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 34,560 | +34,560 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 31,120 | 31,120 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Man Group plc | 0 | 30,481 | +30,481 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 33,829 | 30,252 | -3,577 | 0.01 | 0.01 | -0.00 | sell |
| GW&K Investment Management, LLC | 34,100 | 30,175 | -3,925 | 0.06 | 0.04 | -0.02 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 24,929 | 26,638 | +1,709 | 0.02 | 0.01 | -0.01 | buy |
| Verition Fund Management LLC | 18,625 | 26,514 | +7,889 | 0.02 | 0.02 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 27,311 | 26,151 | -1,160 | 0.01 | 0.01 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 32,366 | 24,680 | -7,686 | 0.01 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 23,382 | 23,382 | 0 | 0.01 | 0.00 | -0.00 | hold |
| EFG Asset Management (North America) Corp. | 17,371 | 22,878 | +5,507 | 0.52 | 0.44 | -0.08 | buy |
| Biondo Investment Advisors, LLC | 0 | 21,240 | +21,240 | 0.00 | 0.38 | +0.38 | buy |
| CANADA LIFE ASSURANCE Co | 24,609 | 20,847 | -3,762 | 0.01 | 0.00 | -0.00 | sell |
| SYNOVUS FINANCIAL CORP | 0 | 20,643 | +20,643 | 0.00 | 0.03 | +0.03 | buy |
| Atle Fund Management AB | 23,491 | 20,158 | -3,333 | 1.87 | 1.19 | -0.68 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 20,126 | 20,126 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 40,268 | 20,080 | -20,188 | 0.01 | 0.00 | -0.00 | sell |
| Edgestream Partners, L.P. | 0 | 19,678 | +19,678 | 0.00 | 0.08 | +0.08 | buy |
| SEI INVESTMENTS CO | 18,691 | 19,300 | +609 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 21,737 | 19,135 | -2,602 | 0.00 | 0.00 | -0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 18,590 | 18,700 | +110 | 0.01 | 0.01 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 19,013 | 18,425 | -588 | 0.00 | 0.00 | -0.00 | sell |
| Erste Asset Management GmbH | 18,200 | 18,200 | 0 | 0.04 | 0.02 | -0.02 | hold |
| ALPS ADVISORS INC | 1,920 | 17,462 | +15,542 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 17,135 | 16,547 | -588 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 15,979 | 15,650 | -329 | 0.01 | 0.00 | -0.00 | sell |
| Fiera Capital Corp | 15,645 | 15,511 | -134 | 0.01 | 0.01 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 15,503 | 15,503 | 0 | 0.01 | 0.00 | -0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15,893 | 15,283 | -610 | 0.01 | 0.00 | -0.00 | sell |
| State of Alaska, Department of Revenue | 14,024 | 15,130 | +1,106 | 0.03 | 0.02 | -0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 12,399 | 15,116 | +2,717 | 0.00 | 0.00 | -0.00 | buy |
| State of New Jersey Common Pension Fund D | 10,351 | 15,033 | +4,682 | 0.01 | 0.01 | -0.00 | buy |
| MetLife Investment Management, LLC | 14,524 | 14,746 | +222 | 0.01 | 0.01 | -0.00 | buy |
| Fieldview Capital Management, LLC | 16,342 | 14,546 | -1,796 | 0.42 | 0.30 | -0.11 | sell |
| Rhenman & Partners Asset Management AB | 17,750 | 12,750 | -5,000 | 0.37 | 0.22 | -0.15 | sell |
| SG Americas Securities, LLC | 1,312 | 12,607 | +11,295 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 60,388 | 12,562 | -47,826 | 0.01 | 0.00 | -0.01 | sell |
| Illinois Municipal Retirement Fund | 12,762 | 12,311 | -451 | 0.03 | 0.02 | -0.01 | sell |
| Evolutionary Tree Capital Management, LLC | 13,343 | 12,296 | -1,047 | 2.80 | 1.79 | -1.00 | sell |